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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34151

FusionGeneSummary for SLC22A23_TRAF3

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC22A23_TRAF3
Fusion gene ID: 34151
HgeneTgene
Gene symbol

SLC22A23

TRAF3

Gene ID

63027

7187

Gene namesolute carrier family 22 member 23TNF receptor associated factor 3
SynonymsC6orf85CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118
Cytomap

6p25.2

14q32.32

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 22 member 23ion transporter proteinTNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3
Modification date2018052220180527
UniProtAcc

A1A5C7

Q13114

Ensembl transtripts involved in fusion geneENST00000436008, ENST00000406686, 
ENST00000380302, ENST00000490273, 
ENST00000380298, ENST00000433689, 
ENST00000560371, ENST00000347662, 
ENST00000392745, ENST00000539721, 
ENST00000351691, 
Fusion gene scores* DoF score9 X 4 X 8=2884 X 4 X 4=64
# samples 94
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC22A23 [Title/Abstract] AND TRAF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-21-1081-01ASLC22A23chr6

3410422

-TRAF3chr14

103336522

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000436008ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000436008ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000436008ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000436008ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000436008ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000406686ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000406686ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000406686ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000406686ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000406686ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380302ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380302ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380302ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380302ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380302ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000490273ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000490273ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000490273ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000490273ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000490273ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380298ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380298ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380298ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380298ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
5CDS-5UTRENST00000380298ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
intron-5UTRENST00000433689ENST00000560371SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
intron-5UTRENST00000433689ENST00000347662SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
intron-5UTRENST00000433689ENST00000392745SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
intron-5UTRENST00000433689ENST00000539721SLC22A23chr6

3410422

-TRAF3chr14

103336522

+
intron-5UTRENST00000433689ENST00000351691SLC22A23chr6

3410422

-TRAF3chr14

103336522

+

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FusionProtFeatures for SLC22A23_TRAF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC22A23

A1A5C7

TRAF3

Q13114

Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in theregulation of B-cell survival. Part of signaling pathways leadingto the production of cytokines and interferon. Required for normalantibody isotype switching from IgM to IgG. Plays a role T-celldependent immune responses. Plays a role in the regulation ofantiviral responses. Is an essential constituent of several E3ubiquitin-protein ligase complexes. May have E3 ubiquitin-proteinligase activity and promote 'Lys-63'-linked ubiquitination oftarget proteins. Inhibits activation of NF-kappa-B in response toLTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and therebyinhibits non-canonical activation of NF-kappa-B. Promotesubiquitination and proteasomal degradation of MAP3K14.{ECO:0000269|PubMed:15084608, ECO:0000269|PubMed:15383523,ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:19937093,ECO:0000269|PubMed:20097753, ECO:0000269|PubMed:20185819}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC22A23_TRAF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC22A23_TRAF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC22A23KRTAP5-9, PSMA3, KRTAP10-8, NOTCH2NL, LGALS8, CLEC2D, ATP6V0D1, BMP4, DLK2, SIRT2, PAXBP1, KPRP, TAX1BP1, DSCC1TRAF3TANK, CASP3, SRC, MAP3K5, CD40, TNFSF14, TNFRSF9, TDP2, LTBR, NGFR, TNFRSF18, CD27, CFLAR, EDA2R, TNFRSF17, TRAF3IP2, TNFRSF14, RIPK1, TNFRSF11A, NUP62, TRAF3, TRAF3IP1, MAP3K14, TRIM37, USP7, OTUD5, TBK1, SMURF1, TRAIP, BIRC2, BIRC3, OTUB1, OTUB2, RNF216, MAVS, ZBP1, IRF1, AZI2, TLR3, TLR4, TLR9, TRAF2, USO1, TRAF5, WDR5, NLRX1, TNIP1, TAX1BP1, TICAM1, OPTN, CBLB, MYD88, TNFRSF1B, TNFRSF1A, FAS, TNFRSF8, PDLIM7, TRAF3IP3, TNAP, TNFRSF13C, TNFRSF13B, TRAF1, TNFRSF4, IKBKE, IRF3, NFATC2IP, ZMYND11, PPP3CA, PPP3R1, UBE2O, SNAP29, TFG, SEC16A, RBM14, DCAF7, GALC, DYRK1A, ETV6, TROAP, MYT1, UCHL1, SYK, SAR1A, DAXX, EWSR1, IL15, ABCC1, APOBEC3C, IKBKG, UBE2I, PPP1CC, TMEM173, NMRAL1, RIPK2, ECH1, FAM53C, IFIT3, RNF166, ESR1, CREB1, MAP3K7, TRIM14, CSNK1E, FOSL1, DDX3X, VAV3, SPP1, TSKS, SHPK, CELF2, HNRNPC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC22A23_TRAF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC22A23_TRAF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC22A23C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTRAF3C3553868HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 31UNIPROT