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Fusion gene ID: 33791 |
FusionGeneSummary for SHISA6_HDHD2 |
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Fusion gene information | Fusion gene name: SHISA6_HDHD2 | Fusion gene ID: 33791 | Hgene | Tgene | Gene symbol | SHISA6 | HDHD2 | Gene ID | 388336 | 84064 |
Gene name | shisa family member 6 | haloacid dehalogenase like hydrolase domain containing 2 | |
Synonyms | - | 3110052N05Rik|HEL-S-301 | |
Cytomap | 17p12 | 18q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein shisa-6protein shisa-6 homologshisa homolog 6 | haloacid dehalogenase-like hydrolase domain-containing protein 2epididymis secretory protein Li 301 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q6ZSJ9 | Q9H0R4 | |
Ensembl transtripts involved in fusion gene | ENST00000432116, ENST00000441885, ENST00000409168, | ENST00000300605, ENST00000587841, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 1=4 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: SHISA6 [Title/Abstract] AND HDHD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE771617 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000432116 | ENST00000300605 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
intron-intron | ENST00000432116 | ENST00000587841 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
intron-3CDS | ENST00000441885 | ENST00000300605 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
intron-intron | ENST00000441885 | ENST00000587841 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
intron-3CDS | ENST00000409168 | ENST00000300605 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
intron-intron | ENST00000409168 | ENST00000587841 | SHISA6 | chr17 | 11177527 | + | HDHD2 | chr18 | 44660908 | - |
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FusionProtFeatures for SHISA6_HDHD2 |
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Hgene | Tgene |
SHISA6 | HDHD2 |
Involved in maintenance of high-frequency synaptictransmission at hippocampal CA3-CA1 synapses. Regulates AMPA-typeglutamate receptor (AMPAR) immobilization at postsynaptic densitykeeping the channels in an activated state in the presence ofglutamate and preventing synaptic depression. May play a role inself-renewal and differentiation of spermatogonial stem cells byinhibiting canonical Wnt signaling pathway.{ECO:0000250|UniProtKB:Q3UH99}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SHISA6_HDHD2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SHISA6_HDHD2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHISA6_HDHD2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHISA6_HDHD2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | HDHD2 | C0043094 | Weight Gain | 1 | CTD_human |