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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34059

FusionGeneSummary for SLC14A2_ABHD3

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC14A2_ABHD3
Fusion gene ID: 34059
HgeneTgene
Gene symbol

SLC14A2

ABHD3

Gene ID

8170

171586

Gene namesolute carrier family 14 member 2abhydrolase domain containing 3
SynonymsHUT2|UT-A2|UT2|UTA|UTR|hUT-A6LABH3
Cytomap

18q12.3

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionurea transporter 2solute carrier family 14 (urea transporter), member 2urea transporter, kidneyphospholipase ABHD3abhydrolase domain-containing protein 3alpha/beta hydrolase domain containing protein 3lung alpha/beta hydrolase 3
Modification date2018051920180523
UniProtAcc

Q15849

Q8WU67

Ensembl transtripts involved in fusion geneENST00000586448, ENST00000255226, 
ENST00000589658, 
ENST00000289119, 
ENST00000580981, ENST00000578270, 
ENST00000579875, 
Fusion gene scores* DoF score3 X 2 X 2=124 X 5 X 5=100
# samples 37
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC14A2 [Title/Abstract] AND ABHD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-44-7667-01ASLC14A2chr18

42793156

+ABHD3chr18

19244191

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000586448ENST00000289119SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
5UTR-intronENST00000586448ENST00000580981SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
5UTR-5UTRENST00000586448ENST00000578270SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
5UTR-5UTRENST00000586448ENST00000579875SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-3CDSENST00000255226ENST00000289119SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-intronENST00000255226ENST00000580981SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-5UTRENST00000255226ENST00000578270SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-5UTRENST00000255226ENST00000579875SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-3CDSENST00000589658ENST00000289119SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-intronENST00000589658ENST00000580981SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-5UTRENST00000589658ENST00000578270SLC14A2chr18

42793156

+ABHD3chr18

19244191

-
intron-5UTRENST00000589658ENST00000579875SLC14A2chr18

42793156

+ABHD3chr18

19244191

-

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FusionProtFeatures for SLC14A2_ABHD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC14A2

Q15849

ABHD3

Q8WU67

Specialized low-affinity vasopressin-regulated ureatransporter. Mediates rapid transepithelial urea transport acrossthe inner medullary collecting duct and plays a major role in theurinary concentrating mechanism. {ECO:0000269|PubMed:11502588,ECO:0000269|PubMed:8647271}. Phospholipase that may play a role in phospholipidsremodeling. May selectively cleave myristate (C14)-containingphosphatidylcholines through its predominant phospholipase 1activity, cleaving preferentially acyl groups in sn1 position. Inparallel, may have a minor phospholipase 2 activity acting on acylgroups in position sn2. In addition to (C14)-containingphosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.{ECO:0000269|PubMed:21926997}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC14A2_ABHD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC14A2_ABHD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC14A2PKP2ABHD3KLK15, ATP1B3, HTR3C, MAS1, HTR3A, IL17RC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC14A2_ABHD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC14A2_ABHD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource