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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 34

FusionGeneSummary for AAK1_LHX2

check button Fusion gene summary
Fusion gene informationFusion gene name: AAK1_LHX2
Fusion gene ID: 34
HgeneTgene
Gene symbol

AAK1

LHX2

Gene ID

22848

9355

Gene nameAP2 associated kinase 1LIM homeobox 2
Synonyms-LH2|hLhx2
Cytomap

2p13.3

9q33.3

Type of geneprotein-codingprotein-coding
DescriptionAP2-associated protein kinase 1adaptor-associated kinase 1LIM/homeobox protein Lhx2LIM HOX gene 2LIM homeobox protein 2homeobox protein LH-2
Modification date2018052320180519
UniProtAcc

Q2M2I8

P50458

Ensembl transtripts involved in fusion geneENST00000409068, ENST00000409085, 
ENST00000406297, ENST00000470281, 
ENST00000373615, 
Fusion gene scores* DoF score9 X 6 X 7=3783 X 2 X 3=18
# samples 93
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AAK1 [Title/Abstract] AND LHX2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTranscription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAAK1

GO:0006468

protein phosphorylation

17494869|18657069

HgeneAAK1

GO:0032880

regulation of protein localization

18657069

HgeneAAK1

GO:0045747

positive regulation of Notch signaling pathway

21464124

HgeneAAK1

GO:0050821

protein stabilization

21464124

HgeneAAK1

GO:2000369

regulation of clathrin-dependent endocytosis

18657069


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-N5-A59F-01AAAK1chr2

69783992

-LHX2chr9

126776240

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409068ENST00000373615AAK1chr2

69783992

-LHX2chr9

126776240

+
In-frameENST00000409085ENST00000373615AAK1chr2

69783992

-LHX2chr9

126776240

+
In-frameENST00000406297ENST00000373615AAK1chr2

69783992

-LHX2chr9

126776240

+
intron-3CDSENST00000470281ENST00000373615AAK1chr2

69783992

-LHX2chr9

126776240

+

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FusionProtFeatures for AAK1_LHX2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAK1

Q2M2I8

LHX2

P50458

Regulates clathrin-mediated endocytosis byphosphorylating the AP2M1/mu2 subunit of the adaptor proteincomplex 2 (AP-2) which ensures high affinity binding of AP-2 tocargo membrane proteins during the initial stages of endocytosis.Isoform 1 and isoform 2 display similar levels of kinase activitytowards AP2M1. Regulates phosphorylation of other AP-2 subunits aswell as AP-2 localization and AP-2-mediated internalization ofligand complexes. Phosphorylates NUMB and regulates its cellularlocalization, promoting NUMB localization to endosomes. Binds toand stabilizes the activated form of NOTCH1, increases itslocalization in endosomes and regulates its transcriptionalactivity. {ECO:0000269|PubMed:12952931,ECO:0000269|PubMed:17494869, ECO:0000269|PubMed:18657069,ECO:0000269|PubMed:21464124}. Acts as a transcriptional activator. Stimulates thepromoter of the alpha-glycoprotein gene. Transcriptionalregulatory protein involved in the control of cell differentiationin developing lymphoid and neural cell types (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69783992chr9:126776240ENST00000406297-31812_4294864Compositional biasNote=Gly-rich
HgeneAAK1chr2:69783992chr9:126776240ENST00000409085-32212_4294962Compositional biasNote=Gly-rich
HgeneAAK1chr2:69783992chr9:126776240ENST00000406297-31852_6094864Nucleotide bindingATP
HgeneAAK1chr2:69783992chr9:126776240ENST00000409085-32252_6094962Nucleotide bindingATP
TgeneLHX2chr2:69783992chr9:126776240ENST00000373615+05187_19640407Compositional biasNote=Poly-Ala
TgeneLHX2chr2:69783992chr9:126776240ENST00000373615+05266_32540407DNA bindingHomeobox
TgeneLHX2chr2:69783992chr9:126776240ENST00000373615+05115_16840407DomainLIM zinc-binding 2
TgeneLHX2chr2:69783992chr9:126776240ENST00000373615+0553_10540407DomainLIM zinc-binding 1
TgeneLHX2chr2:69783992chr9:126776240ENST00000373615+05307_32340407MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAAK1chr2:69783992chr9:126776240ENST00000406297-318397_61494864Compositional biasNote=Gln-rich
HgeneAAK1chr2:69783992chr9:126776240ENST00000406297-318658_66394864Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69783992chr9:126776240ENST00000409085-322397_61494962Compositional biasNote=Gln-rich
HgeneAAK1chr2:69783992chr9:126776240ENST00000409085-322658_66394962Compositional biasNote=Poly-Ala
HgeneAAK1chr2:69783992chr9:126776240ENST00000406297-31846_31594864DomainProtein kinase
HgeneAAK1chr2:69783992chr9:126776240ENST00000409085-32246_31594962DomainProtein kinase


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FusionGeneSequence for AAK1_LHX2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_461aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASE
MVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNG
VGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLT
KRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHS

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_461aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASE
MVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNG
VGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLT
KRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHS

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_461aa
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKRE
IQIMTMPSISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYCKEDYYRRFSVQRCARCHLGISASE
MVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKDSLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGAAGANPLGLPYYNG
VGTVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLT
KRVLQVWFQNARAKFRRNLLRQENTGVDKSTDAALQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGHEPHS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_1383nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGCTGTGCGCCGGCTGCGGGGGCAAGATCTCGGACCGCTACTACCTG
CTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCGAGTGCAAGCTCAACCTGGAGTCGGAGCTCACCTGTTTCAGCAAG
GACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTGTGCAGCGCTGCGCCCGCTGCCACCTGGGCATCTCGGCCTCGGAG
ATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCACGTGCACCACGTGTAACAAGATGCTGACCACGGGCGACCACTTC
GGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGCTGCTGCAGGGCGAGTACCCCGCACACTTCAACCATGCCGACGTG
GCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGGGCGCAGCAGGGGCCAACCCTCTGGGTCTTCCCTACTACAATGGC
GTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGGGCCCCGGTGCGGATCTGGCGGCCTACAACGCTGCGCTAAGCTGC
AACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGAGCAGCCAGAAGACCAAGCGCATGCGCACGTCCTTCAAGCACCAC
CAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCGACGCCAAGGACTTGAAGCAGCTCGCGCAAAAGACGGGCCTCACC
AAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCAGGCGCAACCTCTTACGGCAGGAAAACACGGGCGTGGACAAGTCG
ACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGGAGCTCTCCAACGCCTCGCTCAGCCCCTCCAGCACGCCCACCACC
CTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCTTAACTTCTGTGCCTGGCAACCTGGAGGGCCATGAGCCTCACAGC

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_1383nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGCTGTGCGCCGGCTGCGGGGGCAAGATCTCGGACCGCTACTACCTG
CTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCGAGTGCAAGCTCAACCTGGAGTCGGAGCTCACCTGTTTCAGCAAG
GACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTGTGCAGCGCTGCGCCCGCTGCCACCTGGGCATCTCGGCCTCGGAG
ATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCACGTGCACCACGTGTAACAAGATGCTGACCACGGGCGACCACTTC
GGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGCTGCTGCAGGGCGAGTACCCCGCACACTTCAACCATGCCGACGTG
GCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGGGCGCAGCAGGGGCCAACCCTCTGGGTCTTCCCTACTACAATGGC
GTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGGGCCCCGGTGCGGATCTGGCGGCCTACAACGCTGCGCTAAGCTGC
AACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGAGCAGCCAGAAGACCAAGCGCATGCGCACGTCCTTCAAGCACCAC
CAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCGACGCCAAGGACTTGAAGCAGCTCGCGCAAAAGACGGGCCTCACC
AAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCAGGCGCAACCTCTTACGGCAGGAAAACACGGGCGTGGACAAGTCG
ACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGGAGCTCTCCAACGCCTCGCTCAGCCCCTCCAGCACGCCCACCACC
CTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCTTAACTTCTGTGCCTGGCAACCTGGAGGGCCATGAGCCTCACAGC

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_1383nt
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTG
GGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAA
ATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGCTGTGCGCCGGCTGCGGGGGCAAGATCTCGGACCGCTACTACCTG
CTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCGAGTGCAAGCTCAACCTGGAGTCGGAGCTCACCTGTTTCAGCAAG
GACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTGTGCAGCGCTGCGCCCGCTGCCACCTGGGCATCTCGGCCTCGGAG
ATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCACGTGCACCACGTGTAACAAGATGCTGACCACGGGCGACCACTTC
GGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGCTGCTGCAGGGCGAGTACCCCGCACACTTCAACCATGCCGACGTG
GCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGGGCGCAGCAGGGGCCAACCCTCTGGGTCTTCCCTACTACAATGGC
GTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGGGCCCCGGTGCGGATCTGGCGGCCTACAACGCTGCGCTAAGCTGC
AACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGAGCAGCCAGAAGACCAAGCGCATGCGCACGTCCTTCAAGCACCAC
CAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCGACGCCAAGGACTTGAAGCAGCTCGCGCAAAAGACGGGCCTCACC
AAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCAGGCGCAACCTCTTACGGCAGGAAAACACGGGCGTGGACAAGTCG
ACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGGAGCTCTCCAACGCCTCGCTCAGCCCCTCCAGCACGCCCACCACC
CTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCTTAACTTCTGTGCCTGGCAACCTGGAGGGCCATGAGCCTCACAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_AAK1_ENST00000409068_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_2291nt
CTCTGCGTCGCAGGCCGGCCCGGCGGCCGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTT
ACACGAATCGCTTTCTGGAGGAGGAGGGGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCAC
GGCCGGATTCGGGTGGCTCCTCTCCGAGGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAAT
CTAGAAACCATCGGTATTTTGCTTTGCTGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCC
TGGGCTCCGGCTCCAGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGG
TCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCA
TGTTTGTCAACAATGAGCATGATCTCCAGGTGTGCAAGAGAGAAATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGC
TGTGCGCCGGCTGCGGGGGCAAGATCTCGGACCGCTACTACCTGCTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCG
AGTGCAAGCTCAACCTGGAGTCGGAGCTCACCTGTTTCAGCAAGGACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTG
TGCAGCGCTGCGCCCGCTGCCACCTGGGCATCTCGGCCTCGGAGATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCA
CGTGCACCACGTGTAACAAGATGCTGACCACGGGCGACCACTTCGGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGC
TGCTGCAGGGCGAGTACCCCGCACACTTCAACCATGCCGACGTGGCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGG
GCGCAGCAGGGGCCAACCCTCTGGGTCTTCCCTACTACAATGGCGTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGG
GCCCCGGTGCGGATCTGGCGGCCTACAACGCTGCGCTAAGCTGCAACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGA
GCAGCCAGAAGACCAAGCGCATGCGCACGTCCTTCAAGCACCACCAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCG
ACGCCAAGGACTTGAAGCAGCTCGCGCAAAAGACGGGCCTCACCAAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCA
GGCGCAACCTCTTACGGCAGGAAAACACGGGCGTGGACAAGTCGACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGG
AGCTCTCCAACGCCTCGCTCAGCCCCTCCAGCACGCCCACCACCCTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCT
TAACTTCTGTGCCTGGCAACCTGGAGGGCCATGAGCCTCACAGCCCCTCACAAACGACTCTTACCAACCTTTTCTAATGACTCGCAACCC
CTCACCCCACAATTTCTTTAAAAAAGAAATTATCTTTAGTTGAATTCCAAGTGTATTTTAAAATAGAGGCTTTGAGCAACTAACTAACCA
CATTTTAGGATCTCGCCTGGAAACAGAGGTAAAAAAAAGAAGTGTGCGCCCGGCTAATGCAGCGGTGTGGACCGAGGAACAACTTGGAAG
ATCTACCTGCAACACAACATTTGTGTCACTGTACAGTTTTGTGGACTGAGCGAGGAAAAACAACAAATAATTTAAGTTGGCTAGAGCTTC
TGTATTTTCAAAGACTGCCACGTGCCTTAGGAATACTGTTTTATCTCCATACTTTGGATGACTTGTTCATTTTTCTCTCCCTCTTTTTCT
CTGTATATTTATGACCAGAGCAAAAATGTAAAAAACAAAAAAAACAACAAAAAAAGTTTGTTACTTTGAATAGTCCTAAAAAGAAAAAAA
GAAAAAAAAAAAAGGAAAAATCAAACCCCCTCCAACGGTCGCTTTGTTGTTTTAGAATTTTAAGGTGGAAGTCTGTTCGAATATCAGAAT

>In-frame_AAK1_ENST00000409085_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_2354nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGCTGTGCGCCGGCTGCGGGGGCAAGATCT
CGGACCGCTACTACCTGCTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCGAGTGCAAGCTCAACCTGGAGTCGGAGC
TCACCTGTTTCAGCAAGGACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTGTGCAGCGCTGCGCCCGCTGCCACCTGG
GCATCTCGGCCTCGGAGATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCACGTGCACCACGTGTAACAAGATGCTGA
CCACGGGCGACCACTTCGGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGCTGCTGCAGGGCGAGTACCCCGCACACT
TCAACCATGCCGACGTGGCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGGGCGCAGCAGGGGCCAACCCTCTGGGTC
TTCCCTACTACAATGGCGTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGGGCCCCGGTGCGGATCTGGCGGCCTACA
ACGCTGCGCTAAGCTGCAACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGAGCAGCCAGAAGACCAAGCGCATGCGCA
CGTCCTTCAAGCACCACCAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCGACGCCAAGGACTTGAAGCAGCTCGCGC
AAAAGACGGGCCTCACCAAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCAGGCGCAACCTCTTACGGCAGGAAAACA
CGGGCGTGGACAAGTCGACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGGAGCTCTCCAACGCCTCGCTCAGCCCCT
CCAGCACGCCCACCACCCTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCTTAACTTCTGTGCCTGGCAACCTGGAGG
GCCATGAGCCTCACAGCCCCTCACAAACGACTCTTACCAACCTTTTCTAATGACTCGCAACCCCTCACCCCACAATTTCTTTAAAAAAGA
AATTATCTTTAGTTGAATTCCAAGTGTATTTTAAAATAGAGGCTTTGAGCAACTAACTAACCACATTTTAGGATCTCGCCTGGAAACAGA
GGTAAAAAAAAGAAGTGTGCGCCCGGCTAATGCAGCGGTGTGGACCGAGGAACAACTTGGAAGATCTACCTGCAACACAACATTTGTGTC
ACTGTACAGTTTTGTGGACTGAGCGAGGAAAAACAACAAATAATTTAAGTTGGCTAGAGCTTCTGTATTTTCAAAGACTGCCACGTGCCT
TAGGAATACTGTTTTATCTCCATACTTTGGATGACTTGTTCATTTTTCTCTCCCTCTTTTTCTCTGTATATTTATGACCAGAGCAAAAAT
GTAAAAAACAAAAAAAACAACAAAAAAAGTTTGTTACTTTGAATAGTCCTAAAAAGAAAAAAAGAAAAAAAAAAAAGGAAAAATCAAACC
CCCTCCAACGGTCGCTTTGTTGTTTTAGAATTTTAAGGTGGAAGTCTGTTCGAATATCAGAATTTGTAAAATCTAACCAGTAATAAAACC

