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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34016

FusionGeneSummary for SLC10A7_TTC29

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC10A7_TTC29
Fusion gene ID: 34016
HgeneTgene
Gene symbol

SLC10A7

TTC29

Gene ID

84068

83894

Gene namesolute carrier family 10 member 7tetratricopeptide repeat domain 29
SynonymsC4orf13|P7NYD-SP14|TBPP2A
Cytomap

4q31.22

4q31.22

Type of geneprotein-codingprotein-coding
Descriptionsodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7tetratricopeptide repeat protein 29TPR repeat protein 29testicular secretory protein Li 62testis development protein NYD-SP14
Modification date2018051920180519
UniProtAcc

Q0GE19

Q8NA56

Ensembl transtripts involved in fusion geneENST00000432059, ENST00000335472, 
ENST00000264986, ENST00000507030, 
ENST00000394062, ENST00000394059, 
ENST00000511315, ENST00000511374, 
ENST00000502607, 
ENST00000513335, 
ENST00000398886, ENST00000325106, 
ENST00000506019, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 2 X 2=12
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SLC10A7 [Title/Abstract] AND TTC29 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVOVTCGA-13-0760-01ASLC10A7chr4

147438190

-TTC29chr4

147628703

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000432059ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000432059ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000432059ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000432059ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000335472ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000335472ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000335472ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000335472ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000264986ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000264986ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000264986ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000264986ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000507030ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000507030ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000507030ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000507030ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394062ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394062ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394062ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000394062ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394059ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394059ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000394059ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000394059ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5UTR-3CDSENST00000511315ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5UTR-3CDSENST00000511315ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5UTR-3CDSENST00000511315ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5UTR-intronENST00000511315ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000511374ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000511374ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000511374ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000511374ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000502607ENST00000513335SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000502607ENST00000398886SLC10A7chr4

147438190

-TTC29chr4

147628703

-
Frame-shiftENST00000502607ENST00000325106SLC10A7chr4

147438190

-TTC29chr4

147628703

-
5CDS-intronENST00000502607ENST00000506019SLC10A7chr4

147438190

-TTC29chr4

147628703

-

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FusionProtFeatures for SLC10A7_TTC29


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC10A7

Q0GE19

TTC29

Q8NA56


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC10A7_TTC29


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC10A7_TTC29


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC10A7ISLR, DPY19L4, ATP6V0D1, CD79A, MME, PCDHA4, IQCF1, EIF2B2, TOR1AIP2, KIAA0368, APOBTTC29ABCE1, LSG1, EIF5B, DHX16, ANKFY1, OBSL1, SUPT6H, CDK18, FBXW8, TBL1XR1, IKBIP, MACF1, CSTF2, NELFE, TAF8, PPIL4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC10A7_TTC29


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC10A7_TTC29


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC10A7C0008370Cholestasis1CTD_human
HgeneSLC10A7C4277682Chemical and Drug Induced Liver Injury1CTD_human