	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 33924

FusionGeneSummary for SIRT1_CELF2

Fusion gene summary

Fusion gene information	Fusion gene name: SIRT1_CELF2
	Fusion gene ID: 33924
		Hgene	Tgene
	Gene symbol	SIRT1	CELF2
	Gene ID	23411	10659
	Gene name	sirtuin 1	CUGBP Elav-like family member 2
	Synonyms	SIR2\|SIR2L1\|SIR2alpha	BRUNOL3\|CELF-2\|CUG-BP2\|CUGBP2\|ETR-3\|ETR3\|NAPOR
	Cytomap	10q21.3	10p14
	Type of gene	protein-coding	protein-coding
	Description	NAD-dependent protein deacetylase sirtuin-1SIR2-like protein 1regulatory protein SIR2 homolog 1sirtuin type 1	CUGBP Elav-like family member 2CUG triplet repeat RNA-binding protein 2CUG-BP- and ETR-3-like factor 2ELAV-type RNA-binding protein 3KDM2B/CELF2 fusionRNA-binding protein BRUNOL-3bruno-like protein 3neuroblastoma apoptosis-related RNA-binding prote
	Modification date	20180527	20180523
	UniProtAcc	Q96EB6	O95319
	Ensembl transtripts involved in fusion gene	ENST00000212015, ENST00000497639, ENST00000432464, ENST00000406900, ENST00000403579,	ENST00000379261, ENST00000416382, ENST00000450189, ENST00000542579, ENST00000399850, ENST00000417956, ENST00000354440, ENST00000427450, ENST00000315874, ENST00000608830, ENST00000609692, ENST00000354897, ENST00000537122,
Fusion gene scores	* DoF score	2 X 1 X 2=4	6 X 7 X 2=84
	# samples	2	7
	** MAII score	log2(2/4*10)=2.32192809488736	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SIRT1 [Title/Abstract] AND CELF2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SIRT1	GO:0000122	negative regulation of transcription by RNA polymerase II	12535671\|15692560\|20955178
Hgene	SIRT1	GO:0000183	chromatin silencing at rDNA	18485871
Hgene	SIRT1	GO:0001525	angiogenesis	20620956
Hgene	SIRT1	GO:0002821	positive regulation of adaptive immune response	21890893
Hgene	SIRT1	GO:0006343	establishment of chromatin silencing	15469825
Hgene	SIRT1	GO:0006476	protein deacetylation	18203716\|18662546\|20027304\|20955178
Hgene	SIRT1	GO:0006974	cellular response to DNA damage stimulus	18203716
Hgene	SIRT1	GO:0006979	response to oxidative stress	14976264
Hgene	SIRT1	GO:0007179	transforming growth factor beta receptor signaling pathway	23960241
Hgene	SIRT1	GO:0007346	regulation of mitotic cell cycle	15692560
Hgene	SIRT1	GO:0016239	positive regulation of macroautophagy	18296641
Hgene	SIRT1	GO:0016567	protein ubiquitination	21841822
Hgene	SIRT1	GO:0016575	histone deacetylation	12006491\|15469825\|16079181\|17172643
Hgene	SIRT1	GO:0031648	protein destabilization	20955178
Hgene	SIRT1	GO:0032088	negative regulation of NF-kappaB transcription factor activity	15152190
Hgene	SIRT1	GO:0034983	peptidyl-lysine deacetylation	15469825
Hgene	SIRT1	GO:0042542	response to hydrogen peroxide	19934257
Hgene	SIRT1	GO:0043065	positive regulation of apoptotic process	15152190
Hgene	SIRT1	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	17680780
Hgene	SIRT1	GO:0043433	negative regulation of DNA binding transcription factor activity	11672523\|20955178
Hgene	SIRT1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	11672523
Hgene	SIRT1	GO:0043536	positive regulation of blood vessel endothelial cell migration	23960241
Hgene	SIRT1	GO:0045348	positive regulation of MHC class II biosynthetic process	21890893
Hgene	SIRT1	GO:0045766	positive regulation of angiogenesis	23960241\|25217442
Hgene	SIRT1	GO:0045892	negative regulation of transcription, DNA-templated	11672523\|20074560
Hgene	SIRT1	GO:0045944	positive regulation of transcription by RNA polymerase II	12837246\|21807113
Hgene	SIRT1	GO:0046628	positive regulation of insulin receptor signaling pathway	21241768
Hgene	SIRT1	GO:0051097	negative regulation of helicase activity	18203716
Hgene	SIRT1	GO:0070301	cellular response to hydrogen peroxide	20027304
Hgene	SIRT1	GO:0070932	histone H3 deacetylation	20027304
Hgene	SIRT1	GO:0071356	cellular response to tumor necrosis factor	15152190
Hgene	SIRT1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	20203304
Hgene	SIRT1	GO:2000757	negative regulation of peptidyl-lysine acetylation	20100829
Hgene	SIRT1	GO:2000773	negative regulation of cellular senescence	20203304
Hgene	SIRT1	GO:2000774	positive regulation of cellular senescence	18687677
Tgene	CELF2	GO:0006376	mRNA splice site selection	11158314

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUAD	TCGA-69-7978-01A	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000212015	ENST00000379261	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000416382	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000450189	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000542579	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000399850	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000417956	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000354440	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000427450	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000315874	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000608830	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000609692	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000354897	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000212015	ENST00000537122	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000379261	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000416382	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000450189	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000542579	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000399850	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000417956	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000354440	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000427450	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000315874	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000608830	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000609692	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000354897	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000497639	ENST00000537122	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000379261	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000416382	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000450189	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000542579	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000399850	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000417956	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000354440	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000427450	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000315874	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000608830	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000609692	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000354897	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
Frame-shift	ENST00000432464	ENST00000537122	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000379261	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000416382	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000450189	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000542579	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000399850	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000417956	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000354440	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000427450	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000315874	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000608830	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000609692	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000354897	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
5UTR-3CDS	ENST00000406900	ENST00000537122	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000379261	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000416382	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000450189	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000542579	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000399850	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000417956	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000354440	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000427450	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000315874	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000608830	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000609692	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000354897	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+
intron-3CDS	ENST00000403579	ENST00000537122	SIRT1	chr10	69651312	+	CELF2	chr10	11299701	+

Top

FusionProtFeatures for SIRT1_CELF2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SIRT1 Q96EB6	CELF2 O95319
NAD-dependent protein deacetylase that linkstranscriptional regulation directly to intracellular energeticsand participates in the coordination of several separated cellularfunctions such as cell cycle, response to DNA damage, metobolism,apoptosis and autophagy. Can modulate chromatin function throughdeacetylation of histones and can promote alterations in themethylation of histones and DNA, leading to transcriptionalrepression. Deacetylates a broad range of transcription factorsand coregulators, thereby regulating target gene expressionpositively and negatively. Serves as a sensor of the cytosolicratio of NAD(+)/NADH which is altered by glucose deprivation andmetabolic changes associated with caloric restriction. Isessential in skeletal muscle cell differentiation and in responseto low nutrients mediates the inhibitory effect on skeletalmyoblast differentiation which also involves 5'-AMP-activatedprotein kinase (AMPK) and nicotinamide phosphoribosyltransferase(NAMPT). Component of the eNoSC (energy-dependent nucleolarsilencing) complex, a complex that mediates silencing of rDNA inresponse to intracellular energy status and acts by recruitinghistone-modifying enzymes. The eNoSC complex is able to sense theenergy status of cell: upon glucose starvation, elevation ofNAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2)by SUV39H1 and the formation of silent chromatin in the rDNAlocus. Deacetylates 'Lys-266' of SUV39H1, leading to itsactivation. Inhibits skeletal muscle differentiation bydeacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' ofHIST1H1E. Deacetylates 'Lys-16' of histone H4 (in vitro). Involvedin NR0B2/SHP corepression function through chromatin remodeling:Recruited to LRH1 target gene promoters by NR0B2/SHP therebystimulating histone H3 and H4 deacetylation leading totranscriptional repression. Proposed to contribute to genomicintegrity via positive regulation of telomere length; however,reports on localization to pericentromeric heterochromatin areconflicting. Proposed to play a role in constitutiveheterochromatin (CH) formation and/or maintenance throughregulation of the available pool of nuclear SUV39H1. Uponoxidative/metabolic stress decreases SUV39H1 degradation byinhibiting SUV39H1 polyubiquitination by MDM2. This increase inSUV39H1 levels enhances SUV39H1 turnover in CH, which in turnseems to accelerate renewal of the heterochromatin whichcorrelates with greater genomic integrity during stress response.Deacetylates 'Lys-382' of p53/TP53 and impairs its ability toinduce transcription-dependent proapoptotic program and modulatecell senescence. Deacetylates TAF1B and thereby represses rDNAtranscription by the RNA polymerase I. Deacetylates MYC, promotesthe association of MYC with MAX and decreases MYC stabilityleading to compromised transformational capability. DeacetylatesFOXO3 in response to oxidative stress thereby increasing itsability to induce cell cycle arrest and resistance to oxidativestress but inhibiting FOXO3-mediated induction of apoptosistranscriptional activity; also leading to FOXO3 ubiquitination andprotesomal degradation. Appears to have a similar effect onMLLT7/FOXO4 in regulation of transcriptional activity andapoptosis. Deacetylates DNMT1; thereby impairs DNMT1methyltransferase-independent transcription repressor activity,modulates DNMT1 cell cycle regulatory function and DNMT1-mediatedgene silencing. Deacetylates RELA/NF-kappa-B p65 therebyinhibiting its transactivating potential and augments apoptosis inresponse to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1 andHIC1. Deacetylates FOXO1 resulting in its nuclear retention andenhancement of its transcriptional activity leading to increasedgluconeogenesis in liver. Inhibits E2F1 transcriptional activityand apoptotic function, possibly by deacetylation. Involved inHES1- and HEY2-mediated transcriptional repression. In cooperationwith MYCN seems to be involved in transcriptional repression ofDUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediatedtranscription suppression of AR-dependent genes which may belinked to local deacetylation of histone H3. Represses HNF1A-mediated transcription. Required for the repression of ESRRG byCREBZF. Modulates AP-1 transcription factor activity. DeacetylatesNR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positivelyregulates transcription of NR1H3:RXR target genes, promotes NR1H3proteosomal degradation and results in cholesterol efflux; apromoter clearing mechanism after reach round of transcription isproposed. Involved in lipid metabolism. Implicated in regulationof adipogenesis and fat mobilization in white adipocytes byrepression of PPARG which probably involves association with NCOR1and SMRT/NCOR2. Deacetylates ACSS2 leading to its activation, andHMGCS1. Involved in liver and muscle metabolism. Throughdeacteylation and activation of PPARGC1A is required to activatefatty acid oxidation in skeletel muscle under low-glucoseconditions and is involved in glucose homeostasis. Involved inregulation of PPARA and fatty acid beta-oxidation in liver.Involved in positive regulation of insulin secretion in pancreaticbeta cells in response to glucose; the function seems to implytranscriptional repression of UCP2. Proposed to deacetylate IRS2thereby facilitating its insulin-induced tyrosine phosphorylation.Deacetylates SREBF1 isoform SREBP-1C thereby decreasing itsstability and transactivation in lipogenic gene expression.Involved in DNA damage response by repressing genes which areinvolved in DNA repair, such as XPC and TP73, deacetylatingXRCC6/Ku70, and faciliting recruitment of additional factors tosites of damaged DNA, such as SIRT1-deacetylated NBN can recruitATM to initiate DNA repair and SIRT1-deacetylated XPA interactswith RPA2. Also involved in DNA repair of DNA double-strand breaksby homologous recombination and specifically single-strandannealing independently of XRCC6/Ku70 and NBN. Transcriptionalsuppression of XPC probably involves an E2F4:RBL2 suppressorcomplex and protein kinase B (AKT) signaling. Transcriptionalsuppression of TP73 probably involves E2F4 and PCAF. DeacetylatesWRN thereby regulating its helicase and exonuclease activities andregulates WRN nuclear translocation in response to DNA damage.Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellularAP endonuclease activity by promoting the association of APEX1 toXRCC1. Increases p53/TP53-mediated transcription-independentapoptosis by blocking nuclear translocation of cytoplasmicp53/TP53 and probably redirecting it to mitochondria. DeacetylatesXRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAXaway from mitochondria thereby inhibiting stress-inducedapoptosis. Is involved in autophagy, presumably by deacetylatingATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads toenhanced binding of AKT1 and PDK1 to PIP3 and promotes theiractivation. Proposed to play role in regulation of STK11/LBK1-dependent AMPK signaling pathways implicated in cellularsenescence which seems to involve the regulation of theacetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 andthereby increase its activity, cytoplasmic localization andassociation with STRAD; however, the relevance of such activity innormal cells is unclear. In endothelial cells is shown to inhibitSTK11/LBK1 activity and to promote its degradation. DeacetylatesSMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation.Deacetylates CIITA and augments its MHC class II transactivationand contributes to its stability. Deacteylates MECOM/EVI1.Deacetylates PML at 'Lys-487' and this deacetylation promotes PMLcontrol of PER2 nuclear localization. During the neurogenictransition, repress selective NOTCH1-target genes through histonedeacetylation in a BCL6-dependent manner and leading to neuronaldifferentiation. Regulates the circadian expression of severalcore clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 andplays a critical role in maintaining a controlled rhythmicity inhistone acetylation, thereby contributing to circadian chromatinremodeling. Deacetylates ARNTL/BMAL1 and histones at the circadiangene promoters in order to facilitate repression by inhibitorycomponents of the circadian oscillator. Deacetylates PER2,facilitating its ubiquitination and degradation by the proteosome.Protects cardiomyocytes against palmitate-induced apoptosis(PubMed:11672523, PubMed:12006491, PubMed:14976264,PubMed:14980222, PubMed:15126506, PubMed:15152190,PubMed:15205477, PubMed:15469825, PubMed:15692560,PubMed:16079181, PubMed:16166628, PubMed:16892051,PubMed:16998810, PubMed:17283066, PubMed:17334224,PubMed:17505061, PubMed:17612497, PubMed:17620057,PubMed:17936707, PubMed:18203716, PubMed:18296641,PubMed:18662546, PubMed:18687677, PubMed:19188449,PubMed:19220062, PubMed:19364925, PubMed:19690166,PubMed:19934257, PubMed:20097625, PubMed:20100829,PubMed:20203304, PubMed:20375098, PubMed:20620956,PubMed:20670893, PubMed:20817729, PubMed:21149730,PubMed:21245319, PubMed:21471201, PubMed:21504832,PubMed:21555002, PubMed:21698133, PubMed:21701047,PubMed:21775285, PubMed:21807113, PubMed:21841822,PubMed:21890893, PubMed:21909281, PubMed:21947282,PubMed:22274616). Deacetylates XBP1 isoform 2; deacetylationdecreases protein stability of XBP1 isoform 2 and inhibits itstranscriptional activity (PubMed:20955178). Involved in the CCAR2-mediated regulation of PCK1 and NR1D1 (PubMed:24415752).Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro-opiomelanocortin) neurons, required for leptin-induced activationof PI3K signaling (By similarity). {ECO:0000250\|UniProtKB:Q923E4,ECO:0000269\|PubMed:11672523, ECO:0000269\|PubMed:12006491,ECO:0000269\|PubMed:14976264, ECO:0000269\|PubMed:14980222,ECO:0000269\|PubMed:15126506, ECO:0000269\|PubMed:15152190,ECO:0000269\|PubMed:15205477, ECO:0000269\|PubMed:15469825,ECO:0000269\|PubMed:15692560, ECO:0000269\|PubMed:16079181,ECO:0000269\|PubMed:16166628, ECO:0000269\|PubMed:16892051,ECO:0000269\|PubMed:16998810, ECO:0000269\|PubMed:17283066,ECO:0000269\|PubMed:17290224, ECO:0000269\|PubMed:17334224,ECO:0000269\|PubMed:17505061, ECO:0000269\|PubMed:17612497,ECO:0000269\|PubMed:17620057, ECO:0000269\|PubMed:17936707,ECO:0000269\|PubMed:18203716, ECO:0000269\|PubMed:18296641,ECO:0000269\|PubMed:18662546, ECO:0000269\|PubMed:18687677,ECO:0000269\|PubMed:19188449, ECO:0000269\|PubMed:19220062,ECO:0000269\|PubMed:19364925, ECO:0000269\|PubMed:19690166,ECO:0000269\|PubMed:19934257, ECO:0000269\|PubMed:20097625,ECO:0000269\|PubMed:20100829, ECO:0000269\|PubMed:20203304,ECO:0000269\|PubMed:20375098, ECO:0000269\|PubMed:20620956,ECO:0000269\|PubMed:20670893, ECO:0000269\|PubMed:20817729,ECO:0000269\|PubMed:20955178, ECO:0000269\|PubMed:21149730,ECO:0000269\|PubMed:21245319, ECO:0000269\|PubMed:21471201,ECO:0000269\|PubMed:21504832, ECO:0000269\|PubMed:21555002,ECO:0000269\|PubMed:21698133, ECO:0000269\|PubMed:21701047,ECO:0000269\|PubMed:21775285, ECO:0000269\|PubMed:21807113,ECO:0000269\|PubMed:21841822, ECO:0000269\|PubMed:21890893,ECO:0000269\|PubMed:21909281, ECO:0000269\|PubMed:21947282,ECO:0000269\|PubMed:22274616, ECO:0000269\|PubMed:24415752,ECO:0000269\|PubMed:24824780}. Isoform 2: Deacetylates 'Lys-382' of p53/TP53, howeverwith lower activity than isoform 1. In combination, the twoisoforms exert an additive effect. Isoform 2 regulates p53/TP53expression and cellular stress response and is in turn repressedby p53/TP53 presenting a SIRT1 isoform-dependent auto-regulatoryloop. {ECO:0000269\|PubMed:20975832}. (Microbial infection) In case of HIV-1 infection,interacts with and deacetylates the viral Tat protein. The viralTat protein inhibits SIRT1 deacetylation activity toward RELA/NF-kappa-B p65, thereby potentiates its transcriptional activity andSIRT1 is proposed to contribute to T-cell hyperactivation duringinfection. {ECO:0000269\|PubMed:18329615}. SirtT1 75 kDa fragment: Catalytically inactive 75SirT1may be involved in regulation of apoptosis. May be involved inprotecting chondrocytes from apoptotic death by associating withcytochrome C and interfering with apoptosome assembly.{ECO:0000269\|PubMed:21987377}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

FusionGeneSequence for SIRT1_CELF2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SIRT1_CELF2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SIRT1	HES1, HEY2, NR1H3, NR1H2, USP22, KAT5, MAPK8, ZBTB7A, HSF1, SUV39H1, KAT2B, E2F1, NUDT21, PAPOLA, PPARGC1A, MEF2C, MYOD1, RELA, CTTN, AKIP1, AR, NCOR1, JUN, DOT1L, CLOCK, ARNTL, HDAC4, FOXO1, RRP8, EZH2, SUZ12, BCL11A, BRINP1, TP53, SIRT2, RBP1, ARID4B, ING2, ING1, FOXO4, FOXO3, BHLHE41, TLE1, ESRRA, NBN, HIC1, DVL1, DVL2, CSNK2A1, CTNNB1, MLLT3, MLLT1, NPM1, NR0B2, HNF4A, SETD7, STK4, SMAD7, MAPT, NR1H4, VDR, SREBF1, HNF1A, SKI, GAPDH, ACACA, HSPA4, WRN, HSPD1, CHCHD2, DIAPH3, YBX1, DYNC1H1, HSPA1L, HSPA5, HIST1H2BC, HIST2H2AB, HSPA9, HDAC2, CMYA5, KPNA2, KPNA3, LAMA3, EEF1G, ARHGAP29, MCF2L2, ELL3, USP9Y, NAT10, UGDH, CACNA1C, LANCL1, ATG7, ATG5, GABARAPL1, ZEB1, BRD4, MECOM, KAT8, CSNK2B, DNMT1, ESR1, STAT3, JAK1, HSP90AA1, TRIM28, KAT2A, HNRNPK, ELAVL1, SATB1, MYCN, PML, FOS, LTA4H, NUDCD2, GTF2A1, AHCY, RBM25, SMARCD2, KYNU, AKT1, ECT2, SUPT7L, ATXN7L3, CREB1, RPS19BP1, PUS7, SPDL1, TULP3, PIP5K1A, PHLDB3, AKIRIN2, IQCB1, JUND, ZNHIT6, KRT79, WDR70, NOP14, PICALM, SERPINB4, ARRB2, TSPYL1, RECQL4, SCNM1, ZNF346, NOC4L, SART1, TAF2, RAP1A, CHD3, RPTOR, MTOR, CDK6, EED, DNMT3B, UVSSA, CDKL1, CAP1, FASN, KIAA1598, TPM4, POP1, PPARA, KCNA5, KCNA4, KCNAB2, EP300, VHL, PSME3, STK11, CDK1, CCNB1, IRS2, IRS1, UBE2I, PARP1, FOXP3, HIST1H3A, RICTOR, EPAS1, CSNK2A2, NMNAT1, APEX1, SNW1, RARA, TSC2, NOS3, SIRT1, RB1, TP73, PIK3R1, MTA1, HOXB5, RPL6, RPS2, AKR1D1, FGF10, CWC15, ZBTB38, TADA2B, SFRP4, CCAR2, CHEK2, MCM10, EWSR1, CEP44, THOC5, LRPPRC, FBXO7, SMEK1, HNRNPA1L2, USP37, MPHOSPH8, MYC, ZMIZ1, ZYX, FOXL2, CHFR, HERC2, MDM2, NDN, CERKL, ZNF263, SOST, RBFA, ZNF785, CLK3, APEX2, ZNF550, VWA3B, ZNF354C, MTFR2, ZNF669, TBCCD1, ZNF707, TNNI2, PTPN4, HOXB9, SIRT7	CELF2	A1CF, PCBP1, APP, FN1, PTGS2, ELAVL1, PDK1, TRAF3

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

RelatedDrugs for SIRT1_CELF2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for SIRT1_CELF2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SIRT1	C0015695	Fatty Liver	5	CTD_human
Hgene	SIRT1	C0021655	Insulin Resistance	5	CTD_human
Hgene	SIRT1	C0009319	Colitis	3	CTD_human
Hgene	SIRT1	C0005586	Bipolar Disorder	2	PSYGENET
Hgene	SIRT1	C0011853	Diabetes Mellitus, Experimental	2	CTD_human
Hgene	SIRT1	C0036341	Schizophrenia	2	PSYGENET
Hgene	SIRT1	C0524851	Neurodegenerative Disorders	2	CTD_human
Hgene	SIRT1	C0525045	Mood Disorders	2	PSYGENET
Hgene	SIRT1	C0004153	Atherosclerosis	1	CTD_human
Hgene	SIRT1	C0004364	Autoimmune Diseases	1	CTD_human
Hgene	SIRT1	C0006118	Brain Neoplasms	1	CTD_human
Hgene	SIRT1	C0011303	Demyelinating Diseases	1	CTD_human
Hgene	SIRT1	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	SIRT1	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	SIRT1	C0011884	Diabetic Retinopathy	1	CTD_human
Hgene	SIRT1	C0014072	Experimental Autoimmune Encephalomyelitis	1	CTD_human
Hgene	SIRT1	C0016059	Fibrosis	1	CTD_human
Hgene	SIRT1	C0018799	Heart Diseases	1	CTD_human
Hgene	SIRT1	C0018801	Heart failure	1	CTD_human
Hgene	SIRT1	C0019693	HIV Infections	1	CTD_human
Hgene	SIRT1	C0020564	Hypertrophy	1	CTD_human
Hgene	SIRT1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	SIRT1	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Hgene	SIRT1	C0027746	Nerve Degeneration	1	CTD_human
Hgene	SIRT1	C0028754	Obesity	1	CTD_human
Hgene	SIRT1	C0032285	Pneumonia	1	CTD_human
Hgene	SIRT1	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	SIRT1	C0033937	Psychoses, Drug	1	PSYGENET
Hgene	SIRT1	C0035309	Retinal Diseases	1	CTD_human
Hgene	SIRT1	C0036421	Systemic Scleroderma	1	CTD_human
Hgene	SIRT1	C0036939	Shared Paranoid Disorder	1	PSYGENET
Hgene	SIRT1	C0040053	Thrombosis	1	CTD_human
Hgene	SIRT1	C0043020	Wallerian Degeneration	1	CTD_human
Hgene	SIRT1	C0085762	Alcohol abuse	1	PSYGENET
Hgene	SIRT1	C0155862	Streptococcal pneumonia	1	CTD_human
Hgene	SIRT1	C0271650	Impaired glucose tolerance	1	CTD_human
Hgene	SIRT1	C0273115	Lung Injury	1	CTD_human
Hgene	SIRT1	C0400966	Non-alcoholic Fatty Liver Disease	1	CTD_human
Hgene	SIRT1	C0522224	Paralysed	1	CTD_human
Hgene	SIRT1	C0524620	Metabolic Syndrome X	1	CTD_human
Hgene	SIRT1	C0751955	Brain Infarction	1	CTD_human
Hgene	SIRT1	C0919532	Genomic Instability	1	CTD_human
Hgene	SIRT1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	SIRT1	C2609414	Acute kidney injury	1	CTD_human
Hgene	SIRT1	C2931673	Ceroid lipofuscinosis, neuronal 1, infantile	1	CTD_human
Tgene	CELF2	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	CELF2	C0036341	Schizophrenia	1	CTD_human
Tgene	CELF2	C0038325	Stevens-Johnson Syndrome	1	CTD_human

Home

Download

Statistics

Examples

Help

Contact

Fusion gene ID: 33924

FusionGeneSummary for SIRT1_CELF2

FusionProtFeatures for SIRT1_CELF2

FusionGeneSequence for SIRT1_CELF2

FusionGenePPI for SIRT1_CELF2

RelatedDrugs for SIRT1_CELF2

RelatedDiseases for SIRT1_CELF2