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Fusion gene ID: 33812 |
FusionGeneSummary for SHROOM3_ASAH1 |
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Fusion gene information | Fusion gene name: SHROOM3_ASAH1 | Fusion gene ID: 33812 | Hgene | Tgene | Gene symbol | SHROOM3 | ASAH1 | Gene ID | 57619 | 427 |
Gene name | shroom family member 3 | N-acylsphingosine amidohydrolase 1 | |
Synonyms | APXL3|MSTP013|SHRM|ShrmL | AC|ACDase|ASAH|PHP|PHP32|SMAPME | |
Cytomap | 4q21.1 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Shroom3F-actin-binding proteinshroom-related protein | acid ceramidaseN-acylsphingosine amidohydrolase (acid ceramidase) 1acid CDaseacylsphingosine deacylaseputative 32 kDa heart protein | |
Modification date | 20180523 | 20180529 | |
UniProtAcc | Q8TF72 | Q13510 | |
Ensembl transtripts involved in fusion gene | ENST00000296043, ENST00000473602, | ENST00000262097, ENST00000381733, ENST00000417108, ENST00000520781, ENST00000314146, ENST00000520051, | |
Fusion gene scores | * DoF score | 15 X 11 X 9=1485 | 6 X 6 X 5=180 |
# samples | 17 | 7 | |
** MAII score | log2(17/1485*10)=-3.12685627955043 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHROOM3 [Title/Abstract] AND ASAH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB172989 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000296043 | ENST00000262097 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000296043 | ENST00000381733 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000296043 | ENST00000417108 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-5UTR | ENST00000296043 | ENST00000520781 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000296043 | ENST00000314146 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-5UTR | ENST00000296043 | ENST00000520051 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-5UTR | ENST00000473602 | ENST00000262097 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000473602 | ENST00000381733 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000473602 | ENST00000417108 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-5UTR | ENST00000473602 | ENST00000520781 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-intron | ENST00000473602 | ENST00000314146 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
intron-5UTR | ENST00000473602 | ENST00000520051 | SHROOM3 | chr4 | 77547922 | + | ASAH1 | chr8 | 17941617 | - |
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FusionProtFeatures for SHROOM3_ASAH1 |
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Hgene | Tgene |
SHROOM3 | ASAH1 |
Controls cell shape changes in the neuroepitheliumduring neural tube closure. Induces apical constriction inepithelial cells by promoting the apical accumulation of F-actinand myosin II, and probably by bundling stress fibers. Inducesapicobasal cell elongation by redistributing gamma-tubulin anddirecting the assembly of robust apicobasal microtubule arrays (Bysimilarity). {ECO:0000250}. | Hydrolyzes the sphingolipid ceramide into sphingosineand free fatty acid. {ECO:0000269|PubMed:7744740}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SHROOM3_ASAH1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SHROOM3_ASAH1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHROOM3_ASAH1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHROOM3_ASAH1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ASAH1 | C0268255 | Farber Lipogranulomatosis | 8 | CTD_human;ORPHANET;UNIPROT |
Tgene | ASAH1 | C0023794 | Lipoidosis | 2 | CTD_human |
Tgene | ASAH1 | C1834569 | Jankovic Rivera syndrome | 2 | ORPHANET;UNIPROT |
Tgene | ASAH1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ASAH1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ASAH1 | C0221765 | Chronic schizophrenia | 1 | PSYGENET |