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Fusion gene ID: 34015 |
FusionGeneSummary for SLC10A7_FKBP15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SLC10A7_FKBP15 | Fusion gene ID: 34015 | Hgene | Tgene | Gene symbol | SLC10A7 | FKBP15 | Gene ID | 84068 | 23307 |
| Gene name | solute carrier family 10 member 7 | FK506 binding protein 15 | |
| Synonyms | C4orf13|P7 | FKBP133|KIAA0674|PPP1R76 | |
| Cytomap | 4q31.22 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7 | FK506-binding protein 15133 kDa FK506-binding protein133 kDa FKBPFK506 binding protein 15, 133kDaFK506-binding protein 133kDaFKBP-133FKBP-15WAFLWASP and FKBP-like proteinprotein phosphatase 1, regulatory subunit 76 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q0GE19 | Q5T1M5 | |
| Ensembl transtripts involved in fusion gene | ENST00000432059, ENST00000335472, ENST00000264986, ENST00000507030, ENST00000394062, ENST00000394059, ENST00000511315, ENST00000511374, ENST00000502607, | ENST00000238256, ENST00000493847, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 8 X 8 X 2=128 |
| # samples | 3 | 9 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SLC10A7 [Title/Abstract] AND FKBP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FKBP15 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-G9-6361-01A | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000432059 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000432059 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000335472 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000335472 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 3UTR-3CDS | ENST00000264986 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 3UTR-intron | ENST00000264986 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000507030 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000507030 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| In-frame | ENST00000394062 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| 5CDS-intron | ENST00000394062 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000394059 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000394059 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000511315 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000511315 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000511374 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000511374 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-3CDS | ENST00000502607 | ENST00000238256 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
| intron-intron | ENST00000502607 | ENST00000493847 | SLC10A7 | chr4 | 147363935 | - | FKBP15 | chr9 | 115932909 | - |
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FusionProtFeatures for SLC10A7_FKBP15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SLC10A7 | FKBP15 |
| May be involved in the cytoskeletal organization ofneuronal growth cones. Seems to be inactive as a PPIase (Bysimilarity). Involved in the transport of early endosomes at thelevel of transition between microfilament-based and microtubule-based movement. {ECO:0000250, ECO:0000269|PubMed:19121306}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SLC10A7_FKBP15 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SLC10A7_ENST00000335472_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_479aa MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWL FLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTI KMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGD SEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSD PEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDE >In-frame_SLC10A7_ENST00000507030_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_479aa MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWL FLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTI KMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGD SEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSD PEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDE >In-frame_SLC10A7_ENST00000394062_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_479aa MRLLERMRKDWFMVGIVLAIAGAKLEPSIGVNGGPLKPEITVSYIAVATIFFNSGLSLKTEELTSALVHLKLHLFIQIFTLAFFPATIWL FLQLLSITPINEWLLKGLQTVGCMPPPVSSAVILTKAVGGNEAAAIFNSAFGSFLVKKIMNQVFQSLRREFELEESYNGRTILGTIMNTI KMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQSASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGD SEAEALSEIKDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCVREVAPDGPLQESSTRLSLTSD PEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSSTEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SLC10A7_ENST00000335472_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_1437nt ATGAGGCTGCTGGAGAGAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTGGCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGG GTGAATGGGGGACCACTGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCAACAATATTCTTTAACAGTGGACTATCATTGAAAACA GAGGAGCTGACCAGTGCTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATCTTTACTCTTGCATTCTTCCCAGCAACAATATGGCTT TTTCTTCAGCTTTTATCAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTGCAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCT GCAGTGATTTTAACCAAGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAATTCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATG AACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATC AAGATGGTGACTCTTCAGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGCAGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGG CCACGAAGACCTTCCCAGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAAGCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATG GTGCCCTCAGAGCAGGTGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTCACCACTTCCCAGGATGGACACAGAAGGAAAGGGGAC TCAGAAGCTGAGGCACTCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTGTCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCG ACTTCAATTCCACCTGAGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAGGAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCC GACAACCCATCAGGAAAGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTACAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGAC CCCGAGGAGGGGGACCCACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAGCCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCC ACCGGTCCCCACAAGGAGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGAGCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCC AGTCTCTCTGGGGATGAAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCTCTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAA >In-frame_SLC10A7_ENST00000507030_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_1437nt ATGAGGCTGCTGGAGAGAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTGGCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGG GTGAATGGGGGACCACTGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCAACAATATTCTTTAACAGTGGACTATCATTGAAAACA GAGGAGCTGACCAGTGCTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATCTTTACTCTTGCATTCTTCCCAGCAACAATATGGCTT TTTCTTCAGCTTTTATCAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTGCAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCT GCAGTGATTTTAACCAAGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAATTCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATG AACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATC AAGATGGTGACTCTTCAGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGCAGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGG CCACGAAGACCTTCCCAGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAAGCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATG GTGCCCTCAGAGCAGGTGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTCACCACTTCCCAGGATGGACACAGAAGGAAAGGGGAC TCAGAAGCTGAGGCACTCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTGTCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCG ACTTCAATTCCACCTGAGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAGGAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCC GACAACCCATCAGGAAAGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTACAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGAC CCCGAGGAGGGGGACCCACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAGCCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCC ACCGGTCCCCACAAGGAGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGAGCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCC AGTCTCTCTGGGGATGAAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCTCTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAA >In-frame_SLC10A7_ENST00000394062_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_1437nt ATGAGGCTGCTGGAGAGAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTGGCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGG GTGAATGGGGGACCACTGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCAACAATATTCTTTAACAGTGGACTATCATTGAAAACA GAGGAGCTGACCAGTGCTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATCTTTACTCTTGCATTCTTCCCAGCAACAATATGGCTT TTTCTTCAGCTTTTATCAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTGCAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCT GCAGTGATTTTAACCAAGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAATTCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATG AACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATC AAGATGGTGACTCTTCAGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGCAGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGG CCACGAAGACCTTCCCAGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAAGCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATG GTGCCCTCAGAGCAGGTGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTCACCACTTCCCAGGATGGACACAGAAGGAAAGGGGAC TCAGAAGCTGAGGCACTCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTGTCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCG ACTTCAATTCCACCTGAGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAGGAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCC GACAACCCATCAGGAAAGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTACAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGAC CCCGAGGAGGGGGACCCACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAGCCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCC ACCGGTCCCCACAAGGAGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGAGCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCC AGTCTCTCTGGGGATGAAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCTCTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SLC10A7_ENST00000335472_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_2211nt GAGACTTTCCTGTCACTGGCTACTACTACTCCCAACCCTCCTCAAAGCCGCCGGAGCAACCCCCAGGTCTTTACTTTACAATCGGCAATT TGACTTGCTCTGCTGCATGTCTGGAGGGACCAAGGAAAGTGTGGAGACGCTCCAAGGATTAGGTGATCGGAGCTTGAAAAGAAAAAAAGC CAAACAAATAAACAAAACCCACCCACCCTAACAAATATGAGGCTGCTGGAGAGAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTG GCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGGGTGAATGGGGGACCACTGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCA ACAATATTCTTTAACAGTGGACTATCATTGAAAACAGAGGAGCTGACCAGTGCTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATC TTTACTCTTGCATTCTTCCCAGCAACAATATGGCTTTTTCTTCAGCTTTTATCAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTG CAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCTGCAGTGATTTTAACCAAGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAAT TCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATGAACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAAT GGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGATGGTGACTCTTCAGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGC AGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGGCCACGAAGACCTTCCCAGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAA GCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATGGTGCCCTCAGAGCAGGTGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTC ACCACTTCCCAGGATGGACACAGAAGGAAAGGGGACTCAGAAGCTGAGGCACTCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTG TCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCGACTTCAATTCCACCTGAGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAG GAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCCGACAACCCATCAGGAAAGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTA CAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGACCCCGAGGAGGGGGACCCACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAG CCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCCACCGGTCCCCACAAGGAGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGA GCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCCAGTCTCTCTGGGGATGAAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCT CTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAAGACGAGGTGAGCATGAAGGGACGCCCGCCCCCAACGCCCCTTTTTGGAGATGAT GATGATGACGATGACATTGACTGGCTGGGATGAAGACCCAGGAAACTGGTGCAAAGGTTTCTCTGCAACCCTTCCCTAAGCATGATTTTG CACAGCCAACCCTGGGTCTAGGCGAACCACAGGGTGAGGTCAAGGTGAGCATTCTGGGAACAATATTTGGGCTCAGAGGGTGGGTTGGCC ACCTTCTGAGCCCCACCCCCGCCAGACCTGGTGAAGAGGATCATAACCCTGTCTTCAAGAACACTGGGATTTCAGCAGCAAGTTGGAAGA AGGACTGGTAGGTTCCCCTCCAAGCCAGTCACCTGTAAGAGTCCTGTCCTCTGCCAGACTTTTTAATCTCTTCATTAACTCTCAGACTGA CCTGGGAGCCCTCCTCTACCTGAATCCAGTGCTCAACTGTGCCCCGGCAACAAGACCTGGGCTGAGGTCTCCCTGGTAGAACTAAGGGAG ATTACACCATCTAAATCCCAGTGCAGTCAACAGCCTGGCCTATAGTCCTGGGACATGTATCTTCTTCTTTGCCTTAAATCTGATACAAGA >In-frame_SLC10A7_ENST00000507030_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_1995nt ATGAGGCTGCTGGAGAGAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTGGCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGG GTGAATGGGGGACCACTGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCAACAATATTCTTTAACAGTGGACTATCATTGAAAACA GAGGAGCTGACCAGTGCTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATCTTTACTCTTGCATTCTTCCCAGCAACAATATGGCTT TTTCTTCAGCTTTTATCAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTGCAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCT GCAGTGATTTTAACCAAGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAATTCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATG AACCAGGTGTTCCAGTCCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATC AAGATGGTGACTCTTCAGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGCAGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGG CCACGAAGACCTTCCCAGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAAGCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATG GTGCCCTCAGAGCAGGTGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTCACCACTTCCCAGGATGGACACAGAAGGAAAGGGGAC TCAGAAGCTGAGGCACTCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTGTCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCG ACTTCAATTCCACCTGAGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAGGAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCC GACAACCCATCAGGAAAGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTACAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGAC CCCGAGGAGGGGGACCCACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAGCCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCC ACCGGTCCCCACAAGGAGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGAGCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCC AGTCTCTCTGGGGATGAAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCTCTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAA GACGAGGTGAGCATGAAGGGACGCCCGCCCCCAACGCCCCTTTTTGGAGATGATGATGATGACGATGACATTGACTGGCTGGGATGAAGA CCCAGGAAACTGGTGCAAAGGTTTCTCTGCAACCCTTCCCTAAGCATGATTTTGCACAGCCAACCCTGGGTCTAGGCGAACCACAGGGTG AGGTCAAGGTGAGCATTCTGGGAACAATATTTGGGCTCAGAGGGTGGGTTGGCCACCTTCTGAGCCCCACCCCCGCCAGACCTGGTGAAG AGGATCATAACCCTGTCTTCAAGAACACTGGGATTTCAGCAGCAAGTTGGAAGAAGGACTGGTAGGTTCCCCTCCAAGCCAGTCACCTGT AAGAGTCCTGTCCTCTGCCAGACTTTTTAATCTCTTCATTAACTCTCAGACTGACCTGGGAGCCCTCCTCTACCTGAATCCAGTGCTCAA CTGTGCCCCGGCAACAAGACCTGGGCTGAGGTCTCCCTGGTAGAACTAAGGGAGATTACACCATCTAAATCCCAGTGCAGTCAACAGCCT GGCCTATAGTCCTGGGACATGTATCTTCTTCTTTGCCTTAAATCTGATACAAGAGGTCAATGACTTTGAAAATAAAACTAAAATAAATGT >In-frame_SLC10A7_ENST00000394062_chr4_147363935_-_FKBP15_ENST00000238256_chr9_115932909_-_2249nt GTATTCTGAGGCGCGTGGTAGTGATGGCGGCGCTCAGTGAGACTTTCCTGTCACTGGCTACTACTACTCCCAACCCTCCTCAAAGCCGCC GGAGCAACCCCCAGGTCTTTACTTTACAATCGGCAATTTGACTTGCTCTGCTGCATGTCTGGAGGGACCAAGGAAAGTGTGGAGACGCTC CAAGGATTAGGTGATCGGAGCTTGAAAAGAAAAAAAGCCAAACAAATAAACAAAACCCACCCACCCTAACAAATATGAGGCTGCTGGAGA GAATGAGGAAAGACTGGTTCATGGTCGGAATAGTGCTGGCGATCGCTGGAGCTAAACTGGAGCCGTCCATAGGGGTGAATGGGGGACCAC TGAAGCCAGAAATAACTGTATCCTACATTGCTGTTGCAACAATATTCTTTAACAGTGGACTATCATTGAAAACAGAGGAGCTGACCAGTG CTTTGGTGCATCTAAAACTGCATCTTTTTATTCAGATCTTTACTCTTGCATTCTTCCCAGCAACAATATGGCTTTTTCTTCAGCTTTTAT CAATCACACCCATCAACGAATGGCTTTTAAAAGGTTTGCAGACAGTAGGTTGCATGCCTCCGCCTGTGTCTTCTGCAGTGATTTTAACCA AGGCAGTTGGTGGAAATGAGGCAGCTGCAATATTTAATTCAGCCTTTGGAAGTTTTTTGGTCAAGAAGATCATGAACCAGGTGTTCCAGT CCTTACGGAGAGAGTTTGAGCTGGAGGAATCTTACAATGGCAGGACCATTCTGGGAACCATCATGAATACGATCAAGATGGTGACTCTTC AGCTGTTAAACCAACAGGAGCAAGAGAAGGAAGAGAGCAGCAGTGAAGAAGAAGAAGAAAAAGCAGAAGAGCGGCCACGAAGACCTTCCC AGGAGCAGTCAGCCTCAGCCAGTTCTGGGCAGCCTCAAGCACCCCTGAATAGGGAGAGGCCAGAGTCCCCCATGGTGCCCTCAGAGCAGG TGGTCGAGGAAGCTGTCCCGTTGCCTCCTCAGGCCCTCACCACTTCCCAGGATGGACACAGAAGGAAAGGGGACTCAGAAGCTGAGGCAC TCTCAGAGATAAAAGATGGTTCCCTTCCACCCGAACTGTCTTGCATCCCATCCCACAGAGTTCTAGGGCCCCCGACTTCAATTCCACCTG AGCCCCTAGGCCCTGTATCCATGGACTCTGAGTGTGAGGAGTCACTTGCTGCCAGCCCAATGGCAGCTAAGCCCGACAACCCATCAGGAA AGGTCTGTGTCAGGGAAGTAGCACCAGATGGCCCACTACAAGAAAGCTCCACAAGACTGTCCCTGACTTCAGACCCCGAGGAGGGGGACC CACTGGCCTTAGGGCCTGAAAGCCCAGGAGAGCCTCAGCCTCCACAGCTCAAGAAAGATGATGTCACTAGCTCCACCGGTCCCCACAAGG AGCTGTCAAGCACAGAGGCAGGTTCCACAGTTGCAGGAGCAGCCCTCAGACCCAGCCATCATTCCCAGCGTTCCAGTCTCTCTGGGGATG AAGAGGATGAACTGTTTAAAGGGGCAACTCTGAAAGCTCTGAGGCCCAAAGCACAGCCTGAGGAGGAGGATGAAGACGAGGTGAGCATGA AGGGACGCCCGCCCCCAACGCCCCTTTTTGGAGATGATGATGATGACGATGACATTGACTGGCTGGGATGAAGACCCAGGAAACTGGTGC AAAGGTTTCTCTGCAACCCTTCCCTAAGCATGATTTTGCACAGCCAACCCTGGGTCTAGGCGAACCACAGGGTGAGGTCAAGGTGAGCAT TCTGGGAACAATATTTGGGCTCAGAGGGTGGGTTGGCCACCTTCTGAGCCCCACCCCCGCCAGACCTGGTGAAGAGGATCATAACCCTGT CTTCAAGAACACTGGGATTTCAGCAGCAAGTTGGAAGAAGGACTGGTAGGTTCCCCTCCAAGCCAGTCACCTGTAAGAGTCCTGTCCTCT GCCAGACTTTTTAATCTCTTCATTAACTCTCAGACTGACCTGGGAGCCCTCCTCTACCTGAATCCAGTGCTCAACTGTGCCCCGGCAACA AGACCTGGGCTGAGGTCTCCCTGGTAGAACTAAGGGAGATTACACCATCTAAATCCCAGTGCAGTCAACAGCCTGGCCTATAGTCCTGGG |
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FusionGenePPI for SLC10A7_FKBP15 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SLC10A7 | ISLR, DPY19L4, ATP6V0D1, CD79A, MME, PCDHA4, IQCF1, EIF2B2, TOR1AIP2, KIAA0368, APOB | FKBP15 | SP1, FAM21C, CDK19, VCP, STRN3, RPA1, RPA2, RPA3, LGR4, SNAP29, SSFA2, NUDT12, FBF1, XPO1, PRPF4, VPS26A, CTR9, VPS26B, KIAA0196, KIAA1033, TTBK2, UBC, MCM2, RHOU, WWOX, EXOC1, COMMD10, ZYX, ATP6V0D2, SERPINB2, STX11, C1orf87, AIPL1, MIOS, FGFR1OP, PDE5A, VPS29, HDAC6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SLC10A7_FKBP15 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC10A7_FKBP15 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SLC10A7 | C0008370 | Cholestasis | 1 | CTD_human |
| Hgene | SLC10A7 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | FKBP15 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
| Tgene | FKBP15 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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