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Fusion gene ID: 33911 |
FusionGeneSummary for SIPA1L3_LPAR3 |
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Fusion gene information | Fusion gene name: SIPA1L3_LPAR3 | Fusion gene ID: 33911 | Hgene | Tgene | Gene symbol | SIPA1L3 | LPAR3 | Gene ID | 23094 | 23566 |
Gene name | signal induced proliferation associated 1 like 3 | lysophosphatidic acid receptor 3 | |
Synonyms | CTRCT45|SPAL3|SPAR3 | EDG7|Edg-7|GPCR|HOFNH30|LP-A3|LPA3|RP4-678I3 | |
Cytomap | 19q13.13-q13.2 | 1p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | signal-induced proliferation-associated 1-like protein 3SIPA1-like protein 3SPA-1-like protein 3 | lysophosphatidic acid receptor 3LPA receptor 3LPA receptor EDG7LPA-3calcium-mobilizing lysophosphatidic acid receptor LP-A3endothelial cell differentiation gene 7endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7lysoph | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O60292 | Q9UBY5 | |
Ensembl transtripts involved in fusion gene | ENST00000222345, ENST00000476317, | ENST00000440886, ENST00000370611, ENST00000491034, | |
Fusion gene scores | * DoF score | 17 X 10 X 9=1530 | 3 X 3 X 2=18 |
# samples | 17 | 3 | |
** MAII score | log2(17/1530*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SIPA1L3 [Title/Abstract] AND LPAR3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SIPA1L3 | GO:0003382 | epithelial cell morphogenesis | 26231217 |
Hgene | SIPA1L3 | GO:0090162 | establishment of epithelial cell polarity | 26231217 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW593591 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000222345 | ENST00000440886 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
intron-intron | ENST00000222345 | ENST00000370611 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
intron-intron | ENST00000222345 | ENST00000491034 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
intron-intron | ENST00000476317 | ENST00000440886 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
intron-intron | ENST00000476317 | ENST00000370611 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
intron-intron | ENST00000476317 | ENST00000491034 | SIPA1L3 | chr19 | 38535190 | - | LPAR3 | chr1 | 85355514 | + |
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FusionProtFeatures for SIPA1L3_LPAR3 |
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Hgene | Tgene |
SIPA1L3 | LPAR3 |
Plays a critical role in epithelial cell morphogenesis,polarity, adhesion and cytoskeletal organization in the lens(PubMed:26231217). {ECO:0000269|PubMed:26231217}. | Receptor for lysophosphatidic acid (LPA), a mediator ofdiverse cellular activities. May play a role in the development ofovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q)families of heteromeric G proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SIPA1L3_LPAR3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SIPA1L3_LPAR3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIPA1L3_LPAR3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SIPA1L3_LPAR3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |