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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34185

FusionGeneSummary for SLC25A13_STK31

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A13_STK31
Fusion gene ID: 34185
HgeneTgene
Gene symbol

SLC25A13

STK31

Gene ID

10165

56164

Gene namesolute carrier family 25 member 13serine/threonine kinase 31
SynonymsARALAR2|CITRIN|CTLN2SGK396|TDRD8
Cytomap

7q21.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding mitochondrial carrier protein Aralar2mitochondrial aspartate glutamate carrier 2solute carrier family 25 (aspartate/glutamate carrier), member 13serine/threonine-protein kinase 31serine/threonine-protein kinase NYD-SPKsugen kinase 396testis tissue sperm-binding protein Li 78mtudor domain containing 8
Modification date2018052320180523
UniProtAcc

Q9UJS0

Q9BXU1

Ensembl transtripts involved in fusion geneENST00000265631, ENST00000416240, 
ENST00000542654, ENST00000494085, 
ENST00000355870, ENST00000433467, 
ENST00000354639, ENST00000428484, 
ENST00000405627, 
Fusion gene scores* DoF score9 X 7 X 8=5042 X 2 X 2=8
# samples 82
** MAII scorelog2(8/504*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SLC25A13 [Title/Abstract] AND STK31 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC25A13

GO:0006754

ATP biosynthetic process

12851387

HgeneSLC25A13

GO:0015810

aspartate transmembrane transport

11566871

HgeneSLC25A13

GO:0015813

L-glutamate transmembrane transport

11566871

HgeneSLC25A13

GO:0043490

malate-aspartate shuttle

11566871

HgeneSLC25A13

GO:0045333

cellular respiration

12851387

HgeneSLC25A13

GO:0051592

response to calcium ion

11566871


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A8-A08R-01ASLC25A13chr7

95906508

-STK31chr7

23792336

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000265631ENST00000355870SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000265631ENST00000433467SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000265631ENST00000354639SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000265631ENST00000428484SLC25A13chr7

95906508

-STK31chr7

23792336

+
5CDS-3UTRENST00000265631ENST00000405627SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000416240ENST00000355870SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000416240ENST00000433467SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000416240ENST00000354639SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000416240ENST00000428484SLC25A13chr7

95906508

-STK31chr7

23792336

+
5CDS-3UTRENST00000416240ENST00000405627SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000542654ENST00000355870SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000542654ENST00000433467SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000542654ENST00000354639SLC25A13chr7

95906508

-STK31chr7

23792336

+
Frame-shitENST00000542654ENST00000428484SLC25A13chr7

95906508

-STK31chr7

23792336

+
5CDS-3UTRENST00000542654ENST00000405627SLC25A13chr7

95906508

-STK31chr7

23792336

+
intron-3CDSENST00000494085ENST00000355870SLC25A13chr7

95906508

-STK31chr7

23792336

+
intron-3CDSENST00000494085ENST00000433467SLC25A13chr7

95906508

-STK31chr7

23792336

+
intron-3CDSENST00000494085ENST00000354639SLC25A13chr7

95906508

-STK31chr7

23792336

+
intron-3CDSENST00000494085ENST00000428484SLC25A13chr7

95906508

-STK31chr7

23792336

+
intron-3UTRENST00000494085ENST00000405627SLC25A13chr7

95906508

-STK31chr7

23792336

+

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FusionProtFeatures for SLC25A13_STK31


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC25A13

Q9UJS0

STK31

Q9BXU1

Mitochondrial and calcium-binding carrier that catalyzesthe calcium-dependent exchange of cytoplasmic glutamate withmitochondrial aspartate across the mitochondrial inner membrane(PubMed:11566871, PubMed:25410934). May have a function in theurea cycle (PubMed:11566871). {ECO:0000269|PubMed:11566871,ECO:0000269|PubMed:25410934}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC25A13_STK31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC25A13_STK31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC25A13USP50, BRE, BABAM1, SLX1B, UBC, MYC, ICT1, AGO4, SIRT7, MRPL46, ALB, ATF2, GRB2, CLN3, CLN5, ADRB2, FBXO6, PARK2, ASB8, CCDC8, EGFR, AATK, ARAF, IKBKB, ILK, IRAK1, LIMK2, SIK2, PPT1, NTRK1, ELAVL1, IMMT, CRK, XRCC3, NEIL3, SKI, MCM2, NF2, OTUB1, ZNF746, SLC25A12, CYLD, DLST, PDHA1, SOAT1, VDAC1, TRIM25STK31NEDD4, CLK1, FBXL17, SMURF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC25A13_STK31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC25A13_STK31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC25A13C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneSLC25A13C1853942CITRULLINEMIA, TYPE II, NEONATAL-ONSET1CTD_human;ORPHANET;UNIPROT
HgeneSLC25A13C1863844Adult-onset citrullinemia type 21CTD_human;ORPHANET