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Fusion gene ID: 33820 |
FusionGeneSummary for SHROOM3_LUC7L |
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Fusion gene information | Fusion gene name: SHROOM3_LUC7L | Fusion gene ID: 33820 | Hgene | Tgene | Gene symbol | SHROOM3 | LUC7L | Gene ID | 57619 | 55692 |
Gene name | shroom family member 3 | LUC7 like | |
Synonyms | APXL3|MSTP013|SHRM|ShrmL | LUC7B1|Luc7|SR+89|hLuc7B1 | |
Cytomap | 4q21.1 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Shroom3F-actin-binding proteinshroom-related protein | putative RNA-binding protein Luc7-like 1putative SR protein LUC7B1sarcoplasmic reticulum protein LUC7B1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TF72 | Q9NQ29 | |
Ensembl transtripts involved in fusion gene | ENST00000296043, ENST00000473602, | ENST00000293872, ENST00000337351, ENST00000397783, ENST00000397780, ENST00000494366, | |
Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 11 X 10 X 6=660 |
# samples | 17 | 12 | |
** MAII score | log2(17/1485*10)=-3.12685627955043 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/660*10)=-2.4594316186373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHROOM3 [Title/Abstract] AND LUC7L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | ESCA | TCGA-L5-A8NI-01A | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000296043 | ENST00000293872 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000296043 | ENST00000337351 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000296043 | ENST00000397783 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000296043 | ENST00000397780 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-intron | ENST00000296043 | ENST00000494366 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000473602 | ENST00000293872 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000473602 | ENST00000337351 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000473602 | ENST00000397783 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-3CDS | ENST00000473602 | ENST00000397780 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
intron-intron | ENST00000473602 | ENST00000494366 | SHROOM3 | chr4 | 77507622 | + | LUC7L | chr16 | 258187 | - |
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FusionProtFeatures for SHROOM3_LUC7L |
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Hgene | Tgene |
SHROOM3 | LUC7L |
Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. | May bind to RNA via its Arg/Ser-rich domain.{ECO:0000269|PubMed:11170747}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SHROOM3_LUC7L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SHROOM3_LUC7L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHROOM3 | SFN, SAAL1, YWHAB, UBTD1, CDK2, ILK, RPS6KA2, SIK2, RPS6KB2, MYH9, RAB32, SNW1, CDC5L, CDH1, TRIM25 | LUC7L | RNPS1, NFKBIL1, FAM173A, USP50, TADA2A, CALM1, JMJD6, TCERG1, GADD45G, BARD1, CHERP, CTNNBL1, LUC7L, FBXO25, PRDX1, SRPK2, SRPK1, CLK2, SRPK3, PRMT5, CCDC8, SUZ12, EAF1, TRA2A, ZRANB2, LUC7L2, RBM27, RBM26, ZFP91, MRPL46, EIF2B1, ZC3H18, NKAP, BCLAF1, THRAP3, RECQL4, PRPF4B, C1QBP, SRRM2, FXR1, PTCD3, ZNF638, RBM23, GPATCH8, MRPS27, U2AF2, NRD1, UBE2O, LSM14B, SRRM1, CMAS, PPIG, PNN, VANGL1, ZCCHC8, LBR, DDX50, MRPS5, RBBP6, CSNK2A2, RBM25, MRPS9, SRRT, LARP1, CLK3, PRPF40A, CSNK2A1, PSME3, LUC7L3, TNPO3, RNMTL1, RBM7, SRSF11, MRPS22, MEPCE, CASC3, ACIN1, SCAF4, PHF10, RNASEH1, NKTR, CLASRP, SETD2, FTL, PRPF38B, MRS2, CPSF7, KBTBD6, VANGL2, MKRN1, YY1AP1, CHCHD2P9, SRSF10, SRSF8, PRRC2A, IBA57, HNRNPR, SF3B3, SNRNP70, SNRPD1, SNRPD2, SNRPD3, SYNCRIP, NTRK1, XPO1, NLRP3, SNW1, CDC5L, NANOG, RC3H1, CHCHD10, MRPL52, SRSF1, NCBP1, MRPL35, ZC3H14, INO80B, DLST, PDHA1, FOXA1, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHROOM3_LUC7L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHROOM3_LUC7L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |