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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 33954

FusionGeneSummary for SKAP1_SP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SKAP1_SP2
Fusion gene ID: 33954
HgeneTgene
Gene symbol

SKAP1

SP2

Gene ID

8631

6668

Gene namesrc kinase associated phosphoprotein 1Sp2 transcription factor
SynonymsHEL-S-81p|SCAP1|SKAP55-
Cytomap

17q21.32

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionsrc kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDatranscription factor Sp2
Modification date2018052320180523
UniProtAcc

Q86WV1

Q02086

Ensembl transtripts involved in fusion geneENST00000336915, ENST00000584924, 
ENST00000376741, 
Fusion gene scores* DoF score16 X 4 X 7=4488 X 5 X 6=240
# samples 169
** MAII scorelog2(16/448*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKAP1 [Title/Abstract] AND SP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

11909961

TgeneSP2

GO:0000122

negative regulation of transcription by RNA polymerase II

10744779


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1549-01ASKAP1chr17

46423267

-SP2chr17

45992678

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336915ENST00000376741SKAP1chr17

46423267

-SP2chr17

45992678

+
In-frameENST00000584924ENST00000376741SKAP1chr17

46423267

-SP2chr17

45992678

+

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FusionProtFeatures for SKAP1_SP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKAP1

Q86WV1

SP2

Q02086

Positively regulates T-cell receptor signaling byenhancing the MAP kinase pathway. Required for optimal conjugationbetween T-cells and antigen-presenting cells by promoting theclustering of integrin ITGAL on the surface of T-cells. May beinvolved in high affinity immunoglobulin epsilon receptorsignaling in mast cells. {ECO:0000269|PubMed:10856234,ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296,ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}. Binds to GC box promoters elements and selectivelyactivates mRNA synthesis from genes that contain functionalrecognition sites.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSP2chr17:46423267chr17:45992678ENST00000376741+07525_5492614Zinc fingerC2H2-type 1
TgeneSP2chr17:46423267chr17:45992678ENST00000376741+07555_5792614Zinc fingerC2H2-type 2
TgeneSP2chr17:46423267chr17:45992678ENST00000376741+07585_6072614Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKAP1chr17:46423267chr17:45992678ENST00000336915-413220_23093448Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423267chr17:45992678ENST00000584924-412220_23093360Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423267chr17:45992678ENST00000336915-413107_21093448DomainPH
HgeneSKAP1chr17:46423267chr17:45992678ENST00000336915-413294_35593448DomainSH3
HgeneSKAP1chr17:46423267chr17:45992678ENST00000584924-412107_21093360DomainPH
HgeneSKAP1chr17:46423267chr17:45992678ENST00000584924-412294_35593360DomainSH3


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FusionGeneSequence for SKAP1_SP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_705aa
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSS
KGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPI
KPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVL
IETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTP
SGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGV
PVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKT

>In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_705aa
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSS
KGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPI
KPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVL
IETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTP
SGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGV
PVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKT


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_2115nt
ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC
AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG
GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT
CAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGAC
TCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCC
CCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCC
AAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATG
ATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAG
CCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATC
AAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAAT
GTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCG
CTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTG
ATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAG
CAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCC
ACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCT
TCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCC
CGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGG
AGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTG
CCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCC
ACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAAC
TGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACG
TCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGT
GACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCAC

>In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_2115nt
ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC
AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG
GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT
CAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGAC
TCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCC
CCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCC
AAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATG
ATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAG
CCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATC
AAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAAT
GTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCG
CTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTG
ATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAG
CAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCC
ACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCT
TCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCC
CGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGG
AGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTG
CCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCC
ACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAAC
TGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACG
TCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGT
GACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_3318nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGATCCACAGAC
CAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGACTCCCAGCCATCTCCCTTAGC
CCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCCCCACAGCCCACACCGCGGAA
ACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCCAAAGGAAATATACTTCAGAT
TCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATGATCAACAAAGGGACCCGATC
AAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAGCCCAATCTCACCAACCAGAT
CCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATCAAGCCAGCCCCCATCCAGAA
GTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAATGTGACGCTCACTCTGCCCGT
CAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCGCTGTCTAAGACTAACAAGAA
AGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTGATCGAGACCACCGCGGACAA
CATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAGCAGGTCCAGGTGGTGCCCCC
CAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCCACCCTCCCCACTGTACCCCA
GAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCTTCCGGTGAGGTGCAGACAGT
CCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCCCGTGCTCCCCATCTGAGTGG
GACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGGAGCATCATCAGCCTGAATGC
AGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTGCCTGTCACCATCACCAACAC
AGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCCACCCAGATCCAGCTGCAAAT
GGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAACTGCAAGGATGGGGAGAAGAG
GTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACGTCCTTGCTGCGTGCCCATGT
GCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGTGACGAGCTCCAACGGCATGC
TCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCACCTCACCAAGCATTACAAGAC
CCACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGCGGGAGGCCCTGAAGATGCAGTCCCCCACCTGTGTCCTCCCTGGGCCCCTGGT
GGAAAGGAGCCCTGTGGCTGCCTTGGGCCTGCCCTCAGCCCCACTCCTGTTCTGCAACTGTCCCCACAGGAAGGGGCTCTGTTCCCTGTA
TTGTCCTCCTTCTGAAGCCCCTTGGCTCTGCCTTGGCCCTTCCCCTCACCACGAGCTCCCGGCCTGCCCAGACTGTGGACACTGGCCGTG
CCCAATGAGACGTTCTAAACCAGGACGCGTGGGAACCCTTATTTCCAAAGGAAAAACATGCATTTCACTCCGTCGAGGAGCAAAGTGAGC
CCCTACCCCCCACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGCCATGCCCCCTCTCCTGCACCTCCCTGGCCCTGCCGGC
CACTGTGGACGCCCTGGGGCTTGGCACCCACCTCTGGAGAAACTCGGGGCCACCTCCACTCCATGTGCCCAGCCCCGCCACAACCTCTCC
TCCAGCACATTCCAGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCCCCCTCTTTTTCTATGGAGAACGTTGCCTTATACTC
TACTTCAGATGATGAACACTGTGTACTGTGTGTGCTTTAAAGAAGTTTTATTTAATTGCTCCCTTCTTCCTTTCCTTGTTATTCACCTCC
CTGATGCCTGCTTTCAGTTGAGGGTTGGGGGCAATGATGAGCATATGAATTTTTTCTCACTCTAGCAATTCCCTTTTCTAAATGACACAG
CATTTAAACTCAAATCTGGATTCAGATAACAGCACCTGCACATCCTGCACCTCCTCCCTCTCCCTTCACCTCACCCCTGCCCGGCCCAAG
CTCTACTTGTGTACAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGTTTAAAAACACATTGCTTGTTATTTTTGAGGCTTTTA
AATTAAACAAAAATCCAACTTTATTTTTAGTTGTAACTGCTTGAGGTATGTTTTATGAATTAAGTGACAGATTTGTTATCCTTTATTAAC

>In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_3347nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACC
ACCCAGGACTCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCT
CCTGCTCCCCCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATC
TTGTCCTCCAAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAAT
CCCACCATGATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATC
CAAGTACAGCCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCT
GTCCCCATCAAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGG
GGCGGCAATGTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCC
CCAACCCCGCTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAG
ACGGTGCTGATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCT
GTGGTCCAGCAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCG
GCATCTGCCACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATC
CGCACGCCTTCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGC
CCTGCATCCCGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCC
CCAGCCGGGAGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTC
CAGGGCGTGCCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGG
CTGAGCCCCACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACG
TGTCCCAACTGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTC
CGTAAGACGTCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTC
ACACGGAGTGACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGG
AGTGACCACCTCACCAAGCATTACAAGACCCACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGCGGGAGGCCCTGAAGATGCAGTCC
CCCACCTGTGTCCTCCCTGGGCCCCTGGTGGAAAGGAGCCCTGTGGCTGCCTTGGGCCTGCCCTCAGCCCCACTCCTGTTCTGCAACTGT
CCCCACAGGAAGGGGCTCTGTTCCCTGTATTGTCCTCCTTCTGAAGCCCCTTGGCTCTGCCTTGGCCCTTCCCCTCACCACGAGCTCCCG
GCCTGCCCAGACTGTGGACACTGGCCGTGCCCAATGAGACGTTCTAAACCAGGACGCGTGGGAACCCTTATTTCCAAAGGAAAAACATGC
ATTTCACTCCGTCGAGGAGCAAAGTGAGCCCCTACCCCCCACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGCCATGCCCC
CTCTCCTGCACCTCCCTGGCCCTGCCGGCCACTGTGGACGCCCTGGGGCTTGGCACCCACCTCTGGAGAAACTCGGGGCCACCTCCACTC
CATGTGCCCAGCCCCGCCACAACCTCTCCTCCAGCACATTCCAGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCCCCCTCT
TTTTCTATGGAGAACGTTGCCTTATACTCTACTTCAGATGATGAACACTGTGTACTGTGTGTGCTTTAAAGAAGTTTTATTTAATTGCTC
CCTTCTTCCTTTCCTTGTTATTCACCTCCCTGATGCCTGCTTTCAGTTGAGGGTTGGGGGCAATGATGAGCATATGAATTTTTTCTCACT
CTAGCAATTCCCTTTTCTAAATGACACAGCATTTAAACTCAAATCTGGATTCAGATAACAGCACCTGCACATCCTGCACCTCCTCCCTCT
CCCTTCACCTCACCCCTGCCCGGCCCAAGCTCTACTTGTGTACAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGTTTAAAAA
CACATTGCTTGTTATTTTTGAGGCTTTTAAATTAAACAAAAATCCAACTTTATTTTTAGTTGTAACTGCTTGAGGTATGTTTTATGAATT
AAGTGACAGATTTGTTATCCTTTATTAACGTACTTTGTTGGTCAGCACTGGGCTGACAAAAATTTTTTCTTGCTAATAAATTTAGTTGCC


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FusionGenePPI for SKAP1_SP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SKAP1PTPRC, FYB, SRC, LYN, FYN, LCK, SKAP1, GRB2, APP, BLCAP, SH2D4A, PRAM1, FAM102A, AP3M1, MYO9B, MYO9A, POLR1B, LOC81691, EML3, WRN, ASPM, JPH1, POLR1A, POLR3A, RECQL4, HPS3, ZNF324, FAM208A, UXT, NCAPD3, MYCBP2, CUL2, PIP5K1A, NEK1, PLEKHH3, PHLDB3, PIK3C3, SEC63, SKAP2, GTF3C1, URI1, PIK3R2, PIK3R3, POLRMT, PLD2, UCKL1, PRR14L, KSR1, ZNHIT6, PDRG1, SETX, NEFL, ALMS1, APPBP2, DDX11L8, UTP15, SENP5, NCAPH2, PAX3, TBL2, ZNHIT2, ZNF644, SUGCT, PKN3, TTF2, PPHLN1, NPHP4, MTMR1, PKN2, C21orf2, POLA1, POLR3B, POLR2L, CCP110, SETD5, ELP3, DOCK7, USP54, POLR1E, TRMT44, POLR1D, EXPH5, NEK4, ATXN2, SBF1, GTPBP6, TRMT1, CD3EAP, PER1, SUPT6H, MCM8, RTEL1, TIGD5, PUSL1, KLHDC3, DYNLL2, MAP7D1SP2E2F1, NR0B2, NKX3-1, ESR1, IRF1, APP, SOX2, HECW2, FHL2, MCM7, BANP, ZDHHC17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSKAP1chr17:46423267chr17:45992678ENST00000336915-413290_29593448FYB1
HgeneSKAP1chr17:46423267chr17:45992678ENST00000584924-412290_29593360FYB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SKAP1_SP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SKAP1_SP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSKAP1C0919267ovarian neoplasm1CTD_human