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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34261

FusionGeneSummary for SLC25A4_POGZ

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A4_POGZ
Fusion gene ID: 34261
HgeneTgene
Gene symbol

SLC25A4

POGZ

Gene ID

291

23126

Gene namesolute carrier family 25 member 4pogo transposable element derived with ZNF domain
SynonymsAAC1|ANT|ANT 1|ANT1|MTDPS12|MTDPS12A|PEO2|PEO3|PEOA2|T1MRD37|WHSUS|ZNF280E|ZNF635|ZNF635m
Cytomap

4q35.1

1q21.3

Type of geneprotein-codingprotein-coding
DescriptionADP/ATP translocase 1ADP,ATP carrier protein 1ADP,ATP carrier protein, heart/skeletal muscleadenine nucleotide translocator 1 (skeletal muscle)heart/skeletal muscle ATP/ADP translocatorsolute carrier family 25 (mitochondrial carrier; adenine nucleotipogo transposable element with ZNF domainputative protein product of Nbla00003zinc finger protein 280Ezinc finger protein 635
Modification date2018052320180523
UniProtAcc

P12235

Q7Z3K3

Ensembl transtripts involved in fusion geneENST00000281456, ENST00000392723, 
ENST00000361398, ENST00000271715, 
ENST00000368863, ENST00000409503, 
ENST00000531094, ENST00000540984, 
ENST00000491586, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC25A4 [Title/Abstract] AND POGZ [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1N45527SLC25A4chr4

186068790

+POGZchr1

151418993

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000281456ENST00000392723SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000361398SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000271715SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000368863SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000409503SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000531094SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000540984SLC25A4chr4

186068790

+POGZchr1

151418993

-
3UTR-intronENST00000281456ENST00000491586SLC25A4chr4

186068790

+POGZchr1

151418993

-

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FusionProtFeatures for SLC25A4_POGZ


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A4

P12235

POGZ

Q7Z3K3

Involved in mitochondrial ADP/ATP transport. Catalyzesthe exchange of cytoplasmic ADP with mitochondrial ATP across themitochondrial inner membrane. {ECO:0000269|PubMed:27693233}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A4_POGZ


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A4_POGZ


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A4_POGZ


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC25A4P12235DB00720Clodronic AcidADP/ATP translocase 1small moleculeapproved|investigational|vet_approved

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RelatedDiseases for SLC25A4_POGZ


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A4C1836460Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Dominant, 24CTD_human;UNIPROT
HgeneSLC25A4C0005586Bipolar Disorder2PSYGENET
HgeneSLC25A4C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC25A4C0853897Diabetic Cardiomyopathies1CTD_human