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Fusion gene ID: 3375 |
FusionGeneSummary for ATP2C2_WFDC1 |
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Fusion gene information | Fusion gene name: ATP2C2_WFDC1 | Fusion gene ID: 3375 | Hgene | Tgene | Gene symbol | ATP2C2 | WFDC1 | Gene ID | 9914 | 58189 |
Gene name | ATPase secretory pathway Ca2+ transporting 2 | WAP four-disulfide core domain 1 | |
Synonyms | SPCA2 | PS20 | |
Cytomap | 16q24.1 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | calcium-transporting ATPase type 2C member 2ATPase 2C2ATPase, Ca++ transporting, type 2C, member 2secretory pathway Ca(2+)-ATPase 2secretory pathway calcium ATPase 2 | WAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75185 | Q9HC57 | |
Ensembl transtripts involved in fusion gene | ENST00000262429, ENST00000416219, ENST00000420010, | ENST00000219454, ENST00000568638, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 2 X 1 X 2=4 |
# samples | 6 | 2 | |
** MAII score | log2(6/60*10)=0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ATP2C2 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-94-8491-01A | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000262429 | ENST00000219454 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000262429 | ENST00000568638 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000416219 | ENST00000219454 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
Frame-shift | ENST00000416219 | ENST00000568638 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000420010 | ENST00000219454 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
intron-3CDS | ENST00000420010 | ENST00000568638 | ATP2C2 | chr16 | 84402320 | + | WFDC1 | chr16 | 84358025 | + |
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FusionProtFeatures for ATP2C2_WFDC1 |
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Hgene | Tgene |
ATP2C2 | WFDC1 |
This magnesium-dependent enzyme catalyzes the hydrolysisof ATP coupled with the transport of calcium. {ECO:0000250}. | Has growth inhibitory activity. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP2C2_WFDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP2C2_WFDC1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATP2C2 | WFDC1 | EZR, XRCC2, FOSL1, RAB40B, ZNF677, MOV10, NXF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP2C2_WFDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP2C2_WFDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | WFDC1 | C0025202 | melanoma | 1 | CTD_human |