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Fusion gene ID: 33754 |
FusionGeneSummary for SHC1_ASH1L |
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Fusion gene information | Fusion gene name: SHC1_ASH1L | Fusion gene ID: 33754 | Hgene | Tgene | Gene symbol | SHC1 | ASH1L | Gene ID | 6464 | 55870 |
Gene name | SHC adaptor protein 1 | ASH1 like histone lysine methyltransferase | |
Synonyms | SHC|SHCA | ASH1|ASH1L1|KMT2H|MRD52 | |
Cytomap | 1q21.3 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A | histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P29353 | Q9NR48 | |
Ensembl transtripts involved in fusion gene | ENST00000368445, ENST00000368449, ENST00000448116, ENST00000368450, ENST00000368453, ENST00000606391, ENST00000490667, | ENST00000368346, ENST00000392403, ENST00000548830, | |
Fusion gene scores | * DoF score | 10 X 7 X 7=490 | 9 X 8 X 5=360 |
# samples | 10 | 9 | |
** MAII score | log2(10/490*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SHC1 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SHC1 | GO:0000165 | MAPK cascade | 14676841 |
Hgene | SHC1 | GO:0000187 | activation of MAPK activity | 14676841 |
Hgene | SHC1 | GO:0071363 | cellular response to growth factor stimulus | 20010870 |
Tgene | ASH1L | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-55-7903-01A | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000368445 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000368445 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-intron | ENST00000368445 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000368449 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000368449 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-intron | ENST00000368449 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000448116 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000448116 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-intron | ENST00000448116 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-3CDS | ENST00000368450 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-3CDS | ENST00000368450 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-intron | ENST00000368450 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-3CDS | ENST00000368453 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-3CDS | ENST00000368453 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
5UTR-intron | ENST00000368453 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000606391 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000606391 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-intron | ENST00000606391 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000490667 | ENST00000368346 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-3CDS | ENST00000490667 | ENST00000392403 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
intron-intron | ENST00000490667 | ENST00000548830 | SHC1 | chr1 | 154946724 | - | ASH1L | chr1 | 155309159 | - |
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FusionProtFeatures for SHC1_ASH1L |
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Hgene | Tgene |
SHC1 | ASH1L |
Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SHC1_ASH1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SHC1_ASH1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SHC1 | FLT1, DDR2, PTPN12, MAPKAPK2, CALCOCO2, EGFR, ERBB2, ERBB3, ERBB4, PIK3R1, DOK1, DOK2, INPP5D, PLSCR1, LRP1, GRB2, CDH5, KDR, IL2RB, ABL1, INPPL1, CD22, IL4R, PLCG2, ITGB4, PTK2, EPHA2, PLCG1, CBLB, CEACAM1, CSF3R, PRKCD, ALK, FLT4, SOS1, SOS2, RET, CSF2RB, IL2RG, IGF1R, GAB2, SHCBP1, DAG1, NTRK1, ZAP70, PAG1, EPOR, VAV3, CSK, AP2A2, NTRK2, NTRK3, ESR1, APP, NGFR, LYN, CBL, EPS8, PDGFRB, CRKL, RAPGEF1, MAPK1, STAT5A, STAT5B, GH1, JAK2, GHR, MET, PIK3C2B, CALD1, MST1R, DDR1, IL6ST, INSR, FCGR2B, HIF1A, HMOX2, OSGEP, CBLC, NUDT21, MRPL44, ILK, FAM118B, SUV39H2, DUSP23, MAPK6, PRKRA, GEMIN7, C11orf58, CSF1R, LCP2, SH2B2, LRRK1, GAB1, PIK3R2, SPTBN1, SPTAN1, USP9X, AP2A1, KRT1, HSPA8, MYH10, KRT10, KRT9, KRT2, TUBB, TUBB4B, TUBA1B, TUBA1C, TUBA1A, AP2B1, USP9Y, TUBB2B, ACACA, KRT5, ACTN4, HSPA1B, SPTA1, TUBB3, KRT6A, FASN, HSPA5, MYH9, ACTB, CAD, IQGAP1, TUBA8, PSTPIP2, KRT14, MYO1D, HSPA9, HSPA1L, KRT16, ACTA1, TUBB6, HSP90AB1, HSPA6, MYH11, ACLY, RUVBL2, EEF1A1P5, KRT3, UBASH3B, DNM2, HSP90AA1, CRK, RAB3GAP2, MYH14, PRKDC, KRT17, AP2M1, IKBKAP, TUBAL3, RUVBL1, BCR, CORO1C, TIMM50, PRMT5, SEC16A, KRT77, DNAJA2, PPP1R9B, TUBA4B, MYO1C, KRT4, KRT13, DNAJA1, IARS, IGHG1, S100A8, RPS19, ATAD3B, CCT2, AIFM1, VARS, S100A9, HNRNPH1, ARAP1, CLTC, USP15, PRDX1, TEC, DDX5, HAX1, CCT6A, DDB1, S100A7, ANXA2, ERRFI1, MOV10, NXF1, RFFL, CLIC4, MAT1A, PLS3, PSPH, PPP1R8, RMDN1, STXBP1, ARHGAP32, CEP170, SCLT1, XPO1, TRIM15, CDC5L, ACTG1, ARHGEF5, GFAP, HNRNPU, LGALS3BP, SHC1, PRSS3, HSPA1A, HNRNPA2B1, ITGAV, ITGB3, ITGB1, KRAS, LTK, SHC2, OXT, RASAL2, CORO2B, PEAK1, GAREM, CDC25C, AMD1, AP1B1 | ASH1L | HIST1H3A, H3F3A, SMAD7, THAP7, MORF4L1, PARD6A, SIKE1, MORF4L2, NXF2, CDX1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SHC1_ASH1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SHC1_ASH1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SHC1 | C0018800 | Cardiomegaly | 1 | CTD_human |
Hgene | SHC1 | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
Tgene | ASH1L | C0023903 | Liver neoplasms | 1 | CTD_human |