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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34196

FusionGeneSummary for SLC25A1_HSPA13

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A1_HSPA13
Fusion gene ID: 34196
HgeneTgene
Gene symbol

SLC25A1

HSPA13

Gene ID

6576

6782

Gene namesolute carrier family 25 member 1heat shock protein family A (Hsp70) member 13
SynonymsCTP|D2L2AD|SEA|SLC20A3STCH
Cytomap

22q11.21

21q11.2

Type of geneprotein-codingprotein-coding
Descriptiontricarboxylate transport protein, mitochondrialcitrate transport proteinsolute carrier family 20 (mitochondrial citrate transporter), member 3solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1tricarboxylate carrier proteinheat shock 70 kDa protein 13heat shock protein 70kDa family, member 13microsomal stress 70 protein ATPase corestress 70 protein chaperone, microsome-associated, 60kDstress 70 protein chaperone, microsome-associated, 60kDastress-70 protein chaperone m
Modification date2018052320180523
UniProtAcc

P53007

P48723

Ensembl transtripts involved in fusion geneENST00000215882, ENST00000451283, 
ENST00000461267, 
ENST00000285667, 
ENST00000544452, ENST00000478035, 
Fusion gene scores* DoF score5 X 5 X 2=503 X 3 X 2=18
# samples 73
** MAII scorelog2(7/50*10)=0.485426827170242
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC25A1 [Title/Abstract] AND HSPA13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1D16945SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000215882ENST00000285667SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000215882ENST00000544452SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000215882ENST00000478035SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-3UTRENST00000451283ENST00000285667SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000451283ENST00000544452SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000451283ENST00000478035SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-3UTRENST00000461267ENST00000285667SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000461267ENST00000544452SLC25A1chr22

19164171

-HSPA13chr21

15743768

-
intron-intronENST00000461267ENST00000478035SLC25A1chr22

19164171

-HSPA13chr21

15743768

-

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FusionProtFeatures for SLC25A1_HSPA13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A1

P53007

HSPA13

P48723

Involved in citrate-H(+)/malate exchange. Important forthe bioenergetics of hepatic cells as it provides a carbon sourcefor fatty acid and sterol biosyntheses, and NAD(+) for theglycolytic pathway. Has peptide-independent ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A1_HSPA13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A1_HSPA13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A1_HSPA13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A1_HSPA13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A1C2746066Combined D-2- and L-2-hydroxyglutaric aciduria2ORPHANET;UNIPROT
HgeneSLC25A1C0036341Schizophrenia1PSYGENET