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Fusion gene ID: 33844 |
FusionGeneSummary for SIK1_HUNK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SIK1_HUNK | Fusion gene ID: 33844 | Hgene | Tgene | Gene symbol | SIK1 | HUNK | Gene ID | 150094 | 30811 |
| Gene name | salt inducible kinase 1 | hormonally up-regulated Neu-associated kinase | |
| Synonyms | MSK|SIK|SIK-1|SNF1LK | - | |
| Cytomap | 21q22.3 | 21q22.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase SIK1SNF1-like kinasemyocardial SNF1-like kinasesalt-inducible protein kinase 1serine/threonine-protein kinase SNF1-like kinase 1serine/threonine-protein kinase SNF1LK | hormonally up-regulated neu tumor-associated kinaseB19hormonally upregulated Neu-associated kinasehormonally upregulated neu tumor-associated kinaseserine/threonine protein kinase MAK-V | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P57059 | P57058 | |
| Ensembl transtripts involved in fusion gene | ENST00000270162, | ENST00000270112, ENST00000465574, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 4 X 4=64 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SIK1 [Title/Abstract] AND HUNK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SIK1 | GO:0006468 | protein phosphorylation | 14976552 |
| Hgene | SIK1 | GO:0035556 | intracellular signal transduction | 14976552 |
| Hgene | SIK1 | GO:0046777 | protein autophosphorylation | 18348280 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7372-01A | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000270162 | ENST00000270112 | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
| 5CDS-intron | ENST00000270162 | ENST00000465574 | SIK1 | chr21 | 44845287 | - | HUNK | chr21 | 33312477 | + |
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FusionProtFeatures for SIK1_HUNK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SIK1 | HUNK |
| Serine/threonine-protein kinase involved in variousprocesses such as cell cycle regulation, gluconeogenesis andlipogenesis regulation, muscle growth and differentiation andtumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1,CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and playsa key role in p53/TP53-dependent anoikis, a type of apoptosistriggered by cell detachment: required for phosphorylation ofp53/TP53 in response to loss of adhesion and is able to suppressmetastasis. Part of a sodium-sensing signaling network, probablyby mediating phosphorylation of PPME1: following increases inintracellular sodium, SIK1 is activated by CaMK1 andphosphorylates PPME1 subunit of protein phosphatase 2A (PP2A),leading to dephosphorylation of sodium/potassium-transportingATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts asa regulator of muscle cells by phosphorylating and inhibitingclass II histone deacetylases HDAC4 and HDAC5, leading to promoteexpression of MEF2 target genes in myocytes. Also required duringcardiomyogenesis by regulating the exit of cardiomyoblasts fromthe cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as aregulator of hepatic gluconeogenesis by phosphorylating andrepressing the CREB-specific coactivators CRTC1/TORC1 andCRTC2/TORC2, leading to inhibit CREB activity. Also regulateshepatic lipogenesis by phosphorylating and inhibiting SREBF1. Inconcert with CRTC1/TORC1, regulates the light-induced entrainmentof the circadian clock by attenuating PER1 induction; repressesCREB-mediated transcription of PER1 by phosphorylating anddeactivating CRTC1/TORC1 (By similarity).{ECO:0000250|UniProtKB:Q60670, ECO:0000269|PubMed:14976552,ECO:0000269|PubMed:16306228, ECO:0000269|PubMed:18348280,ECO:0000269|PubMed:19622832}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SIK1 | chr21:44845287 | chr21:33312477 | ENST00000270162 | - | 3 | 14 | 33_41 | 91 | 784 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SIK1 | chr21:44845287 | chr21:33312477 | ENST00000270162 | - | 3 | 14 | 27_278 | 91 | 784 | Domain | Protein kinase |
| Hgene | >SIK1 | chr21:44845287 | chr21:33312477 | ENST00000270162 | - | 3 | 14 | 303_343 | 91 | 784 | Domain | UBA |
| Hgene | >SIK1 | chr21:44845287 | chr21:33312477 | ENST00000270162 | - | 3 | 14 | 584_610 | 91 | 784 | Region | RK-rich region |
| Tgene | HUNK | chr21:44845287 | chr21:33312477 | ENST00000270112 | + | 1 | 11 | 62_320 | 184 | 715 | Domain | Protein kinase |
| Tgene | HUNK | chr21:44845287 | chr21:33312477 | ENST00000270112 | + | 1 | 11 | 68_76 | 184 | 715 | Nucleotide binding | ATP |
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FusionGeneSequence for SIK1_HUNK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SIK1_ENST00000270162_chr21_44845287_-_HUNK_ENST00000270112_chr21_33312477_+_621aa MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLY QRLEDREFATRXRQXYQADXLWFEQLRRDPGLLGSVQHTVWQPCLRCTXTARQEEIRPQNRCLVHRCEHVCHVDRDAAFHGGAFQPEGFV PEDGRQRNEPPPHSALHRCHQFPALSPGTGSCEEAKYSAGTGESLAXXELHGQSALXCHLSQQDFSGRSEPERRAAHDREAGLQEQRRDQ HCALQPRLPHPGHLLPLKQETGALFVREIXHPGQPLLQDPALPDRKVQGPQGVLXGLSGHLDTRSXIPCRAGXKAQRTRKKRGFSSSTIL QEVGQEPALAQTALRLAYDTDSEHQSPPEGPEGLQVQLPRQRFLWLPQYFPQNLRFQLCGFFFHGVHPRATAQDPEDCEETGAPSARARK HWHPPQGRPPDAGHGALLRVCGSRRPRRSAVSLSSLQDSELPGQLGSQKFQREDAVPGSAIRKHVASPYSFASNSGLFCSRRXEQPPKRG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SIK1_ENST00000270162_chr21_44845287_-_HUNK_ENST00000270112_chr21_33312477_+_1864nt ATGGTTATCATGTCGGAGTTCAGCGCGGACCCCGCGGGCCAGGGTCAGGGCCAGCAGAAGCCCCTCCGGGTGGGTTTTTACGACATCGAG CGGACCCTGGGCAAAGGCAACTTCGCGGTGGTGAAGCTGGCGCGGCATCGAGTCACCAAAACGCAGGTTGCAATAAAAATAATTGATAAA ACACGATTAGATTCAAGCAATTTGGAGAAAATCTATCGTGAGGTTCAGCTGATGAAGCTTCTGAACCATCCACACATCATAAAGCTTTAC CAGAGACTTGAAGATAGAGAATTTGCTACTAGATGAAGACAATAATATCAAGCTGATTGACTTTGGTTTGAGCAACTGCGCAGGGATCCT GGGTTACTCGGATCCGTTCAGCACACAGTGTGGCAGCCCTGCCTACGCTGCACCTGAACTGCTCGCCAGGAAGAAATACGGCCCCAAAAT CGATGTCTGGTCCATAGGTGTGAACATGTATGCCATGTTGACCGGGACGCTGCCTTTCACGGTGGAGCCTTTCAGCCTGAGGGCTTTGTA CCAGAAGATGGTAGACAAAGAAATGAACCCCCTCCCCACTCAGCTCTCCACAGGTGCCATCAGTTTCCTGCGCTCTCTCCTGGAACCGGA TCCTGTGAAGAGGCCAAATATTCAGCAGGCACTGGCGAATCGCTGGCTTAATGAGAATTACACGGGCAAAGTGCCCTGTAATGTCACCTA TCCCAACAGGATTTCTCTGGAAGATCTGAGCCCGAGCGTCGTGCTGCACATGACCGAGAAGCTGGGTTACAAGAACAGCGACGTGATCAA CACTGTGCTCTCCAACCGCGCCTGCCACATCCTGGCCATCTACTTCCTCTTAAACAAGAAACTGGAGCGCTATTTGTCAGGGAAATCTGA CATCCAGGACAGCCTCTGCTACAAGACCCGGCTCTACCAGATAGAAAAGTACAGGGCCCCCAAGGAGTCCTATGAGGCCTCTCTGGACAC CTGGACACGAGATCTTGAATTCCATGCCGTGCAGGATAAAAAGCCCAAAGAACAAGAAAAAAGAGGGGATTTTCTTCATCGACCATTCTC CAAGAAGTTGGACAAGAACCTGCCCTCGCACAAACAGCCCTCAGGCTCGCTTATGACACAGATTCAGAACACCAAAGCCCTCCTGAAGGA CCGGAAGGCCTCCAAGTCCAGCTTCCCCGACAAAGATTCCTTTGGCTGCCGCAATATTTTCCGCAAAACCTCAGATTCCAATTGTGTGGC TTCTTCTTCCATGGAGTTCATCCCCGTGCCACCGCCCAGGACCCCGAGGATTGTGAAGAAACCGGAGCCCCATCAGCCAGGGCCCGGAAG CACTGGCATCCCCCACAAGGAAGACCCCCTGATGCTGGACATGGTGCGCTCCTTCGAGTCTGTGGATCGCGACGACCACGTAGAAGTGCT GTCTCCCTCTCATCACTACAGGATTCTGAACTCCCCGGTCAGCTTGGCTCGCAGAAATTCCAGCGAGAGGACGCTGTCCCCGGGTCTGCC ATCCGGAAGCATGTCGCCTCTCCATACTCCTTTGCATCCAACTCTGGTCTCTTTTGCTCACGAAGATAAGAACAGCCCCCCAAAAGAGGA GGGCCTGTGTTGCCCACCTCCGGTTCCCAGCAATGGCCCCATGCAGCCTCTGGGGAGCCCCAATTGTGTGAAAAGCCGAGGCCGGTTCCC TATGATGGGCATCGGACAGATGTTAAGGAAGCGCCATCAGAGTCTGCAGCCATCTGCAGATAGGCCCCTGGAGGCCAGCCTGCCCCCACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SIK1_ENST00000270162_chr21_44845287_-_HUNK_ENST00000270112_chr21_33312477_+_6877nt ATGCGGCGCGGCCCCGGAGGCAGCAGCAGCGGCGGCGGCAGCCGGAGCAGTAGGCACCCGAGCAGCGCCAGCGGCCGAGCGGGCGGCTTC CTGGCCTGGGCGCTCCGGTGGCGGCGGAGGTGCGCGCGGAGCCATGGTTATCATGTCGGAGTTCAGCGCGGACCCCGCGGGCCAGGGTCA GGGCCAGCAGAAGCCCCTCCGGGTGGGTTTTTACGACATCGAGCGGACCCTGGGCAAAGGCAACTTCGCGGTGGTGAAGCTGGCGCGGCA TCGAGTCACCAAAACGCAGGTTGCAATAAAAATAATTGATAAAACACGATTAGATTCAAGCAATTTGGAGAAAATCTATCGTGAGGTTCA GCTGATGAAGCTTCTGAACCATCCACACATCATAAAGCTTTACCAGAGACTTGAAGATAGAGAATTTGCTACTAGATGAAGACAATAATA TCAAGCTGATTGACTTTGGTTTGAGCAACTGCGCAGGGATCCTGGGTTACTCGGATCCGTTCAGCACACAGTGTGGCAGCCCTGCCTACG CTGCACCTGAACTGCTCGCCAGGAAGAAATACGGCCCCAAAATCGATGTCTGGTCCATAGGTGTGAACATGTATGCCATGTTGACCGGGA CGCTGCCTTTCACGGTGGAGCCTTTCAGCCTGAGGGCTTTGTACCAGAAGATGGTAGACAAAGAAATGAACCCCCTCCCCACTCAGCTCT CCACAGGTGCCATCAGTTTCCTGCGCTCTCTCCTGGAACCGGATCCTGTGAAGAGGCCAAATATTCAGCAGGCACTGGCGAATCGCTGGC TTAATGAGAATTACACGGGCAAAGTGCCCTGTAATGTCACCTATCCCAACAGGATTTCTCTGGAAGATCTGAGCCCGAGCGTCGTGCTGC ACATGACCGAGAAGCTGGGTTACAAGAACAGCGACGTGATCAACACTGTGCTCTCCAACCGCGCCTGCCACATCCTGGCCATCTACTTCC TCTTAAACAAGAAACTGGAGCGCTATTTGTCAGGGAAATCTGACATCCAGGACAGCCTCTGCTACAAGACCCGGCTCTACCAGATAGAAA AGTACAGGGCCCCCAAGGAGTCCTATGAGGCCTCTCTGGACACCTGGACACGAGATCTTGAATTCCATGCCGTGCAGGATAAAAAGCCCA AAGAACAAGAAAAAAGAGGGGATTTTCTTCATCGACCATTCTCCAAGAAGTTGGACAAGAACCTGCCCTCGCACAAACAGCCCTCAGGCT CGCTTATGACACAGATTCAGAACACCAAAGCCCTCCTGAAGGACCGGAAGGCCTCCAAGTCCAGCTTCCCCGACAAAGATTCCTTTGGCT GCCGCAATATTTTCCGCAAAACCTCAGATTCCAATTGTGTGGCTTCTTCTTCCATGGAGTTCATCCCCGTGCCACCGCCCAGGACCCCGA GGATTGTGAAGAAACCGGAGCCCCATCAGCCAGGGCCCGGAAGCACTGGCATCCCCCACAAGGAAGACCCCCTGATGCTGGACATGGTGC GCTCCTTCGAGTCTGTGGATCGCGACGACCACGTAGAAGTGCTGTCTCCCTCTCATCACTACAGGATTCTGAACTCCCCGGTCAGCTTGG CTCGCAGAAATTCCAGCGAGAGGACGCTGTCCCCGGGTCTGCCATCCGGAAGCATGTCGCCTCTCCATACTCCTTTGCATCCAACTCTGG TCTCTTTTGCTCACGAAGATAAGAACAGCCCCCCAAAAGAGGAGGGCCTGTGTTGCCCACCTCCGGTTCCCAGCAATGGCCCCATGCAGC CTCTGGGGAGCCCCAATTGTGTGAAAAGCCGAGGCCGGTTCCCTATGATGGGCATCGGACAGATGTTAAGGAAGCGCCATCAGAGTCTGC AGCCATCTGCAGATAGGCCCCTGGAGGCCAGCCTGCCCCCACTGCAGCCCCTAGCCCCTGTGAACCTTGCCTTTGACATGGCCGATGGGG TCAAGACCCAGTGCTAACTTGGGCCAGCGGGGTTTGGGGTATCTCTAGAAAACAGCAACTGAACAGAGCTCCACACATCTGTCAGGGTGT GAGCACTCCAAGGCCTCGCGTGGAGCATCCTTAGTCCCACCTGTAGCTGAATCCACAGACCCAAAGCCTGCACAACCCAACCTCGCTTAG GGACCCCCAGAGATGCTGGAATCGCTAGGAGGGTTGGCTCCAGGGGCAGCCAATTCCTATCATTCAGATCTTCCTTCCTCCCAAGTACTC ACCAACCCCTTCCACTTCCCACTTCCCCCAGGCTTGGGGGGAAAACAGGGCATGAGCCTTCTGGGGCACTCAGATTATGGACTGTTACCA GATCTTTCTTCACGCTGTGCTACATGTGTGCCTCTCACAGCAGTTGGCCACAGTTACAGGGAGAGAACAATATCACAGTCATTCATCCAG GCCACGTTTCCTCTGCGGAGTGTAGCAGCCCTGCCTTTCATAGCAGGGATTACCTGAAGGCCAGCAGGAGCCGGGGGCAGGCCCAGGATC CTCAGAGGAAGATGGAGAGGAGCTTCGGACCAAGATCAAACCAAACAGTGGGGACCCCAACAGAAGAGAAAGACTGAAGGAGACACTCAT TTCCCAAGCAAGATTTTGATAGATTTTTGTTGTTGTTGTTGTTGAAACATGCTAATGATTGAATTATCTTTTCCAAAGATTTTTTTTAAA TGTGATGTCGGTAAATTGAAATAACATAATTTTTTAAAACTTGGATGGAGAGATGAGAAGCAATTCCACCAAACTCATGTTTTCACAGGA GGGTTCAGTGTGGAGAGCAAAAAAGCTGACTGTGGTGATTTGCTGAGTGCTGTGGCCCACAGGCAGGGCAAGTCTCGGTGGCCCTGTGTT CATCCTGTTGTTTAAGGCATAGCCCTGATCCTTCTGGAAGGCATAGAACACGGTTACAGCTGGTTCTGTAGAAAGAGGGAAAAGATGATT GTGACAATTCAGAGCATAACTCAGATGGCGAGAAGGCAGCATTATCTCTGTGCGATGCTGATTTCAAGCTGCCCACAGAACTGGTGCGGC TCAGAGCTCGGCGAGTTTGCTGGGAGCTGGGAGCAGGCTTGCCTGGCAGAGAACCTGTTCAGATACAGGCCAGTTTCTTCTTCGAGGAAA GCCAAGCTCCTCAAACAGGGTTCAGTCCACGTTGTGTTTTCACACCTTTCTCCAAGGATCGAACCAAAGATGTGTCTCCAGTATTGTGTC TGTGCCCCTGTGTGTGTTTTGTGGACAGCCGTGTTGTCTGACTGTATCCAGCTGGCACTTGACAGGGTGCAGTCATTGGTGAGAAGAATC AGAAAAAGAAGACCCATCAGCACAGGTTGGATAGGGGTTAGTGTAGGAGACCAGTTACAGAATGGCCTGGAGTCTTCAACTTTTGACCGG TGCAGGTGTGACCAGAGACCACCTCTGTGGCCACCTCAGATAGTCATCTCAGTCCAAGGATCCCAAAACACAAATCTAGAATTGCAAAGC CAGCCTTTATTTCCCTGGCAGGCAGCCTTGCCAGAAGGCAGAGAGGCAGTTCTGAATCATTCTCTCATTCACCAGTGGTGACATCCTTCA GTCCCTCACATCTCTGACAGAGCGGGACAGAATGGATATTTGGCTGACCTTGGTGAGACCTGGAGCTGCCTGTTTCTTCCCTAGGGGATC ACCACGGCTCTAGGGCATTCTAGGATGAGGTCAGACCCCTTGGCCATTGGTGTTATTTTTTGTATAGCTTCAGACTGGGTTCCAGAACTT ACCATTGAAAACAGAGCTTTTAGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGA GCTCAGGAGTTCGAGAGCAGCCTGGGCAACATGGTGAAAGCCCGTCTCTACCGAAAAATACAAAAAAAAATAGCTGGGTGTGGTGGTACG TGCCTGTAGTCCCAGCTACTTCGGGGACTGAGGTGGGAGGATCACTTGAACCTAGGAGGTCGAGGCTGCAGTGAGCCAAGATCATGCTAC TGCACTCCAGCTTAGGTGGCAAAGTGAGACCCTGTCTCCAAAAAAAGAAAATAGAGCTTTATAAGCAGAGAGAAGAAAATAATCATCTAA GACCATCTCTCCATTCGACATGAAGTGTACCTTTTCTAAAGACGGTTTCCAGCTGCAACGGCTCCACTTTGCAGGCTTGCAGGGTGTATA CCTGCGCATTGGGAACTTGCTGGAACCCCTGATGCATTTTCCTTGAGAGCAGGGGTACTTCCGCCTTGCCGTTAGCTTGTGGAGAACGTG CTTCTTATTCCTGGCAGGCTTCAAGAACAGCTGCACATGTGCCGCTAACTGACCGCGTTGCCATTGGCGACCTGGACTCTGAACTCAGGT TTATTCTAAACCCAGTGAGAGGTGAGGGGGAGTGATGAAAGGGGATCAGCTGTATTTGTGTGTGTGTGTGTGTGTGAGCACCTGACAAAT CTATGAAACCGAGTGAAAGGAGAAATGTTAGATTCTTTATTATTTTATTATATTTATATGGAAAGCTCGACTCTCCCTTTGGTAAGTCCG AAGCATGTTGTCTGTTCGACCGTGACTGTCTTCCTCAGTCTGTGCCTGTGATTCCAGTCACCCTGTAGTTACTGACAGAAATTGACTGGA CTGTCATTGTGTGAAGTCTAGGAGGAAATGTCCATTTTAATTGTATGATTTGGTCATAAGTAAGGACTATATTTATGTCACCATTATTAG ATATATGTACTTTTGTAATGACTGTGAAATACACTTTTCCCTCACTACGACTGCTTCTTTATTTGCTGATAAATCTTAAAACAACTAAGT ACGTTGCAAATAATAGTACAGGTACCATCTTTTATGTGAAGTTCTTTTTCTTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGA GTGCAGTGGCACAATCACAGTTCACTGCAGCCTCAACCTCTCCAGATTCAAGTGATCCTCCCATCTCAGCCTCCCAAGTAGCTGGGACTA CAGTTGTGCACCACAATGCCTAGCTAATTTTTTTTGTATTTTGTAGAAATGGGGTTTCGCCATGTTGCTCAGGCTGATCTCAAACTCCTG GGCTCCAACGATCTGCCCACCTTGGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACTGTGCCTGGCCTTATGTAAAGCTCTTGACC TAGCATCTGACTGGAAACAAGCGGGAATTGCATTGGGGGGCATTTTCTGGGCCAGTTTCCCTGCCTTATTTTACCTGCAATAGGTGTGCC TACAAAAGTCTTTCTGACATACACACTGCAGGTGGCAGTTCAAGAAGAATCAACCTTTTTCATTTGGGGATATTAGGATCTTCCTTGGAG ACTCTGAAAATGGCACACAAAGAATGGCAGTTATGAACGTGACTTCTAGATTTTGTCCTTGTAGGAGGCCTTGGTCATGGATAGGGGAAG AGGGATGATGGGATGGAATGGGAGGGTGGGATCTAGATGACCTCTTGAAATTGTCCCAGTTACTGCTTCCTTCATAACTGTTCACAAAAC GTTTTTCATATATACCACCTTGTTTCCCCTGGGAAGTGAGGGGACGAAGCCTTAGAGGGTGACATAGCTAGAAAGTGGAGAAGCTCACTG TTCACTGTGCAAAGCCCCAGTAGTCGGATTCCGGGGAAAAGAACAAGTATCTAGTTTTGATGACAATGTTTTCTTGTAAGAATCCCAACA CTTTAGAATAGAAAAGGACCTAAGATTCTCTGGCTCAGCCCCAGCCTTTCTGAAGAAGGGAAAACTAGGGACCCAGATGGTTTAAGGACA CCCCAGAGTCCCCAGATGAGCTGGCATTTGAGCTGGTCTGGAGCAGAGTTTCTCCCTCAAAGAACACAGAGAAATCAGAGAGTGGCTGCC ATGGTCAGAGGGGGATGTCAACAACAGATCAAGCCGTCATCACAACAGGTATTTCTGAAGTTCCTGCAGGGACTAGGTCTTGCATTTTTA AGTCCTTTTCAAAACTGTGCAGCTTCCTGAACCTTATGCTGTTTGTCCCATCCACTCTTGAAGCTGGGGAAAGACAGCTTTCTTTGGGAA CTCTGTCTTTCTCAGTTGACTTCCCAAGTAAGCAGCAAACCCCTGGATAGCCTTGTTATCTACTTTAGGTATTAAGAGGCTATTGGGTTT TACTAGATTAAATCAATAAAACATTTCCTATAGAGCCATATCATACACTGAAGCAAATTCAGAAAGAATGCAAAACTGCTATCTTTTGGG GGAGTCTGGAAGCCTGTTGGTTAGTGTATTTATTTTCTTTGTGGGGTCTTCTGTGAGCTACAGGCACAGTAAGAATAATTCAGAGCGGTA CTGGGAGTTGGTTCAATTTCATGTCATCACTTTTCAATGAAGGGAGTGCATTTCCTGAGTAGTAAATGAGTATATTATTTGTGGCAGCTT TTCTGTTAAGGGAGCTTTCCAGACATCTGGTTGCAAAGACAAATAGGATATATATTTGTACTTCTTCTCTGTGGACATGTTTTTGTGACA CACAGTTATCTCTAGGAGTTGACGTCTGTGGGCACTAAGGGACTGAGGTTGGGGGAGAAAGCTGAGGAGGCTTTGGAAGAGAAGGTGAGG AGCATTTCAGGATTTGCAGTCCCCCTCCACATGTATCCACATCTGAGCTGGTGGTGTTCCAATAATGAGGCATTTGGGGCAACCAATTTT GGAAGGATAGAATAGCTTTATGTGGAGCAAACTTGAGGATCAATTGGAGTTGAGTGGTTTAAAACTTAAAGATGGCACAGGAAGCTGTAT |
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FusionGenePPI for SIK1_HUNK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SIK1 | PRKAA1, YWHAZ, ELAVL1, STK11, PRKACA, HDAC5, RPL3, SUPT5H, NMNAT1, TAB2, MAP3K7, XPO1, RNF2, GINS2, SIK2, GINS4, UBE2E1, SIK3 | HUNK | RABEP1, LNX1, GRB2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SIK1_HUNK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | SIK1 | P57059 | DB08912 | Dabrafenib | Serine/threonine-protein kinase SIK1 | small molecule | approved|investigational |
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RelatedDiseases for SIK1_HUNK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SIK1 | C0007193 | Cardiomyopathy, Dilated | 1 | CTD_human |
| Hgene | SIK1 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | SIK1 | C4225360 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 30 | 1 | UNIPROT |
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