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Fusion gene ID: 34139 |
FusionGeneSummary for SLC20A2_ZNHIT6 |
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Fusion gene information | Fusion gene name: SLC20A2_ZNHIT6 | Fusion gene ID: 34139 | Hgene | Tgene | Gene symbol | SLC20A2 | ZNHIT6 | Gene ID | 6575 | 54680 |
Gene name | solute carrier family 20 member 2 | zinc finger HIT-type containing 6 | |
Synonyms | GLVR-2|GLVR2|IBGC1|IBGC3|MLVAR|PIT-2|PIT2|RAM1|Ram-1 | BCD1|C1orf181|NY-BR-75 | |
Cytomap | 8p11.21 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | sodium-dependent phosphate transporter 2gibbon ape leukemia virus receptor 2murine leukemia virus, amphotropic, receptor formurine leukemia virus, amphotropic; receptorsolute carrier family 20 (phosphate transporter), member 2 | box C/D snoRNA protein 1box C/D snoRNA essential 1 homologserologically defined breast cancer antigen NY-BR-75zinc finger HIT domain-containing protein 6zinc finger, HIT type 6 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q08357 | Q9NWK9 | |
Ensembl transtripts involved in fusion gene | ENST00000342228, ENST00000520262, ENST00000520179, ENST00000523340, | ENST00000431532, ENST00000370574, | |
Fusion gene scores | * DoF score | 12 X 9 X 6=648 | 4 X 4 X 3=48 |
# samples | 15 | 4 | |
** MAII score | log2(15/648*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC20A2 [Title/Abstract] AND ZNHIT6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF851482 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000342228 | ENST00000431532 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000342228 | ENST00000370574 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000520262 | ENST00000431532 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000520262 | ENST00000370574 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000520179 | ENST00000431532 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000520179 | ENST00000370574 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000523340 | ENST00000431532 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
intron-3CDS | ENST00000523340 | ENST00000370574 | SLC20A2 | chr8 | 42308736 | + | ZNHIT6 | chr1 | 86173833 | - |
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FusionProtFeatures for SLC20A2_ZNHIT6 |
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Hgene | Tgene |
SLC20A2 | ZNHIT6 |
Sodium-phosphate symporter which seems to play afundamental housekeeping role in phosphate transport by absorbingphosphate from interstitial fluid for normal cellular functionssuch as cellular metabolism, signal transduction, and nucleic acidand lipid synthesis. In vitro, sodium-dependent phosphate uptakeis not siginificantly affected by acidic and alkaline conditions,however sodium-independent phosphate uptake occurs at acidicconditions. May play a role in extracellular matrix, cartilage andvascular calcification. Functions as a retroviral receptor andconfers human cells susceptibility to infection to amphotropicmurine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.{ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090,ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504,ECO:0000269|PubMed:8302848}. | Required for box C/D snoRNAs accumulation involved insnoRNA processing, snoRNA transport to the nucleolus and ribosomebiogenesis. {ECO:0000269|PubMed:17636026}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC20A2_ZNHIT6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC20A2_ZNHIT6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC20A2_ZNHIT6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC20A2_ZNHIT6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC20A2 | C0393590 | Fahr's syndrome (disorder) | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | SLC20A2 | C0004782 | Basal Ganglia Diseases | 1 | CTD_human |
Hgene | SLC20A2 | C0006663 | Calcinosis | 1 | CTD_human |