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Fusion gene ID: 3414 |
FusionGeneSummary for ATP5I_OS9 |
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Fusion gene information | Fusion gene name: ATP5I_OS9 | Fusion gene ID: 3414 | Hgene | Tgene | Gene symbol | ATP5I | OS9 | Gene ID | 10956 |
Gene name | OS9, endoplasmic reticulum lectin | ||
Synonyms | ERLEC2|OS-9 | ||
Cytomap | 12q13.3-q14.1 | ||
Type of gene | protein-coding | ||
Description | protein OS-9amplified in osteosarcoma 9endoplasmic reticulum lectin 2erlectin 2osteosarcoma amplified 9, endoplasmic reticulum associated proteinosteosarcoma amplified 9, endoplasmic reticulum lectin | ||
Modification date | 20180523 | ||
UniProtAcc | Q13438 | ||
Ensembl transtripts involved in fusion gene | ENST00000304312, ENST00000506525, | ENST00000552285, ENST00000315970, ENST00000439210, ENST00000389146, ENST00000413095, ENST00000551035, ENST00000435406, ENST00000257966, ENST00000389142, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 21 X 10 X 11=2310 |
# samples | 4 | 27 | |
** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(27/2310*10)=-3.09686153925259 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATP5I [Title/Abstract] AND OS9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | OS9 | GO:0006621 | protein retention in ER lumen | 18417469 |
Tgene | OS9 | GO:0034976 | response to endoplasmic reticulum stress | 19084021 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW001413 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000304312 | ENST00000552285 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000315970 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000439210 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000389146 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000413095 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000551035 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000435406 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000257966 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000304312 | ENST00000389142 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000552285 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000315970 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000439210 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000389146 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000413095 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000551035 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000435406 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000257966 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
intron-3CDS | ENST00000506525 | ENST00000389142 | ATP5I | chr4 | 667171 | + | OS9 | chr12 | 58112054 | - |
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FusionProtFeatures for ATP5I_OS9 |
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Hgene | Tgene |
ATP5I | OS9 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP5I_OS9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP5I_OS9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP5I_OS9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP5I_OS9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |