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Fusion gene ID: 34205 |
FusionGeneSummary for SLC25A23_SLC2A9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC25A23_SLC2A9 | Fusion gene ID: 34205 | Hgene | Tgene | Gene symbol | SLC25A23 | SLC2A9 | Gene ID | 79085 | 56606 |
| Gene name | solute carrier family 25 member 23 | solute carrier family 2 member 9 | |
| Synonyms | APC2|MCSC2|SCaMC-3 | GLUT9|GLUTX|UAQTL2|URATv1 | |
| Cytomap | 19p13.3 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcium-binding mitochondrial carrier protein SCaMC-3mitochondrial ATP-Mg/Pi carrier protein 2mitochondrial Ca(2+)-dependent solute carrier protein 2mitochondrial Ca2+-dependent solute carrier protein 2short calcium-binding mitochondrial carrier 3sma | solute carrier family 2, facilitated glucose transporter member 9GLUT-9glucose transporter type 9human glucose transporter-like protein-9solute carrier family 2 (facilitated glucose transporter), member 9urate voltage-driven efflux transporter 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9BV35 | Q9NRM0 | |
| Ensembl transtripts involved in fusion gene | ENST00000601760, ENST00000301454, ENST00000414491, ENST00000334510, | ENST00000264784, ENST00000506583, ENST00000309065, ENST00000481042, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 2=18 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SLC25A23 [Title/Abstract] AND SLC2A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-B6-A0RT-01A | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000601760 | ENST00000264784 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000601760 | ENST00000506583 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000601760 | ENST00000309065 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000601760 | ENST00000481042 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000301454 | ENST00000264784 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000301454 | ENST00000506583 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000301454 | ENST00000309065 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000301454 | ENST00000481042 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000414491 | ENST00000264784 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000414491 | ENST00000506583 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000414491 | ENST00000309065 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| intron-intron | ENST00000414491 | ENST00000481042 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000334510 | ENST00000264784 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000334510 | ENST00000506583 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000334510 | ENST00000309065 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
| 5CDS-intron | ENST00000334510 | ENST00000481042 | SLC25A23 | chr19 | 6456431 | - | SLC2A9 | chr4 | 9772993 | - |
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FusionProtFeatures for SLC25A23_SLC2A9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC25A23 | SLC2A9 |
| Calcium-dependent mitochondrial solute carrier.Mitochondrial solute carriers shuttle metabolites, nucleotides,and cofactors through the mitochondrial inner membrane(PubMed:15123600). May act as a ATP-Mg/Pi exchanger that mediatesthe transport of Mg-ATP in exchange for phosphate, catalyzing thenet uptake or efflux of adenine nucleotides into or from themitochondria (PubMed:15123600). Acts as a regulator ofmitochondrial calcium uptake via interaction with MCU and MICU1(PubMed:24430870). {ECO:0000269|PubMed:15123600,ECO:0000269|PubMed:24430870}. | Transport urate and fructose. May have a role in theurate reabsorption by proximal tubules. Also transports glucose atlow rate. {ECO:0000269|PubMed:14739288,ECO:0000269|PubMed:18327257}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC25A23_SLC2A9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC25A23_SLC2A9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC25A23 | ELAVL1, CUL3, TARDBP, APPBP2, NRG1, SLC25A25, IL13RA2, SYP, CD79B, PDCD1, SLC22A6, SLC2A12, AIFM1, APLNR, VSIG4, TMEM108, SLC5A8, LRP1 | SLC2A9 | TKT |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A23_SLC2A9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A23_SLC2A9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SLC2A9 | C2677549 | Hypouricemia, Renal, 2 | 3 | CTD_human;UNIPROT |
| Tgene | SLC2A9 | C0018099 | Gout | 2 | CTD_human |
| Tgene | SLC2A9 | C0473219 | Renal hypouricemia | 2 | CTD_human;ORPHANET |
| Tgene | SLC2A9 | C0740394 | Hyperuricemia | 1 | CTD_human |
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