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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3375

FusionGeneSummary for ATP2C2_WFDC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2C2_WFDC1
Fusion gene ID: 3375
HgeneTgene
Gene symbol

ATP2C2

WFDC1

Gene ID

9914

58189

Gene nameATPase secretory pathway Ca2+ transporting 2WAP four-disulfide core domain 1
SynonymsSPCA2PS20
Cytomap

16q24.1

16q24.1

Type of geneprotein-codingprotein-coding
Descriptioncalcium-transporting ATPase type 2C member 2ATPase 2C2ATPase, Ca++ transporting, type 2C, member 2secretory pathway Ca(2+)-ATPase 2secretory pathway calcium ATPase 2WAP four-disulfide core domain protein 1WAP four-disulfide core domain 1 homologprostate stromal protein ps20ps20 growth inhibitor
Modification date2018052320180523
UniProtAcc

O75185

Q9HC57

Ensembl transtripts involved in fusion geneENST00000262429, ENST00000416219, 
ENST00000420010, 
ENST00000219454, 
ENST00000568638, 
Fusion gene scores* DoF score4 X 5 X 3=602 X 1 X 2=4
# samples 62
** MAII scorelog2(6/60*10)=0log2(2/4*10)=2.32192809488736
Context

PubMed: ATP2C2 [Title/Abstract] AND WFDC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-94-8491-01AATP2C2chr16

84402320

+WFDC1chr16

84358025

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000262429ENST00000219454ATP2C2chr16

84402320

+WFDC1chr16

84358025

+
Frame-shitENST00000262429ENST00000568638ATP2C2chr16

84402320

+WFDC1chr16

84358025

+
Frame-shitENST00000416219ENST00000219454ATP2C2chr16

84402320

+WFDC1chr16

84358025

+
Frame-shitENST00000416219ENST00000568638ATP2C2chr16

84402320

+WFDC1chr16

84358025

+
intron-3CDSENST00000420010ENST00000219454ATP2C2chr16

84402320

+WFDC1chr16

84358025

+
intron-3CDSENST00000420010ENST00000568638ATP2C2chr16

84402320

+WFDC1chr16

84358025

+

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FusionProtFeatures for ATP2C2_WFDC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2C2

O75185

WFDC1

Q9HC57

This magnesium-dependent enzyme catalyzes the hydrolysisof ATP coupled with the transport of calcium. {ECO:0000250}. Has growth inhibitory activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP2C2_WFDC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP2C2_WFDC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP2C2WFDC1EZR, XRCC2, FOSL1, RAB40B, ZNF677, MOV10, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP2C2_WFDC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP2C2_WFDC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWFDC1C0025202melanoma1CTD_human