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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34255

FusionGeneSummary for SLC25A44_RAB33A

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A44_RAB33A
Fusion gene ID: 34255
HgeneTgene
Gene symbol

SLC25A44

RAB33A

Gene ID

9673

9363

Gene namesolute carrier family 25 member 44RAB33A, member RAS oncogene family
Synonyms-RabS10
Cytomap

1q22

Xq26.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 25 member 44ras-related protein Rab-33ASmall GTP-binding protein S10
Modification date2018052220180523
UniProtAcc

Q96H78

Q14088

Ensembl transtripts involved in fusion geneENST00000359511, ENST00000423538, 
ENST00000469537, 
ENST00000257017, 
Fusion gene scores* DoF score10 X 5 X 5=2502 X 1 X 2=4
# samples 102
** MAII scorelog2(10/250*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: SLC25A44 [Title/Abstract] AND RAB33A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A2H4-01ASLC25A44chr1

156164038

+RAB33AchrX

129318259

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000359511ENST00000257017SLC25A44chr1

156164038

+RAB33AchrX

129318259

+
5UTR-3CDSENST00000423538ENST00000257017SLC25A44chr1

156164038

+RAB33AchrX

129318259

+
intron-3CDSENST00000469537ENST00000257017SLC25A44chr1

156164038

+RAB33AchrX

129318259

+

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FusionProtFeatures for SLC25A44_RAB33A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A44

Q96H78

RAB33A

Q14088


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A44_RAB33A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A44_RAB33A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A44ELAVL1, JUP, NME2P1, IMPDH2, LASP1, IMPDH1RAB33ARABAC1, RTN3, RTN4, ATG16L1, SIAH1, ARL6IP1, CCDC136


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A44_RAB33A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A44_RAB33A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource