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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33697

FusionGeneSummary for SH3RF3_PPP1R16B

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3RF3_PPP1R16B
Fusion gene ID: 33697
HgeneTgene
Gene symbol

SH3RF3

PPP1R16B

Gene ID

344558

26051

Gene nameSH3 domain containing ring finger 3protein phosphatase 1 regulatory subunit 16B
SynonymsPOSH2|SH3MD4ANKRD4|TIMAP
Cytomap

2q13

20q11.23

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2protein phosphatase 1 regulatory inhibitor subunit 16BCAAX box protein TIMAPTGF-beta-inhibited membrane-associated proteinankyrin repeat domain protein 4ankyrin repeat domain-containing protein 4hTIMAPprotein phosphatase 1, regulatory (inhibitor) su
Modification date2018051920180519
UniProtAcc

Q8TEJ3

Q96T49

Ensembl transtripts involved in fusion geneENST00000309415, ENST00000299824, 
ENST00000373331, ENST00000468265, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: SH3RF3 [Title/Abstract] AND PPP1R16B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP1R16B

GO:0035307

positive regulation of protein dephosphorylation

16263087

TgenePPP1R16B

GO:0035308

negative regulation of protein dephosphorylation

21466834


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA407504SH3RF3chr2

109795464

+PPP1R16Bchr20

37547693

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000309415ENST00000299824SH3RF3chr2

109795464

+PPP1R16Bchr20

37547693

+
intron-3UTRENST00000309415ENST00000373331SH3RF3chr2

109795464

+PPP1R16Bchr20

37547693

+
intron-intronENST00000309415ENST00000468265SH3RF3chr2

109795464

+PPP1R16Bchr20

37547693

+

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FusionProtFeatures for SH3RF3_PPP1R16B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3RF3

Q8TEJ3

PPP1R16B

Q96T49

Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}. Regulator of protein phosphatase 1 (PP1) that acts as apositive regulator of pulmonary endothelial cell (EC) barrierfunction (PubMed:18586956). Involved in the regulation of thePI3K/AKT signaling pathway, angiogenesis and endothelial cellproliferation (PubMed:25007873). Regulates angiogenesis andendothelial cell proliferation through the control of ECE1dephosphorylation, trafficking and activity (By similarity).Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in theregulation of endothelial cell filopodia extension (Bysimilarity). May be a downstream target for TGF-beta1 signalingcascade in endothelial cells (PubMed:16263087, PubMed:18586956).Involved in PKA-mediated moesin dephosphorylation which isimportant in EC barrier protection against thrombin stimulation(PubMed:18586956). Promotes the interaction of PPP1CA withRPSA/LAMR1 and in turn facilitates the dephosphorylation ofRPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation ofEEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3,ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087,ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873,ECO:0000269|PubMed:26497934}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3RF3_PPP1R16B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3RF3_PPP1R16B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3RF3_PPP1R16B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3RF3_PPP1R16B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3RF3C0236733Amphetamine-Related Disorders1CTD_human