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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33986

FusionGeneSummary for SKIV2L_HCP5

check button Fusion gene summary
Fusion gene informationFusion gene name: SKIV2L_HCP5
Fusion gene ID: 33986
HgeneTgene
Gene symbol

SKIV2L

HCP5

Gene ID

6499

10866

Gene nameSki2 like RNA helicaseHLA complex P5
Synonyms170A|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L1|THES26S2650E|D6S2650E|P5-1
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingncRNA
Descriptionhelicase SKI2WSKI2 homolog, superkiller viralicidic activity 2-likehelicase-like proteinsuperkiller viralicidic activity 2-likeHLA class I histocompatibility antigen protein P5HLA complex P5 (non-protein coding)HLA complex protein P5MHC class I region ORF
Modification date2018052320180519
UniProtAcc

Q15477

Ensembl transtripts involved in fusion geneENST00000375394, ENST00000488648, 
ENST00000544581, ENST00000448219, 
ENST00000471547, ENST00000429465, 
ENST00000476338, ENST00000412823, 
ENST00000480914, ENST00000383336, 
ENST00000461360, ENST00000421789, 
ENST00000466463, 		ENST00000414046, 
ENST00000419355, ENST00000457127, 
ENST00000423496, 
Fusion gene scores* DoF score4 X 4 X 3=481 X 1 X 1=1
# samples 41
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SKIV2L [Title/Abstract] AND HCP5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-AJ-A3QS-01ASKIV2Lchr6

31935154

+HCP5chr6

31444804

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375394ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000375394ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000375394ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000375394ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000488648ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000488648ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000488648ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000488648ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000544581ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000544581ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000544581ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
5CDS-intronENST00000544581ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000448219ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000448219ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000448219ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000448219ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000471547ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000471547ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000471547ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000471547ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000429465ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000429465ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000429465ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000429465ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000476338ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000476338ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000476338ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000476338ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000412823ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000412823ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000412823ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000412823ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000480914ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000480914ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000480914ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000480914ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000383336ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000383336ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000383336ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000383336ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000461360ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000461360ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000461360ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000461360ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000421789ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000421789ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000421789ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000421789ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000466463ENST00000414046SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000466463ENST00000419355SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000466463ENST00000457127SKIV2Lchr6

31935154

+HCP5chr6

31444804

+
intron-intronENST00000466463ENST00000423496SKIV2Lchr6

31935154

+HCP5chr6

31444804

+

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FusionProtFeatures for SKIV2L_HCP5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKIV2L

Q15477

HCP5

Helicase; has ATPase activity. Component of the SKIcomplex which is thought to be involved in exosome-mediated RNAdecay and associates with transcriptionally active genes in amanner dependent on PAF1 complex (PAF1C). Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SKIV2L_HCP5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SKIV2L_HCP5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SKIV2LCDK11A, SIRT7, NDOR1, ITSN1, CDK9, FBXW4, CDKL5, TSSK2, EXOSC10, EXOSC4, XRN1, SNRPB, PMPCA, GALNT13, TNRC17, WDR1, LGR4, EGFR, ALYREF, CBS, RAN, FERMT1, PLCG1, TTC37, NTRK1, NPM1, RPL10, RAB4B, RHOU, ZNF746, TESHCP5APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SKIV2L_HCP5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SKIV2L_HCP5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSKIV2LC3281289TRICHOHEPATOENTERIC SYNDROME 21UNIPROT