![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 34254 |
FusionGeneSummary for SLC25A44_PRKACB |
![]() |
Fusion gene information | Fusion gene name: SLC25A44_PRKACB | Fusion gene ID: 34254 | Hgene | Tgene | Gene symbol | SLC25A44 | PRKACB | Gene ID | 9673 | 5567 |
Gene name | solute carrier family 25 member 44 | protein kinase cAMP-activated catalytic subunit beta | |
Synonyms | - | PKA C-beta|PKACB | |
Cytomap | 1q22 | 1p31.1 | |
Type of gene | protein-coding | protein-coding | |
Description | solute carrier family 25 member 44 | cAMP-dependent protein kinase catalytic subunit betacAMP-dependent protein kinase catalytic beta subunit isoform 4abprotein kinase A catalytic subunit betaprotein kinase, cAMP-dependent, beta catalytic subunitprotein kinase, cAMP-dependent, catalytic, | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q96H78 | P22694 | |
Ensembl transtripts involved in fusion gene | ENST00000359511, ENST00000423538, ENST00000469537, | ENST00000370689, ENST00000370685, ENST00000394838, ENST00000370682, ENST00000394839, ENST00000370688, ENST00000470673, ENST00000370680, | |
Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 6 X 5 X 5=150 |
# samples | 10 | 6 | |
** MAII score | log2(10/250*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC25A44 [Title/Abstract] AND PRKACB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PRKACB | GO:0006468 | protein phosphorylation | 12420224|21880142 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA223586 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000359511 | ENST00000370689 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000370685 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000394838 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000370682 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000394839 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000370688 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000470673 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000359511 | ENST00000370680 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000370689 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000370685 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000394838 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000370682 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000394839 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000370688 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000470673 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
5CDS-intron | ENST00000423538 | ENST00000370680 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000370689 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000370685 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000394838 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000370682 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000394839 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000370688 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000470673 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
3UTR-intron | ENST00000469537 | ENST00000370680 | SLC25A44 | chr1 | 156169881 | + | PRKACB | chr1 | 84630378 | + |
Top |
FusionProtFeatures for SLC25A44_PRKACB |
![]() |
Hgene | Tgene |
SLC25A44 | PRKACB |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SLC25A44_PRKACB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SLC25A44_PRKACB |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SLC25A44_PRKACB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SLC25A44_PRKACB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PRKACB | C0005426 | Biliary Tract Neoplasm | 1 | CTD_human |
Tgene | PRKACB | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | PRKACB | C0206698 | Cholangiocarcinoma | 1 | CTD_human |