![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 33818 |
FusionGeneSummary for SHROOM3_FIP1L1 |
![]() |
Fusion gene information | Fusion gene name: SHROOM3_FIP1L1 | Fusion gene ID: 33818 | Hgene | Tgene | Gene symbol | SHROOM3 | FIP1L1 | Gene ID | 57619 | 81608 |
Gene name | shroom family member 3 | factor interacting with PAPOLA and CPSF1 | |
Synonyms | APXL3|MSTP013|SHRM|ShrmL | FIP1|Rhe|hFip1 | |
Cytomap | 4q21.1 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Shroom3F-actin-binding proteinshroom-related protein | pre-mRNA 3'-end-processing factor FIP1FIP1 like 1FIP1-like 1 proteinFIP1L1 cleavage and polyadenylation specific factor subunitfactor interacting with PAPrearranged in hypereosinophilia | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8TF72 | Q6UN15 | |
Ensembl transtripts involved in fusion gene | ENST00000296043, ENST00000473602, | ENST00000507166, ENST00000358575, ENST00000337488, ENST00000507922, ENST00000306932, ENST00000510668, | |
Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 9 X 10 X 5=450 |
# samples | 17 | 13 | |
** MAII score | log2(17/1485*10)=-3.12685627955043 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHROOM3 [Title/Abstract] AND FIP1L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-EW-A1PB-01A | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000296043 | ENST00000507166 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000296043 | ENST00000358575 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000296043 | ENST00000337488 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000296043 | ENST00000507922 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000296043 | ENST00000306932 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3UTR | ENST00000296043 | ENST00000510668 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000473602 | ENST00000507166 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000473602 | ENST00000358575 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000473602 | ENST00000337488 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000473602 | ENST00000507922 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3CDS | ENST00000473602 | ENST00000306932 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
intron-3UTR | ENST00000473602 | ENST00000510668 | SHROOM3 | chr4 | 77507622 | + | FIP1L1 | chr4 | 54249940 | + |
Top |
FusionProtFeatures for SHROOM3_FIP1L1 |
![]() |
Hgene | Tgene |
SHROOM3 | FIP1L1 |
Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SHROOM3_FIP1L1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SHROOM3_FIP1L1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHROOM3 | SFN, SAAL1, YWHAB, UBTD1, CDK2, ILK, RPS6KA2, SIK2, RPS6KB2, MYH9, RAB32, SNW1, CDC5L, CDH1, TRIM25 | FIP1L1 | CPSF4, SRRM2, HNRNPA1, COPS5, APP, CPSF1, CPSF2, CPSF3, WDR33, NUP153, LIG4, CSNK2A1, HDAC9, CLK2, PRMT2, PRMT6, WWOX, STAU1, GOLGA2, SGTA, NAA10, ZMYND19, CUL7, OBSL1, EZH2, SUZ12, RNF2, EAF1, CPSF4L, NTRK1, HIST1H1C, PCF11, CSTF2T, PAPOLA, CSTF3, MED4, SRPK2, XPO1, CSTF1, CSTF2, LSS, P4HA1, P4HB, PML, SYMPK, P4HA2, CRTAP, WWP2, KIF2A, LLGL2, SEC16A, POLK, KIF21A, CDCA5, CEP170P1, FOXL2, ESR1, SNW1, ZC3H18, PDHA1, FOXA1 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SHROOM3_FIP1L1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SHROOM3_FIP1L1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | FIP1L1 | C1540912 | Hypereosinophilic syndrome | 1 | CTD_human |