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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 34110

FusionGeneSummary for SLC1A3_FYB

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC1A3_FYB
Fusion gene ID: 34110
HgeneTgene
Gene symbol

SLC1A3

FYB

Gene ID

6507

Gene namesolute carrier family 1 member 3
SynonymsEA6|EAAT1|GLAST|GLAST1
Cytomap

5p13.2

Type of geneprotein-coding
Descriptionexcitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3
Modification date20180519
UniProtAcc

P43003

Ensembl transtripts involved in fusion geneENST00000265113, ENST00000506725, 
ENST00000381918, 		ENST00000351578, 
ENST00000515010, ENST00000505428, 
ENST00000512982, ENST00000540520, 
ENST00000503065, 
Fusion gene scores* DoF score11 X 9 X 6=5947 X 7 X 5=245
# samples 128
** MAII scorelog2(12/594*10)=-2.30742852519225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/245*10)=-1.61470984411521
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC1A3 [Title/Abstract] AND FYB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC1A3

GO:0015813

L-glutamate transmembrane transport

26690923

HgeneSLC1A3

GO:0051938

L-glutamate import

7521911

HgeneSLC1A3

GO:0070779

D-aspartate import across plasma membrane

7521911

HgeneSLC1A3

GO:0071805

potassium ion transmembrane transport

20477940

HgeneSLC1A3

GO:0098712

L-glutamate import across plasma membrane

26690923

HgeneSLC1A3

GO:0140009

L-aspartate import across plasma membrane

20477940

HgeneSLC1A3

GO:1902476

chloride transmembrane transport

20477940


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1998-01ASLC1A3chr5

36608706

+FYBchr5

39110491

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265113ENST00000351578SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000265113ENST00000515010SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000265113ENST00000505428SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000265113ENST00000512982SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000265113ENST00000540520SLC1A3chr5

36608706

+FYBchr5

39110491

-
5CDS-intronENST00000265113ENST00000503065SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-3CDSENST00000506725ENST00000351578SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-3CDSENST00000506725ENST00000515010SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-3CDSENST00000506725ENST00000505428SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-3CDSENST00000506725ENST00000512982SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-3CDSENST00000506725ENST00000540520SLC1A3chr5

36608706

+FYBchr5

39110491

-
3UTR-intronENST00000506725ENST00000503065SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000381918ENST00000351578SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000381918ENST00000515010SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000381918ENST00000505428SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000381918ENST00000512982SLC1A3chr5

36608706

+FYBchr5

39110491

-
In-frameENST00000381918ENST00000540520SLC1A3chr5

36608706

+FYBchr5

39110491

-
5CDS-intronENST00000381918ENST00000503065SLC1A3chr5

36608706

+FYBchr5

39110491

-

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FusionProtFeatures for SLC1A3_FYB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC1A3

P43003

FYB

Sodium-dependent, high-affinity amino acid transporterthat mediates the uptake of L-glutamate and also L-aspartate andD-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940,PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as asymporter that transports one amino acid molecule together withtwo or three Na(+) ions and one proton, in parallel with thecounter-transport of one K(+) ion (PubMed:20477940). MediatesCl(-) flux that is not coupled to amino acid transport; thisavoids the accumulation of negative charges due to aspartate andNa(+) symport (PubMed:20477940). Plays a redundant role in therapid removal of released glutamate from the synaptic cleft, whichis essential for terminating the postsynaptic action of glutamate(By similarity). {ECO:0000250|UniProtKB:P56564,ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923,ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515,ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+2101_4760543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+181_4760498Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210346_37660543IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210426_45960543IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18346_37660498IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18426_45960498IntramembraneDiscontinuously helical
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210363_36560543RegionAspartate binding
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210443_44760543RegionAspartate binding
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18363_36560498RegionAspartate binding
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18443_44760498RegionAspartate binding
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210109_12260543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210146_23660543Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210261_26960543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210298_31860543Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210341_34560543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210377_38560543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210413_42560543Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210460_47260543Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210495_54260543Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+21069_8660543Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18109_12260498Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18146_23660498Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18261_26960498Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18298_31860498Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18341_34560498Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18377_38560498Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18413_42560498Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18460_47260498Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18495_54260498Topological domainCytoplasmic
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+1869_8660498Topological domainExtracellular
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210123_14560543TransmembraneHelical%3B Name%3D3
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210237_26060543TransmembraneHelical%3B Name%3D4
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210270_29760543TransmembraneHelical%3B Name%3D5
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210319_34060543TransmembraneHelical%3B Name%3D6
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210386_41260543TransmembraneHelical%3B Name%3D7
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+210473_49460543TransmembraneHelical%3B Name%3D8
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+21048_6860543TransmembraneHelical%3B Name%3D1
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000265113+21087_10860543TransmembraneHelical%3B Name%3D2
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18123_14560498TransmembraneHelical%3B Name%3D3
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18237_26060498TransmembraneHelical%3B Name%3D4
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18270_29760498TransmembraneHelical%3B Name%3D5
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18319_34060498TransmembraneHelical%3B Name%3D6
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18386_41260498TransmembraneHelical%3B Name%3D7
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+18473_49460498TransmembraneHelical%3B Name%3D8
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+1848_6860498TransmembraneHelical%3B Name%3D1
HgeneSLC1A3chr5:36608706chr5:39110491ENST00000381918+1887_10860498TransmembraneHelical%3B Name%3D2
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418456_507754784Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519456_507800830Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519456_507800830Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317456_507754784Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519456_507810840Coiled coilOntology_term=ECO:0000255
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418355_360754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418393_397754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418617_620754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519355_360800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519393_397800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519617_620800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519355_360800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519393_397800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519617_620800830Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317355_360754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317393_397754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317617_620754784Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519355_360810840Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519393_397810840Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519617_620810840Compositional biasNote=Poly-Pro
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418511_572754784DomainSH3 1
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418700_768754784DomainSH3 2
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519511_572800830DomainSH3 1
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519700_768800830DomainSH3 2
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519511_572800830DomainSH3 1
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519700_768800830DomainSH3 2
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317511_572754784DomainSH3 1
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317700_768754784DomainSH3 2
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519511_572810840DomainSH3 1
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519700_768810840DomainSH3 2
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418462_465754784MotifSH2-binding
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418469_505754784MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418595_598754784MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418625_628754784MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418674_700754784MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519462_465800830MotifSH2-binding
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519469_505800830MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519595_598800830MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519625_628800830MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519674_700800830MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519462_465800830MotifSH2-binding
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519469_505800830MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519595_598800830MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519625_628800830MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519674_700800830MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317462_465754784MotifSH2-binding
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317469_505754784MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317595_598754784MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317625_628754784MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317674_700754784MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519462_465810840MotifSH2-binding
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519469_505810840MotifNuclear localization signal
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519595_598810840MotifNote=SH2-binding%3B to LCP2
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519625_628810840MotifNote=SH2-binding%3B to FYN
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519674_700810840MotifNuclear localization signal


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FusionGeneSequence for SLC1A3_FYB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_90aa
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVDGYVLRSYLADNDGEIYDDIADGCIYDNDX


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_270nt
ATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGGCCAAG
AAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCATTGTG
GATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATGACTAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_2953nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTG
ATGGCTGCATCTATGACAATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGG
CATGTTATTGGGTATCAAGAAAATTAATGCACAAAACCACTTATTATCATTTGTTATGAAATCCCAATTATCTTTACAAAGTGTTTAAAG
TTTGAACATAGAAAATAATCTCTCTGCTTAATTGTTAACTCAGAAGACTACATTAGTGAGATGTAAGAATTATTAAATATTCCATTTCCG
CTTTGGCTACAATTATGAAGAAGTTGAAGGTACTTCTTTTAGACCACCAGTAAATAATCCTCCTTCAAAAAATAAAAATAAAAGAAAAAG
GAAAATCATTCAGGAAGAAATGACCTGTCTAAAAAAACCTAAGGAAGAATAATAATATAAGAAAGGAAATTTAAAAACATTCCACAAGAA
GAAAAATTATTGTTTATACTTCTACTTATGGTTATATCTTATATTCTCTATTCAAGTGACCTGTCTTTTAAAAAGGCAGTGCTGTCTTAC
CTCTTGCTAGTGGGTTAAATGTTTTCAAAAATTATAGCAGTAGTAGAAGTTTTGTATAAAATTTGTCCTTATTTGTTAATTGTATATAAA
TGTTAATTATTTGATACGAATGTTATGCATTTAGTATGCACATTGAAGTCTAAACTGTAGAAGAGTCTAAAACAAGTTCTCTTTTTGCAG
ATTCACATACTAATGGTTTAATTCTGTGCTCTGTTTAAAGTACTATTATAACTAGAGTAGATCTGAATGAGGATAACCCTAAAATCATGA
GGAATGGAAGAATGGACCTTGAAACTACCTAGGCTTTTATGCATGGCACCTCTTTATAATGAAGACACTTTTTAAAGTTTTTGTTTTTGT
TTCAATTACCGCTAGATTTTTTTTTCTCTTTTTTTAAAATCCATTTTACTGGAAAGTTGGCCAGCAGAGGGAGTAGAAATTATTAAAATT
CTAGTGTTTGGATTGGGCCCTTCTCTAACAGTACATACTCATTCCCAAAGCAATCCAAAAACAAAATGTGAACCATTTGGGTTTCAAATG
TTAAGAACACTAAATAGCATGATTTAAAAAATGAAAAATGCTAACACCCAAGAAAAGAAGATATTAAGTGCTTTTTAACAACTCCTAGAG
TACAAAATGAGTACATCATAATGCTGGCTCTTCTACTAATGAACCATCGAGTGATATTGAATAAATTATTTATCTTCTCAGTTTCCTTAT
CTGTAAATTACAATATTAGACTAAGTAAGTTTTTCCAACTCTTCACTACCAATTACCTTAGGCTTTTATAATGCTCCGCCTACTTCAGTC
CCATGTTTCAGAAGCTTTTGTCTATTTTTTAAACTCATTGATTAAATAATGATTAATGCATTCTCCACATTTTAATATTGCAAAGGCCCA
TTGGAGTTTCTGAAGTGGCTCCACAGAATTGAAATAATTTCAAATAACTGTAAAGGAACTGAAAATCTTCACAGAGATGAAGTGGGGTTT
CCATTAGGTGCTTTGAAATTTGATAACAAATCATCAACTTCCACTGGTCAATATATAGATTTTGGGTGTCTGAGGCCCCAAGATTAGATG
CCACTAATCTCCAAAGATTCCCTCCAATTATGAAATATTTTAATGTCTACTTTTAGAGAGCACTAGCCAGTATATGACCATGTGATTAAT
TTCTTTTCACACTAGATAAAATTACCTGGTTCAAAAGTGGTTTTTGTTTATTAAATTTGGTAATAAATATATATAATACACAGACAGGAT
AGTTTTTATGCTGAAGTTTTTGGCCAGCTTTAGTTTGAGGACTCCTTGATAAGCTTGCTAAACTTTCAGAGTGCCCTGAGACACTTCCAG
CCATCCCTCCTCCTGCCTTCATTGGGGCAGACTTGCATTGCAGTCTGACAGTAATTTTTTTTCTGATTGAGAATTATGTAAATTCAGTAC
AATGTCAGTTTTTAAAAGTCAAAGTTAGATCAAGAGAATATTTCAGAGTTTTGGTTTACACATCAAGAAACAGACACACATACCTAGGAA
AGATTTACACAATAGATAATCATCTTAATGTGAAAGATATTTGAAGTATTAATTTTAATATATTAAATATGATTTCTGTTATAGTCTTCT

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_905nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTG
ATGGCTGCATCTATGACAATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGG
CATGTTATTGGGTATCAAGAAAATTAATGCACAAAACCACTTATTATCATTTGTTATGAAATCCCAATTATCTTTACAAAGTGTTTAAAG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_887nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTG
ATGGCTGCATCTATGACAATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_887nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTG
ATGGCTGCATCTATGACAATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGG

>In-frame_SLC1A3_ENST00000265113_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_887nt
GCTTTATTTTTCAATTCTTCCTAGTCCCGGTTTTGCATTTCTAATGACAGTGAACTGACAAAGCGTGAAAGTGGTCTAAGGAGCAAAACA
AAGCCAGCAAGCCTGCTTCTGGTGTGCCAAGATTAATCAATATTCCAGAAACCTCGGGGTTTCCCCCTCCTCCCTGTGCGGTTTCCATTC
CCCACTCCTCCTTTCCCGGGCACAGACTCCTCCCCTTTTCTTAAGTTGCCCTGATAGTAACTTGCAGTTTCAGAGCACATGCACACTGTC
AGGGCTAGCCTGCCTGCTTACGCGCGCTGCGGATTGTTGCTCCGTTGTACCTGCTGGGGAATTCACCTCGTTACTGCTTGATATCTTCCA
CCCCTTACAAAATCAGAAAAGTTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAG
AAGAGACCCTCCTAGAAAAGTAAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAG
TCCGTAAACGCACACTTTTGGCCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGC
TGCTCACAGTCACCGCTGTCATTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTG
ATGGCTGCATCTATGACAATGACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGG

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000351578_chr5_39110491_-_2572nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATG
ACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAAGAA
AATTAATGCACAAAACCACTTATTATCATTTGTTATGAAATCCCAATTATCTTTACAAAGTGTTTAAAGTTTGAACATAGAAAATAATCT
CTCTGCTTAATTGTTAACTCAGAAGACTACATTAGTGAGATGTAAGAATTATTAAATATTCCATTTCCGCTTTGGCTACAATTATGAAGA
AGTTGAAGGTACTTCTTTTAGACCACCAGTAAATAATCCTCCTTCAAAAAATAAAAATAAAAGAAAAAGGAAAATCATTCAGGAAGAAAT
GACCTGTCTAAAAAAACCTAAGGAAGAATAATAATATAAGAAAGGAAATTTAAAAACATTCCACAAGAAGAAAAATTATTGTTTATACTT
CTACTTATGGTTATATCTTATATTCTCTATTCAAGTGACCTGTCTTTTAAAAAGGCAGTGCTGTCTTACCTCTTGCTAGTGGGTTAAATG
TTTTCAAAAATTATAGCAGTAGTAGAAGTTTTGTATAAAATTTGTCCTTATTTGTTAATTGTATATAAATGTTAATTATTTGATACGAAT
GTTATGCATTTAGTATGCACATTGAAGTCTAAACTGTAGAAGAGTCTAAAACAAGTTCTCTTTTTGCAGATTCACATACTAATGGTTTAA
TTCTGTGCTCTGTTTAAAGTACTATTATAACTAGAGTAGATCTGAATGAGGATAACCCTAAAATCATGAGGAATGGAAGAATGGACCTTG
AAACTACCTAGGCTTTTATGCATGGCACCTCTTTATAATGAAGACACTTTTTAAAGTTTTTGTTTTTGTTTCAATTACCGCTAGATTTTT
TTTTCTCTTTTTTTAAAATCCATTTTACTGGAAAGTTGGCCAGCAGAGGGAGTAGAAATTATTAAAATTCTAGTGTTTGGATTGGGCCCT
TCTCTAACAGTACATACTCATTCCCAAAGCAATCCAAAAACAAAATGTGAACCATTTGGGTTTCAAATGTTAAGAACACTAAATAGCATG
ATTTAAAAAATGAAAAATGCTAACACCCAAGAAAAGAAGATATTAAGTGCTTTTTAACAACTCCTAGAGTACAAAATGAGTACATCATAA
TGCTGGCTCTTCTACTAATGAACCATCGAGTGATATTGAATAAATTATTTATCTTCTCAGTTTCCTTATCTGTAAATTACAATATTAGAC
TAAGTAAGTTTTTCCAACTCTTCACTACCAATTACCTTAGGCTTTTATAATGCTCCGCCTACTTCAGTCCCATGTTTCAGAAGCTTTTGT
CTATTTTTTAAACTCATTGATTAAATAATGATTAATGCATTCTCCACATTTTAATATTGCAAAGGCCCATTGGAGTTTCTGAAGTGGCTC
CACAGAATTGAAATAATTTCAAATAACTGTAAAGGAACTGAAAATCTTCACAGAGATGAAGTGGGGTTTCCATTAGGTGCTTTGAAATTT
GATAACAAATCATCAACTTCCACTGGTCAATATATAGATTTTGGGTGTCTGAGGCCCCAAGATTAGATGCCACTAATCTCCAAAGATTCC
CTCCAATTATGAAATATTTTAATGTCTACTTTTAGAGAGCACTAGCCAGTATATGACCATGTGATTAATTTCTTTTCACACTAGATAAAA
TTACCTGGTTCAAAAGTGGTTTTTGTTTATTAAATTTGGTAATAAATATATATAATACACAGACAGGATAGTTTTTATGCTGAAGTTTTT
GGCCAGCTTTAGTTTGAGGACTCCTTGATAAGCTTGCTAAACTTTCAGAGTGCCCTGAGACACTTCCAGCCATCCCTCCTCCTGCCTTCA
TTGGGGCAGACTTGCATTGCAGTCTGACAGTAATTTTTTTTCTGATTGAGAATTATGTAAATTCAGTACAATGTCAGTTTTTAAAAGTCA
AAGTTAGATCAAGAGAATATTTCAGAGTTTTGGTTTACACATCAAGAAACAGACACACATACCTAGGAAAGATTTACACAATAGATAATC
ATCTTAATGTGAAAGATATTTGAAGTATTAATTTTAATATATTAAATATGATTTCTGTTATAGTCTTCTGTATGGAATTTTGTCACTTAA

