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Fusion gene ID: 33954 |
FusionGeneSummary for SKAP1_SP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SKAP1_SP2 | Fusion gene ID: 33954 | Hgene | Tgene | Gene symbol | SKAP1 | SP2 | Gene ID | 8631 | 6668 |
| Gene name | src kinase associated phosphoprotein 1 | Sp2 transcription factor | |
| Synonyms | HEL-S-81p|SCAP1|SKAP55 | - | |
| Cytomap | 17q21.32 | 17q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | src kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa | transcription factor Sp2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q86WV1 | Q02086 | |
| Ensembl transtripts involved in fusion gene | ENST00000336915, ENST00000584924, | ENST00000376741, | |
| Fusion gene scores | * DoF score | 16 X 4 X 7=448 | 8 X 5 X 6=240 |
| # samples | 16 | 9 | |
| ** MAII score | log2(16/448*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SKAP1 [Title/Abstract] AND SP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SKAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11909961 |
| Tgene | SP2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10744779 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-24-1549-01A | SKAP1 | chr17 | 46423267 | - | SP2 | chr17 | 45992678 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336915 | ENST00000376741 | SKAP1 | chr17 | 46423267 | - | SP2 | chr17 | 45992678 | + |
| In-frame | ENST00000584924 | ENST00000376741 | SKAP1 | chr17 | 46423267 | - | SP2 | chr17 | 45992678 | + |
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FusionProtFeatures for SKAP1_SP2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SKAP1 | SP2 |
| Positively regulates T-cell receptor signaling byenhancing the MAP kinase pathway. Required for optimal conjugationbetween T-cells and antigen-presenting cells by promoting theclustering of integrin ITGAL on the surface of T-cells. May beinvolved in high affinity immunoglobulin epsilon receptorsignaling in mast cells. {ECO:0000269|PubMed:10856234,ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296,ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}. | Binds to GC box promoters elements and selectivelyactivates mRNA synthesis from genes that contain functionalrecognition sites. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SP2 | chr17:46423267 | chr17:45992678 | ENST00000376741 | + | 0 | 7 | 525_549 | 2 | 614 | Zinc finger | C2H2-type 1 |
| Tgene | >SP2 | chr17:46423267 | chr17:45992678 | ENST00000376741 | + | 0 | 7 | 555_579 | 2 | 614 | Zinc finger | C2H2-type 2 |
| Tgene | >SP2 | chr17:46423267 | chr17:45992678 | ENST00000376741 | + | 0 | 7 | 585_607 | 2 | 614 | Zinc finger | C2H2-type 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000336915 | - | 4 | 13 | 220_230 | 93 | 448 | Compositional bias | Note=Poly-Glu |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000584924 | - | 4 | 12 | 220_230 | 93 | 360 | Compositional bias | Note=Poly-Glu |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000336915 | - | 4 | 13 | 107_210 | 93 | 448 | Domain | PH |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000336915 | - | 4 | 13 | 294_355 | 93 | 448 | Domain | SH3 |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000584924 | - | 4 | 12 | 107_210 | 93 | 360 | Domain | PH |
| Hgene | >SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000584924 | - | 4 | 12 | 294_355 | 93 | 360 | Domain | SH3 |
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FusionGeneSequence for SKAP1_SP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_705aa MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY QDEDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSS KGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPI KPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVL IETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTP SGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGV PVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKT >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_705aa MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY QDEDPQTSMAATAAVSPSDYLQPAASTTQDSQPSPLALLAATCSKIGPPAVEAAVTPPAPPQPTPRKLVPIKPAPLPLSPGKNSFGILSS KGNILQIQGSQLSASYPGGQLVFAIQNPTMINKGTRSNANIQYQAVPQIQASNSQTIQVQPNLTNQIQIIPGTNQAIITPSPSSHKPVPI KPAPIQKSSTTTTPVQSGANVVKLTGGGGNVTLTLPVNNLVNASDTGAPTQLLTESPPTPLSKTNKKARKKSLPASQPPVAVAEQVETVL IETTADNIIQAGNNLLIVQSPGGGQPAVVQQVQVVPPKAEQQQVVQIPQQALRVVQAASATLPTVPQKPSQNFQIQAAEPTPTQVYIRTP SGEVQTVLVQDSPPATAAATSNTTCSSPASRAPHLSGTSKKHSAAILRKERPLPKIAPAGSIISLNAAQLAAAAQAMQTININGVQVQGV PVTITNTGGQQQLTVQNVSGNNLTISGLSPTQIQLQMEQALAGETQPGEKRRRMACTCPNCKDGEKRSGEQGKKKHVCHIPDCGKTFRKT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_2115nt ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT CAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGAC TCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCC CCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCC AAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATG ATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAG CCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATC AAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAAT GTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCG CTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTG ATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAG CAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCC ACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCT TCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCC CGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGG AGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTG CCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCC ACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAAC TGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACG TCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGT GACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCAC >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_2115nt ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT CAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGAC TCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCC CCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCC AAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATG ATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAG CCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATC AAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAAT GTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCG CTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTG ATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAG CAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCC ACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCT TCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCC CGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGG AGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTG CCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCC ACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAAC TGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACG TCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGT GACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SKAP1_ENST00000336915_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_3318nt GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGATCCACAGAC CAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACCACCCAGGACTCCCAGCCATCTCCCTTAGC CCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCCCCACAGCCCACACCGCGGAA ACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATCTTGTCCTCCAAAGGAAATATACTTCAGAT TCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATGATCAACAAAGGGACCCGATC AAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATCCAAGTACAGCCCAATCTCACCAACCAGAT CCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATCAAGCCAGCCCCCATCCAGAA GTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGGGGCGGCAATGTGACGCTCACTCTGCCCGT CAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCGCTGTCTAAGACTAACAAGAA AGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAGACGGTGCTGATCGAGACCACCGCGGACAA CATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAGCAGGTCCAGGTGGTGCCCCC CAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCGGCATCTGCCACCCTCCCCACTGTACCCCA GAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCTTCCGGTGAGGTGCAGACAGT CCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGCCCTGCATCCCGTGCTCCCCATCTGAGTGG GACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGGAGCATCATCAGCCTGAATGC AGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTCCAGGGCGTGCCTGTCACCATCACCAACAC AGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCCACCCAGATCCAGCTGCAAAT GGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACGTGTCCCAACTGCAAGGATGGGGAGAAGAG GTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACGTCCTTGCTGCGTGCCCATGT GCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTCACACGGAGTGACGAGCTCCAACGGCATGC TCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCACCTCACCAAGCATTACAAGAC CCACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGCGGGAGGCCCTGAAGATGCAGTCCCCCACCTGTGTCCTCCCTGGGCCCCTGGT GGAAAGGAGCCCTGTGGCTGCCTTGGGCCTGCCCTCAGCCCCACTCCTGTTCTGCAACTGTCCCCACAGGAAGGGGCTCTGTTCCCTGTA TTGTCCTCCTTCTGAAGCCCCTTGGCTCTGCCTTGGCCCTTCCCCTCACCACGAGCTCCCGGCCTGCCCAGACTGTGGACACTGGCCGTG CCCAATGAGACGTTCTAAACCAGGACGCGTGGGAACCCTTATTTCCAAAGGAAAAACATGCATTTCACTCCGTCGAGGAGCAAAGTGAGC CCCTACCCCCCACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGCCATGCCCCCTCTCCTGCACCTCCCTGGCCCTGCCGGC CACTGTGGACGCCCTGGGGCTTGGCACCCACCTCTGGAGAAACTCGGGGCCACCTCCACTCCATGTGCCCAGCCCCGCCACAACCTCTCC TCCAGCACATTCCAGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCCCCCTCTTTTTCTATGGAGAACGTTGCCTTATACTC TACTTCAGATGATGAACACTGTGTACTGTGTGTGCTTTAAAGAAGTTTTATTTAATTGCTCCCTTCTTCCTTTCCTTGTTATTCACCTCC CTGATGCCTGCTTTCAGTTGAGGGTTGGGGGCAATGATGAGCATATGAATTTTTTCTCACTCTAGCAATTCCCTTTTCTAAATGACACAG CATTTAAACTCAAATCTGGATTCAGATAACAGCACCTGCACATCCTGCACCTCCTCCCTCTCCCTTCACCTCACCCCTGCCCGGCCCAAG CTCTACTTGTGTACAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGTTTAAAAACACATTGCTTGTTATTTTTGAGGCTTTTA AATTAAACAAAAATCCAACTTTATTTTTAGTTGTAACTGCTTGAGGTATGTTTTATGAATTAAGTGACAGATTTGTTATCCTTTATTAAC >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_SP2_ENST00000376741_chr17_45992678_+_3347nt GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG TCAGATTATCAGGATGAGGATCCACAGACCAGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACC ACCCAGGACTCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGCCCTCCAGCAGTTGAAGCTGCTGTGACACCT CCTGCTCCCCCACAGCCCACACCGCGGAAACTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATC TTGTCCTCCAAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCTGGAGGGCAGCTGGTGTTCGCTATCCAGAAT CCCACCATGATCAACAAAGGGACCCGATCAAATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATC CAAGTACAGCCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATCATCACCCCCTCACCGTCCAGTCACAAGCCT GTCCCCATCAAGCCAGCCCCCATCCAGAAGTCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGCTGACAGGTGGG GGCGGCAATGTGACGCTCACTCTGCCCGTCAACAACCTTGTGAACGCCAGTGACACCGGGGCCCCTACTCAGCTCCTCACTGAAAGCCCC CCAACCCCGCTGTCTAAGACTAACAAGAAAGCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAG ACGGTGCTGATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATTGTTCAGAGCCCTGGTGGGGGCCAGCCAGCT GTGGTCCAGCAGGTCCAGGTGGTGCCCCCCAAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCG GCATCTGCCACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCAGCTGAGCCGACACCTACTCAGGTCTACATC CGCACGCCTTCCGGTGAGGTGCAGACAGTCCTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGC CCTGCATCCCGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTCCGAAAAGAGCGTCCCCTGCCAAAGATTGCC CCAGCCGGGAGCATCATCAGCCTGAATGCAGCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTC CAGGGCGTGCCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAATGTTTCTGGGAACAACCTGACCATCAGTGGG CTGAGCCCCACCCAGATCCAGCTGCAAATGGAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACG TGTCCCAACTGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTGTGCCACATCCCCGACTGTGGCAAGACGTTC CGTAAGACGTCCTTGCTGCGTGCCCATGTGCGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTC ACACGGAGTGACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAGTGCGCCCAGTGTCAGAAGCGCTTCATGAGG AGTGACCACCTCACCAAGCATTACAAGACCCACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGCGGGAGGCCCTGAAGATGCAGTCC CCCACCTGTGTCCTCCCTGGGCCCCTGGTGGAAAGGAGCCCTGTGGCTGCCTTGGGCCTGCCCTCAGCCCCACTCCTGTTCTGCAACTGT CCCCACAGGAAGGGGCTCTGTTCCCTGTATTGTCCTCCTTCTGAAGCCCCTTGGCTCTGCCTTGGCCCTTCCCCTCACCACGAGCTCCCG GCCTGCCCAGACTGTGGACACTGGCCGTGCCCAATGAGACGTTCTAAACCAGGACGCGTGGGAACCCTTATTTCCAAAGGAAAAACATGC ATTTCACTCCGTCGAGGAGCAAAGTGAGCCCCTACCCCCCACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGCCATGCCCC CTCTCCTGCACCTCCCTGGCCCTGCCGGCCACTGTGGACGCCCTGGGGCTTGGCACCCACCTCTGGAGAAACTCGGGGCCACCTCCACTC CATGTGCCCAGCCCCGCCACAACCTCTCCTCCAGCACATTCCAGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCCCCCTCT TTTTCTATGGAGAACGTTGCCTTATACTCTACTTCAGATGATGAACACTGTGTACTGTGTGTGCTTTAAAGAAGTTTTATTTAATTGCTC CCTTCTTCCTTTCCTTGTTATTCACCTCCCTGATGCCTGCTTTCAGTTGAGGGTTGGGGGCAATGATGAGCATATGAATTTTTTCTCACT CTAGCAATTCCCTTTTCTAAATGACACAGCATTTAAACTCAAATCTGGATTCAGATAACAGCACCTGCACATCCTGCACCTCCTCCCTCT CCCTTCACCTCACCCCTGCCCGGCCCAAGCTCTACTTGTGTACAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGTTTAAAAA CACATTGCTTGTTATTTTTGAGGCTTTTAAATTAAACAAAAATCCAACTTTATTTTTAGTTGTAACTGCTTGAGGTATGTTTTATGAATT AAGTGACAGATTTGTTATCCTTTATTAACGTACTTTGTTGGTCAGCACTGGGCTGACAAAAATTTTTTCTTGCTAATAAATTTAGTTGCC 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FusionGenePPI for SKAP1_SP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SKAP1 | PTPRC, FYB, SRC, LYN, FYN, LCK, SKAP1, GRB2, APP, BLCAP, SH2D4A, PRAM1, FAM102A, AP3M1, MYO9B, MYO9A, POLR1B, LOC81691, EML3, WRN, ASPM, JPH1, POLR1A, POLR3A, RECQL4, HPS3, ZNF324, FAM208A, UXT, NCAPD3, MYCBP2, CUL2, PIP5K1A, NEK1, PLEKHH3, PHLDB3, PIK3C3, SEC63, SKAP2, GTF3C1, URI1, PIK3R2, PIK3R3, POLRMT, PLD2, UCKL1, PRR14L, KSR1, ZNHIT6, PDRG1, SETX, NEFL, ALMS1, APPBP2, DDX11L8, UTP15, SENP5, NCAPH2, PAX3, TBL2, ZNHIT2, ZNF644, SUGCT, PKN3, TTF2, PPHLN1, NPHP4, MTMR1, PKN2, C21orf2, POLA1, POLR3B, POLR2L, CCP110, SETD5, ELP3, DOCK7, USP54, POLR1E, TRMT44, POLR1D, EXPH5, NEK4, ATXN2, SBF1, GTPBP6, TRMT1, CD3EAP, PER1, SUPT6H, MCM8, RTEL1, TIGD5, PUSL1, KLHDC3, DYNLL2, MAP7D1 | SP2 | E2F1, NR0B2, NKX3-1, ESR1, IRF1, APP, SOX2, HECW2, FHL2, MCM7, BANP, ZDHHC17 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000336915 | - | 4 | 13 | 290_295 | 93 | 448 | FYB1 |
| Hgene | SKAP1 | chr17:46423267 | chr17:45992678 | ENST00000584924 | - | 4 | 12 | 290_295 | 93 | 360 | FYB1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SKAP1_SP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SKAP1_SP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SKAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
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