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Fusion gene ID: 34261 |
FusionGeneSummary for SLC25A4_POGZ |
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Fusion gene information | Fusion gene name: SLC25A4_POGZ | Fusion gene ID: 34261 | Hgene | Tgene | Gene symbol | SLC25A4 | POGZ | Gene ID | 291 | 23126 |
Gene name | solute carrier family 25 member 4 | pogo transposable element derived with ZNF domain | |
Synonyms | AAC1|ANT|ANT 1|ANT1|MTDPS12|MTDPS12A|PEO2|PEO3|PEOA2|T1 | MRD37|WHSUS|ZNF280E|ZNF635|ZNF635m | |
Cytomap | 4q35.1 | 1q21.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ADP/ATP translocase 1ADP,ATP carrier protein 1ADP,ATP carrier protein, heart/skeletal muscleadenine nucleotide translocator 1 (skeletal muscle)heart/skeletal muscle ATP/ADP translocatorsolute carrier family 25 (mitochondrial carrier; adenine nucleoti | pogo transposable element with ZNF domainputative protein product of Nbla00003zinc finger protein 280Ezinc finger protein 635 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P12235 | Q7Z3K3 | |
Ensembl transtripts involved in fusion gene | ENST00000281456, | ENST00000392723, ENST00000361398, ENST00000271715, ENST00000368863, ENST00000409503, ENST00000531094, ENST00000540984, ENST00000491586, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 3=36 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SLC25A4 [Title/Abstract] AND POGZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | N45527 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000281456 | ENST00000392723 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000361398 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000271715 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000368863 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000409503 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000531094 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000540984 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
3UTR-intron | ENST00000281456 | ENST00000491586 | SLC25A4 | chr4 | 186068790 | + | POGZ | chr1 | 151418993 | - |
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FusionProtFeatures for SLC25A4_POGZ |
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Hgene | Tgene |
SLC25A4 | POGZ |
Involved in mitochondrial ADP/ATP transport. Catalyzesthe exchange of cytoplasmic ADP with mitochondrial ATP across themitochondrial inner membrane. {ECO:0000269|PubMed:27693233}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC25A4_POGZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC25A4_POGZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A4_POGZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SLC25A4 | P12235 | DB00720 | Clodronic Acid | ADP/ATP translocase 1 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for SLC25A4_POGZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC25A4 | C1836460 | Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 2 | 4 | CTD_human;UNIPROT |
Hgene | SLC25A4 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Hgene | SLC25A4 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SLC25A4 | C0853897 | Diabetic Cardiomyopathies | 1 | CTD_human |