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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3371

FusionGeneSummary for ATP2C1_SYT17

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2C1_SYT17
Fusion gene ID: 3371
HgeneTgene
Gene symbol

ATP2C1

SYT17

Gene ID

27032

51760

Gene nameATPase secretory pathway Ca2+ transporting 1synaptotagmin 17
SynonymsATP2C1A|BCPM|HHD|PMR1|SPCA1|hSPCA1sytXVII
Cytomap

3q22.1

16p12.3

Type of geneprotein-codingprotein-coding
Descriptioncalcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1HUSSY-28secretory pathway Ca2+/Mn2+ ATPase 1synaptotagmin-17B/K proteinsynaptotagmin XVII
Modification date2018052320180523
UniProtAcc

P98194

Q9BSW7

Ensembl transtripts involved in fusion geneENST00000505330, ENST00000504381, 
ENST00000507488, ENST00000393221, 
ENST00000533801, ENST00000510168, 
ENST00000508532, ENST00000504948, 
ENST00000513801, ENST00000328560, 
ENST00000428331, ENST00000359644, 
ENST00000422190, ENST00000509150, 
ENST00000355377, ENST00000562034, 
ENST00000562711, ENST00000568433, 
ENST00000568115, 
Fusion gene scores* DoF score10 X 10 X 6=6003 X 3 X 2=18
# samples 103
** MAII scorelog2(10/600*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATP2C1 [Title/Abstract] AND SYT17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2C1

GO:0006816

calcium ion transport

12810057

HgeneATP2C1

GO:0006874

cellular calcium ion homeostasis

12810057

TgeneSYT17

GO:1903861

positive regulation of dendrite extension

23999003


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE792646ATP2C1chr3

130613182

+SYT17chr16

19191712

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000505330ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000505330ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000505330ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000505330ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000505330ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000504381ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000504381ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000504381ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000504381ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000504381ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000507488ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000507488ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000507488ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000507488ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000507488ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000393221ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000393221ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000393221ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000393221ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000393221ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000533801ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000533801ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000533801ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000533801ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000533801ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-3CDSENST00000510168ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000510168ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000510168ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-intronENST00000510168ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000510168ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-3CDSENST00000508532ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000508532ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000508532ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-intronENST00000508532ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000508532ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-3CDSENST00000504948ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000504948ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000504948ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-intronENST00000504948ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000504948ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-3CDSENST00000513801ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000513801ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000513801ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-intronENST00000513801ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
5UTR-5UTRENST00000513801ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000328560ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000328560ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000328560ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000328560ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000328560ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000428331ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000428331ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000428331ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000428331ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000428331ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000359644ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000359644ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000359644ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000359644ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000359644ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000422190ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000422190ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000422190ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000422190ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000422190ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-3CDSENST00000509150ENST00000355377ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000509150ENST00000562034ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000509150ENST00000562711ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-intronENST00000509150ENST00000568433ATP2C1chr3

130613182

+SYT17chr16

19191712

+
intron-5UTRENST00000509150ENST00000568115ATP2C1chr3

130613182

+SYT17chr16

19191712

+

Top

FusionProtFeatures for ATP2C1_SYT17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2C1

P98194

SYT17

Q9BSW7

Plays a role in dendrite formation by melanocytes(PubMed:23999003). {ECO:0000269|PubMed:23999003}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP2C1_SYT17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ATP2C1_SYT17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP2C1ELAVL1, RNF2, HLA-DPA1, TMEM231, OGFOD3, TMEFF1, VSIG4, NTRK1, TMEM17, RAB5C, GOLT1B, FAF2, TMEM165, GTF2IRD1SYT17CCDC85B, CHMP4A, NINL, TSC22D4, APTX, APP, MEOX1, MEOX2, TRAF2, IKZF1, RUNDC3A, MID2, NIF3L1, GMCL1, CEP63, CEP70, SSX2IP, FAM9B, TF, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ATP2C1_SYT17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATP2C1P98194DB01189DesfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved
HgeneATP2C1P98194DB00228EnfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|investigational|vet_approved
HgeneATP2C1P98194DB01028MethoxyfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|investigational|vet_approved
HgeneATP2C1P98194DB01373CalciumCalcium-transporting ATPase type 2C member 1small moleculeapproved|nutraceutical
HgeneATP2C1P98194DB00753IsofluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved
HgeneATP2C1P98194DB01159HalothaneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved
HgeneATP2C1P98194DB01236SevofluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved

Top

RelatedDiseases for ATP2C1_SYT17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP2C1C0085106Familial benign pemphigus7CTD_human;ORPHANET;UNIPROT