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Fusion gene ID: 34059 |
FusionGeneSummary for SLC14A2_ABHD3 |
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Fusion gene information | Fusion gene name: SLC14A2_ABHD3 | Fusion gene ID: 34059 | Hgene | Tgene | Gene symbol | SLC14A2 | ABHD3 | Gene ID | 8170 | 171586 |
Gene name | solute carrier family 14 member 2 | abhydrolase domain containing 3 | |
Synonyms | HUT2|UT-A2|UT2|UTA|UTR|hUT-A6 | LABH3 | |
Cytomap | 18q12.3 | 18q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | urea transporter 2solute carrier family 14 (urea transporter), member 2urea transporter, kidney | phospholipase ABHD3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q15849 | Q8WU67 | |
Ensembl transtripts involved in fusion gene | ENST00000586448, ENST00000255226, ENST00000589658, | ENST00000289119, ENST00000580981, ENST00000578270, ENST00000579875, | |
Fusion gene scores | * DoF score | 3 X 2 X 2=12 | 4 X 5 X 5=100 |
# samples | 3 | 7 | |
** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC14A2 [Title/Abstract] AND ABHD3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-44-7667-01A | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000586448 | ENST00000289119 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
5UTR-intron | ENST00000586448 | ENST00000580981 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
5UTR-5UTR | ENST00000586448 | ENST00000578270 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
5UTR-5UTR | ENST00000586448 | ENST00000579875 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-3CDS | ENST00000255226 | ENST00000289119 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-intron | ENST00000255226 | ENST00000580981 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-5UTR | ENST00000255226 | ENST00000578270 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-5UTR | ENST00000255226 | ENST00000579875 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-3CDS | ENST00000589658 | ENST00000289119 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-intron | ENST00000589658 | ENST00000580981 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-5UTR | ENST00000589658 | ENST00000578270 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
intron-5UTR | ENST00000589658 | ENST00000579875 | SLC14A2 | chr18 | 42793156 | + | ABHD3 | chr18 | 19244191 | - |
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FusionProtFeatures for SLC14A2_ABHD3 |
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Hgene | Tgene |
SLC14A2 | ABHD3 |
Specialized low-affinity vasopressin-regulated ureatransporter. Mediates rapid transepithelial urea transport acrossthe inner medullary collecting duct and plays a major role in theurinary concentrating mechanism. {ECO:0000269|PubMed:11502588,ECO:0000269|PubMed:8647271}. | Phospholipase that may play a role in phospholipidsremodeling. May selectively cleave myristate (C14)-containingphosphatidylcholines through its predominant phospholipase 1activity, cleaving preferentially acyl groups in sn1 position. Inparallel, may have a minor phospholipase 2 activity acting on acylgroups in position sn2. In addition to (C14)-containingphosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.{ECO:0000269|PubMed:21926997}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC14A2_ABHD3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC14A2_ABHD3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SLC14A2 | PKP2 | ABHD3 | KLK15, ATP1B3, HTR3C, MAS1, HTR3A, IL17RC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC14A2_ABHD3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC14A2_ABHD3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |