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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3414

FusionGeneSummary for ATP5I_OS9

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP5I_OS9
Fusion gene ID: 3414
HgeneTgene
Gene symbol

ATP5I

OS9

Gene ID

10956

Gene nameOS9, endoplasmic reticulum lectin
SynonymsERLEC2|OS-9
Cytomap

12q13.3-q14.1

Type of geneprotein-coding
Descriptionprotein OS-9amplified in osteosarcoma 9endoplasmic reticulum lectin 2erlectin 2osteosarcoma amplified 9, endoplasmic reticulum associated proteinosteosarcoma amplified 9, endoplasmic reticulum lectin
Modification date20180523
UniProtAcc

Q13438

Ensembl transtripts involved in fusion geneENST00000304312, ENST00000506525, 
ENST00000552285, ENST00000315970, 
ENST00000439210, ENST00000389146, 
ENST00000413095, ENST00000551035, 
ENST00000435406, ENST00000257966, 
ENST00000389142, 
Fusion gene scores* DoF score4 X 4 X 1=1621 X 10 X 11=2310
# samples 427
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/2310*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP5I [Title/Abstract] AND OS9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOS9

GO:0006621

protein retention in ER lumen

18417469

TgeneOS9

GO:0034976

response to endoplasmic reticulum stress

19084021


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW001413ATP5Ichr4

667171

+OS9chr12

58112054

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000304312ENST00000552285ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000315970ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000439210ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000389146ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000413095ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000551035ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000435406ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000257966ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000304312ENST00000389142ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000552285ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000315970ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000439210ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000389146ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000413095ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000551035ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000435406ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000257966ATP5Ichr4

667171

+OS9chr12

58112054

-
intron-3CDSENST00000506525ENST00000389142ATP5Ichr4

667171

+OS9chr12

58112054

-

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FusionProtFeatures for ATP5I_OS9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP5I

OS9

Q13438

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP5I_OS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP5I_OS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP5I_OS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP5I_OS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource