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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33958

FusionGeneSummary for SKAP2_INPP4B

check button Fusion gene summary
Fusion gene informationFusion gene name: SKAP2_INPP4B
Fusion gene ID: 33958
HgeneTgene
Gene symbol

SKAP2

INPP4B

Gene ID

8935

8821

Gene namesrc kinase associated phosphoprotein 2inositol polyphosphate-4-phosphatase type II B
SynonymsPRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R-
Cytomap

7p15.2

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionsrc kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa
Modification date2018052320180523
UniProtAcc

O75563

O15327

Ensembl transtripts involved in fusion geneENST00000345317, ENST00000539623, 
ENST00000489977, 		ENST00000513000, 
ENST00000509777, ENST00000262992, 
ENST00000308502, ENST00000508116, 
ENST00000507861, ENST00000506217, 
ENST00000508084, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 7 X 6=378
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKAP2 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF895764SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000345317ENST00000513000SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000509777SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000262992SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000308502SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000508116SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000507861SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000506217SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000345317ENST00000508084SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000513000SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000509777SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000262992SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000308502SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000508116SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000507861SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000506217SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000539623ENST00000508084SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000513000SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000509777SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000262992SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000308502SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000508116SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000507861SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000506217SKAP2chr7

26813470

+INPP4Bchr4

143233000

+
intron-intronENST00000489977ENST00000508084SKAP2chr7

26813470

+INPP4Bchr4

143233000

+

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FusionProtFeatures for SKAP2_INPP4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKAP2

O75563

INPP4B

O15327

May be involved in B-cell and macrophage adhesionprocesses. In B-cells, may act by coupling the B-cell receptor(BCR) to integrin activation. May play a role in src signalingpathway. {ECO:0000269|PubMed:12893833,ECO:0000269|PubMed:9837776}. Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SKAP2_INPP4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SKAP2_INPP4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SKAP2_INPP4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SKAP2_INPP4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSKAP2C0023893Liver Cirrhosis, Experimental1CTD_human