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Fusion gene ID: 33969 |
FusionGeneSummary for SKIV2L2_IGF2R |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SKIV2L2_IGF2R | Fusion gene ID: 33969 | Hgene | Tgene | Gene symbol | SKIV2L2 | IGF2R | Gene ID | 3482 |
| Gene name | insulin like growth factor 2 receptor | ||
| Synonyms | CD222|CI-M6PR|CIMPR|M6P-R|M6P/IGF2R|MPR 300|MPR1|MPR300|MPRI | ||
| Cytomap | 6q25.3 | ||
| Type of gene | protein-coding | ||
| Description | cation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptor | ||
| Modification date | 20180527 | ||
| UniProtAcc | P11717 | ||
| Ensembl transtripts involved in fusion gene | ENST00000230640, ENST00000545714, ENST00000504388, | ENST00000356956, ENST00000475584, | |
| Fusion gene scores | * DoF score | 22 X 8 X 8=1408 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/1408*10)=-3.55254102302878 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SKIV2L2 [Title/Abstract] AND IGF2R [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-02-2486-01A | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000230640 | ENST00000356956 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| 5CDS-intron | ENST00000230640 | ENST00000475584 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| Frame-shift | ENST00000545714 | ENST00000356956 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| 5CDS-intron | ENST00000545714 | ENST00000475584 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| 3UTR-3CDS | ENST00000504388 | ENST00000356956 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
| 3UTR-intron | ENST00000504388 | ENST00000475584 | SKIV2L2 | chr5 | 54603975 | + | IGF2R | chr6 | 160412216 | + |
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FusionProtFeatures for SKIV2L2_IGF2R |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SKIV2L2 | IGF2R |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Transport of phosphorylated lysosomal enzymes from theGolgi complex and the cell surface to lysosomes. Lysosomal enzymesbearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resultingreceptor-ligand complex is transported to an acidic prelyosomalcompartment where the low pH mediates the dissociation of thecomplex. This receptor also binds IGF2. Acts as a positiveregulator of T-cell coactivation, by binding DPP4.{ECO:0000269|PubMed:10900005}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1898_1944 | 49 | 2492 | Domain | Fibronectin type-II |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1100_1243 | 49 | 2492 | Repeat | Note=8 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1244_1384 | 49 | 2492 | Repeat | Note=9 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1385_1532 | 49 | 2492 | Repeat | Note=10 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1533_1666 | 49 | 2492 | Repeat | Note=11 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1667_1820 | 49 | 2492 | Repeat | Note=12 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 1821_2008 | 49 | 2492 | Repeat | Note=13 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 190_344 | 49 | 2492 | Repeat | Note=2 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 2009_2137 | 49 | 2492 | Repeat | Note=14 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 2165_2289 | 49 | 2492 | Repeat | Note=15 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 345_489 | 49 | 2492 | Repeat | Note=3 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 490_643 | 49 | 2492 | Repeat | Note=4 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 644_783 | 49 | 2492 | Repeat | Note=5 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 784_950 | 49 | 2492 | Repeat | Note=6 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 951_1099 | 49 | 2492 | Repeat | Note=7 |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 2328_2491 | 49 | 2492 | Topological domain | Cytoplasmic |
| Tgene | >IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 2305_2327 | 49 | 2492 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SKIV2L2 | chr5:54603975 | chr6:160412216 | ENST00000230640 | + | 1 | 27 | 148_304 | 44 | 1043 | Domain | Helicase ATP-binding |
| Hgene | >SKIV2L2 | chr5:54603975 | chr6:160412216 | ENST00000230640 | + | 1 | 27 | 405_577 | 44 | 1043 | Domain | Helicase C-terminal |
| Hgene | >SKIV2L2 | chr5:54603975 | chr6:160412216 | ENST00000230640 | + | 1 | 27 | 252_255 | 44 | 1043 | Motif | Note=DEIH box |
| Hgene | >SKIV2L2 | chr5:54603975 | chr6:160412216 | ENST00000230640 | + | 1 | 27 | 161_168 | 44 | 1043 | Nucleotide binding | ATP |
| Tgene | IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 40_189 | 49 | 2492 | Repeat | Note=1 |
| Tgene | IGF2R | chr5:54603975 | chr6:160412216 | ENST00000356956 | + | 0 | 48 | 41_2304 | 49 | 2492 | Topological domain | Lumenal |
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FusionGeneSequence for SKIV2L2_IGF2R |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SKIV2L2_ENST00000230640_chr5_54603975_+_IGF2R_ENST00000356956_chr6_160412216_+_2487aa MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDLKTRTYHS VGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFDEELRKHD LNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREEAGKLDFC DGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKEYLFYLNV CGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVFTGEVDCT YFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVCAVDKNGS KNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCTVFDSQAG FSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNERHTPRAT LITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRKYYINVCR PLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRLNSHPIFS LNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCEAETQTEE LKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACVPSPVDCQ VTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLSIMYVNGD KCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYYFRVCGKL SSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSDCSYLFEW RTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLGRVRDGPQ WRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFDLSSLSGR AGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEARPTNRPM LISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPAGAAVCKV PIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDEVRMDGCT LTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYVNGDRCPP ETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVTFEWKTKV VCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVIGDKVVVT YSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLFRASGDMR TNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHCDPLVEDG IPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISKLTTCCRR SSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SKIV2L2_ENST00000230640_chr5_54603975_+_IGF2R_ENST00000356956_chr6_160412216_+_7461nt ATGGCGGACGCATTCGGAGATGAGCTGTTCAGCGTGTTCGAGGGCGACTCGACCACTGCGGCGGGAACCAAAAAAGACAAGGAAAAGGAC AAGGGGAAATGGAAGGGGCCTCCAGGGTCTGCAGACAAGGCAGGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAA ATCAACATCTGTGGAAGTGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCA GTGGGTGACTCTGTTTTGAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGA GTCCAGAGCAGCATTGCCTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGG AGGACCACTGCAGCCTGCAAGAAAGACATATTTAAAGCAAATAAGGAGGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGAAGCATGAT CTCAATCCTCTGATCAAGCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTAGAGACATA GACACACTACGAGACCCAGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGTTTGATGTT GGCCAGCCCCGGGACGGACTGAAGCTGGTGCGCAAGGACAGGCTTGTCCTGAGTTACGTGAGGGAAGAGGCAGGAAAGCTAGACTTTTGT GATGGTCACAGCCCTGCGGTGACTATTACATTTGTTTGCCCGTCGGAGCGGAGAGAGGGCACCATTCCCAAACTCACAGCTAAATCCAAC TGCCGCTATGAAATTGAGTGGATTACTGAGTATGCCTGCCACAGAGATTACCTGGAAAGTAAAACTTGTTCTCTGAGCGGCGAGCAGCAG GATGTCTCCATAGACCTCACACCACTTGCCCAGAGCGGAGGTTCATCCTATATTTCAGATGGAAAAGAATATTTGTTTTATTTGAATGTC TGTGGAGAAACTGAAATACAGTTCTGTAATAAAAAACAAGCTGCAGTTTGCCAAGTGAAAAAGAGCGATACCTCTCAAGTCAAAGCAGCA GGAAGATACCACAATCAGACCCTCCGATATTCGGATGGAGACCTCACCTTGATATATTTTGGAGGTGATGAATGCAGCTCAGGGTTTCAG CGGATGAGCGTCATAAACTTTGAGTGCAATAAAACCGCAGGTAACGATGGGAAAGGAACTCCTGTATTCACAGGGGAGGTTGACTGCACC TACTTCTTCACATGGGACACGGAATACGCCTGTGTTAAGGAGAAGGAAGACCTCCTCTGCGGTGCCACCGACGGGAAGAAGCGCTATGAC CTGTCCGCGCTGGTCCGCCATGCAGAACCAGAGCAGAATTGGGAAGCTGTGGATGGCAGTCAGACGGAAACAGAGAAGAAGCATTTTTTC ATTAATATTTGTCACAGAGTGCTGCAGGAAGGCAAGGCACGAGGGTGTCCCGAGGACGCGGCAGTGTGTGCAGTGGATAAAAATGGAAGT AAAAATCTGGGAAAATTTATTTCCTCTCCCATGAAAGAGAAAGGAAACATTCAACTCTCTTATTCAGATGGTGATGATTGTGGTCATGGC AAGAAAATTAAAACTAATATCACACTTGTATGCAAGCCAGGTGATCTGGAAAGTGCACCAGTGTTGAGAACTTCTGGGGAAGGCGGTTGC TTTTATGAGTTTGAGTGGCACACAGCTGCGGCCTGTGTGCTGTCTAAGACAGAAGGGGAGAACTGCACGGTCTTTGACTCCCAGGCAGGG TTTTCTTTTGACTTATCACCTCTCACAAAGAAAAATGGTGCCTATAAAGTTGAGACAAAGAAGTATGACTTTTATATAAATGTGTGTGGC CCGGTGTCTGTGAGCCCCTGTCAGCCAGACTCAGGAGCCTGCCAGGTGGCAAAAAGTGATGAGAAGACTTGGAACTTGGGTCTGAGTAAT GCGAAGCTTTCATATTATGATGGGATGATCCAACTGAACTACAGAGGCGGCACACCCTATAACAATGAAAGACACACACCGAGAGCTACG CTCATCACCTTTCTCTGTGATCGAGACGCGGGAGTGGGCTTCCCTGAATATCAGGAAGAGGATAACTCCACCTACAACTTCCGGTGGTAC ACCAGCTATGCCTGCCCGGAGGAGCCCCTGGAATGCGTAGTGACCGACCCCTCCACGCTGGAGCAGTACGACCTCTCCAGTCTGGCAAAA TCTGAAGGTGGCCTTGGAGGAAACTGGTATGCCATGGACAACTCAGGGGAACATGTCACGTGGAGGAAATACTACATTAACGTGTGTCGG CCTCTGAATCCAGTGCCGGGCTGCAACCGATATGCATCGGCTTGCCAGATGAAGTATGAAAAAGATCAGGGCTCCTTCACTGAAGTGGTT TCCATCAGTAACTTGGGAATGGCAAAGACCGGCCCGGTGGTTGAGGACAGCGGCAGCCTCCTTCTGGAATACGTGAATGGGTCGGCCTGC ACCACCAGCGATGGCAGACAGACCACATATACCACGAGGATCCATCTCGTCTGCTCCAGGGGCAGGCTGAACAGCCACCCCATCTTTTCT