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000515010_chr5_39110491_-_524nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATG
ACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAAGAA

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000505428_chr5_39110491_-_506nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATG
ACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAAGAA

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000512982_chr5_39110491_-_506nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATG
ACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAAGAA

>In-frame_SLC1A3_ENST00000381918_chr5_36608706_+_FYB_ENST00000540520_chr5_39110491_-_506nt
TTGTGTTTTCTAATACCAAAGAGGAGGTTTGGCTTTCTGTGGGTGATTCCCAGACACTGAAGTGCAAAGAAGAGACCCTCCTAGAAAAGT
AAAATATGACTAAAAGCAATGGAGAAGAGCCCAAGATGGGGGGCAGGATGGAGAGATTCCAGCAGGGAGTCCGTAAACGCACACTTTTGG
CCAAGAAGAAAGTGCAGAACATTACAAAGGAGGATGTTAAAAGTTACCTGTTTCGGAATGCTTTTGTGCTGCTCACAGTCACCGCTGTCA
TTGTGGATGGTTATGTCCTTCGGAGTTACCTAGCGGACAATGATGGAGAGATCTATGATGATATTGCTGATGGCTGCATCTATGACAATG
ACTAGCACTCAACTTTGGTCATTCTGCTGTGTTCATTAGGTGCCAATGTGAAGTCTGGATTTTAATTGGCATGTTATTGGGTATCAAGAA


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FusionGenePPI for SLC1A3_FYB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC1A3CUL3, ZDHHC17, LGALS3, TCTN3, TMEM17, PDZK1FYBSKAP1, FYN, VASP, WAS, PRKCQ, MAP3K7, BCL10, CARD11, CBL, FASLG, LCP2, NCK2, UBE2I


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFYBchr5:36608706chr5:39110491ENST00000351578-1418348_448754784SKAP1
TgeneFYBchr5:36608706chr5:39110491ENST00000505428-1519348_448800830SKAP1
TgeneFYBchr5:36608706chr5:39110491ENST00000512982-1519348_448800830SKAP1
TgeneFYBchr5:36608706chr5:39110491ENST00000515010-1317348_448754784SKAP1
TgeneFYBchr5:36608706chr5:39110491ENST00000540520-1519348_448810840SKAP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC1A3_FYB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSLC1A3P43003DB00142Glutamic AcidExcitatory amino acid transporter 1 {ECO:0000303|PubMed:16042756, ECO:0000303|PubMed:8647279}small moleculeapproved|nutraceutical

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RelatedDiseases for SLC1A3_FYB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC1A3C0036341Schizophrenia4PSYGENET
HgeneSLC1A3C0004352Autistic Disorder1CTD_human
HgeneSLC1A3C0005586Bipolar Disorder1PSYGENET
HgeneSLC1A3C0014544Epilepsy1CTD_human;HPO
HgeneSLC1A3C0178417Anhedonia1PSYGENET
HgeneSLC1A3C2675211EPISODIC ATAXIA, TYPE 6 (disorder)1CTD_human;ORPHANET;UNIPROT