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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33911

FusionGeneSummary for SIPA1L3_LPAR3

check button Fusion gene summary
Fusion gene informationFusion gene name: SIPA1L3_LPAR3
Fusion gene ID: 33911
HgeneTgene
Gene symbol

SIPA1L3

LPAR3

Gene ID

23094

23566

Gene namesignal induced proliferation associated 1 like 3lysophosphatidic acid receptor 3
SynonymsCTRCT45|SPAL3|SPAR3EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3
Cytomap

19q13.13-q13.2

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionsignal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3lysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysoph
Modification date2018051920180519
UniProtAcc

O60292

Q9UBY5

Ensembl transtripts involved in fusion geneENST00000222345, ENST00000476317, 
ENST00000440886, ENST00000370611, 
ENST00000491034, 
Fusion gene scores* DoF score17 X 10 X 9=15303 X 3 X 2=18
# samples 173
** MAII scorelog2(17/1530*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SIPA1L3 [Title/Abstract] AND LPAR3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSIPA1L3

GO:0003382

epithelial cell morphogenesis

26231217

HgeneSIPA1L3

GO:0090162

establishment of epithelial cell polarity

26231217


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW593591SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000222345ENST00000440886SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
intron-intronENST00000222345ENST00000370611SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
intron-intronENST00000222345ENST00000491034SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
intron-intronENST00000476317ENST00000440886SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
intron-intronENST00000476317ENST00000370611SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+
intron-intronENST00000476317ENST00000491034SIPA1L3chr19

38535190

-LPAR3chr1

85355514

+

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FusionProtFeatures for SIPA1L3_LPAR3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SIPA1L3

O60292

LPAR3

Q9UBY5

Plays a critical role in epithelial cell morphogenesis,polarity, adhesion and cytoskeletal organization in the lens(PubMed:26231217). {ECO:0000269|PubMed:26231217}. Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SIPA1L3_LPAR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SIPA1L3_LPAR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SIPA1L3_LPAR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SIPA1L3_LPAR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource