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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33791

FusionGeneSummary for SHISA6_HDHD2

check button Fusion gene summary
Fusion gene informationFusion gene name: SHISA6_HDHD2
Fusion gene ID: 33791
HgeneTgene
Gene symbol

SHISA6

HDHD2

Gene ID

388336

84064

Gene nameshisa family member 6haloacid dehalogenase like hydrolase domain containing 2
Synonyms-3110052N05Rik|HEL-S-301
Cytomap

17p12

18q21.1

Type of geneprotein-codingprotein-coding
Descriptionprotein shisa-6protein shisa-6 homologshisa homolog 6haloacid dehalogenase-like hydrolase domain-containing protein 2epididymis secretory protein Li 301
Modification date2018052320180523
UniProtAcc

Q6ZSJ9

Q9H0R4

Ensembl transtripts involved in fusion geneENST00000432116, ENST00000441885, 
ENST00000409168, 
ENST00000300605, 
ENST00000587841, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 1=4
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: SHISA6 [Title/Abstract] AND HDHD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE771617SHISA6chr17

11177527

+HDHD2chr18

44660908

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000432116ENST00000300605SHISA6chr17

11177527

+HDHD2chr18

44660908

-
intron-intronENST00000432116ENST00000587841SHISA6chr17

11177527

+HDHD2chr18

44660908

-
intron-3CDSENST00000441885ENST00000300605SHISA6chr17

11177527

+HDHD2chr18

44660908

-
intron-intronENST00000441885ENST00000587841SHISA6chr17

11177527

+HDHD2chr18

44660908

-
intron-3CDSENST00000409168ENST00000300605SHISA6chr17

11177527

+HDHD2chr18

44660908

-
intron-intronENST00000409168ENST00000587841SHISA6chr17

11177527

+HDHD2chr18

44660908

-

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FusionProtFeatures for SHISA6_HDHD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHISA6

Q6ZSJ9

HDHD2

Q9H0R4

Involved in maintenance of high-frequency synaptictransmission at hippocampal CA3-CA1 synapses. Regulates AMPA-typeglutamate receptor (AMPAR) immobilization at postsynaptic densitykeeping the channels in an activated state in the presence ofglutamate and preventing synaptic depression. May play a role inself-renewal and differentiation of spermatogonial stem cells byinhibiting canonical Wnt signaling pathway.{ECO:0000250|UniProtKB:Q3UH99}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHISA6_HDHD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHISA6_HDHD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHISA6_HDHD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHISA6_HDHD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHDHD2C0043094Weight Gain1CTD_human