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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34014

FusionGeneSummary for SLC10A7_EYS

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC10A7_EYS
Fusion gene ID: 34014
HgeneTgene
Gene symbol

SLC10A7

EYS

Gene ID

84068

346007

Gene namesolute carrier family 10 member 7eyes shut homolog (Drosophila)
SynonymsC4orf13|P7C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1
Cytomap

4q31.22

6q12

Type of geneprotein-codingprotein-coding
Descriptionsodium/bile acid cotransporter 7Na(+)/bile acid cotransporter 7SBF-domain containing proteinsolute carrier family 10 (sodium/bile acid cotransporter family), member 7protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
Modification date2018051920180519
UniProtAcc

Q0GE19

Q5T1H1

Ensembl transtripts involved in fusion geneENST00000432059, ENST00000335472, 
ENST00000264986, ENST00000507030, 
ENST00000394062, ENST00000394059, 
ENST00000511315, ENST00000511374, 
ENST00000502607, 
ENST00000503581, 
ENST00000370621, ENST00000370616, 
ENST00000393380, ENST00000342421, 
ENST00000370618, ENST00000486069, 
Fusion gene scores* DoF score3 X 3 X 2=1826 X 15 X 12=4680
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC10A7 [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-A632-01ASLC10A7chr4

147442770

-EYSchr6

65767620

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000432059ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000432059ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000432059ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000432059ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000432059ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000432059ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000432059ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000335472ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000335472ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000335472ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000335472ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000335472ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000335472ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000335472ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000264986ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000264986ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000264986ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000264986ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000264986ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000264986ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000264986ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000507030ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000507030ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000507030ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000507030ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000507030ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000507030ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000507030ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394062ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394062ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394062ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394062ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394062ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394062ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394062ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394059ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394059ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000394059ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394059ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394059ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394059ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000394059ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-3CDSENST00000511315ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-3CDSENST00000511315ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-3CDSENST00000511315ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-intronENST00000511315ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-intronENST00000511315ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-intronENST00000511315ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5UTR-intronENST00000511315ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000511374ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000511374ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000511374ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000511374ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000511374ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000511374ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000511374ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000502607ENST00000503581SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000502607ENST00000370621SLC10A7chr4

147442770

-EYSchr6

65767620

-
Frame-shiftENST00000502607ENST00000370616SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000502607ENST00000393380SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000502607ENST00000342421SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000502607ENST00000370618SLC10A7chr4

147442770

-EYSchr6

65767620

-
5CDS-intronENST00000502607ENST00000486069SLC10A7chr4

147442770

-EYSchr6

65767620

-

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FusionProtFeatures for SLC10A7_EYS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC10A7

Q0GE19

EYS

Q5T1H1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SLC10A7_EYS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SLC10A7_EYS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SLC10A7ISLR, DPY19L4, ATP6V0D1, CD79A, MME, PCDHA4, IQCF1, EIF2B2, TOR1AIP2, KIAA0368, APOBEYSEGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SLC10A7_EYS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC10A7_EYS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC10A7C0008370Cholestasis1CTD_human
HgeneSLC10A7C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneEYSC1864446Retinitis Pigmentosa 252CTD_human;UNIPROT
TgeneEYSC0035334Retinitis Pigmentosa1CTD_human;ORPHANET