>In-frame_AAK1_ENST00000406297_chr2_69783992_-_LHX2_ENST00000373615_chr9_126776240_+_2354nt
GATCAGCTGGCGGGCGGGCGGGAGCCGAGCGCGGCCCCGGCTCTCGCTGCAGCGCCGCCTCTTCTCTGCGTCGCAGGCCGGCCCGGCGGC
CGTGACAATGTCGCGGGGCTGGTAGCAGGGCGCCGGCCGCCGAGCCGTCTCAAGTTTAAACTTACACGAATCGCTTTCTGGAGGAGGAGG
GGACCCGCTGCGCGATTGACACGCATATTCCTATAGGCATCCTCCCTCAGCCCCCACCCCCACGGCCGGATTCGGGTGGCTCCTCTCCGA
GGTGAAATCTGAGAAGAAATCCTTGGATCTCTTTTCTTAAAAAAAAAAAAAAAAAAAAAAAATCTAGAAACCATCGGTATTTTGCTTTGC
TGCTCCCTATTCGCAAGATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCCAGCGGAGGAGGGG
GCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGCATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAG
GTGGATTTGCTATTGTATTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAATGAGCATGATCTCC
AGGTGTGCAAGAGAGAAATCCAGATAATGACCATGCCGTCCATCAGCAGTGACCGCGCCGCGCTGTGCGCCGGCTGCGGGGGCAAGATCT
CGGACCGCTACTACCTGCTGGCGGTGGACAAGCAGTGGCACATGCGCTGCCTCAAGTGCTGCGAGTGCAAGCTCAACCTGGAGTCGGAGC
TCACCTGTTTCAGCAAGGACGGTAGCATCTACTGCAAGGAAGACTACTACAGGCGCTTCTCTGTGCAGCGCTGCGCCCGCTGCCACCTGG
GCATCTCGGCCTCGGAGATGGTGATGCGCGCTCGGGACTTGGTTTATCACCTCAACTGCTTCACGTGCACCACGTGTAACAAGATGCTGA
CCACGGGCGACCACTTCGGCATGAAGGACAGCCTGGTCTACTGCCGCTTGCACTTCGAGGCGCTGCTGCAGGGCGAGTACCCCGCACACT
TCAACCATGCCGACGTGGCAGCGGCGGCCGCTGCAGCCGCGGCGGCCAAGAGCGCGGGGCTGGGCGCAGCAGGGGCCAACCCTCTGGGTC
TTCCCTACTACAATGGCGTGGGCACTGTGCAGAAGGGGCGGCCGAGGAAACGTAAGAGCCCGGGCCCCGGTGCGGATCTGGCGGCCTACA
ACGCTGCGCTAAGCTGCAACGAAAACGACGCAGAGCACCTGGACCGTGACCAGCCATACCCGAGCAGCCAGAAGACCAAGCGCATGCGCA
CGTCCTTCAAGCACCACCAGCTTCGGACCATGAAGTCTTACTTTGCCATTAACCACAACCCCGACGCCAAGGACTTGAAGCAGCTCGCGC
AAAAGACGGGCCTCACCAAGCGGGTCCTCCAGGTCTGGTTCCAGAACGCCCGAGCCAAGTTCAGGCGCAACCTCTTACGGCAGGAAAACA
CGGGCGTGGACAAGTCGACAGACGCGGCGCTGCAGACAGGGACGCCATCGGGCCCGGCCTCGGAGCTCTCCAACGCCTCGCTCAGCCCCT
CCAGCACGCCCACCACCCTGACAGACTTGACTAGCCCCACCCTGCCAACTGTGACGTCCGTCTTAACTTCTGTGCCTGGCAACCTGGAGG
GCCATGAGCCTCACAGCCCCTCACAAACGACTCTTACCAACCTTTTCTAATGACTCGCAACCCCTCACCCCACAATTTCTTTAAAAAAGA
AATTATCTTTAGTTGAATTCCAAGTGTATTTTAAAATAGAGGCTTTGAGCAACTAACTAACCACATTTTAGGATCTCGCCTGGAAACAGA
GGTAAAAAAAAGAAGTGTGCGCCCGGCTAATGCAGCGGTGTGGACCGAGGAACAACTTGGAAGATCTACCTGCAACACAACATTTGTGTC
ACTGTACAGTTTTGTGGACTGAGCGAGGAAAAACAACAAATAATTTAAGTTGGCTAGAGCTTCTGTATTTTCAAAGACTGCCACGTGCCT
TAGGAATACTGTTTTATCTCCATACTTTGGATGACTTGTTCATTTTTCTCTCCCTCTTTTTCTCTGTATATTTATGACCAGAGCAAAAAT
GTAAAAAACAAAAAAAACAACAAAAAAAGTTTGTTACTTTGAATAGTCCTAAAAAGAAAAAAAGAAAAAAAAAAAAGGAAAAATCAAACC
CCCTCCAACGGTCGCTTTGTTGTTTTAGAATTTTAAGGTGGAAGTCTGTTCGAATATCAGAATTTGTAAAATCTAACCAGTAATAAAACC


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FusionGenePPI for AAK1_LHX2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AAK1AP2M1, ATP13A2, APP, AP2A1, AP2B1, NTRK1, DYNLT1, XPO1, CLTB, CLTC, GAK, HSPA5, GTSE1, ANLN, CDH1, AP2S1, REPS1, RUNDC3A, RALBP1, PLEC, PPIP5K2, SEC24B, CCDC88A, EYA4, UBE2D2, LUZP1, URGCP, NUP88, DVL3, QSER1, WNK1LHX2CITED2, PAX6, MSX1, LDB1, DNMT3L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AAK1_LHX2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AAK1_LHX2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneLHX2C0003873Rheumatoid Arthritis1CTD_human