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Fusion gene ID: 34232 |
FusionGeneSummary for SLC25A39_EFCAB13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC25A39_EFCAB13 | Fusion gene ID: 34232 | Hgene | Tgene | Gene symbol | SLC25A39 | EFCAB13 | Gene ID | 51629 | 124989 |
| Gene name | solute carrier family 25 member 39 | EF-hand calcium binding domain 13 | |
| Synonyms | CGI-69|CGI69 | C17orf57 | |
| Cytomap | 17q21.31 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | solute carrier family 25 member 39 | EF-hand calcium-binding domain-containing protein 13EF-hand domain-containing protein C17orf57 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9BZJ4 | Q8IY85 | |
| Ensembl transtripts involved in fusion gene | ENST00000225308, ENST00000377095, ENST00000590194, ENST00000586016, ENST00000537904, | ENST00000331493, ENST00000517484, ENST00000520802, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 3 X 3 X 3=27 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLC25A39 [Title/Abstract] AND EFCAB13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-G9-6494-01A | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000225308 | ENST00000331493 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000225308 | ENST00000517484 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000225308 | ENST00000520802 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| Frame-shift | ENST00000377095 | ENST00000331493 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000377095 | ENST00000517484 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000377095 | ENST00000520802 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| Frame-shift | ENST00000590194 | ENST00000331493 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000590194 | ENST00000517484 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000590194 | ENST00000520802 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| In-frame | ENST00000586016 | ENST00000331493 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000586016 | ENST00000517484 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000586016 | ENST00000520802 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| Frame-shift | ENST00000537904 | ENST00000331493 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000537904 | ENST00000517484 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
| 5CDS-intron | ENST00000537904 | ENST00000520802 | SLC25A39 | chr17 | 42398426 | - | EFCAB13 | chr17 | 45438744 | + |
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FusionProtFeatures for SLC25A39_EFCAB13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC25A39 | EFCAB13 |
| Required for normal heme biosynthesis. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC25A39_EFCAB13 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLC25A39_ENST00000586016_chr17_42398426_-_EFCAB13_ENST00000331493_chr17_45438744_+_852aa MTVPATAIYFTAYDQLKAFLCGRALTSDLYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLGWGPT ALRDVPFSAFQDALKIFCRIKGGRVSTDDVFAVLDSMGIPINREILEEVTKHTYIDSNHMVDIGDIIFTLNELQEQYEDVSITEGSPLNE ITSDRKLSSVAGCYLKYKKKNSLSSKLPEPSISKKLNKKSNQYYSKIMENDDLESKRPKNTWQIRKFLGGVGSSNVGVQEPYSKNGINFK KHSEKGEIHDSKSKPQSLKSSTSLSKSLDKSDISSIPKLQKPAVRKHSSLQKQVSSTEKTAISTLENFCEAISKLQENYIAAEELQSILP STGINLLDEEFQKIVTDTSRNENGMVELDDFVNALAKERSFPECNALPGVIKAIDKIKDKNVDYEDLNTCLQNFGIYLSKPEFKKITELT EAGETKKVNFKEFIDTMMSNTECFSEKLVLPDAIETLDDLRKETMSVSDLWNTLSSLNSNLKKDEFLAALELVTVDEGDKVQFEEFAKVV RNMRDAARLEELQEVVLAADLLEGDMIAGKNLEDFLRNVGIKSPKEEVEKILQSDFVSEDNMVNIKDCMRALRDTQKFSNYIDFRKEASN LKLPKVNEIKEAANILSHVDNGKIGIPDLEHALKCLNVNLTEEDFNEALNCCNVSDNMEVDLKDFLMKMKESPHFQKSKATQILLATTQI LQNDLVDVSDLKTLLMDKDLHTANAILTVMLRHVPEHESGKVSIQEFMTKLSDILTIPKAAGKFYLICTYCPDLERQAVVYMLKTIQDSI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLC25A39_ENST00000586016_chr17_42398426_-_EFCAB13_ENST00000331493_chr17_45438744_+_2556nt ATGACTGTGCCAGCTACCGCCATCTACTTCACTGCCTATGACCAACTGAAGGCCTTCCTGTGTGGTCGAGCCCTGACCTCTGACCTCTAC GCACCCATGGTGGCTGGCGCGCTGGCCCGCCTGGGCACCGTGACTGTGATCAGCCCCCTGGAGCTTATGCGGACAAAGCTGCAGGCTCAG CATGTGTCGTACCGGGAGCTGGGTGCCTGTGTTCGAACTGCAGTGGCTCAGGGTGGCTGGCGCTCACTGTGGCTGGGCTGGGGCCCCACT GCCCTTCGAGATGTGCCCTTCTCAGCATTCCAGGATGCCTTGAAGATTTTCTGTAGGATAAAAGGTGGTCGAGTTTCAACTGATGACGTG TTTGCTGTTTTGGATAGCATGGGTATCCCTATAAACCGTGAAATTTTAGAAGAAGTGACAAAACATACCTATATTGACAGTAACCACATG GTGGATATTGGGGATATTATATTTACTTTGAATGAGCTACAGGAACAGTATGAGGATGTTTCAATTACAGAAGGATCACCTTTGAATGAA ATTACTTCAGACAGAAAGTTATCAAGTGTAGCAGGATGCTATCTAAAATATAAGAAGAAAAATAGTTTGTCTTCCAAACTCCCTGAACCT TCAATATCCAAAAAGTTAAATAAAAAAAGCAACCAATATTATAGCAAAATTATGGAGAATGATGACCTTGAATCTAAAAGACCAAAAAAT ACTTGGCAAATAAGAAAATTTCTGGGTGGGGTTGGCAGCAGTAATGTAGGAGTCCAAGAACCATATTCAAAGAATGGCATAAACTTTAAA AAACATTCAGAGAAGGGTGAAATTCATGACTCAAAGTCTAAACCACAAAGCTTGAAGAGTAGTACAAGCCTCAGTAAGTCTCTGGATAAA AGTGATATTTCTAGTATCCCAAAACTTCAGAAGCCAGCTGTAAGAAAGCATTCCAGTCTCCAAAAACAGGTTTCGTCTACGGAAAAAACT GCAATTAGTACTCTGGAAAACTTCTGTGAAGCTATCAGTAAACTTCAAGAAAATTACATTGCAGCAGAAGAACTTCAGTCTATTTTGCCT TCAACAGGAATTAATTTATTAGATGAAGAATTCCAGAAGATTGTGACAGACACTAGTAGAAATGAGAATGGAATGGTGGAGTTAGATGAC TTTGTAAATGCTCTCGCCAAGGAGCGAAGTTTTCCTGAATGCAATGCGTTGCCTGGTGTCATTAAAGCCATTGATAAAATTAAAGATAAA AATGTGGATTATGAGGATCTAAATACTTGTCTTCAAAATTTTGGTATTTACCTTTCTAAGCCAGAATTTAAGAAGATCACAGAACTGACT GAAGCTGGTGAAACAAAAAAAGTGAATTTTAAAGAATTCATTGATACTATGATGAGCAACACGGAATGCTTCTCTGAAAAATTAGTATTG CCTGATGCTATTGAAACCCTCGACGATCTCAGAAAGGAGACGATGAGTGTTTCTGACCTGTGGAATACTCTGTCTAGTTTGAATAGTAAT TTAAAAAAGGATGAATTTCTAGCTGCATTGGAACTAGTGACAGTTGATGAAGGTGACAAAGTACAATTTGAAGAATTTGCAAAAGTAGTA AGGAATATGCGTGATGCTGCCAGGTTAGAAGAGTTACAGGAAGTTGTCTTAGCTGCTGATTTGCTGGAAGGTGACATGATAGCTGGGAAG AACTTGGAAGACTTTCTAAGAAATGTTGGGATTAAGTCACCTAAAGAAGAGGTAGAGAAAATTCTTCAATCAGATTTTGTTTCTGAAGAT AACATGGTGAACATTAAAGACTGTATGAGGGCTTTGAGGGACACCCAGAAATTTTCCAATTATATTGATTTCAGGAAAGAGGCTTCAAAT CTAAAATTACCAAAGGTAAACGAGATTAAAGAAGCTGCTAACATCTTGTCACATGTCGATAATGGCAAGATTGGTATACCTGATTTGGAG CATGCCTTGAAATGTTTGAATGTTAATTTAACTGAGGAGGACTTCAATGAAGCCCTTAACTGTTGTAACGTCAGTGATAATATGGAGGTG GATTTAAAAGATTTCTTAATGAAAATGAAAGAAAGTCCACATTTCCAAAAGTCCAAGGCTACACAGATACTCTTAGCTACTACCCAAATT CTCCAGAATGATCTAGTTGATGTCTCTGACCTCAAGACATTATTGATGGACAAGGACCTTCATACAGCTAATGCTATACTTACTGTAATG TTAAGACATGTACCTGAACATGAAAGTGGCAAGGTTAGCATTCAAGAATTTATGACTAAATTATCCGATATATTGACAATTCCTAAAGCT GCAGGTAAGTTTTATTTAATATGTACTTATTGCCCAGATCTAGAAAGGCAAGCAGTGGTTTACATGTTAAAAACAATACAGGATTCGATA GTTAAAGCACAGGTAAGTAAGAAGCAATACAATATGAATATAAAACAACACAAGATTAGTTTACATAACTTCTGTTTGAATTCTAAGGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLC25A39_ENST00000586016_chr17_42398426_-_EFCAB13_ENST00000331493_chr17_45438744_+_3298nt ACAGGCGGCGGAGCCGGTATGGGCCCGCCTGACCCTGGGCGCCGCGCCGCACGAGCACCAGCCTAGAGCCAGGATGCCTTCGTGAAGATC GTGAGGCACGAGGGCACCAGGACCCTCTGGAGCGGCCTCCCCGCCACCCTGGTGATGACTGTGCCAGCTACCGCCATCTACTTCACTGCC TATGACCAACTGAAGGCCTTCCTGTGTGGTCGAGCCCTGACCTCTGACCTCTACGCACCCATGGTGGCTGGCGCGCTGGCCCGCCTGGGC ACCGTGACTGTGATCAGCCCCCTGGAGCTTATGCGGACAAAGCTGCAGGCTCAGCATGTGTCGTACCGGGAGCTGGGTGCCTGTGTTCGA ACTGCAGTGGCTCAGGGTGGCTGGCGCTCACTGTGGCTGGGCTGGGGCCCCACTGCCCTTCGAGATGTGCCCTTCTCAGCATTCCAGGAT GCCTTGAAGATTTTCTGTAGGATAAAAGGTGGTCGAGTTTCAACTGATGACGTGTTTGCTGTTTTGGATAGCATGGGTATCCCTATAAAC CGTGAAATTTTAGAAGAAGTGACAAAACATACCTATATTGACAGTAACCACATGGTGGATATTGGGGATATTATATTTACTTTGAATGAG CTACAGGAACAGTATGAGGATGTTTCAATTACAGAAGGATCACCTTTGAATGAAATTACTTCAGACAGAAAGTTATCAAGTGTAGCAGGA TGCTATCTAAAATATAAGAAGAAAAATAGTTTGTCTTCCAAACTCCCTGAACCTTCAATATCCAAAAAGTTAAATAAAAAAAGCAACCAA TATTATAGCAAAATTATGGAGAATGATGACCTTGAATCTAAAAGACCAAAAAATACTTGGCAAATAAGAAAATTTCTGGGTGGGGTTGGC AGCAGTAATGTAGGAGTCCAAGAACCATATTCAAAGAATGGCATAAACTTTAAAAAACATTCAGAGAAGGGTGAAATTCATGACTCAAAG TCTAAACCACAAAGCTTGAAGAGTAGTACAAGCCTCAGTAAGTCTCTGGATAAAAGTGATATTTCTAGTATCCCAAAACTTCAGAAGCCA GCTGTAAGAAAGCATTCCAGTCTCCAAAAACAGGTTTCGTCTACGGAAAAAACTGCAATTAGTACTCTGGAAAACTTCTGTGAAGCTATC AGTAAACTTCAAGAAAATTACATTGCAGCAGAAGAACTTCAGTCTATTTTGCCTTCAACAGGAATTAATTTATTAGATGAAGAATTCCAG AAGATTGTGACAGACACTAGTAGAAATGAGAATGGAATGGTGGAGTTAGATGACTTTGTAAATGCTCTCGCCAAGGAGCGAAGTTTTCCT GAATGCAATGCGTTGCCTGGTGTCATTAAAGCCATTGATAAAATTAAAGATAAAAATGTGGATTATGAGGATCTAAATACTTGTCTTCAA AATTTTGGTATTTACCTTTCTAAGCCAGAATTTAAGAAGATCACAGAACTGACTGAAGCTGGTGAAACAAAAAAAGTGAATTTTAAAGAA TTCATTGATACTATGATGAGCAACACGGAATGCTTCTCTGAAAAATTAGTATTGCCTGATGCTATTGAAACCCTCGACGATCTCAGAAAG GAGACGATGAGTGTTTCTGACCTGTGGAATACTCTGTCTAGTTTGAATAGTAATTTAAAAAAGGATGAATTTCTAGCTGCATTGGAACTA GTGACAGTTGATGAAGGTGACAAAGTACAATTTGAAGAATTTGCAAAAGTAGTAAGGAATATGCGTGATGCTGCCAGGTTAGAAGAGTTA CAGGAAGTTGTCTTAGCTGCTGATTTGCTGGAAGGTGACATGATAGCTGGGAAGAACTTGGAAGACTTTCTAAGAAATGTTGGGATTAAG TCACCTAAAGAAGAGGTAGAGAAAATTCTTCAATCAGATTTTGTTTCTGAAGATAACATGGTGAACATTAAAGACTGTATGAGGGCTTTG AGGGACACCCAGAAATTTTCCAATTATATTGATTTCAGGAAAGAGGCTTCAAATCTAAAATTACCAAAGGTAAACGAGATTAAAGAAGCT GCTAACATCTTGTCACATGTCGATAATGGCAAGATTGGTATACCTGATTTGGAGCATGCCTTGAAATGTTTGAATGTTAATTTAACTGAG GAGGACTTCAATGAAGCCCTTAACTGTTGTAACGTCAGTGATAATATGGAGGTGGATTTAAAAGATTTCTTAATGAAAATGAAAGAAAGT CCACATTTCCAAAAGTCCAAGGCTACACAGATACTCTTAGCTACTACCCAAATTCTCCAGAATGATCTAGTTGATGTCTCTGACCTCAAG ACATTATTGATGGACAAGGACCTTCATACAGCTAATGCTATACTTACTGTAATGTTAAGACATGTACCTGAACATGAAAGTGGCAAGGTT AGCATTCAAGAATTTATGACTAAATTATCCGATATATTGACAATTCCTAAAGCTGCAGGTAAGTTTTATTTAATATGTACTTATTGCCCA GATCTAGAAAGGCAAGCAGTGGTTTACATGTTAAAAACAATACAGGATTCGATAGTTAAAGCACAGGTAAGTAAGAAGCAATACAATATG AATATAAAACAACACAAGATTAGTTTACATAACTTCTGTTTGAATTCTAAGGCAAATATTGCTAAGCTTAACCCAAACTCAAAATTTTAG GTAGTCTTACTTGATAGTGCTAGAAAATTACTAGATTATATATTATTCAGTATGCATATTTGACTTCTGAAATTATTAGAAAATAATTTT TAAAACTTTTGACAAATCCAGTAGAATTTTTATCACTATCTGTTATGTTCTCATGTATCTTCAGCGACTCTCTTGATCACACTTTTTAAA CATTCATGCTTTTTGAGGTATAATGTACATATGGCAAAATTCACTCTTTTTAGGTATACAGTTCTTTGGATTCTTAAAAATAATGTAATG TAACCCTTACTATACACAACATATAGACTATATTATCCCCCAGAAGTCTCTTATGCCCTTTTGGTAATCCATTTCTTCCTCTACCCTGAG CCCCTGGCAACTACTGATTCATTCTTTGTCCCTCTAGTTTTGCCTTTTGTGGAATATCATGTAAATGATTAAATATGAAGTGGTTTGAGT TTGGCAGTCATTGCATGCATATACCTTGAATTTACTTTGTTTATACTCTCATTTATACTACCAACCCTCCCTAGAAAAAATGGATTCTGA |
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FusionGenePPI for SLC25A39_EFCAB13 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC25A39 | ENO1, MOV10, NXF1, HSPD1 | EFCAB13 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A39_EFCAB13 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A39_EFCAB13 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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