FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 34201

FusionGeneSummary for SLC25A21_FOXA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A21_FOXA1
Fusion gene ID: 34201
HgeneTgene
Gene symbol

SLC25A21

FOXA1

Gene ID

89874

3169

Gene namesolute carrier family 25 member 21forkhead box A1
SynonymsODC|ODC1HNF3A|TCF3A
Cytomap

14q13.3

14q21.1

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial 2-oxodicarboxylate carrieroxodicarboxylate carriersolute carrier family 25 (mitochondrial oxoadipate carrier), member 21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21hepatocyte nuclear factor 3-alphaHNF-3-alphaHNF-3ATCF-3Aforkhead box protein A1transcription factor 3A
Modification date2018052320180523
UniProtAcc

Q9BQT8

P55317

Ensembl transtripts involved in fusion geneENST00000555449, ENST00000331299, 
ENST00000557611, 
ENST00000250448, 
ENST00000540786, ENST00000545425, 
Fusion gene scores* DoF score2 X 3 X 3=185 X 4 X 3=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A21 [Title/Abstract] AND FOXA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFOXA1

GO:0032355

response to estradiol

16087863

TgeneFOXA1

GO:0043065

positive regulation of apoptotic process

19127412

TgeneFOXA1

GO:0045944

positive regulation of transcription by RNA polymerase II

16331276|19127412|20160041


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-G9-6366-01ASLC25A21chr14

37344160

-FOXA1chr14

38061915

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000555449ENST00000250448SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5CDS-5UTRENST00000555449ENST00000540786SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5CDS-5UTRENST00000555449ENST00000545425SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
In-frameENST00000331299ENST00000250448SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5CDS-5UTRENST00000331299ENST00000540786SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5CDS-5UTRENST00000331299ENST00000545425SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5UTR-3CDSENST00000557611ENST00000250448SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5UTR-5UTRENST00000557611ENST00000540786SLC25A21chr14

37344160

-FOXA1chr14

38061915

-
5UTR-5UTRENST00000557611ENST00000545425SLC25A21chr14

37344160

-FOXA1chr14

38061915

-

Top

FusionProtFeatures for SLC25A21_FOXA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A21

Q9BQT8

FOXA1

P55317

Transports C5-C7 oxodicarboxylates across the innermembranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent,pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, andcitrate. Transcription factor that is involved in embryonicdevelopment, establishment of tissue-specific gene expression andregulation of gene expression in differentiated tissues. Isthought to act as a 'pioneer' factor opening the compactedchromatin for other proteins through interactions with nucleosomalcore histones and thereby replacing linker histones at targetenhancer and/or promoter sites. Binds DNA with the consensussequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity).Proposed to play a role in translating the epigenetic signaturesinto cell type-specific enhancer-driven transcriptional programs.Its differential recruitment to chromatin is dependent ondistribution of histone H3 methylated at 'Lys-5' (H3K4me2) inestrogen-regulated genes. Involved in the development of multipleendoderm-derived organ systems such as liver, pancreas, lung andprostate; FOXA1 and FOXA2 seem to have at least in part redundantroles (By similarity). Modulates the transcriptional activity ofnuclear hormone receptors. Is involved in ESR1-mediatedtranscription; required for ESR1 binding to the NKX2-1 promoter inbreast cancer cells; binds to the RPRM promoter and is requiredfor the estrogen-induced repression of RPRM. Involved inregulation of apoptosis by inhibiting the expression of BCL2.Involved in cell cycle regulation by activating expression ofCDKN1B, alone or in conjunction with BRCA1. Originally describedas a transcription activator for a number of liver genes such asAFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interactswith the cis-acting regulatory regions of these genes. Involved inglucose homeostasis. {ECO:0000250, ECO:0000269|PubMed:16087863,ECO:0000269|PubMed:16331276, ECO:0000269|PubMed:18358809,ECO:0000269|PubMed:19127412, ECO:0000269|PubMed:19917725}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-21017_3739300TransmembraneHelical%3B Name%3D1
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-21117_3739299TransmembraneHelical%3B Name%3D1
TgeneFOXA1chr14:37344160chr14:38061915ENST00000250448-02169_26024473DNA bindingFork-head

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210107_19639300RepeatNote=Solcar 2
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-21011_10039300RepeatNote=Solcar 1
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210205_29439300RepeatNote=Solcar 3
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211107_19639299RepeatNote=Solcar 2
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-21111_10039299RepeatNote=Solcar 1
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211205_29439299RepeatNote=Solcar 3
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210113_13339300TransmembraneHelical%3B Name%3D3
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210167_18739300TransmembraneHelical%3B Name%3D4
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210205_22539300TransmembraneHelical%3B Name%3D5
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-210277_29739300TransmembraneHelical%3B Name%3D6
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000331299-21070_8939300TransmembraneHelical%3B Name%3D2
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211113_13339299TransmembraneHelical%3B Name%3D3
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211167_18739299TransmembraneHelical%3B Name%3D4
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211205_22539299TransmembraneHelical%3B Name%3D5
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-211277_29739299TransmembraneHelical%3B Name%3D6
HgeneSLC25A21chr14:37344160chr14:38061915ENST00000555449-21170_8939299TransmembraneHelical%3B Name%3D2


Top

FusionGeneSequence for SLC25A21_FOXA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC25A21_ENST00000555449_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_488aa
MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRPTPPSRSATXTQAWAPXTPXTPTXPXTPXLRAATXPRRPSTCPMPTRAXG
PAXVPAQXPACRGARRAPXTAXLRPAXRPWVRRXARAAWAPWVRSRRPPXMAWAPTRPPXTRAXAPWRTRRPTWAAAARAAAATPRRSSA
ATRTPSRPTRTSRSSPWPSSRRPARCSRXARSTSGSWTSSPITGRTSSAGRTPSATRCPSMTASSRWHAPRTSRARAPTGRCTRTPATCS
RTAATCAARSASSARSSRGPAAGAGAEAGAAAPRAALRAARTPLAPLTPAPTRPSIGVCTGRPASXRARRPPGPPPAPRLWTTVGRRRQG
APRSXRLQPPQLRPPXAPGPGRWPLCPPLTRHTAWHPTSPSCTXKGTPTTPSTTRSPSTTSCPPRSSSISWTSRHTNRHCNTRLTALRCP

>In-frame_SLC25A21_ENST00000331299_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_488aa
MSAKPEVSLVREASRQIVAGGSAGLVEICLMHPLDVVKTRPTPPSRSATXTQAWAPXTPXTPTXPXTPXLRAATXPRRPSTCPMPTRAXG
PAXVPAQXPACRGARRAPXTAXLRPAXRPWVRRXARAAWAPWVRSRRPPXMAWAPTRPPXTRAXAPWRTRRPTWAAAARAAAATPRRSSA
ATRTPSRPTRTSRSSPWPSSRRPARCSRXARSTSGSWTSSPITGRTSSAGRTPSATRCPSMTASSRWHAPRTSRARAPTGRCTRTPATCS
RTAATCAARSASSARSSRGPAAGAGAEAGAAAPRAALRAARTPLAPLTPAPTRPSIGVCTGRPASXRARRPPGPPPAPRLWTTVGRRRQG
APRSXRLQPPQLRPPXAPGPGRWPLCPPLTRHTAWHPTSPSCTXKGTPTTPSTTRSPSTTSCPPRSSSISWTSRHTNRHCNTRLTALRCP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC25A21_ENST00000555449_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_1466nt
ATGTCCGCCAAGCCTGAAGTCAGCTTAGTGCGCGAGGCTTCTCGGCAGATCGTGGCCGGTGGTTCTGCAGGTCTTGTAGAAATTTGCCTG
ATGCACCCCCTAGATGTGGTGAAAACCAGGCCTACTCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACTCCATGA
ACACCTACATGACCATGAACACCATGACTACGAGCGGCAACATGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGG
CCGGCCTGAGTCCCGGCGCAGTAGCCGGCATGCCGGGGGGCTCGGCGGGCGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGG
GTACGGCGCTGAGCCCGAGCGGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTCCATGAATGGCCTGGGCCCCTACGCGGCCGCCATGA
ACCCGTGCATGAGCCCCATGGCGTACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGGCGGCGGCGACGCCAAGACGTTCAAGCGCA
GCTACCCGCACGCCAAGCCGCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCCAGCAAGATGCTCACGCTGAGCG
AGATCTACCAGTGGATCATGGACCTCTTCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGTCCTTCA
ATGACTGCTTCGTCAAGGTGGCACGCTCCCCGGACAAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAACATGTTCG
AGAACGGCTGCTACTTGCGCCGCCAGAAGCGCTTCAAGTGCGAGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGCA
GCGGCGCCAAGGGCGGCCCTGAGAGCCGCAAGGACCCCTCTGGCGCCTCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACG
GGAAGACCGGCCAGCTAGAGGGCGCGCCGGCCCCCGGGCCCGCCGCCAGCCCCCAGACTCTGGACCACAGTGGGGCGACGGCGACAGGGG
GCGCCTCGGAGTTGAAGACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGGGGCGCTGGCCTCTGTGCCCGCCTCTCACC
CGGCACACGGCTTGGCACCCCACGAGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACCACCCGTTCTCCATCAACAACC
TCATGTCCTCCTCGGAGCAGCAGCATAAGCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGCTCTACGTTGCCCG
CCAGCCTGCCTCTAGGCAGCGCCTCGGTGACCACCAGGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTGTGTATT

>In-frame_SLC25A21_ENST00000331299_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_1466nt
ATGTCCGCCAAGCCTGAAGTCAGCTTAGTGCGCGAGGCTTCTCGGCAGATCGTGGCCGGTGGTTCTGCAGGTCTTGTAGAAATTTGCCTG
ATGCACCCCCTAGATGTGGTGAAAACCAGGCCTACTCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACTCCATGA
ACACCTACATGACCATGAACACCATGACTACGAGCGGCAACATGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGG
CCGGCCTGAGTCCCGGCGCAGTAGCCGGCATGCCGGGGGGCTCGGCGGGCGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGG
GTACGGCGCTGAGCCCGAGCGGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTCCATGAATGGCCTGGGCCCCTACGCGGCCGCCATGA
ACCCGTGCATGAGCCCCATGGCGTACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGGCGGCGGCGACGCCAAGACGTTCAAGCGCA
GCTACCCGCACGCCAAGCCGCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCCAGCAAGATGCTCACGCTGAGCG
AGATCTACCAGTGGATCATGGACCTCTTCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGTCCTTCA
ATGACTGCTTCGTCAAGGTGGCACGCTCCCCGGACAAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAACATGTTCG
AGAACGGCTGCTACTTGCGCCGCCAGAAGCGCTTCAAGTGCGAGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGCA
GCGGCGCCAAGGGCGGCCCTGAGAGCCGCAAGGACCCCTCTGGCGCCTCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACG
GGAAGACCGGCCAGCTAGAGGGCGCGCCGGCCCCCGGGCCCGCCGCCAGCCCCCAGACTCTGGACCACAGTGGGGCGACGGCGACAGGGG
GCGCCTCGGAGTTGAAGACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGGGGCGCTGGCCTCTGTGCCCGCCTCTCACC
CGGCACACGGCTTGGCACCCCACGAGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACCACCCGTTCTCCATCAACAACC
TCATGTCCTCCTCGGAGCAGCAGCATAAGCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGCTCTACGTTGCCCG
CCAGCCTGCCTCTAGGCAGCGCCTCGGTGACCACCAGGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTGTGTATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC25A21_ENST00000555449_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_2920nt
ATCAGTAGGCTGTGCAGGCTGCGAGCTCGTTGACGCATCTCAGCCCACTCCCTTGTCCTCCCGCCTGGCGAAGATGTCCGCCAAGCCTGA
AGTCAGCTTAGTGCGCGAGGCTTCTCGGCAGATCGTGGCCGGTGGTTCTGCAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGT
GGTGAAAACCAGGCCTACTCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACTCCATGAACACCTACATGACCATG
AACACCATGACTACGAGCGGCAACATGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGGCCGGCCTGAGTCCCGGC
GCAGTAGCCGGCATGCCGGGGGGCTCGGCGGGCGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGGGTACGGCGCTGAGCCCG
AGCGGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTCCATGAATGGCCTGGGCCCCTACGCGGCCGCCATGAACCCGTGCATGAGCCCC
ATGGCGTACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGGCGGCGGCGACGCCAAGACGTTCAAGCGCAGCTACCCGCACGCCAAG
CCGCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCCAGCAAGATGCTCACGCTGAGCGAGATCTACCAGTGGATC
ATGGACCTCTTCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGTCCTTCAATGACTGCTTCGTCAAG
GTGGCACGCTCCCCGGACAAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAACATGTTCGAGAACGGCTGCTACTTG
CGCCGCCAGAAGCGCTTCAAGTGCGAGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGCAGCGGCGCCAAGGGCGGC
CCTGAGAGCCGCAAGGACCCCTCTGGCGCCTCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACGGGAAGACCGGCCAGCTA
GAGGGCGCGCCGGCCCCCGGGCCCGCCGCCAGCCCCCAGACTCTGGACCACAGTGGGGCGACGGCGACAGGGGGCGCCTCGGAGTTGAAG
ACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGGGGCGCTGGCCTCTGTGCCCGCCTCTCACCCGGCACACGGCTTGGCA
CCCCACGAGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACCACCCGTTCTCCATCAACAACCTCATGTCCTCCTCGGAG
CAGCAGCATAAGCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGCTCTACGTTGCCCGCCAGCCTGCCTCTAGGC
AGCGCCTCGGTGACCACCAGGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTGTGTATTCCAGACCCGTCCTAAAC
ACTTCCTAGCTCCCGGGACTGGGGGGTTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAGAAAAAATCAACAGCAAACAAAACCACACAA
ACCAAACCGTCAACAGCATAATAAAATCCCAACAACTATTTTTATTTCATTTTTCATGCACAACCTTTCCCCCAGTGCAAAAGACTGTTA
CTTTATTATTGTATTCAAAATTCATTGTGTATATTACTACAAAGACAACCCCAAACCAATTTTTTTCCTGCGAAGTTTAATGATCCACAA
GTGTATATATGAAATTCTCCTCCTTCCTTGCCCCCCTCTCTTTCTTCCCTCTTTCCCCTCCAGACATTCTAGTTTGTGGAGGGTTATTTA
AAAAAACAAAAAAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGCTTTTTCCCCCTCCTTACCTGACCCCCTACGAGTTTACAGGT
CTGTGGCAATACTCTTAACCATAAGAATTGAAATGGTGAAGAAACAAGTATACACTAGAGGCTCTTAAAAGTATTGAAAGACAATACTGC
TGTTATATAGCAAGACATAAACAGATTATAAACATCAGAGCCATTTGCTTCTCAGTTTACATTTCTGATACATGCAGATAGCAGATGTCT
TTAAATGAAATACATGTATATTGTGTATGGACTTAATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAACATATAG
AGGTAATAGATAGGTGATATACATGATACATTCTCAAGAGTTGCTTGACCGAAAGTTACAAGGACCCCAACCCCTTTGTCCTCTCTACCC
ACAGATGGCCCTGGGAATCAATTCCTCAGGAATTGCCCTCAAGAACTCTGCTTCTTGCTTTGCAGAGTGCCATGGTCATGTCATTCTGAG
GTCACATAACACATAAAATTAGTTTCTATGAGTGTATACCATTTAAAGAATTTTTTTTTCAGTAAAAGGGAATATTACAATGTTGGAGGA
GAGATAAGTTATAGGGAGCTGGATTTCAAAACGTGGTCCAAGATTCAAAAATCCTATTGATAGTGGCCATTTTAATCATTGCCATCGTGT
GCTTGTTTCATCCAGTGTTATGCACTTTCCACAGTTGGACATGGTGTTAGTATAGCCAGACGGGTTTCATTATTATTTCTCTTTGCTTTC
TCAATGTTAATTTATTGCATGGTTTATTCTTTTTCTTTACAGCTGAAATTGCTTTAAATGATGGTTAAAATTACAAATTAAATTGTTAAT
TTTTATCAATGTGATTGTAATTAAAAATATTTTGATTTAAATAACAAAAATAATACCAGATTTTAAGCCGTGGAAAATGTTCTTGATCAT

>In-frame_SLC25A21_ENST00000331299_chr14_37344160_-_FOXA1_ENST00000250448_chr14_38061915_-_3363nt
TTATAGGACAACTAACTGAGGAATTTATTCACTTGTCCCTTCTTTTGAACCTCACTGTGCTCTGGCTTGCCAGGAGGTGCAAGTGTCGTC
CCCGCTTTGTACTTGGCGCTCCAGGCCTGGGTCACTTCACTTGAGTTATCAGAGGCAACCGTCTAGTTTGACAAACTACCGGAGGCTCCT
GATAGAGAAGGGCGTGGGCGCCAATCTAGGAGACAAAGCCTGAGCCGCTGCGGTGAGCCAACCCAAACCCATCCGCGGGTCTTCTTTCCA
GAGACATTTTCGGAGCCGAGGGCGCCTCTGCGAGAGCGCTGCGAACAGGTTCCGACGCGCCGGAGATCGCGCGACGAATCTGCGCCTCGA
ACCCTCGCTTTCCAGCAGTCGCCGGATTGCTGCTCCACAGGGAGCCAACGCGCTTGAGGACCAGCCCAGCCGGGGCTCTCTGGATCAGTA
GGCTGTGCAGGCTGCGAGCTCGTTGACGCATCTCAGCCCACTCCCTTGTCCTCCCGCCTGGCGAAGATGTCCGCCAAGCCTGAAGTCAGC
TTAGTGCGCGAGGCTTCTCGGCAGATCGTGGCCGGTGGTTCTGCAGGTCTTGTAGAAATTTGCCTGATGCACCCCCTAGATGTGGTGAAA
ACCAGGCCTACTCCTCCGTCCCGGTCAGCAACATGAACTCAGGCCTGGGCTCCATGAACTCCATGAACACCTACATGACCATGAACACCA
TGACTACGAGCGGCAACATGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCGGGCCTAGGGGCCGGCCTGAGTCCCGGCGCAGTAG
CCGGCATGCCGGGGGGCTCGGCGGGCGCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGGGTACGGCGCTGAGCCCGAGCGGCA
TGGGCGCCATGGGTGCGCAGCAGGCGGCCTCCATGAATGGCCTGGGCCCCTACGCGGCCGCCATGAACCCGTGCATGAGCCCCATGGCGT
ACGCGCCGTCCAACCTGGGCCGCAGCCGCGCGGGCGGCGGCGGCGACGCCAAGACGTTCAAGCGCAGCTACCCGCACGCCAAGCCGCCCT
ACTCGTACATCTCGCTCATCACCATGGCCATCCAGCAGGCGCCCAGCAAGATGCTCACGCTGAGCGAGATCTACCAGTGGATCATGGACC
TCTTCCCCTATTACCGGCAGAACCAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGTCCTTCAATGACTGCTTCGTCAAGGTGGCAC
GCTCCCCGGACAAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCCGGCAACATGTTCGAGAACGGCTGCTACTTGCGCCGCC
AGAAGCGCTTCAAGTGCGAGAAGCAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGCAGCGGCGCCAAGGGCGGCCCTGAGA
GCCGCAAGGACCCCTCTGGCGCCTCTAACCCCAGCGCCGACTCGCCCCTCCATCGGGGTGTGCACGGGAAGACCGGCCAGCTAGAGGGCG
CGCCGGCCCCCGGGCCCGCCGCCAGCCCCCAGACTCTGGACCACAGTGGGGCGACGGCGACAGGGGGCGCCTCGGAGTTGAAGACTCCAG
CCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGGGGCGCTGGCCTCTGTGCCCGCCTCTCACCCGGCACACGGCTTGGCACCCCACG
AGTCCCAGCTGCACCTGAAAGGGGACCCCCACTACTCCTTCAACCACCCGTTCTCCATCAACAACCTCATGTCCTCCTCGGAGCAGCAGC
ATAAGCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGCTCTACGTTGCCCGCCAGCCTGCCTCTAGGCAGCGCCT
CGGTGACCACCAGGAGCCCCATCGAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTGTGTATTCCAGACCCGTCCTAAACACTTCCT
AGCTCCCGGGACTGGGGGGTTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAGAAAAAATCAACAGCAAACAAAACCACACAAACCAAAC
CGTCAACAGCATAATAAAATCCCAACAACTATTTTTATTTCATTTTTCATGCACAACCTTTCCCCCAGTGCAAAAGACTGTTACTTTATT
ATTGTATTCAAAATTCATTGTGTATATTACTACAAAGACAACCCCAAACCAATTTTTTTCCTGCGAAGTTTAATGATCCACAAGTGTATA
TATGAAATTCTCCTCCTTCCTTGCCCCCCTCTCTTTCTTCCCTCTTTCCCCTCCAGACATTCTAGTTTGTGGAGGGTTATTTAAAAAAAC
AAAAAAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGCTTTTTCCCCCTCCTTACCTGACCCCCTACGAGTTTACAGGTCTGTGGC
AATACTCTTAACCATAAGAATTGAAATGGTGAAGAAACAAGTATACACTAGAGGCTCTTAAAAGTATTGAAAGACAATACTGCTGTTATA
TAGCAAGACATAAACAGATTATAAACATCAGAGCCATTTGCTTCTCAGTTTACATTTCTGATACATGCAGATAGCAGATGTCTTTAAATG
AAATACATGTATATTGTGTATGGACTTAATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAACATATAGAGGTAAT
AGATAGGTGATATACATGATACATTCTCAAGAGTTGCTTGACCGAAAGTTACAAGGACCCCAACCCCTTTGTCCTCTCTACCCACAGATG
GCCCTGGGAATCAATTCCTCAGGAATTGCCCTCAAGAACTCTGCTTCTTGCTTTGCAGAGTGCCATGGTCATGTCATTCTGAGGTCACAT
AACACATAAAATTAGTTTCTATGAGTGTATACCATTTAAAGAATTTTTTTTTCAGTAAAAGGGAATATTACAATGTTGGAGGAGAGATAA
GTTATAGGGAGCTGGATTTCAAAACGTGGTCCAAGATTCAAAAATCCTATTGATAGTGGCCATTTTAATCATTGCCATCGTGTGCTTGTT
TCATCCAGTGTTATGCACTTTCCACAGTTGGACATGGTGTTAGTATAGCCAGACGGGTTTCATTATTATTTCTCTTTGCTTTCTCAATGT
TAATTTATTGCATGGTTTATTCTTTTTCTTTACAGCTGAAATTGCTTTAAATGATGGTTAAAATTACAAATTAAATTGTTAATTTTTATC
AATGTGATTGTAATTAAAAATATTTTGATTTAAATAACAAAAATAATACCAGATTTTAAGCCGTGGAAAATGTTCTTGATCATTTGCAGT