CTCAACTGGGAGTGTGTGGTCAGTTTCCTGTGGAACACAGAGGCTGCCTGTCCCATTCAGACAACGACGGATACAGACCAGGCTTGCTCT ATAAGGGATCCCAACAGTGGATTTGTGTTTAATCTTAATCCGCTAAACAGTTCGCAAGGATATAACGTCTCTGGCATTGGGAAGATTTTT ATGTTTAATGTCTGCGGCACAATGCCTGTCTGTGGGACCATCCTGGGAAAACCTGCTTCTGGCTGTGAGGCAGAAACCCAAACTGAAGAG CTCAAGAATTGGAAGCCAGCAAGGCCAGTCGGAATTGAGAAAAGCCTCCAGCTGTCCACAGAGGGCTTCATCACTCTGACCTACAAAGGG CCTCTCTCTGCCAAAGGTACCGCTGATGCTTTTATCGTCCGCTTTGTTTGCAATGATGATGTTTACTCAGGGCCCCTCAAATTCCTGCAT CAAGATATCGACTCTGGGCAAGGGATCCGAAACACTTACTTTGAGTTTGAAACCGCGTTGGCCTGTGTTCCTTCTCCAGTGGACTGCCAA GTCACCGACCTGGCTGGAAATGAGTACGACCTGACTGGCCTAAGCACAGTCAGGAAACCTTGGACGGCTGTTGACACCTCTGTCGATGGG AGAAAGAGGACTTTCTATTTGAGCGTTTGCAATCCTCTCCCTTACATTCCTGGATGCCAGGGCAGCGCAGTGGGGTCTTGCTTAGTGTCA GAAGGCAATAGCTGGAATCTGGGTGTGGTGCAGATGAGTCCCCAAGCCGCGGCGAATGGATCTTTGAGCATCATGTATGTCAACGGTGAC AAGTGTGGGAACCAGCGCTTCTCCACCAGGATCACGTTTGAGTGTGCTCAGATATCGGGCTCACCAGCATTTCAGCTTCAGGATGGTTGT GAGTACGTGTTTATCTGGAGAACTGTGGAAGCCTGTCCCGTTGTCAGAGTGGAAGGGGACAACTGTGAGGTGAAAGACCCAAGGCATGGC AACTTGTATGACCTGAAGCCCCTGGGCCTCAACGACACCATCGTGAGCGCTGGCGAATACACTTATTACTTCCGGGTCTGTGGGAAGCTT TCCTCAGACGTCTGCCCCACAAGTGACAAGTCCAAGGTGGTCTCCTCATGTCAGGAAAAGCGGGAACCGCAGGGATTTCACAAAGTGGCA GGTCTCCTGACTCAGAAGCTAACTTATGAAAATGGCTTGTTAAAAATGAACTTCACGGGGGGGGACACTTGCCATAAGGTTTATCAGCGC TCCACAGCCATCTTCTTCTACTGTGACCGCGGCACCCAGCGGCCAGTATTTCTAAAGGAGACTTCAGATTGTTCCTACTTGTTTGAGTGG CGAACGCAGTATGCCTGCCCACCTTTCGATCTGACTGAATGTTCATTCAAAGATGGGGCTGGCAACTCCTTCGACCTCTCGTCCCTGTCA AGGTACAGTGACAACTGGGAAGCCATCACTGGGACGGGGGACCCGGAGCACTACCTCATCAATGTCTGCAAGTCTCTGGCCCCGCAGGCT GGCACTGAGCCGTGCCCTCCAGAAGCAGCCGCGTGTCTGCTGGGTGGCTCCAAGCCCGTGAACCTCGGCAGGGTAAGGGACGGACCTCAG TGGAGAGATGGCATAATTGTCCTGAAATACGTTGATGGCGACTTATGTCCAGATGGGATTCGGAAAAAGTCAACCACCATCCGATTCACC TGCAGCGAGAGCCAAGTGAACTCCAGGCCCATGTTCATCAGCGCCGTGGAGGACTGTGAGTACACCTTTGCCTGGCCCACAGCCACAGCC TGTCCCATGAAGAGCAACGAGCATGATGACTGCCAGGTCACCAACCCAAGCACAGGACACCTGTTTGATCTGAGCTCCTTAAGTGGCAGG GCGGGATTCACAGCTGCTTACAGCGAGAAGGGGTTGGTTTACATGAGCATCTGTGGGGAGAATGAAAACTGCCCTCCTGGCGTGGGGGCC TGCTTTGGACAGACCAGGATTAGCGTGGGCAAGGCCAACAAGAGGCTGAGATACGTGGACCAGGTCCTGCAGCTGGTGTACAAGGATGGG TCCCCTTGTCCCTCCAAATCCGGCCTGAGCTATAAGAGTGTGATCAGTTTCGTGTGCAGGCCTGAGGCCAGGCCAACCAATAGGCCCATG CTCATCTCCCTGGACAAGCAGACATGCACTCTCTTCTTCTCCTGGCACACGCCGCTGGCCTGCGAGCAAGCGACCGAATGTTCCGTGAGG AATGGAAGCTCTATTGTTGACTTGTCTCCCCTTATTCATCGCACTGGTGGTTATGAGGCTTATGATGAGAGTGAGGATGATGCCTCCGAT ACCAACCCTGATTTCTACATCAATATTTGTCAGCCACTAAATCCCATGCACGGAGTGCCCTGTCCTGCCGGAGCCGCTGTGTGCAAAGTT CCTATTGATGGTCCCCCCATAGATATCGGCCGGGTAGCAGGACCACCAATACTCAATCCAATAGCAAATGAGATTTACTTGAATTTTGAA AGCAGTACTCCTTGCTTAGCGGACAAGCATTTCAACTACACCTCGCTCATCGCGTTTCACTGTAAGAGAGGTGTGAGCATGGGAACGCCT AAGCTGTTAAGGACCAGCGAGTGCGACTTTGTGTTCGAATGGGAGACTCCTGTCGTCTGTCCTGATGAAGTGAGGATGGATGGCTGTACC CTGACAGATGAGCAGCTCCTCTACAGCTTCAACTTGTCCAGCCTTTCCACGAGCACCTTTAAGGTGACTCGCGACTCGCGCACCTACAGC GTTGGGGTGTGCACCTTTGCAGTCGGGCCAGAACAAGGAGGCTGTAAGGACGGAGGAGTCTGTCTGCTCTCAGGCACCAAGGGGGCATCC TTTGGACGGCTGCAATCAATGAAACTGGATTACAGGCACCAGGATGAAGCGGTCGTTTTAAGTTACGTGAATGGTGATCGTTGCCCTCCA GAAACCGATGACGGCGTCCCCTGTGTCTTCCCCTTCATATTCAATGGGAAGAGCTACGAGGAGTGCATCATAGAGAGCAGGGCGAAGCTG TGGTGTAGCACAACTGCGGACTACGACAGAGACCACGAGTGGGGCTTCTGCAGACACTCAAACAGCTACCGGACATCCAGCATCATATTT AAGTGTGATGAAGATGAGGACATTGGGAGGCCACAAGTCTTCAGTGAAGTGCGTGGGTGTGATGTGACATTTGAGTGGAAAACAAAAGTT GTCTGCCCTCCAAAGAAGTTGGAGTGCAAATTCGTCCAGAAACACAAAACCTACGACCTGCGGCTGCTCTCCTCTCTCACCGGGTCCTGG TCCCTCGTCCACAACGGAGTCTCGTACTATATAAATCTGTGCCAGAAAATATATAAAGGGCCCCTGGGCTGCTCTGAAAGGGCCAGCATT TGCAGAAGGACCACAACTGGTGACGTCCAGGTCCTGGGACTCGTTCACACGCAGAAGCTGGGTGTCATAGGTGACAAAGTTGTTGTCACG TACTCCAAAGGTTATCCGTGTGGTGGAAATAAGACCGCATCCTCCGTGATAGAATTGACCTGTACAAAGACGGTGGGCAGACCTGCATTC AAGAGGTTTGATATCGACAGCTGCACTTACTACTTCAGCTGGGACTCCCGGGCTGCCTGCGCCGTGAAGCCTCAGGAGGTGCAGATGGTG AATGGGACCATCACCAACCCTATAAATGGCAAGAGCTTCAGCCTCGGAGATATTTATTTTAAGCTGTTCAGAGCCTCTGGGGACATGAGG ACCAATGGGGACAACTACCTGTATGAGATCCAACTTTCCTCCATCACAAGCTCCAGAAACCCGGCGTGCTCTGGAGCCAACATATGCCAG GTGAAGCCCAACGATCAGCACTTCAGTCGGAAAGTTGGAACCTCTGACAAGACCAAGTACTACCTTCAAGACGGCGATCTCGATGTCGTG TTTGCCTCTTCCTCTAAGTGCGGAAAGGATAAGACCAAGTCTGTTTCTTCCACCATCTTCTTCCACTGTGACCCTCTGGTGGAGGACGGG ATCCCCGAGTTCAGTCACGAGACTGCCGACTGCCAGTACCTCTTCTCTTGGTACACCTCAGCCGTGTGTCCTCTGGGGGTGGGCTTTGAC AGCGAGAATCCCGGGGACGACGGGCAGATGCACAAGGGGCTGTCAGAACGGAGCCAGGCAGTCGGCGCGGTGCTCAGCCTGCTGCTGGTG GCGCTCACCTGCTGCCTGCTGGCCCTGTTGCTCTACAAGAAGGAGAGGAGGGAAACAGTGATAAGTAAGCTGACCACTTGCTGTAGGAGA AGTTCCAACGTGTCCTACAAATACTCAAAGGTGAATAAGGAAGAAGAGACAGATGAGAATGAAACAGAGTGGCTGATGGAAGAGATCCAG CTGCCTCCTCCACGGCAGGGAAAGGAAGGGCAGGAGAACGGCCATATTACCACCAAGTCAGTGAAAGCCCTCAGCTCCCTGCATGGGGAT GACCAGGACAGTGAGGATGAGGTTCTGACCATCCCAGAGGTGAAAGTTCACTCGGGCAGGGGAGCTGGGGCAGAGAGCTCCCACCCAGTG AGAAACGCACAGAGCAATGCCCTTCAGGAGCGTGAGGACGATAGGGTGGGGCTGGTCAGGGGTGAGAAGGCGAGGAAAGGGAAGTCCAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SKIV2L2_ENST00000230640_chr5_54603975_+_IGF2R_ENST00000356956_chr6_160412216_+_9182nt GCTGCCTGCCACACGCCAGGCGCCACGCGCCGCCCTCGCTCTTTATCCACTGAGCAGCTTATCCACTTTAGGTCGGAAAGGAAAGGAAAG AAAAGCAGGAAAAAAAAAAAAAGTCAGGGGAACATTTTTGTCGGCTGCGCGACTCGACTACTTTTGTCTCCTGCGGGCCACTGTTGAGCC TTCACGAGACGTCACTGTCTTCGGTCGCGGGGCATCGTGGGTAGGAGGGAGATTTGCTCTCACTGCTCCCAAAAATGGCGGACGCATTCG GAGATGAGCTGTTCAGCGTGTTCGAGGGCGACTCGACCACTGCGGCGGGAACCAAAAAAGACAAGGAAAAGGACAAGGGGAAATGGAAGG GGCCTCCAGGGTCTGCAGACAAGGCAGGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAA GTGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTT TGAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTG CCTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCT GCAAGAAAGACATATTTAAAGCAAATAAGGAGGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGAAGCATGATCTCAATCCTCTGATCA AGCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTAGAGACATAGACACACTACGAGACC CAGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGTTTGATGTTGGCCAGCCCCGGGACG GACTGAAGCTGGTGCGCAAGGACAGGCTTGTCCTGAGTTACGTGAGGGAAGAGGCAGGAAAGCTAGACTTTTGTGATGGTCACAGCCCTG CGGTGACTATTACATTTGTTTGCCCGTCGGAGCGGAGAGAGGGCACCATTCCCAAACTCACAGCTAAATCCAACTGCCGCTATGAAATTG AGTGGATTACTGAGTATGCCTGCCACAGAGATTACCTGGAAAGTAAAACTTGTTCTCTGAGCGGCGAGCAGCAGGATGTCTCCATAGACC TCACACCACTTGCCCAGAGCGGAGGTTCATCCTATATTTCAGATGGAAAAGAATATTTGTTTTATTTGAATGTCTGTGGAGAAACTGAAA TACAGTTCTGTAATAAAAAACAAGCTGCAGTTTGCCAAGTGAAAAAGAGCGATACCTCTCAAGTCAAAGCAGCAGGAAGATACCACAATC AGACCCTCCGATATTCGGATGGAGACCTCACCTTGATATATTTTGGAGGTGATGAATGCAGCTCAGGGTTTCAGCGGATGAGCGTCATAA ACTTTGAGTGCAATAAAACCGCAGGTAACGATGGGAAAGGAACTCCTGTATTCACAGGGGAGGTTGACTGCACCTACTTCTTCACATGGG