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Fusion gene ID: 33948 |
FusionGeneSummary for SKAP1_HOXB9 |
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Fusion gene information | Fusion gene name: SKAP1_HOXB9 | Fusion gene ID: 33948 | Hgene | Tgene | Gene symbol | SKAP1 | HOXB9 | Gene ID | 8631 | 3219 |
Gene name | src kinase associated phosphoprotein 1 | homeobox B9 | |
Synonyms | HEL-S-81p|SCAP1|SKAP55 | HOX-2.5|HOX2|HOX2E | |
Cytomap | 17q21.32 | 17q21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | src kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa | homeobox protein Hox-B9homeo box 2Ehomeo box B9homeobox protein Hox-2.5homeobox protein Hox-2E | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q86WV1 | P17482 | |
Ensembl transtripts involved in fusion gene | ENST00000336915, ENST00000584924, | ENST00000311177, ENST00000550387, | |
Fusion gene scores | * DoF score | 16 X 4 X 7=448 | 3 X 3 X 3=27 |
# samples | 16 | 3 | |
** MAII score | log2(16/448*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SKAP1 [Title/Abstract] AND HOXB9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SKAP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11909961 |
Tgene | HOXB9 | GO:0060326 | cell chemotaxis | 19576624 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | OV | TCGA-VG-A8LO-01A | SKAP1 | chr17 | 46423267 | - | HOXB9 | chr17 | 46700497 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000336915 | ENST00000311177 | SKAP1 | chr17 | 46423267 | - | HOXB9 | chr17 | 46700497 | - |
Frame-shift | ENST00000336915 | ENST00000550387 | SKAP1 | chr17 | 46423267 | - | HOXB9 | chr17 | 46700497 | - |
In-frame | ENST00000584924 | ENST00000311177 | SKAP1 | chr17 | 46423267 | - | HOXB9 | chr17 | 46700497 | - |
Frame-shift | ENST00000584924 | ENST00000550387 | SKAP1 | chr17 | 46423267 | - | HOXB9 | chr17 | 46700497 | - |
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FusionProtFeatures for SKAP1_HOXB9 |
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Hgene | Tgene |
SKAP1 | HOXB9 |
Positively regulates T-cell receptor signaling byenhancing the MAP kinase pathway. Required for optimal conjugationbetween T-cells and antigen-presenting cells by promoting theclustering of integrin ITGAL on the surface of T-cells. May beinvolved in high affinity immunoglobulin epsilon receptorsignaling in mast cells. {ECO:0000269|PubMed:10856234,ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296,ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}. | Sequence-specific transcription factor which is part ofa developmental regulatory system that provides cells withspecific positional identities on the anterior-posterior axis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >HOXB9 | chr17:46423267 | chr17:46700497 | ENST00000311177 | - | 0 | 2 | 185_244 | 172 | 251 | DNA binding | Homeobox |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000336915 | - | 4 | 13 | 220_230 | 93 | 448 | Compositional bias | Note=Poly-Glu |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000584924 | - | 4 | 12 | 220_230 | 93 | 360 | Compositional bias | Note=Poly-Glu |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000336915 | - | 4 | 13 | 107_210 | 93 | 448 | Domain | PH |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000336915 | - | 4 | 13 | 294_355 | 93 | 448 | Domain | SH3 |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000584924 | - | 4 | 12 | 107_210 | 93 | 360 | Domain | PH |
Hgene | >SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000584924 | - | 4 | 12 | 294_355 | 93 | 360 | Domain | SH3 |
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FusionGeneSequence for SKAP1_HOXB9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_172aa MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_172aa MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_516nt ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT CAGGATGAGGCCAACCCCTCCGCCAACTGGCTGCACGCTCGCTCTTCCCGGAAAAAGCGCTGTCCCTACACCAAATACCAGACGCTGGAG CTAGAGAAGGAGTTTCTGTTCAATATGTACCTCACCAGGGACCGTAGGCACGAAGTGGCCAGACTCCTCAATCTGAGTGAGAGACAAGTC >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_516nt ATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTC AGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGG GGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTAT CAGGATGAGGCCAACCCCTCCGCCAACTGGCTGCACGCTCGCTCTTCCCGGAAAAAGCGCTGTCCCTACACCAAATACCAGACGCTGGAG CTAGAGAAGGAGTTTCTGTTCAATATGTACCTCACCAGGGACCGTAGGCACGAAGTGGCCAGACTCCTCAATCTGAGTGAGAGACAAGTC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SKAP1_ENST00000336915_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_2330nt GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGCCAACCCCTC CGCCAACTGGCTGCACGCTCGCTCTTCCCGGAAAAAGCGCTGTCCCTACACCAAATACCAGACGCTGGAGCTAGAGAAGGAGTTTCTGTT CAATATGTACCTCACCAGGGACCGTAGGCACGAAGTGGCCAGACTCCTCAATCTGAGTGAGAGACAAGTCAAAATCTGGTTTCAGAACCG GCGGATGAAAATGAAGAAAATGAATAAGGAGCAGGGCAAAGAGTAAAGATTAAAGATTACCCCCAGTCCTCCCTAGCTCTTCCCCATCTC ACTCTTAGTTATGTGACGACTGCAAAGCCAGTGCTGTCTGGGATGTATTCAAGTGAATGGGGAAGGGAGTCTCTCTTCCAAGTCCTTTAT CTGCACCTAGAACCTCCCTCCTTTCCTTTGCCCTTACCTGTCTCTCTCTTCTCTCTAGGTGTCAGGAGAAAGTTTTGTTGATTTAGAAGA TAGAAATAGTTGGTTCCTAAGAATGTGATGGGCCACAAGGAAAGAGAGACCCCAGTCAAGCTCCTAGTATGCCCTGTAATTTTTCTGGGA AGTCCTAGCCCCTCACTTCCAGCTTGCCTGTTTCTTCTCTACACCCACCCAAAAGTCACCCAGGGACACTCCAACTCTACACAGCTCAGC AGACATCCACACACAGTAATGGGGTGAGCTCACAACCACCATTCAGTCAAGTGAGGTGACACTCCAGTTGCAGACCATCGCACACCAAAT TTGGCAAAACAGCCCTCAGACTGTCAGGCAAGCCCGGGTTCTACCCCTAATGCAAATACCCACCAGGGAGATGTCTAGAGGCAGACTCCT GAGTGAGGTGTTGCAGCCCAAAGGCTGCAGCATTGCCATACCATTCCCATGGAGTTGCCAACTATTCTCAGGCCAAGGGCCATGGGGAAG ATGGAGCAAACCTAGCCCCCAAGCCGGTGGGCTAGAAAGTACAAGAAAAGGCAGCACGTGGTTTTATGAAGCTATCTTAGGTGGAGCTAC TCCCCACCTCCCACCAACATATACATTTTGTTGCAGGAAATGTTTAATTCCGCATGATGTTTCCCTCTCCTTCCAACAAAAGAAGGTCAA ACTGTGGGTCGTAGAGCCTTGACAATGTTGTCCTCCTGTTCATCTGTGCACCACTTGACAGACTGTAGCTTCTCTTGCTCTCGACCGGCC CTGCATTCTTCCGCACCCTCCCTAGCTCTGAAATCAACTCTCTTCGGTCGTATCCACCTTGCACCCGCAAGTCAAGCCGCCCCTTGTAGA AAAATCCCTCCACCTTCCGTTCCCCGCTAGGTCAACCCCACTGTAGACAGGAAAGCCAGGCCAGGAGAGTCCGAATGAGAATTTATTGTG AATCGATTCCCAAGCTCCCTTCCGGGACAAGTGGTCTGGGACAGGGAGGAGCAACGGCCCCAGCGCGCAACGCTCTGCGCGTTCCTCCGA ATCCCGTCGGCTTCTCGACCCACGCAGAGAAGCCCCGGGCTTGGCGGCTCTAGCCCCAGCGCCAAAGGAGACCCGCCCCAGGGCCGGGCT TGGCCTCCTGCTTCATGGGCCTGGATGCAGATCTGCGTGGCTGGTGCGTGCGCGCGCTTCTGGGAAACAGTCCCGCGTGCAAAGGAAAGG GGCAAAATGGCACCTAAGCATCAGATGGAAGCTTACTCTCTGCTTCCGTTCCTCCCCCTGCTCCCCTACTTCTCAGTCCCCTTCAATTTG TAGACTCTTGCTCCTGCTTCTCCTGATCCTGCAAGGGGACATTCCAGTAGAAGTTTTTTGCTTTGTCGGTGGCTGTCGTGAAATTGTGCT TGTGTTTCGTGATTTCTTTGGGGGTGATTGTCTCGCTTGTTTTCAGTTGTCGATTATATGGGAGGGTTCTGGGTGGGAGTGGGGAGGGCG >In-frame_SKAP1_ENST00000584924_chr17_46423267_-_HOXB9_ENST00000311177_chr17_46700497_-_2359nt GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG TCAGATTATCAGGATGAGGCCAACCCCTCCGCCAACTGGCTGCACGCTCGCTCTTCCCGGAAAAAGCGCTGTCCCTACACCAAATACCAG ACGCTGGAGCTAGAGAAGGAGTTTCTGTTCAATATGTACCTCACCAGGGACCGTAGGCACGAAGTGGCCAGACTCCTCAATCTGAGTGAG AGACAAGTCAAAATCTGGTTTCAGAACCGGCGGATGAAAATGAAGAAAATGAATAAGGAGCAGGGCAAAGAGTAAAGATTAAAGATTACC CCCAGTCCTCCCTAGCTCTTCCCCATCTCACTCTTAGTTATGTGACGACTGCAAAGCCAGTGCTGTCTGGGATGTATTCAAGTGAATGGG GAAGGGAGTCTCTCTTCCAAGTCCTTTATCTGCACCTAGAACCTCCCTCCTTTCCTTTGCCCTTACCTGTCTCTCTCTTCTCTCTAGGTG TCAGGAGAAAGTTTTGTTGATTTAGAAGATAGAAATAGTTGGTTCCTAAGAATGTGATGGGCCACAAGGAAAGAGAGACCCCAGTCAAGC TCCTAGTATGCCCTGTAATTTTTCTGGGAAGTCCTAGCCCCTCACTTCCAGCTTGCCTGTTTCTTCTCTACACCCACCCAAAAGTCACCC AGGGACACTCCAACTCTACACAGCTCAGCAGACATCCACACACAGTAATGGGGTGAGCTCACAACCACCATTCAGTCAAGTGAGGTGACA CTCCAGTTGCAGACCATCGCACACCAAATTTGGCAAAACAGCCCTCAGACTGTCAGGCAAGCCCGGGTTCTACCCCTAATGCAAATACCC ACCAGGGAGATGTCTAGAGGCAGACTCCTGAGTGAGGTGTTGCAGCCCAAAGGCTGCAGCATTGCCATACCATTCCCATGGAGTTGCCAA CTATTCTCAGGCCAAGGGCCATGGGGAAGATGGAGCAAACCTAGCCCCCAAGCCGGTGGGCTAGAAAGTACAAGAAAAGGCAGCACGTGG TTTTATGAAGCTATCTTAGGTGGAGCTACTCCCCACCTCCCACCAACATATACATTTTGTTGCAGGAAATGTTTAATTCCGCATGATGTT TCCCTCTCCTTCCAACAAAAGAAGGTCAAACTGTGGGTCGTAGAGCCTTGACAATGTTGTCCTCCTGTTCATCTGTGCACCACTTGACAG ACTGTAGCTTCTCTTGCTCTCGACCGGCCCTGCATTCTTCCGCACCCTCCCTAGCTCTGAAATCAACTCTCTTCGGTCGTATCCACCTTG CACCCGCAAGTCAAGCCGCCCCTTGTAGAAAAATCCCTCCACCTTCCGTTCCCCGCTAGGTCAACCCCACTGTAGACAGGAAAGCCAGGC CAGGAGAGTCCGAATGAGAATTTATTGTGAATCGATTCCCAAGCTCCCTTCCGGGACAAGTGGTCTGGGACAGGGAGGAGCAACGGCCCC AGCGCGCAACGCTCTGCGCGTTCCTCCGAATCCCGTCGGCTTCTCGACCCACGCAGAGAAGCCCCGGGCTTGGCGGCTCTAGCCCCAGCG CCAAAGGAGACCCGCCCCAGGGCCGGGCTTGGCCTCCTGCTTCATGGGCCTGGATGCAGATCTGCGTGGCTGGTGCGTGCGCGCGCTTCT GGGAAACAGTCCCGCGTGCAAAGGAAAGGGGCAAAATGGCACCTAAGCATCAGATGGAAGCTTACTCTCTGCTTCCGTTCCTCCCCCTGC TCCCCTACTTCTCAGTCCCCTTCAATTTGTAGACTCTTGCTCCTGCTTCTCCTGATCCTGCAAGGGGACATTCCAGTAGAAGTTTTTTGC TTTGTCGGTGGCTGTCGTGAAATTGTGCTTGTGTTTCGTGATTTCTTTGGGGGTGATTGTCTCGCTTGTTTTCAGTTGTCGATTATATGG GAGGGTTCTGGGTGGGAGTGGGGAGGGCGAGGGGCCTAGAGCTCTAATTGTTTGTTTTGGAAGAAAAAAAGAAAAAGAACAAAAAATATA |
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FusionGenePPI for SKAP1_HOXB9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SKAP1 | PTPRC, FYB, SRC, LYN, FYN, LCK, SKAP1, GRB2, APP, BLCAP, SH2D4A, PRAM1, FAM102A, AP3M1, MYO9B, MYO9A, POLR1B, LOC81691, EML3, WRN, ASPM, JPH1, POLR1A, POLR3A, RECQL4, HPS3, ZNF324, FAM208A, UXT, NCAPD3, MYCBP2, CUL2, PIP5K1A, NEK1, PLEKHH3, PHLDB3, PIK3C3, SEC63, SKAP2, GTF3C1, URI1, PIK3R2, PIK3R3, POLRMT, PLD2, UCKL1, PRR14L, KSR1, ZNHIT6, PDRG1, SETX, NEFL, ALMS1, APPBP2, DDX11L8, UTP15, SENP5, NCAPH2, PAX3, TBL2, ZNHIT2, ZNF644, SUGCT, PKN3, TTF2, PPHLN1, NPHP4, MTMR1, PKN2, C21orf2, POLA1, POLR3B, POLR2L, CCP110, SETD5, ELP3, DOCK7, USP54, POLR1E, TRMT44, POLR1D, EXPH5, NEK4, ATXN2, SBF1, GTPBP6, TRMT1, CD3EAP, PER1, SUPT6H, MCM8, RTEL1, TIGD5, PUSL1, KLHDC3, DYNLL2, MAP7D1 | HOXB9 | KRTAP4-12, MDFI, RBPMS, SAT1, BTG1, BTG2, SOX15, MYBBP1A, PHTF1, ING4, ZNF408, HOPX, SPZ1, CREBBP, ECT2, TAL1, GOLGA2, KRTAP5-9, TRIP6, PNMA1, CALCOCO2, MID2, KRTAP10-9, MAPK14, TCEAL1, HIST1H2BG, LZTS2, JUN, RBPJ, TEAD2, FOXA1, FOXC1, FOXC2, FOXD3, FOXE1, FOXF1, FOXK2, FOXS1, CYP2S1, ARIH1, AHCYL2, CKLF, VTN, WASF3, NAGK, NOLC1, KAT2B, SIRT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000336915 | - | 4 | 13 | 290_295 | 93 | 448 | FYB1 |
Hgene | SKAP1 | chr17:46423267 | chr17:46700497 | ENST00000584924 | - | 4 | 12 | 290_295 | 93 | 360 | FYB1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SKAP1_HOXB9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SKAP1_HOXB9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SKAP1 | C0919267 | ovarian neoplasm | 1 | CTD_human |