FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34254

FusionGeneSummary for SLC25A44_PRKACB

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A44_PRKACB
Fusion gene ID: 34254
HgeneTgene
Gene symbol

SLC25A44

PRKACB

Gene ID

9673

5567

Gene namesolute carrier family 25 member 44protein kinase cAMP-activated catalytic subunit beta
Synonyms-PKA C-beta|PKACB
Cytomap

1q22

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 25 member 44cAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic beta subunit isoform 4abprotein kinase A catalytic subunit betaprotein kinase, cAMP-dependent, beta catalytic subunitprotein kinase, cAMP-dependent, catalytic,
Modification date2018052220180519
UniProtAcc

Q96H78

P22694

Ensembl transtripts involved in fusion geneENST00000359511, ENST00000423538, 
ENST00000469537, 
ENST00000370689, 
ENST00000370685, ENST00000394838, 
ENST00000370682, ENST00000394839, 
ENST00000370688, ENST00000470673, 
ENST00000370680, 
Fusion gene scores* DoF score10 X 5 X 5=2506 X 5 X 5=150
# samples 106
** MAII scorelog2(10/250*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A44 [Title/Abstract] AND PRKACB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKACB

GO:0006468

protein phosphorylation

12420224|21880142


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA223586SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000359511ENST00000370689SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000370685SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000394838SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000370682SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000394839SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000370688SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000470673SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000359511ENST00000370680SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000370689SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000370685SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000394838SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000370682SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000394839SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000370688SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000470673SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
5CDS-intronENST00000423538ENST00000370680SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000370689SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000370685SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000394838SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000370682SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000394839SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000370688SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000470673SLC25A44chr1

156169881

+PRKACBchr1

84630378

+
3UTR-intronENST00000469537ENST00000370680SLC25A44chr1

156169881

+PRKACBchr1

84630378

+

Top

FusionProtFeatures for SLC25A44_PRKACB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A44

Q96H78

PRKACB

P22694


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SLC25A44_PRKACB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SLC25A44_PRKACB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC25A44_PRKACB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SLC25A44_PRKACB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRKACBC0005426Biliary Tract Neoplasm1CTD_human
TgenePRKACBC0033578Prostatic Neoplasms1CTD_human
TgenePRKACBC0206698Cholangiocarcinoma1CTD_human