![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 33814 |
FusionGeneSummary for SHROOM3_COL8A1 |
![]() |
Fusion gene information | Fusion gene name: SHROOM3_COL8A1 | Fusion gene ID: 33814 | Hgene | Tgene | Gene symbol | SHROOM3 | COL8A1 | Gene ID | 57619 | 1295 |
Gene name | shroom family member 3 | collagen type VIII alpha 1 chain | |
Synonyms | APXL3|MSTP013|SHRM|ShrmL | C3orf7 | |
Cytomap | 4q21.1 | 3q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Shroom3F-actin-binding proteinshroom-related protein | collagen alpha-1(VIII) chaincell proliferation-inducing protein 41collagen VIII, alpha-1 polypeptidecollagen, type VIII, alpha 1endothelial collagensmag-64smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64 | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q8TF72 | P27658 | |
Ensembl transtripts involved in fusion gene | ENST00000296043, ENST00000473602, | ENST00000261037, ENST00000273342, ENST00000463753, | |
Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 4 X 2 X 4=32 |
# samples | 17 | 4 | |
** MAII score | log2(17/1485*10)=-3.12685627955043 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SHROOM3 [Title/Abstract] AND COL8A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-CV-7261-01A | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000296043 | ENST00000261037 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
intron-5UTR | ENST00000296043 | ENST00000273342 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
intron-intron | ENST00000296043 | ENST00000463753 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
intron-5UTR | ENST00000473602 | ENST00000261037 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
intron-5UTR | ENST00000473602 | ENST00000273342 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
intron-intron | ENST00000473602 | ENST00000463753 | SHROOM3 | chr4 | 77507622 | + | COL8A1 | chr3 | 99463741 | + |
Top |
FusionProtFeatures for SHROOM3_COL8A1 |
![]() |
Hgene | Tgene |
SHROOM3 | COL8A1 |
Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. | Macromolecular component of the subendothelium. Majorcomponent of the Descemet's membrane (basement membrane) ofcorneal endothelial cells. Also component of the endothelia ofblood vessels. Necessary for migration and proliferation ofvascular smooth muscle cells and thus, has a potential role in themaintenance of vessel wall integrity and structure, in particularin atherogenesis. {ECO:0000269|PubMed:11708810}. Vastatin, the C-terminal fragment comprising the NC1domain, inhibits aortic endothelial cell proliferation and causescell apoptosis. {ECO:0000269|PubMed:11708810}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SHROOM3_COL8A1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SHROOM3_COL8A1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHROOM3 | SFN, SAAL1, YWHAB, UBTD1, CDK2, ILK, RPS6KA2, SIK2, RPS6KB2, MYH9, RAB32, SNW1, CDC5L, CDH1, TRIM25 | COL8A1 | KLHL12, KRTAP4-12, EFEMP2, COL8A2, UBQLN4, ADAMTSL4, REL, SP4, CREB5, VAC14, KRTAP9-2, KRT40, KRTAP10-7, KRTAP10-8, KRTAP10-3, INCA1, NOTCH2NL, KRTAP26-1, MCM2 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SHROOM3_COL8A1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SHROOM3_COL8A1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | COL8A1 | C0000768 | Congenital Abnormality | 1 | CTD_human |