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Fusion gene ID: 33885 |
FusionGeneSummary for SIN3A_SGCZ |
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Fusion gene information | Fusion gene name: SIN3A_SGCZ | Fusion gene ID: 33885 | Hgene | Tgene | Gene symbol | SIN3A | SGCZ | Gene ID | 25942 | 137868 |
Gene name | SIN3 transcription regulator family member A | sarcoglycan zeta | |
Synonyms | WITKOS | ZSG1 | |
Cytomap | 15q24.2 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | paired amphipathic helix protein Sin3aSIN3 homolog A, transcription regulatorhistone deacetylase complex subunit Sin3atranscriptional co-repressor Sin3Atranscriptional corepressor Sin3atranscriptional regulator, SIN3A | zeta-sarcoglycanzeta-SG | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96ST3 | Q96LD1 | |
Ensembl transtripts involved in fusion gene | ENST00000394947, ENST00000360439, ENST00000394949, ENST00000567289, | ENST00000382080, ENST00000421524, | |
Fusion gene scores | * DoF score | 10 X 6 X 6=360 | 5 X 4 X 5=100 |
# samples | 11 | 5 | |
** MAII score | log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SIN3A [Title/Abstract] AND SGCZ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BI054950 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000394947 | ENST00000382080 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000394947 | ENST00000421524 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000360439 | ENST00000382080 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000360439 | ENST00000421524 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000394949 | ENST00000382080 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000394949 | ENST00000421524 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000567289 | ENST00000382080 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
intron-intron | ENST00000567289 | ENST00000421524 | SIN3A | chr15 | 75705295 | + | SGCZ | chr8 | 14912171 | + |
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FusionProtFeatures for SIN3A_SGCZ |
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Hgene | Tgene |
SIN3A | SGCZ |
Acts as a transcriptional repressor. Corepressor forREST. Interacts with MXI1 to repress MYC responsive genes andantagonize MYC oncogenic activities. Also interacts with MXD1-MAXheterodimers to repress transcription by tethering SIN3A to DNA.Acts cooperatively with OGT to repress transcription in parallelwith histone deacetylation. Involved in he control of thecircadian rhythms. Required for the transcriptional repression ofcircadian target genes, such as PER1, mediated by the large PERcomplex through histone deacetylation. Cooperates with FOXK1 toregulate cell cycle progression probably by repressing cell cycleinhibitor genes expression (By similarity).{ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. | Component of the sarcoglycan complex, a subcomplex ofthe dystrophin-glycoprotein complex which forms a link between theF-actin cytoskeleton and the extracellular matrix. May play a rolein the maintenance of striated muscle membrane stability (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SIN3A_SGCZ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SIN3A_SGCZ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIN3A_SGCZ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SIN3A_SGCZ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SIN3A | C0013336 | Dwarfism | 1 | CTD_human |
Hgene | SIN3A | C0020255 | Hydrocephalus | 1 | CTD_human |
Hgene | SIN3A | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | SIN3A | C0175754 | Agenesis of corpus callosum | 1 | CTD_human |
Hgene | SIN3A | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | SIN3A | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Hgene | SIN3A | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
Tgene | SGCZ | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |