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Fusion gene ID: 34251 |
FusionGeneSummary for SLC25A44_IGF2R |
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Fusion gene information | Fusion gene name: SLC25A44_IGF2R | Fusion gene ID: 34251 | Hgene | Tgene | Gene symbol | SLC25A44 | IGF2R | Gene ID | 9673 | 3482 |
Gene name | solute carrier family 25 member 44 | insulin like growth factor 2 receptor | |
Synonyms | - | CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI | |
Cytomap | 1q22 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | solute carrier family 25 member 44 | cation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptor | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q96H78 | P11717 | |
Ensembl transtripts involved in fusion gene | ENST00000359511, ENST00000423538, ENST00000469537, | ENST00000356956, ENST00000475584, | |
Fusion gene scores | * DoF score | 10 X 5 X 5=250 | 2 X 2 X 2=8 |
# samples | 10 | 2 | |
** MAII score | log2(10/250*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SLC25A44 [Title/Abstract] AND IGF2R [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA740262 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000359511 | ENST00000356956 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
3UTR-intron | ENST00000359511 | ENST00000475584 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
intron-3UTR | ENST00000423538 | ENST00000356956 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
intron-intron | ENST00000423538 | ENST00000475584 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
3UTR-3UTR | ENST00000469537 | ENST00000356956 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
3UTR-intron | ENST00000469537 | ENST00000475584 | SLC25A44 | chr1 | 156182462 | - | IGF2R | chr6 | 160526429 | - |
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FusionProtFeatures for SLC25A44_IGF2R |
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Hgene | Tgene |
SLC25A44 | IGF2R |
Transport of phosphorylated lysosomal enzymes from theGolgi complex and the cell surface to lysosomes. Lysosomal enzymesbearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resultingreceptor-ligand complex is transported to an acidic prelyosomalcompartment where the low pH mediates the dissociation of thecomplex. This receptor also binds IGF2. Acts as a positiveregulator of T-cell coactivation, by binding DPP4.{ECO:0000269|PubMed:10900005}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC25A44_IGF2R |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC25A44_IGF2R |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A44_IGF2R |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IGF2R | P11717 | DB01277 | Mecasermin | Cation-independent mannose-6-phosphate receptor | biotech | approved|investigational |
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RelatedDiseases for SLC25A44_IGF2R |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | IGF2R | C0024115 | Lung diseases | 2 | CTD_human |
Tgene | IGF2R | C0235833 | Congenital diaphragmatic hernia | 2 | CTD_human |
Tgene | IGF2R | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Tgene | IGF2R | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | IGF2R | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | IGF2R | C0752347 | Lewy Body Disease | 1 | CTD_human |
Tgene | IGF2R | C2239176 | Liver carcinoma | 1 | CTD_human;HPO |