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Fusion gene ID: 34050 |
FusionGeneSummary for SLC12A8_HTN1 |
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Fusion gene information | Fusion gene name: SLC12A8_HTN1 | Fusion gene ID: 34050 | Hgene | Tgene | Gene symbol | SLC12A8 | HTN1 | Gene ID | 84561 | 3346 |
Gene name | solute carrier family 12 member 8 | histatin 1 | |
Synonyms | CCC9 | HIS1 | |
Cytomap | 3q21.2 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | solute carrier family 12 member 8cation-chloride cotransporter 9solute carrier family 12 (sodium/potassium/chloride transporters), member 8 | histatin-1PPBhistidine-rich protein 1post-PB protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | A0AV02 | P15515 | |
Ensembl transtripts involved in fusion gene | ENST00000393469, ENST00000423114, ENST00000469902, ENST00000314584, ENST00000430155, ENST00000465475, | ENST00000246896, ENST00000511674, | |
Fusion gene scores | * DoF score | 10 X 9 X 5=450 | 1 X 1 X 1=1 |
# samples | 10 | 1 | |
** MAII score | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SLC12A8 [Title/Abstract] AND HTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AK131070 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000393469 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000393469 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000423114 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000423114 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000469902 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000469902 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000314584 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000314584 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000430155 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000430155 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000465475 | ENST00000246896 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
intron-5UTR | ENST00000465475 | ENST00000511674 | SLC12A8 | chr3 | 124802272 | - | HTN1 | chr4 | 70916155 | + |
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FusionProtFeatures for SLC12A8_HTN1 |
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Hgene | Tgene |
SLC12A8 | HTN1 |
Histatins are salivary proteins that are considered tobe major precursors of the protective proteinaceous structure ontooth surfaces (enamel pellicle). In addition, histatins exhibitantibacterial and antifungal activities. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC12A8_HTN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SLC12A8_HTN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC12A8_HTN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC12A8_HTN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HTN1 | C0004352 | Autistic Disorder | 1 | CTD_human |