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Fusion gene ID: 33927 |
FusionGeneSummary for SIRT3_MED25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIRT3_MED25 | Fusion gene ID: 33927 | Hgene | Tgene | Gene symbol | SIRT3 | MED25 | Gene ID | 23410 | 81857 |
| Gene name | sirtuin 3 | mediator complex subunit 25 | |
| Synonyms | SIR2L3 | ACID1|ARC92|BVSYS|CMT2B2|P78|PTOV2|TCBAP0758 | |
| Cytomap | 11p15.5 | 19q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NAD-dependent protein deacetylase sirtuin-3, mitochondrialNAD-dependent deacetylase sirtuin-3, mitochondrialSIR2-like protein 3mitochondrial nicotinamide adenine dinucleotide-dependent deacetylaseregulatory protein SIR2 homolog 3silent mating type in | mediator of RNA polymerase II transcription subunit 25ARC/mediator transcriptional coactivator subunitactivator interaction domain-containing protein 1activator-recruited cofactor 92 kDa componentmediator of RNA polymerase II transcription, subunit 25 | |
| Modification date | 20180526 | 20180519 | |
| UniProtAcc | Q9NTG7 | Q71SY5 | |
| Ensembl transtripts involved in fusion gene | ENST00000382743, ENST00000525319, ENST00000524564, ENST00000532956, ENST00000529382, ENST00000528702, | ENST00000312865, ENST00000538643, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/1*10)=4.32192809488736 | log2(2/1*10)=4.32192809488736 | |
| Context | PubMed: SIRT3 [Title/Abstract] AND MED25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SIRT3 | GO:0006476 | protein deacetylation | 16788062 |
| Tgene | MED25 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17641689 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF934224 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + | ||
| ChiTaRS3.1 | BI036185 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000382743 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000382743 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000525319 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000525319 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000524564 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000524564 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000532956 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000532956 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000529382 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000529382 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000528702 | ENST00000312865 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
| intron-3CDS | ENST00000528702 | ENST00000538643 | SIRT3 | chr11 | 234864 | - | MED25 | chr19 | 50334666 | + |
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FusionProtFeatures for SIRT3_MED25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIRT3 | MED25 |
| NAD-dependent protein deacetylase (PubMed:12186850,PubMed:12374852, PubMed:16788062, PubMed:18680753,PubMed:18794531, PubMed:23283301, PubMed:24121500,PubMed:24252090, PubMed:19535340). Activates or deactivatesmitochondrial target proteins by deacetylating key lysine residues(PubMed:12186850, PubMed:12374852, PubMed:16788062,PubMed:18680753, PubMed:18794531, PubMed:23283301,PubMed:24121500, PubMed:24252090). Known targets include ACSS1,IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunitATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500,PubMed:24252090, PubMed:19535340). Contributes to the regulationof the cellular energy metabolism (PubMed:24252090). Important forregulating tissue-specific ATP levels (PubMed:18794531). Inresponse to metabolic stress, deacetylates transcription factorFOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMTto mtDNA to promote mtDNA transcription (PubMed:23283301).{ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852,ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753,ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340,ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:24121500,ECO:0000269|PubMed:24252090}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SIRT3_MED25 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SIRT3_MED25 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIRT3_MED25 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SIRT3_MED25 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SIRT3 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | SIRT3 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | SIRT3 | C0028754 | Obesity | 1 | CTD_human |
| Hgene | SIRT3 | C0085207 | Gestational Diabetes | 1 | CTD_human |
| Tgene | MED25 | C1854150 | Charcot-Marie-Tooth disease, Type 2B2 | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | MED25 | C4225323 | BASEL-VANAGAITE-SMIRIN-YOSEF SYNDROME | 1 | ORPHANET;UNIPROT |
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