Top

FusionGenePPI for SLC25A21_FOXA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A21FBXO6, TBX20, NOSIP, DNASE1L2, PPIEFOXA1AR, ONECUT1, HDAC7, TLE1, ELAVL1, AHR, SEZ6L2, EED, PIAS1, SATB1, SATB2, NAA40, RECQL, CREB1, HOXB9, NACC1, NFIX, DLX1, DLX5, HOXD13, LDB1, NFIC, NKX2-5, PBX1, UBA7, UBP1, VARS, H2AFY, RCC1, MGME1, RPA2, ALX4, FOXA3, MSH3, PLOD2, HMGA1, KBTBD7, LDB2, TFAP4, PLOD1, KMT2C, NUP153, KRT13, DDX24, UTP20, UBTF, NOL6, RBM19, DDX47, ADAR, UTP18, WDR75, HNRNPH2, UTP14A, DDX56, DDX52, MPHOSPH10, NOL10, TBL3, DDX31, SKIV2L2, GLTSCR2, ESF1, RACGAP1, SSRP1, DDX50, H2AFX, NOP16, GPATCH4, LOC102724159, NSUN2, NOL8, RPL5, ALYREF, KIF23, XRN2, URB2, NOL11, DDX51, EXOSC10, KDM6A, DNTTIP2, POP1, NIP7, RBM34, TARDBP, RRP15, KRI1, REXO4, NOM1, NKRF, SDAD1, IGLC7, NOC4L, PAK1IP1, WDR12, AATF, DEK, CCDC137, RRP9, RCOR3, ODF2, EIF5A, PWP1, LUC7L2, PARN, C9orf114, DSG2, LOC113230, TOP2A, PHF2, CCDC59, YWHAB, DIMT1, UTP11L, DHX37, RRP36, WDR46, PPP1CC, LUC7L, HIST1H3A, DNAJC9, RPLP0, ISG20L2, DDX49, C11orf98, NR2F2, TMPO, RNH1, GAR1, NOL7, RPL13A, NGDN, USP36, GATA3, NSUN5, C14orf169, C3orf17, RALY, IGHG2, MCM7, PNO1, SRSF6, CIRBP, MCM3, PAXIP1, FUBP3, RPL28, WDR5, GRHL2, RPS27, UHRF1, RSL24D1, RPS17, ESR1, DNMT1, EXOSC2, ABT1, RPL10, NME1, ARL6IP4, SF1, GTF2I, DIEXF, CD3EAP, TSR1, RPS19BP1, DHX33, RAB10, PRSS1, HDGF, NOP10, TRIM33, SRSF9, PRDX2, HNRNPUL2, TUBGCP6, YLPM1, EIF1AY, SNRPGP15, DAZAP1, IGKV3-20, C12orf43, MAGOH, ARF3, CPSF7, ASH2L, DSTN, CMSS1, NOSIP, EZR, RBM4, ALKBH5, SEC14L5, SUMO1, L1RE1, PARP2, RPF1, POLR1E, TPT1, C6orf211, TRPS1, RPS5, EXOSC6, EXOSC9, DPY30, SRSF12, EXOSC4, RPL32, SAFB, FIP1L1, CSNK1A1, TXNDC17, GPI, TRA2A, NCOA3, ACTR3C, PINX1, FAM207A, RPL30, DDX42, ARF6, PRPF3, FCF1, SNRPA1, MCTS1, LAS1L, PHF6, DDX55, WBSCR22, POLR1C, STAU1, NCOA6, XPO1, SF3B4, HBD, TSPYL1, EXOSC3, CDK1, CORO7, TLE3, VPS35, AGR2, CCT6A, VRK1, HBA1, CBX5, PSIP1, CHD4, RBMX2, APRT, EXOSC1, MROH8, PRPF6, DNAJB1, LGALS3, CCDC67, ZFP42, RBM25, CHD3, ARPC2, XPO5, DNAH7, TEX10, DNAJA1, GMPS, SEPT11, OSTF1, FAM50A, CSE1L, RRP7A, MARS, GSTM3, PRMT6, PSMD2, ZYX, VWA8, RBM17, ZFP91, RBBP4, KPNA4, AGBL1, B4GAT1, KAT7, HNRNPUL1, MPHOSPH6, COPG1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SLC25A21_FOXA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SLC25A21_FOXA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFOXA1C0033578Prostatic Neoplasms2CTD_human
TgeneFOXA1C0015695Fatty Liver1CTD_human
TgeneFOXA1C1458155Mammary Neoplasms1CTD_human