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Fusion gene ID: 3389 |
FusionGeneSummary for ATP5B_PTGES3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP5B_PTGES3 | Fusion gene ID: 3389 | Hgene | Tgene | Gene symbol | ATP5B | PTGES3 | Gene ID | 10728 |
| Gene name | prostaglandin E synthase 3 | ||
| Synonyms | P23|TEBP|cPGES | ||
| Cytomap | 12q13.3|12 | ||
| Type of gene | protein-coding | ||
| Description | prostaglandin E synthase 3Hsp90 co-chaperonecytosolic prostaglandin E synthasecytosolic prostaglandin E2 synthaseprogesterone receptor complex p23prostaglandin E synthase 3 (cytosolic)telomerase-binding protein p23unactive progesterone receptor, 23 | ||
| Modification date | 20180523 | ||
| UniProtAcc | Q15185 | ||
| Ensembl transtripts involved in fusion gene | ENST00000262030, ENST00000552919, ENST00000550162, | ENST00000262033, ENST00000537473, ENST00000414274, ENST00000436399, ENST00000448157, ENST00000456859, | |
| Fusion gene scores | * DoF score | 8 X 9 X 4=288 | 4 X 4 X 2=32 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ATP5B [Title/Abstract] AND PTGES3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PTGES3 | GO:0001516 | prostaglandin biosynthetic process | 10922363 |
| Tgene | PTGES3 | GO:0007004 | telomere maintenance via telomerase | 10197982|19740745 |
| Tgene | PTGES3 | GO:0042327 | positive regulation of phosphorylation | 19740745 |
| Tgene | PTGES3 | GO:0051085 | chaperone cofactor-dependent protein refolding | 12853476 |
| Tgene | PTGES3 | GO:0051973 | positive regulation of telomerase activity | 10197982|19740745 |
| Tgene | PTGES3 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW852155 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000262030 | ENST00000262033 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000262030 | ENST00000537473 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000262030 | ENST00000414274 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000262030 | ENST00000436399 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000262030 | ENST00000448157 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000262030 | ENST00000456859 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000262033 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000537473 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000414274 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000436399 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000448157 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000552919 | ENST00000456859 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000262033 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000537473 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000414274 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000436399 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000448157 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
| intron-intron | ENST00000550162 | ENST00000456859 | ATP5B | chr12 | 57033603 | - | PTGES3 | chr12 | 57076115 | + |
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FusionProtFeatures for ATP5B_PTGES3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP5B | PTGES3 |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Cytosolic prostaglandin synthase that catalyzes theoxidoreduction of prostaglandin endoperoxide H2 (PGH2) toprostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperonethat localizes to genomic response elements in a hormone-dependentmanner and disrupts receptor-mediated transcriptional activation,by promoting disassembly of transcriptional regulatory complexes(PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteinshydroxylation via interaction with EGLN1/PHD2, leading to recruitEGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).{ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138,ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP5B_PTGES3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP5B_PTGES3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP5B_PTGES3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP5B_PTGES3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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