ACACGGAATACGCCTGTGTTAAGGAGAAGGAAGACCTCCTCTGCGGTGCCACCGACGGGAAGAAGCGCTATGACCTGTCCGCGCTGGTCC GCCATGCAGAACCAGAGCAGAATTGGGAAGCTGTGGATGGCAGTCAGACGGAAACAGAGAAGAAGCATTTTTTCATTAATATTTGTCACA GAGTGCTGCAGGAAGGCAAGGCACGAGGGTGTCCCGAGGACGCGGCAGTGTGTGCAGTGGATAAAAATGGAAGTAAAAATCTGGGAAAAT TTATTTCCTCTCCCATGAAAGAGAAAGGAAACATTCAACTCTCTTATTCAGATGGTGATGATTGTGGTCATGGCAAGAAAATTAAAACTA ATATCACACTTGTATGCAAGCCAGGTGATCTGGAAAGTGCACCAGTGTTGAGAACTTCTGGGGAAGGCGGTTGCTTTTATGAGTTTGAGT GGCACACAGCTGCGGCCTGTGTGCTGTCTAAGACAGAAGGGGAGAACTGCACGGTCTTTGACTCCCAGGCAGGGTTTTCTTTTGACTTAT CACCTCTCACAAAGAAAAATGGTGCCTATAAAGTTGAGACAAAGAAGTATGACTTTTATATAAATGTGTGTGGCCCGGTGTCTGTGAGCC CCTGTCAGCCAGACTCAGGAGCCTGCCAGGTGGCAAAAAGTGATGAGAAGACTTGGAACTTGGGTCTGAGTAATGCGAAGCTTTCATATT ATGATGGGATGATCCAACTGAACTACAGAGGCGGCACACCCTATAACAATGAAAGACACACACCGAGAGCTACGCTCATCACCTTTCTCT GTGATCGAGACGCGGGAGTGGGCTTCCCTGAATATCAGGAAGAGGATAACTCCACCTACAACTTCCGGTGGTACACCAGCTATGCCTGCC CGGAGGAGCCCCTGGAATGCGTAGTGACCGACCCCTCCACGCTGGAGCAGTACGACCTCTCCAGTCTGGCAAAATCTGAAGGTGGCCTTG GAGGAAACTGGTATGCCATGGACAACTCAGGGGAACATGTCACGTGGAGGAAATACTACATTAACGTGTGTCGGCCTCTGAATCCAGTGC CGGGCTGCAACCGATATGCATCGGCTTGCCAGATGAAGTATGAAAAAGATCAGGGCTCCTTCACTGAAGTGGTTTCCATCAGTAACTTGG GAATGGCAAAGACCGGCCCGGTGGTTGAGGACAGCGGCAGCCTCCTTCTGGAATACGTGAATGGGTCGGCCTGCACCACCAGCGATGGCA GACAGACCACATATACCACGAGGATCCATCTCGTCTGCTCCAGGGGCAGGCTGAACAGCCACCCCATCTTTTCTCTCAACTGGGAGTGTG TGGTCAGTTTCCTGTGGAACACAGAGGCTGCCTGTCCCATTCAGACAACGACGGATACAGACCAGGCTTGCTCTATAAGGGATCCCAACA GTGGATTTGTGTTTAATCTTAATCCGCTAAACAGTTCGCAAGGATATAACGTCTCTGGCATTGGGAAGATTTTTATGTTTAATGTCTGCG GCACAATGCCTGTCTGTGGGACCATCCTGGGAAAACCTGCTTCTGGCTGTGAGGCAGAAACCCAAACTGAAGAGCTCAAGAATTGGAAGC CAGCAAGGCCAGTCGGAATTGAGAAAAGCCTCCAGCTGTCCACAGAGGGCTTCATCACTCTGACCTACAAAGGGCCTCTCTCTGCCAAAG GTACCGCTGATGCTTTTATCGTCCGCTTTGTTTGCAATGATGATGTTTACTCAGGGCCCCTCAAATTCCTGCATCAAGATATCGACTCTG GGCAAGGGATCCGAAACACTTACTTTGAGTTTGAAACCGCGTTGGCCTGTGTTCCTTCTCCAGTGGACTGCCAAGTCACCGACCTGGCTG GAAATGAGTACGACCTGACTGGCCTAAGCACAGTCAGGAAACCTTGGACGGCTGTTGACACCTCTGTCGATGGGAGAAAGAGGACTTTCT ATTTGAGCGTTTGCAATCCTCTCCCTTACATTCCTGGATGCCAGGGCAGCGCAGTGGGGTCTTGCTTAGTGTCAGAAGGCAATAGCTGGA ATCTGGGTGTGGTGCAGATGAGTCCCCAAGCCGCGGCGAATGGATCTTTGAGCATCATGTATGTCAACGGTGACAAGTGTGGGAACCAGC GCTTCTCCACCAGGATCACGTTTGAGTGTGCTCAGATATCGGGCTCACCAGCATTTCAGCTTCAGGATGGTTGTGAGTACGTGTTTATCT GGAGAACTGTGGAAGCCTGTCCCGTTGTCAGAGTGGAAGGGGACAACTGTGAGGTGAAAGACCCAAGGCATGGCAACTTGTATGACCTGA AGCCCCTGGGCCTCAACGACACCATCGTGAGCGCTGGCGAATACACTTATTACTTCCGGGTCTGTGGGAAGCTTTCCTCAGACGTCTGCC CCACAAGTGACAAGTCCAAGGTGGTCTCCTCATGTCAGGAAAAGCGGGAACCGCAGGGATTTCACAAAGTGGCAGGTCTCCTGACTCAGA AGCTAACTTATGAAAATGGCTTGTTAAAAATGAACTTCACGGGGGGGGACACTTGCCATAAGGTTTATCAGCGCTCCACAGCCATCTTCT TCTACTGTGACCGCGGCACCCAGCGGCCAGTATTTCTAAAGGAGACTTCAGATTGTTCCTACTTGTTTGAGTGGCGAACGCAGTATGCCT GCCCACCTTTCGATCTGACTGAATGTTCATTCAAAGATGGGGCTGGCAACTCCTTCGACCTCTCGTCCCTGTCAAGGTACAGTGACAACT GGGAAGCCATCACTGGGACGGGGGACCCGGAGCACTACCTCATCAATGTCTGCAAGTCTCTGGCCCCGCAGGCTGGCACTGAGCCGTGCC CTCCAGAAGCAGCCGCGTGTCTGCTGGGTGGCTCCAAGCCCGTGAACCTCGGCAGGGTAAGGGACGGACCTCAGTGGAGAGATGGCATAA TTGTCCTGAAATACGTTGATGGCGACTTATGTCCAGATGGGATTCGGAAAAAGTCAACCACCATCCGATTCACCTGCAGCGAGAGCCAAG TGAACTCCAGGCCCATGTTCATCAGCGCCGTGGAGGACTGTGAGTACACCTTTGCCTGGCCCACAGCCACAGCCTGTCCCATGAAGAGCA ACGAGCATGATGACTGCCAGGTCACCAACCCAAGCACAGGACACCTGTTTGATCTGAGCTCCTTAAGTGGCAGGGCGGGATTCACAGCTG CTTACAGCGAGAAGGGGTTGGTTTACATGAGCATCTGTGGGGAGAATGAAAACTGCCCTCCTGGCGTGGGGGCCTGCTTTGGACAGACCA GGATTAGCGTGGGCAAGGCCAACAAGAGGCTGAGATACGTGGACCAGGTCCTGCAGCTGGTGTACAAGGATGGGTCCCCTTGTCCCTCCA AATCCGGCCTGAGCTATAAGAGTGTGATCAGTTTCGTGTGCAGGCCTGAGGCCAGGCCAACCAATAGGCCCATGCTCATCTCCCTGGACA AGCAGACATGCACTCTCTTCTTCTCCTGGCACACGCCGCTGGCCTGCGAGCAAGCGACCGAATGTTCCGTGAGGAATGGAAGCTCTATTG TTGACTTGTCTCCCCTTATTCATCGCACTGGTGGTTATGAGGCTTATGATGAGAGTGAGGATGATGCCTCCGATACCAACCCTGATTTCT ACATCAATATTTGTCAGCCACTAAATCCCATGCACGGAGTGCCCTGTCCTGCCGGAGCCGCTGTGTGCAAAGTTCCTATTGATGGTCCCC CCATAGATATCGGCCGGGTAGCAGGACCACCAATACTCAATCCAATAGCAAATGAGATTTACTTGAATTTTGAAAGCAGTACTCCTTGCT TAGCGGACAAGCATTTCAACTACACCTCGCTCATCGCGTTTCACTGTAAGAGAGGTGTGAGCATGGGAACGCCTAAGCTGTTAAGGACCA GCGAGTGCGACTTTGTGTTCGAATGGGAGACTCCTGTCGTCTGTCCTGATGAAGTGAGGATGGATGGCTGTACCCTGACAGATGAGCAGC TCCTCTACAGCTTCAACTTGTCCAGCCTTTCCACGAGCACCTTTAAGGTGACTCGCGACTCGCGCACCTACAGCGTTGGGGTGTGCACCT TTGCAGTCGGGCCAGAACAAGGAGGCTGTAAGGACGGAGGAGTCTGTCTGCTCTCAGGCACCAAGGGGGCATCCTTTGGACGGCTGCAAT CAATGAAACTGGATTACAGGCACCAGGATGAAGCGGTCGTTTTAAGTTACGTGAATGGTGATCGTTGCCCTCCAGAAACCGATGACGGCG TCCCCTGTGTCTTCCCCTTCATATTCAATGGGAAGAGCTACGAGGAGTGCATCATAGAGAGCAGGGCGAAGCTGTGGTGTAGCACAACTG CGGACTACGACAGAGACCACGAGTGGGGCTTCTGCAGACACTCAAACAGCTACCGGACATCCAGCATCATATTTAAGTGTGATGAAGATG AGGACATTGGGAGGCCACAAGTCTTCAGTGAAGTGCGTGGGTGTGATGTGACATTTGAGTGGAAAACAAAAGTTGTCTGCCCTCCAAAGA AGTTGGAGTGCAAATTCGTCCAGAAACACAAAACCTACGACCTGCGGCTGCTCTCCTCTCTCACCGGGTCCTGGTCCCTCGTCCACAACG GAGTCTCGTACTATATAAATCTGTGCCAGAAAATATATAAAGGGCCCCTGGGCTGCTCTGAAAGGGCCAGCATTTGCAGAAGGACCACAA CTGGTGACGTCCAGGTCCTGGGACTCGTTCACACGCAGAAGCTGGGTGTCATAGGTGACAAAGTTGTTGTCACGTACTCCAAAGGTTATC CGTGTGGTGGAAATAAGACCGCATCCTCCGTGATAGAATTGACCTGTACAAAGACGGTGGGCAGACCTGCATTCAAGAGGTTTGATATCG ACAGCTGCACTTACTACTTCAGCTGGGACTCCCGGGCTGCCTGCGCCGTGAAGCCTCAGGAGGTGCAGATGGTGAATGGGACCATCACCA ACCCTATAAATGGCAAGAGCTTCAGCCTCGGAGATATTTATTTTAAGCTGTTCAGAGCCTCTGGGGACATGAGGACCAATGGGGACAACT ACCTGTATGAGATCCAACTTTCCTCCATCACAAGCTCCAGAAACCCGGCGTGCTCTGGAGCCAACATATGCCAGGTGAAGCCCAACGATC AGCACTTCAGTCGGAAAGTTGGAACCTCTGACAAGACCAAGTACTACCTTCAAGACGGCGATCTCGATGTCGTGTTTGCCTCTTCCTCTA AGTGCGGAAAGGATAAGACCAAGTCTGTTTCTTCCACCATCTTCTTCCACTGTGACCCTCTGGTGGAGGACGGGATCCCCGAGTTCAGTC ACGAGACTGCCGACTGCCAGTACCTCTTCTCTTGGTACACCTCAGCCGTGTGTCCTCTGGGGGTGGGCTTTGACAGCGAGAATCCCGGGG ACGACGGGCAGATGCACAAGGGGCTGTCAGAACGGAGCCAGGCAGTCGGCGCGGTGCTCAGCCTGCTGCTGGTGGCGCTCACCTGCTGCC TGCTGGCCCTGTTGCTCTACAAGAAGGAGAGGAGGGAAACAGTGATAAGTAAGCTGACCACTTGCTGTAGGAGAAGTTCCAACGTGTCCT ACAAATACTCAAAGGTGAATAAGGAAGAAGAGACAGATGAGAATGAAACAGAGTGGCTGATGGAAGAGATCCAGCTGCCTCCTCCACGGC AGGGAAAGGAAGGGCAGGAGAACGGCCATATTACCACCAAGTCAGTGAAAGCCCTCAGCTCCCTGCATGGGGATGACCAGGACAGTGAGG ATGAGGTTCTGACCATCCCAGAGGTGAAAGTTCACTCGGGCAGGGGAGCTGGGGCAGAGAGCTCCCACCCAGTGAGAAACGCACAGAGCA ATGCCCTTCAGGAGCGTGAGGACGATAGGGTGGGGCTGGTCAGGGGTGAGAAGGCGAGGAAAGGGAAGTCCAGCTCTGCACAGCAGAAGA CAGTGAGCTCCACCAAGCTGGTGTCCTTCCATGACGACAGCGACGAGGACCTCTTACACATCTGACTCCGCAGTGCCTGCAGGGGAGCAC GGAGCCGCGGGACAGCCAAGCACCTCCAACCAAATAAGACTTCCACTCGATGATGCTTCTATAATTTTGCCTTTAACAGAAACTTTCAAA AGGGAAGAGTTTTTGTGATGGGGGAGAGGGTGAAGGAGGTCAGGCCCCACTCCTTCCTGATTGTTTACAGTCATTGGAATAAGGCATGGC TCAGATCGGCCACAGGGCGGTACCTTGTGCCCAGGGTTTTGCCCCAAGTCCTCATTTAAAAGCATAAGGCCGGACGCATCTCAAAACAGA GGGCTGCATTCGAAGAAACCCTTGCTGCTTTAGTCCCGATAGGGTATTTGACCCCGATATATTTTAGCATTTTAATTCTCTCCCCCTATT TATTGACTTTGACAATTACTCAGGTTTGAGAAAAAGGAAAAAAAAACAGCCACCGTTTCTTCCTGCCAGCAGGGGTGTGATGTACCAGTT TGTCCATCTTGAGATGGTGAGGCTGTCAGTGTATGGGGCAGCTTCCGGCGGGATGTTGAACTGGTCATTAATGTGTCCCCTGAGTTGGAG CTCATTCTGTCTCTTTTCTCTTTTGCTTTCTGTTTCTTAAGGGCACACACACGTGCGTGCGAGCACACACACACATACGTGCACAGGGTC CCCGAGTGCCTAGGTTTTGGAGAGTTTGCCTGTTCTATGCCTTTAGTCAGGAATGGCTGCACCTTTTTGCATGATATCTTCAAGCCTGGG CGTACAGAGCACATTTGTCAGTATTTTTGCCGGCTGGTGAATTCAAACAACCTGCCCAAAGATTGATTTGTGTGTTTGTGTGTGTGTGTG TGTGTGTGTGTGTGTGTGTGAGTGGAGTTGAGGTGTCAGAGAAAATGAATTTTTTCCAGATTTGGGGTATAGGTCTCATCTCTTCAGGTT CTCATGATACCACCTTTACTGTGCTTATTTTTTTAAGAAAAAAGTGTTGATCAACCATTCGACCTATAAGAAGCCTTAATTTGCACAGTG TGTGACTTACAGAAACTGCATGAAAAATCATGGGCCAGAGCCTCGGCCCTAGCATTGCACTTGGCCTCATGCTGGAGGGAGGCTGGGCGG GTACAGCGCGGAGGAGGAGGGAGGCCAGGCGGGCATGGCGTGGAGGAGGAGGGAGGCCGGGCGGTCACAGCATGGAGGAGGAGGGAGGCG CTGCTGGTGTTCTTATTCTGGCGGCAGCGCCTTTCCTGCCATGTTTAGTGAATGACTTTTCTCGCATTGTAGAATTGTATATAGACTCTG GTGTTCTATTGCTGAGAAGCAAACCGCCCTGCAGCATCCCTCAGCCTGTACCGGTTTGGCTGGCTTGTTTGATTTCAACATGAGTGTATT TTTTAAAATTGATTTTTCTCTTCATTTTTTTTTCAATCAACTTTACTGTAATATAAAGTATTCAACAATTTCAATAAAAGATAAATTATT |
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FusionGenePPI for SKIV2L2_IGF2R |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SKIV2L2 | MPP6, RNPS1, TAF10, TERF2, PPP2R1A, PPP2R2A, PPP2R2B, PPP2R2D, RAD21, SIRT7, ZCCHC8, CUL3, CUL1, COPS5, CAND1, GRK5, EXOSC4, DIS3, DIS3L, SNW1, NUDT21, CWC27, SNRPD2, SF3A1, SOX2, XRN1, EXOSC6, UPF2, CLK2, TARDBP, YWHAB, RPA1, RPA2, RPA3, DROSHA, OBSL1, EED, BMI1, BUB1B, RBM7, RBM11, EXOSC3, EXOSC7, EXOSC8, WHSC1, UNK, ANKMY2, CSE1L, DDX5, DHX38, EFTUD1, EIF3H, EIF4A3, EIF4G1, KIAA0020, KIF2C, LIG1, NLE1, NOP2, PABPC1, PABPC4, RRP12, RRS1, CAPN1, CAPN11, CTPS1, DBR1, DHX15, DOHH, EXOSC10, METTL13, SKP2, TRMT61A, TTC27, YBX1, YBX3, TRMT6, NTRK1, IFI16, XPO1, GBA, HSP90AA1, NCBP1, SNCA, NCBP2, KIAA1107, EXOSC5, ZFC3H1, BOD1L1, MZT1, EXOSC1, USP37, CDC5L, RNF126, ZNF746, C1D, NCL, FOXA1, FAM107A, MCM9 | IGF2R | CREG1, PLIN3, PLAUR, USP50, ELAVL1, MYC, SIRT7, GGA2, GGA3, GGA1, CSNK2A1, FBXO6, TM9SF4, COA7, SERINC1, TIMM10B, ATXN1, FN1, CCDC8, ABCE1, EWSR1, TMEM17, TMEM216, RAB5C, XRCC5, GTSE1, CHMP4B, CDH1, PPM1H, NCDN, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SKIV2L2_IGF2R |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IGF2R | P11717 | DB01277 | Mecasermin | Cation-independent mannose-6-phosphate receptor | biotech | approved|investigational |
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RelatedDiseases for SKIV2L2_IGF2R |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IGF2R | C0024115 | Lung diseases | 2 | CTD_human |
| Tgene | IGF2R | C0235833 | Congenital diaphragmatic hernia | 2 | CTD_human |
| Tgene | IGF2R | C0002395 | Alzheimer's Disease | 1 | CTD_human |
| Tgene | IGF2R | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | IGF2R | C0030567 | Parkinson Disease | 1 | CTD_human |
| Tgene | IGF2R | C0752347 | Lewy Body Disease | 1 | CTD_human |
| Tgene | IGF2R | C2239176 | Liver carcinoma | 1 | CTD_human;HPO |
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