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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33743

FusionGeneSummary for SHB_CPEB2

check button Fusion gene summary
Fusion gene informationFusion gene name: SHB_CPEB2
Fusion gene ID: 33743
HgeneTgene
Gene symbol

SHB

CPEB2

Gene ID

6461

132864

Gene nameSH2 domain containing adaptor protein Bcytoplasmic polyadenylation element binding protein 2
SynonymsbA3J10.2CPE-BP2|CPEB-2|hCPEB-2
Cytomap

9p13.1

4p15.32

Type of geneprotein-codingprotein-coding
DescriptionSH2 domain-containing adapter protein BSHB (Src homology 2 domain containing) adaptor protein BSHB adaptor protein (a Src homology 2 protein)Src homology 2 domain containing adaptor protein Bcytoplasmic polyadenylation element-binding protein 2CPE-binding protein 2
Modification date2018052320180523
UniProtAcc

Q15464

Q7Z5Q1

Ensembl transtripts involved in fusion geneENST00000377707, ENST00000377700, 
ENST00000442003, ENST00000538197, 
ENST00000541112, ENST00000507071, 
ENST00000345451, ENST00000259997, 
ENST00000382401, ENST00000382395, 
Fusion gene scores* DoF score12 X 7 X 8=6722 X 2 X 2=8
# samples 132
** MAII scorelog2(13/672*10)=-2.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: SHB [Title/Abstract] AND CPEB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPEB2

GO:0032869

cellular response to insulin stimulus

18752464

TgeneCPEB2

GO:0071456

cellular response to hypoxia

18752464


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A0I6-01ASHBchr9

38067926

-CPEB2chr4

15060045

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377707ENST00000442003SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000538197SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000541112SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000507071SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000345451SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000259997SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000382401SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377707ENST00000382395SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000442003SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000538197SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000541112SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000507071SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000345451SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000259997SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000382401SHBchr9

38067926

-CPEB2chr4

15060045

+
Frame-shiftENST00000377700ENST00000382395SHBchr9

38067926

-CPEB2chr4

15060045

+

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FusionProtFeatures for SHB_CPEB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SHB

Q15464

CPEB2

Q7Z5Q1

Adapter protein which regulates several signaltransduction cascades by linking activated receptors to downstreamsignaling components. May play a role in angiogenesis byregulating FGFR1, VEGFR2 and PDGFR signaling. May also play a rolein T-cell antigen receptor/TCR signaling, interleukin-2 signaling,apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 andIRS2 signaling in insulin-producing cells.{ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138,ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388,ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417,ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685,ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}. May play a role in translational regulation of storedmRNAs in transcriptionally inactive haploid spermatids. Binds topoly(U) RNA oligomers (By similarity). Required for cell cycleprogression, specifically for the transition from metaphase toanaphase (PubMed:26398195). {ECO:0000250|UniProtKB:Q812E0,ECO:0000269|PubMed:26398195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SHB_CPEB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SHB_CPEB2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SHBKDR, IL2RB, IL2RG, JAK1, JAK3, LAT, PLCG1, LCP2, ZAP70, VAV1, GRB2, CRK, EPS8, SRC, PIK3R1, FGFR1, ABL1, NCK2, CDH1, WDYHV1, TRIM25CPEB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SHB_CPEB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SHB_CPEB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource