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Fusion gene ID: 3428 |
FusionGeneSummary for ATP6AP2_EIF3M |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP6AP2_EIF3M | Fusion gene ID: 3428 | Hgene | Tgene | Gene symbol | ATP6AP2 | EIF3M | Gene ID | 10159 | 10480 |
| Gene name | ATPase H+ transporting accessory protein 2 | eukaryotic translation initiation factor 3 subunit M | |
| Synonyms | APT6M8-9|ATP6IP2|ATP6M8-9|ELDF10|HT028|M8-9|MRXE|MRXSH|MSTP009|PRR|RENR|XMRE|XPDS | B5|GA17|PCID1|TANGO7|hfl-B5 | |
| Cytomap | Xp11.4 | 11p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | renin receptorATPase H(+)-transporting lysosomal-interacting protein 2ATPase, H+ transporting, lysosomal (vacuolar proton pump) membrane sector associated protein M8-9ATPase, H+ transporting, lysosomal accessory protein 2ATPase, H+ transporting, lysos | eukaryotic translation initiation factor 3 subunit MB5 receptorPCI domain containing 1 (herpesvirus entry mediator)PCI domain-containing protein 1dendritic cell proteinfetal lung protein B5transport and golgi organization 7 homolog | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | O75787 | Q7L2H7 | |
| Ensembl transtripts involved in fusion gene | ENST00000535539, ENST00000378438, ENST00000544975, ENST00000486558, ENST00000535777, | ENST00000531120, ENST00000524896, ENST00000532054, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 5 X 4=140 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/140*10)=-0.807354922057604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATP6AP2 [Title/Abstract] AND EIF3M [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP6AP2 | GO:0002003 | angiotensin maturation | 12045255|15746149 |
| Hgene | ATP6AP2 | GO:0032914 | positive regulation of transforming growth factor beta1 production | 16374430 |
| Hgene | ATP6AP2 | GO:0043408 | regulation of MAPK cascade | 12045255|15746149 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-6348-01A | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000535539 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535539 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000535539 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| In-frame | ENST00000378438 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| In-frame | ENST00000378438 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| 5CDS-intron | ENST00000378438 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000544975 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000544975 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000544975 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000486558 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000486558 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000486558 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535777 | ENST00000531120 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-3CDS | ENST00000535777 | ENST00000524896 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
| intron-intron | ENST00000535777 | ENST00000532054 | ATP6AP2 | chrX | 40465889 | + | EIF3M | chr11 | 32611132 | + |
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FusionProtFeatures for ATP6AP2_EIF3M |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP6AP2 | EIF3M |
| Component of the eukaryotic translation initiationfactor 3 (eIF-3) complex, which is required for several steps inthe initiation of protein synthesis (PubMed:17403899,PubMed:25849773, PubMed:27462815). The eIF-3 complex associateswith the 40S ribosome and facilitates the recruitment of eIF-1,eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNArecruitment to the 43S PIC and scanning of the mRNA for AUGrecognition. The eIF-3 complex is also required for disassemblyand recycling of post-termination ribosomal complexes andsubsequently prevents premature joining of the 40S and 60Sribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of asubset of mRNAs involved in cell proliferation, including cellcycling, differentiation and apoptosis, and uses different modesof RNA stem-loop binding to exert either translational activationor repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03012,ECO:0000269|PubMed:17403899, ECO:0000269|PubMed:25849773,ECO:0000269|PubMed:27462815}. (Microbial infection) May favor virus entry in case ofinfection with herpes simplex virus 1 (HSV1) or herpes simplexvirus 2 (HSV2). {ECO:0000269|PubMed:15919898}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP6AP2_EIF3M |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000531120_chr11_32611132_+_874aa MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPP GSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVD LLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFD TSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMDXMLPVPELEK GVGNWLFCXNISFSVLXSRXYTLHLXKKIKFCSLFCVCLXCFSRVNYSIDVNPTVVXIPXYAXILXYSHLITLISFCLMNLEICTERNVK HLEXLVLWKKVHXIYXTNLRMLNFFTQHRXKSYLGYCILXTICKCLNLMXITLKQEKRFLTXSSPKIWMCLYNRLVLELYLSNRGQLFFN PLLQVCXPTWANMDTKNTTLIXEETSLVEYIDAFHYTHKNPXGTFXGMNIKHFYFSNFSPCVSYYGLWYNFILXNIKWKWVNSTFYVGVD QCLSRVTNKVNDDSKVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFD HLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAF >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000524896_chr11_32611132_+_874aa MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPP GSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVD LLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFD TSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMDXMLPVPELEK GVGNWLFCXNISFSVLXSRXYTLHLXKKIKFCSLFCVCLXCFSRVNYSIDVNPTVVXIPXYAXILXYSHLITLISFCLMNLEICTERNVK HLEXLVLWKKVHXIYXTNLRMLNFFTQHRXKSYLGYCILXTICKCLNLMXITLKQEKRFLTXSSPKIWMCLYNRLVLELYLSNRGQLFFN PLLQVCXPTWANMDTKNTTLIXEETSLVEYIDAFHYTHKNPXGTFXGMNIKHFYFSNFSPCVSYYGLWYNFILXNIKWKWVNSTFYVGVD QCLSRVTNKVNDDSKVRKWISDWNLTTEKKHTLLRLLYEALVDCKKSDAASKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNAFLFD HLLTLKPVKFLEGELIHDLLTIFVSAKLASYVKFYQNNKDFIDSLGLLHEQNMAKMRLLTFMGMAVENKEISFDTMQQELQIGADDVEAF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000531120_chr11_32611132_+_2622nt ATGGCTGTGTTTGTCGTGCTCCTGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTC CGAAATGGAAATTGGCCTATACCAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGG CCAGGACTCGCAGTGGGTAACCTGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCA GGCAGTGTCATTTCGTACCCTTTGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAA ACTCCTGTTGTTTTGCAGTTGGCTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACC TTGCGCCAGCTCCGTAATCGCCTGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGAC CTGCTCTTTCTTTCTGAACTGCAAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGAT TTATATTCACTGGAGCTGGCAGGTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTT GTTGACGCTCTGCAAAAGTTTGCAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGAC ACCTCCCTCATTAGGAAGACAAGGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAAT TTTGAATATTCCGTGGTTTTCAACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAAC ATGGATCCTGGATATGATAGCATCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAG GGGGTTGGAAATTGGCTGTTTTGTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAA TTTTGTTCTTTATTTTGTGTGTGCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAA TATGCTTGAATATTATGATATAGCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAA CATTTAGAATAGCTCGTGTTATGGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGA AAATCATATTTGGGCTATTGTATACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTA ACTTAGAGTAGCCCTAAAATATGGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAAC CCTCTTCTGCAAGTTTGTTGACCTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTAT ATAGATGCTTTTCATTATACACACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCC TGTGTAAGTTACTATGGTTTGTGGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGAC CAATGTCTATCAAGAGTGACAAATAAAGTTAATGATGATTCCAAAGTTAGAAAATGGATTTCTGACTGGAATCTCACCACTGAAAAAAAG CACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTCAAAAGTCATGGTGGAATTGCTCGGAAGT TACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGAC CACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCA TATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACT TTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTT GTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACA TTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTT >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000524896_chr11_32611132_+_2622nt ATGGCTGTGTTTGTCGTGCTCCTGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTC CGAAATGGAAATTGGCCTATACCAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGG CCAGGACTCGCAGTGGGTAACCTGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCA GGCAGTGTCATTTCGTACCCTTTGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAA ACTCCTGTTGTTTTGCAGTTGGCTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACC TTGCGCCAGCTCCGTAATCGCCTGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGAC CTGCTCTTTCTTTCTGAACTGCAAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGAT TTATATTCACTGGAGCTGGCAGGTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTT GTTGACGCTCTGCAAAAGTTTGCAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGAC ACCTCCCTCATTAGGAAGACAAGGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAAT TTTGAATATTCCGTGGTTTTCAACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAAC ATGGATCCTGGATATGATAGCATCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAG GGGGTTGGAAATTGGCTGTTTTGTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAA TTTTGTTCTTTATTTTGTGTGTGCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAA TATGCTTGAATATTATGATATAGCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAA CATTTAGAATAGCTCGTGTTATGGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGA AAATCATATTTGGGCTATTGTATACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTA ACTTAGAGTAGCCCTAAAATATGGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAAC CCTCTTCTGCAAGTTTGTTGACCTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTAT ATAGATGCTTTTCATTATACACACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCC TGTGTAAGTTACTATGGTTTGTGGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGAC CAATGTCTATCAAGAGTGACAAATAAAGTTAATGATGATTCCAAAGTTAGAAAATGGATTTCTGACTGGAATCTCACCACTGAAAAAAAG CACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTCAAAAGTCATGGTGGAATTGCTCGGAAGT TACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATTGAAAGATCCAAATGCATTTCTTTTTGAC CACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAACCATTTTTGTGAGTGCTAAATTGGCATCA TATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACAGAATATGGCAAAAATGAGACTACTTACT TTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCAGATTGGAGCTGATGATGTTGAAGCATTT GTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGTAGTTGTCAGTCATAGCACACATCGGACA TTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAACAAAGTGAAAAACAGCCTTTTGAGTCTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000531120_chr11_32611132_+_6603nt GTGGAGAAAGCGGCAGCTGTCCCAGCGGAAGCGACGAAGGGACGGGACCCGGGAGCCTGGACGAGTCCGAGCGCGTCACCTCCTCACGCT GCGGCTGTCGCCCGTGTCCCGCCGGCCCGTTCCGTGTCGCCCCGCAGTGCTGCGGCCGCCGCGGCACCATGGCTGTGTTTGTCGTGCTCC TGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATAC CAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACC TGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCGTACCCTT TGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGG CTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTGCGCCAGCTCCGTAATCGCC TGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCTGAACTGC AAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTATATTCACTGGAGCTGGCAG GTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTCTGCAAAAGTTTG CAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTCATTAGGAAGACAA GGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCCGTGGTTTTCA ACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCA TCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAGGGGGTTGGAAATTGGCTGTTTT GTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAATTTTGTTCTTTATTTTGTGTGT GCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAATATGCTTGAATATTATGATATA GCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAACATTTAGAATAGCTCGTGTTAT GGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTA TACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTAACTTAGAGTAGCCCTAAAATAT GGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGAC CTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATATAGATGCTTTTCATTATACAC ACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCCTGTGTAAGTTACTATGGTTTGT GGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAA ATAAAGTTAATGATGATTCCAAAAAAAGCACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTC AAAAGTCATGGTGGAATTGCTCGGAAGTTACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC ATTATTTTAATCTGTTGTTTTTTTCCAACGTCTCTTCTGCTTTTCTTTTCTTTGGCTGGTTGTCATTTTCTAAACTTAGTAAATTTTCAC TTTTATTTAGTTGATTCGTAATGAGGCTCTGCCAGTCATCATCACCAGAAGTATTTTTAGTCGTCTTGATTGCCTGCAAATGGCTTTGTA GTGGAGTTGATATCAGAGGCTTTGTTTTCACCTGGGAAAGATAAACTAATTTTACCTTCGAAATTATTATACAAAAGATTTTAAAGAGTC TGTAAAGCCTCTGCAGTTATGAGTATGTGGTAAAACCACCATCTCTTGGCTGATTTCCACTACCTTAGTAGTTCTGGCACCAGAAAAGTA TACAATGTGAATGTGTAGGCTTATGTAGTAGATCTTCAAAATCTCTAATATATAACTGAAGTAAAGTGTACAAAAACTGCCTTTTACTAC TTCATGTTTCCTCCCATGCTTCAGAACACCATTGTTGAAGAAACAGGAAGGGCAGTGAGATATTTGGAAGTTGGCATGTTTTCAAGACAC TGTATTGGGTAATTTTAAAAATAGTGTGTTAAATAACTTTTTCATTTTAAGGTTCTTTTCTGATGTTAAAATACTTACTGGAAATTTAGA AAATAGAGTAAAGTAGAAAGAAACTAAAAATCATTAGTAATCCCTTATCCAGAGAGGCTTGTTGACATTTTGGTATTATTTGCTGCTAGC GTTTTTTTCTATTTTTAGCCTATTTGATCATTCTATAGAATTTTATGTATTTTCCTCTGTGAGCAGTTTCTTAGGTCATTAAAAACAATT GTCTATGGCTGCAAAATACTCCCTTTTATGGATGTTTGATATATCTCCTACTACTGAATGTTTGTTTCCAGTTTATCCCTACCAAAAATT AATTCGAGTTAATTTCATGCAAAACAATCTTTGATGTTTTTGAGAGATTCCCAGATAAAATTTTCTCTTCAAAAGGAATACTGGGCCAGG CACTGTGACTCATACCTGTAATCCCAGCACTTTGGGAAACTGAGGCGAGTGGATTGCATGAGCTCAGGAGTCGAAAACTAGCCTGAGCAA CATGGCAAAACCCCATCTCTACCAAAAATTAGCTGGGCATGGTGGCATGCAACTGTAGTCCCAGCTCCTCGGAGGGCTGAGGTGCAAGGA TCATTTGAGCCCAGGAGGTGAAGGTTGCAATGAGCCAAGATCATGCCATTGCACTCCAGCCTGGACAACAGAGTGAGACCCTCTCTCAAA AATAAATAATAGATAAAACAAAAGGAATACTGAATTGTTTTCAAAATAACAATTATGGTGGGCTTTCTTTTAAGATAGGGTCTCACCCTG TCACCTAGGCTGGAGTGCAGTGGCACAATCACAGCTCATTGCAGCCTTGACCTCCCTGGATTCAGGTGATCCTCCCACCTTCACCTCCTG AGTACCTTGGACTACAGGCATGTGCCACCACACCCAGGTAATTTTTGTATTTTTTGCCATGTTGCCCAGGCTGGTCTCTCTTAACTCTTG GGCTCAAGTGATCTGACCATCTCGGTCTCCCAAAGTTCTAGGATTACAGGAGTGAGCCATACTGTGTTGTGTTTTAGTTGAAAGGGATAT ACACGTGTATTTTAGAAATATGAAACAGGATAAGAATTACATTAAAATCACCCAAGATCCCAACCACCATTAAAGAGTTTGTGTAAATCT TCTGGTCTCTTTTCTGTATACACTTTTTAAATACTGGGGTCATATTTTTATTGGTTTATATGCTATGTTAAACATTTTTAGCATTTCCTC CTGTTCTTAAGTCTGTTAAGAGGATAGCTCCATCATATTCTGTGTTCTGCAAATTATTTCTGGACATTTAAATTGTAAGAAAATGGTCAC TGTTAACTAGGCTGCAGTGATTATCATTTGTTCATAAATCTTTGTGAAGATCTTTGGGTACTGCCTTACATTAAAATCTTTTTCAATTTG ACCAGTAAAAGTGGCATGTTAGTAACATTGTCATTTTCAGTGTTAGATTATGTAGTACTAAGTTTATTTTATTTTATTTTTGAGACAGAG TCTTGCACTGTCGCCCAGGCTGGAGTGCAGTGGCGCCATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGATTCTTCTGCCTC AGCCTCCCGAGTAGCTGGGATTACAGGCACCCACCACGATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACTATGTTG TCCAGGCTGGTCTCGAACGCCTGACCTCATGATCCACCTGCCTCGGCCTCCCAAAGTGTTGGGATTACAGGCATGAGCCACCCTGCCCGA