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Fusion gene ID: 33697 |
FusionGeneSummary for SH3RF3_PPP1R16B |
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Fusion gene information | Fusion gene name: SH3RF3_PPP1R16B | Fusion gene ID: 33697 | Hgene | Tgene | Gene symbol | SH3RF3 | PPP1R16B | Gene ID | 344558 | 26051 |
Gene name | SH3 domain containing ring finger 3 | protein phosphatase 1 regulatory subunit 16B | |
Synonyms | POSH2|SH3MD4 | ANKRD4|TIMAP | |
Cytomap | 2q13 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | SH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2 | protein phosphatase 1 regulatory inhibitor subunit 16BCAAX box protein TIMAPTGF-beta-inhibited membrane-associated proteinankyrin repeat domain protein 4ankyrin repeat domain-containing protein 4hTIMAPprotein phosphatase 1, regulatory (inhibitor) su | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8TEJ3 | Q96T49 | |
Ensembl transtripts involved in fusion gene | ENST00000309415, | ENST00000299824, ENST00000373331, ENST00000468265, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SH3RF3 [Title/Abstract] AND PPP1R16B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP1R16B | GO:0035307 | positive regulation of protein dephosphorylation | 16263087 |
Tgene | PPP1R16B | GO:0035308 | negative regulation of protein dephosphorylation | 21466834 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA407504 | SH3RF3 | chr2 | 109795464 | + | PPP1R16B | chr20 | 37547693 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000309415 | ENST00000299824 | SH3RF3 | chr2 | 109795464 | + | PPP1R16B | chr20 | 37547693 | + |
intron-3UTR | ENST00000309415 | ENST00000373331 | SH3RF3 | chr2 | 109795464 | + | PPP1R16B | chr20 | 37547693 | + |
intron-intron | ENST00000309415 | ENST00000468265 | SH3RF3 | chr2 | 109795464 | + | PPP1R16B | chr20 | 37547693 | + |
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FusionProtFeatures for SH3RF3_PPP1R16B |
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Hgene | Tgene |
SH3RF3 | PPP1R16B |
Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}. | Regulator of protein phosphatase 1 (PP1) that acts as apositive regulator of pulmonary endothelial cell (EC) barrierfunction (PubMed:18586956). Involved in the regulation of thePI3K/AKT signaling pathway, angiogenesis and endothelial cellproliferation (PubMed:25007873). Regulates angiogenesis andendothelial cell proliferation through the control of ECE1dephosphorylation, trafficking and activity (By similarity).Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in theregulation of endothelial cell filopodia extension (Bysimilarity). May be a downstream target for TGF-beta1 signalingcascade in endothelial cells (PubMed:16263087, PubMed:18586956).Involved in PKA-mediated moesin dephosphorylation which isimportant in EC barrier protection against thrombin stimulation(PubMed:18586956). Promotes the interaction of PPP1CA withRPSA/LAMR1 and in turn facilitates the dephosphorylation ofRPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation ofEEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3,ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087,ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873,ECO:0000269|PubMed:26497934}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SH3RF3_PPP1R16B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SH3RF3_PPP1R16B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SH3RF3_PPP1R16B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SH3RF3_PPP1R16B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SH3RF3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |