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Fusion gene ID: 34185 |
FusionGeneSummary for SLC25A13_STK31 |
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Fusion gene information | Fusion gene name: SLC25A13_STK31 | Fusion gene ID: 34185 | Hgene | Tgene | Gene symbol | SLC25A13 | STK31 | Gene ID | 10165 | 56164 |
Gene name | solute carrier family 25 member 13 | serine/threonine kinase 31 | |
Synonyms | ARALAR2|CITRIN|CTLN2 | SGK396|TDRD8 | |
Cytomap | 7q21.3 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium-binding mitochondrial carrier protein Aralar2mitochondrial aspartate glutamate carrier 2solute carrier family 25 (aspartate/glutamate carrier), member 13 | serine/threonine-protein kinase 31serine/threonine-protein kinase NYD-SPKsugen kinase 396testis tissue sperm-binding protein Li 78mtudor domain containing 8 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UJS0 | Q9BXU1 | |
Ensembl transtripts involved in fusion gene | ENST00000265631, ENST00000416240, ENST00000542654, ENST00000494085, | ENST00000355870, ENST00000433467, ENST00000354639, ENST00000428484, ENST00000405627, | |
Fusion gene scores | * DoF score | 9 X 7 X 8=504 | 2 X 2 X 2=8 |
# samples | 8 | 2 | |
** MAII score | log2(8/504*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SLC25A13 [Title/Abstract] AND STK31 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SLC25A13 | GO:0006754 | ATP biosynthetic process | 12851387 |
Hgene | SLC25A13 | GO:0015810 | aspartate transmembrane transport | 11566871 |
Hgene | SLC25A13 | GO:0015813 | L-glutamate transmembrane transport | 11566871 |
Hgene | SLC25A13 | GO:0043490 | malate-aspartate shuttle | 11566871 |
Hgene | SLC25A13 | GO:0045333 | cellular respiration | 12851387 |
Hgene | SLC25A13 | GO:0051592 | response to calcium ion | 11566871 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-A8-A08R-01A | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000265631 | ENST00000355870 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000265631 | ENST00000433467 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000265631 | ENST00000354639 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000265631 | ENST00000428484 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
5CDS-3UTR | ENST00000265631 | ENST00000405627 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000416240 | ENST00000355870 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000416240 | ENST00000433467 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000416240 | ENST00000354639 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000416240 | ENST00000428484 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
5CDS-3UTR | ENST00000416240 | ENST00000405627 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000542654 | ENST00000355870 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000542654 | ENST00000433467 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000542654 | ENST00000354639 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
Frame-shift | ENST00000542654 | ENST00000428484 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
5CDS-3UTR | ENST00000542654 | ENST00000405627 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
intron-3CDS | ENST00000494085 | ENST00000355870 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
intron-3CDS | ENST00000494085 | ENST00000433467 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
intron-3CDS | ENST00000494085 | ENST00000354639 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
intron-3CDS | ENST00000494085 | ENST00000428484 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
intron-3UTR | ENST00000494085 | ENST00000405627 | SLC25A13 | chr7 | 95906508 | - | STK31 | chr7 | 23792336 | + |
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FusionProtFeatures for SLC25A13_STK31 |
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Hgene | Tgene |
SLC25A13 | STK31 |
Mitochondrial and calcium-binding carrier that catalyzesthe calcium-dependent exchange of cytoplasmic glutamate withmitochondrial aspartate across the mitochondrial inner membrane(PubMed:11566871, PubMed:25410934). May have a function in theurea cycle (PubMed:11566871). {ECO:0000269|PubMed:11566871,ECO:0000269|PubMed:25410934}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC25A13_STK31 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC25A13_STK31 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC25A13 | USP50, BRE, BABAM1, SLX1B, UBC, MYC, ICT1, AGO4, SIRT7, MRPL46, ALB, ATF2, GRB2, CLN3, CLN5, ADRB2, FBXO6, PARK2, ASB8, CCDC8, EGFR, AATK, ARAF, IKBKB, ILK, IRAK1, LIMK2, SIK2, PPT1, NTRK1, ELAVL1, IMMT, CRK, XRCC3, NEIL3, SKI, MCM2, NF2, OTUB1, ZNF746, SLC25A12, CYLD, DLST, PDHA1, SOAT1, VDAC1, TRIM25 | STK31 | NEDD4, CLK1, FBXL17, SMURF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC25A13_STK31 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC25A13_STK31 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC25A13 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | SLC25A13 | C1853942 | CITRULLINEMIA, TYPE II, NEONATAL-ONSET | 1 | CTD_human;ORPHANET;UNIPROT |
Hgene | SLC25A13 | C1863844 | Adult-onset citrullinemia type 2 | 1 | CTD_human;ORPHANET |