CCTAGTAATACTTTTTTTTTTTTTTTTTTTTAATGAACTTAAATGTTTAGAATGGTAAGTTCACGGCTCCCTAAGGAGTGTTCCTTTTGG ATTGCTCTGTTTGGCTCCCTCCCTGAAATCCTATAGTCAGCCACTGGTCCCCTCAGAGAGTTTTACCTCTGATCTTTGGGGTGATTCTTT GTTCATATTTATCTGATTGGCTTTGTTCTTCCAAAAGTGTCTGCACAGGACTGCTAAGAGAACCTAGGCAAGTCATTTAATTTTTCTGGG CTTCAGTTTACTCATTAGCTTCTTTTAGTTCCCAGATGCTATTACTGGAAAGAATAACTAGTAATGGATAAAAACCTACATAAATATTTC CTATTTTGCCATCAAAGTGCTGGGTTCATTTTGGTGTATTTGGCATCCAAGTACAAATTAACAGTTTCCCAAAATCCTGATTCTTTGACT TTTTTATCTTGATGATGGAAAGGAAGGACACGTTTACTTGCTTTAGTTTCTTTCCCCTTAACTACCCACTTGCTGAGAGGGGTAGGAGCA GGGATTGGCTTTAGAGAAACAAGATACAGTGTAGATTAGCTAATGTTTGCGCTTAACAAAACTTGTCCTGTTTAACTTACCTGAGGGTTC TGCAGCCTACCGCAGTAATTTTAGTTCTAGCTGTTTTCAGATATATTGCCTTGTATCTTCGTTCTTTCGTCTCCTATCCTTTTTAGAAAT TTATCACCTGTTTCTCTTTCAGCCTGACTTACAAAATCTAATTTTTGGCCTAAAAATTTCCCCTAGCTTGGTACTAGTCCTTTTATTTCT GCCTGTGATTATATTTTAAAATTAAACTTAAATGAATCTAATTCATTGGATATATAAAAAAAAAAGTAAGTGGCTTGCTTTGCTTACTCT GGTTTTCCATCCTCATTCCTGGATATAATCAAGATTGCAGTAGGCTAACAATCTAATGCTGAAAACAAGAATGAAAAACATACCATCTTT TCAAGTTACTTTGGACCCATAGAGAGAAAGTGGATTGGTACTTAATACCTTCCCTGAATTTAACAGAATTGATGTGGACTGTACATAAAA >In-frame_ATP6AP2_ENST00000378438_chrX_40465889_+_EIF3M_ENST00000524896_chr11_32611132_+_3164nt GTGGAGAAAGCGGCAGCTGTCCCAGCGGAAGCGACGAAGGGACGGGACCCGGGAGCCTGGACGAGTCCGAGCGCGTCACCTCCTCACGCT GCGGCTGTCGCCCGTGTCCCGCCGGCCCGTTCCGTGTCGCCCCGCAGTGCTGCGGCCGCCGCGGCACCATGGCTGTGTTTGTCGTGCTCC TGGCGTTGGTGGCGGGTGTTTTGGGGAACGAGTTTAGTATATTAAAATCACCAGGGTCTGTTGTTTTCCGAAATGGAAATTGGCCTATAC CAGGAGAGCGGATCCCAGACGTGGCTGCATTGTCCATGGGCTTCTCTGTGAAAGAAGACCTTTCTTGGCCAGGACTCGCAGTGGGTAACC TGTTTCATCGTCCTCGGGCTACCGTCATGGTGATGGTGAAGGGAGTGAACAAACTGGCTCTACCCCCAGGCAGTGTCATTTCGTACCCTT TGGAGAATGCAGTTCCTTTTAGTCTTGACAGTGTTGCAAATTCCATTCACTCCTTATTTTCTGAGGAAACTCCTGTTGTTTTGCAGTTGG CTCCCAGTGAGGAAAGAGTGTATATGGTAGGGAAGGCAAACTCAGTGTTTGAAGACCTTTCAGTCACCTTGCGCCAGCTCCGTAATCGCC TGTTTCAAGAAAACTCTGTTCTCAGTTCACTCCCCCTCAATTCTCTGAGTAGGAACAATGAAGTTGACCTGCTCTTTCTTTCTGAACTGC AAGTGCTACATGATATTTCAAGCTTGCTGTCTCGTCATAAGCATCTAGCCAAGGATCATTCTCCTGATTTATATTCACTGGAGCTGGCAG GTTTGGATGAAATTGGGAAGCGTTATGGGGAAGACTCTGAACAATTCAGAGATGCTTCTAAGATCCTTGTTGACGCTCTGCAAAAGTTTG CAGATGACATGTACAGTCTTTATGGTGGGAATGCAGTGGTAGAGTTAGTCACTGTCAAGTCATTTGACACCTCCCTCATTAGGAAGACAA GGACTATCCTTGAGGCAAAACAAGCGAAGAACCCAGCAAGTCCCTATAACCTTGCATATAAGTATAATTTTGAATATTCCGTGGTTTTCA ACATGGTACTTTGGATAATGATCGCCTTGGCCTTGGCTGTGATTATCACCTCTTACAATATTTGGAACATGGATCCTGGATATGATAGCA TCATTTATAGGATGACAAACCAGAAGATTCGAATGGATTGAATGTTACCTGTGCCAGAATTAGAAAAGGGGGTTGGAAATTGGCTGTTTT GTTAAAATATATCTTTTAGTGTGCTTTAAAGTAGATAGTATACTTTACATTTATAAAAAAAAATCAAATTTTGTTCTTTATTTTGTGTGT GCCTGTGATGTTTTTCTAGAGTGAATTATAGTATTGACGTGAATCCCACTGTGGTATAGATTCCATAATATGCTTGAATATTATGATATA GCCATTTAATAACATTGATTTCATTCTGTTTAATGAATTTGGAAATATGCACTGAAAGAAATGTAAAACATTTAGAATAGCTCGTGTTAT GGAAAAAAGTGCACTGAATTTATTAGACAAACTTACGAATGCTTAACTTCTTTACACAGCATAGGTGAAAATCATATTTGGGCTATTGTA TACTATGAACAATTTGTAAATGTCTTAATTTGATGTAAATAACTCTGAAACAAGAGAAAAGGTTTTTAACTTAGAGTAGCCCTAAAATAT GGATGTGCTTATATAATCGCTTAGTTTTGGAACTGTATCTGAGTAACAGAGGACAGCTGTTTTTTAACCCTCTTCTGCAAGTTTGTTGAC CTACATGGGCTAATATGGATACTAAAAATACTACATTGATCTAAGAAGAAACTAGCCTTGTGGAGTATATAGATGCTTTTCATTATACAC ACAAAAATCCCTGAGGGACATTTTGAGGCATGAATATAAAACATTTTTATTTCAGTAACTTTTCCCCCTGTGTAAGTTACTATGGTTTGT GGTACAACTTCATTCTATAGAATATTAAGTGGAAGTGGGTGAATTCTACTTTTTATGTTGGAGTGGACCAATGTCTATCAAGAGTGACAA ATAAAGTTAATGATGATTCCAAAAAAAGCACACCCTTTTAAGACTACTTTATGAGGCACTTGTGGATTGTAAGAAGAGTGATGCTGCTTC AAAAGTCATGGTGGAATTGCTCGGAAGTTACACAGAGGACAATGCTTCCCAGGCTCGAGTTGATGCCCACAGGTGTATTGTACGAGCATT GAAAGATCCAAATGCATTTCTTTTTGACCACCTTCTTACTTTAAAACCAGTCAAGTTTTTGGAAGGCGAGCTTATTCATGATCTTTTAAC CATTTTTGTGAGTGCTAAATTGGCATCATATGTCAAGTTTTATCAGAATAATAAAGACTTCATTGATTCACTTGGCCTGTTACATGAACA GAATATGGCAAAAATGAGACTACTTACTTTTATGGGAATGGCAGTAGAAAATAAGGAAATTTCTTTTGACACAATGCAGCAAGAACTTCA GATTGGAGCTGATGATGTTGAAGCATTTGTTATTGACGCCGTAAGAACTAAAATGGTCTACTGCAAAATTGATCAGACCCAGAGAAAAGT AGTTGTCAGTCATAGCACACATCGGACATTTGGAAAACAGCAGTGGCAACAACTGTATGACACACTTAATGCCTGGAAACAAAATCTGAA CAAAGTGAAAAACAGCCTTTTGAGTCTTTCTGATACCTGAGTTTTTATGCTTATAATTTTTGTTCTTTGAAAAAAAAGCCCTAAATCATA GTAAAACATTATAAACTAAAAAAATTTGCCTAGTCTGGACAGTTATTGTCTCAAATTTATACTAAAATCACAAACTCCAGAGGATATGAA GTAATAAATTACAAGGGGTCACAATGTCTGTCATACAATACATAAATTCTGTTCTTTAAAAAAGGATATTGAAGAAGCAATGAGCACTTT AAAGAAAGGATAATATACAGAGAGAAGACAGAAGTAGAGTAATACAATTTCTTCACATTAGAAAAACTTGGAAAAGCAAAGACAAACTGT AGAGCTTTAAATACAACAGTCATTTTATTCTAGTAAAAACTATACCAGAATTTCAGTTACATAATTTCACTACTGAAAGCACTTATCTAC |
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FusionGenePPI for ATP6AP2_EIF3M |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP6AP2 | REN, USP20, ZBTB16, VKORC1, ATP6AP2, AGT, NXF1, VMA21, TCIRG1, ATP6V0A1, ATP6V0A2, ATP6V0D1, ATP6V1D, ATP6V1F, ATP6V1C1, ATP6AP1, PICK1, TMEM199, ATP6V0C, KIAA2013, ATP6V0D2, CCDC115, UNK, FKBP2, SDHB, WDR1, DTYMK, MECR, TCTN2, TCTN3, EVC2, TMEM17, TMEM216, TMEM67, CREB3, RHOA, RHOG, ATP6V1A, ATP6V1B2, CD59, CLCN7, CLTA, CPM, ENO1, ETFB, FLOT2, GLB1, PDIA3, JUP, KTN1, LGALS1, PLD1, PON2, RALA, RANGAP1, RAP1B, TFRC, RAB7A, NUMB, RAB11A, TOP3B, GPRC5A, GOSR1, ATP6V1G1, SEC22B, CLINT1, IST1, URB2, ACTR2, FLOT1, STUB1, BASP1, LAMTOR5, PPP1R13L, CKAP4, WWP2, RAB11FIP2, SCFD1, CD2AP, SH3BP4, FKBP8, CHMP2B, TES, ZBTB11, CHMP2A, GOLIM4, LAMTOR2, OSTM1, PACSIN3, CERS2, RAB14, SLC38A2, SLC35F6, LAMTOR1, JPH1, ESYT2, KIDINS220, BEGAIN, TMUB1, WDR75, PHLDB2, SPECC1, PRKCDBP, MITD1, PTRF, RABL3, UBAC2, GLP1R, ATP6V1E1 | EIF3M | EIF1B, EIF4A2, EIF3A, EIF3F, EIF3H, TADA2A, EIF3B, APP, EIF3C, EIF3E, EIF3D, EIF3I, EIF3K, EIF3L, EIF3G, MMS19, NPM1, EXOSC10, SRPK1, FAM96B, HUWE1, EGFR, EIF3CL, USP34, HSPB1, AHCYL1, COPS4, RPN1, EIF3J, NTRK1, MED4, HERC2, NF2, PTP4A1, PSMD12, EIF4A1, GPBP1L1, UBE2N, CYLD, DLD, TRIM25, G3BP1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP6AP2_EIF3M |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP6AP2_EIF3M |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATP6AP2 | C0016059 | Fibrosis | 1 | CTD_human |
| Hgene | ATP6AP2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
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