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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33861

FusionGeneSummary for SIK3_SFMBT2

check button Fusion gene summary
Fusion gene informationFusion gene name: SIK3_SFMBT2
Fusion gene ID: 33861
HgeneTgene
Gene symbol

SIK3

SFMBT2

Gene ID

23387

57713

Gene nameSIK family kinase 3Scm like with four mbt domains 2
SynonymsL19|QSK|SIK-3-
Cytomap

11q23.3

10p14

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase SIK3salt-inducible kinase 3serine/threonine-protein kinase QSKscm-like with four MBT domains protein 2Scm-related gene containing four mbt domains 2scm-like with 4 MBT domains protein 2
Modification date2018052320180519
UniProtAcc

Q9Y2K2

Q5VUG0

Ensembl transtripts involved in fusion geneENST00000375300, ENST00000292055, 
ENST00000375288, ENST00000434315, 
ENST00000542607, ENST00000446921, 
ENST00000488337, 
ENST00000361972, 
ENST00000397167, ENST00000379713, 
ENST00000379711, ENST00000397160, 
Fusion gene scores* DoF score14 X 10 X 9=12601 X 1 X 1=1
# samples 151
** MAII scorelog2(15/1260*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SIK3 [Title/Abstract] AND SFMBT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSIK3

GO:0006468

protein phosphorylation

14976552

TgeneSFMBT2

GO:0010629

negative regulation of gene expression

23385818


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W28136SIK3chr11

116900687

-SFMBT2chr10

7391745

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000375300ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375300ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375300ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375300ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375300ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000292055ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000292055ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000292055ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000292055ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000292055ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375288ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375288ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375288ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375288ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000375288ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000434315ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000434315ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000434315ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000434315ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000434315ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000542607ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000542607ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000542607ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000542607ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000542607ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000446921ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000446921ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000446921ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000446921ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000446921ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000488337ENST00000361972SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000488337ENST00000397167SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000488337ENST00000379713SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000488337ENST00000379711SIK3chr11

116900687

-SFMBT2chr10

7391745

+
intron-intronENST00000488337ENST00000397160SIK3chr11

116900687

-SFMBT2chr10

7391745

+

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FusionProtFeatures for SIK3_SFMBT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SIK3

Q9Y2K2

SFMBT2

Q5VUG0

Transcriptional repressor of HOXB13 gene.{ECO:0000269|PubMed:23385818}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SIK3_SFMBT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SIK3_SFMBT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SIK3_SFMBT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SIK3_SFMBT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource