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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 33689

FusionGeneSummary for SH3RF1_NEK1

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3RF1_NEK1
Fusion gene ID: 33689
HgeneTgene
Gene symbol

SH3RF1

NEK1

Gene ID

57630

4750

Gene nameSH3 domain containing ring finger 1NIMA related kinase 1
SynonymsPOSH|RNF142|SH3MD2ALS24|NY-REN-55|SRPS2|SRPS2A|SRTD6
Cytomap

4q32.3-q33

4q33

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SH3RF1RING-type E3 ubiquitin transferase SH3RF1SH3 domain-containing RING finger protein 1SH3 multiple domains 2SH3 multiple domains protein 2plenty of SH3 domainsplenty of SH3sputative E3 ubiquitin-protein ligase SH3RF1serine/threonine-protein kinase Nek1NIMA (never in mitosis gene a)-related kinase 1never in mitosis A-related kinase 1nimA-related protein kinase 1protein-serine/threonine kinaserenal carcinoma antigen NY-REN-55
Modification date2018051920180523
UniProtAcc

Q7Z6J0

Q96PY6

Ensembl transtripts involved in fusion geneENST00000284637, ENST00000508685, 
ENST00000439128, ENST00000511633, 
ENST00000510533, ENST00000507142, 
ENST00000512193, 
Fusion gene scores* DoF score6 X 6 X 4=1442 X 2 X 2=8
# samples 62
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SH3RF1 [Title/Abstract] AND NEK1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNEK1

GO:0006468

protein phosphorylation

19158487


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRPTCGA-G7-6793-01ASH3RF1chr4

170037420

-NEK1chr4

170327898

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000284637ENST00000439128SH3RF1chr4

170037420

-NEK1chr4

170327898

-
In-frameENST00000284637ENST00000511633SH3RF1chr4

170037420

-NEK1chr4

170327898

-
In-frameENST00000284637ENST00000510533SH3RF1chr4

170037420

-NEK1chr4

170327898

-
In-frameENST00000284637ENST00000507142SH3RF1chr4

170037420

-NEK1chr4

170327898

-
In-frameENST00000284637ENST00000512193SH3RF1chr4

170037420

-NEK1chr4

170327898

-
Frame-shiftENST00000508685ENST00000439128SH3RF1chr4

170037420

-NEK1chr4

170327898

-
Frame-shiftENST00000508685ENST00000511633SH3RF1chr4

170037420

-NEK1chr4

170327898

-
Frame-shiftENST00000508685ENST00000510533SH3RF1chr4

170037420

-NEK1chr4

170327898

-
Frame-shiftENST00000508685ENST00000507142SH3RF1chr4

170037420

-NEK1chr4

170327898

-
Frame-shiftENST00000508685ENST00000512193SH3RF1chr4

170037420

-NEK1chr4

170327898

-

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FusionProtFeatures for SH3RF1_NEK1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3RF1

Q7Z6J0

NEK1

Q96PY6

Has E3 ubiquitin-protein ligase activity. In the absenceof an external substrate, it can catalyze self-ubiquitination(PubMed:15659549, PubMed:20696164). Stimulates ubiquitination ofpotassium channel KCNJ1, enhancing it's dynamin-dependent andclathrin-independent endocytosis (PubMed:19710010). Acts as ascaffold protein that coordinates with MAPK8IP1/JIP1 in organizingdifferent components of the JNK pathway, including RAC1 or RAC2,MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/orMAPK9/JNK2 into a functional multiprotein complex to ensure theeffective activation of the JNK signaling pathway. Regulates thedifferentiation of CD4(+) and CD8(+) T-cells and promotes T-helper1 (Th1) cell differentiation. Regulates the activation ofMAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation ofMAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in themigration of neocortical neurons in the developing brain. Controlsproper cortical neuronal migration and the formation of proximalcytoplasmic dilation in the leading process (PCDLP) in migratoryneocortical neurons by regulating the proper localization ofactivated RAC1 and F-actin assembly (By similarity).{ECO:0000250|UniProtKB:Q69ZI1, ECO:0000269|PubMed:15659549,ECO:0000269|PubMed:19710010, ECO:0000269|PubMed:20696164}. (Microbial infection) Plays an essential role in thetargeting of HIV-1 Gag to the plasma membrane, this function isdependent on it's RING domain, and hence it's E3 ligase activity.{ECO:0000269|PubMed:15659549}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012397_403713889Compositional biasNote=Poly-Pro
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012417_424713889Compositional biasNote=Poly-Ala
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012657_662713889Compositional biasNote=Poly-Ala
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012134_193713889DomainSH3 1
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012196_259713889DomainSH3 2
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012445_506713889DomainSH3 3
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-101212_53713889Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012829_888713889DomainSH3 4
TgeneNEK1chr4:170037420chr4:170327898ENST00000439128-28344_25810461259DomainProtein kinase
TgeneNEK1chr4:170037420chr4:170327898ENST00000507142-30364_25810741287DomainProtein kinase
TgeneNEK1chr4:170037420chr4:170327898ENST00000510533-27334_25810021215DomainProtein kinase
TgeneNEK1chr4:170037420chr4:170327898ENST00000511633-29354_25810301243DomainProtein kinase
TgeneNEK1chr4:170037420chr4:170327898ENST00000512193-27334_2589771190DomainProtein kinase
TgeneNEK1chr4:170037420chr4:170327898ENST00000439128-283410_1810461259Nucleotide bindingATP
TgeneNEK1chr4:170037420chr4:170327898ENST00000507142-303610_1810741287Nucleotide bindingATP
TgeneNEK1chr4:170037420chr4:170327898ENST00000510533-273310_1810021215Nucleotide bindingATP
TgeneNEK1chr4:170037420chr4:170327898ENST00000511633-293510_1810301243Nucleotide bindingATP
TgeneNEK1chr4:170037420chr4:170327898ENST00000512193-273310_189771190Nucleotide bindingATP


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FusionGeneSequence for SH3RF1_NEK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000439128_chr4_170327898_-_926aa
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLAS
PQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKMLRTCSL
PDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTAN
GTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGN

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000511633_chr4_170327898_-_926aa
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLAS
PQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKMLRTCSL
PDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTAN
GTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGN

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000510533_chr4_170327898_-_926aa
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLAS
PQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKMLRTCSL
PDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTAN
GTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGN

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000507142_chr4_170327898_-_926aa
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLAS
PQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKMLRTCSL
PDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTAN
GTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGN

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000512193_chr4_170327898_-_926aa
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHIS
TTGLIVTPPPSSPVTTGPSFTFPSDVPYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSVY
VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVPMSTAGQTSRGVTMVSPSTAGGPA
QKLQGNGVAGSPSVVPAAVVSAAHIQTSPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHSLAS
PQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKMLRTCSL
PDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTAN
GTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000439128_chr4_170327898_-_2778nt
ATGGATGAATCAGCCTTGTTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCAT
ACGTTTTGCAAGCGATGTTTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTC
GAGGAGCTTCCCAGTAACATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGG
ACCAACTGCACAAATGCATTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAG
CCTCGGGTGCAATCCTGGAGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCT
GGAGACCTTAAATTCAGCAAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCAT
GGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAA
GACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGA
ATGCTGGCAGACAAAATAGGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCT
GTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAA
AAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTC
CTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGT
ACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCT
GCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCT
GCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTAT
GTTGCTATATATCCATACACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGAT
GGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAAT
GCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCC
CAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAG
GCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGC
CCCACGGCAGCAGTGACACCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCC
CCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCA
GCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCC
ACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTT
CCAGATCTCTCAAAGCTGTTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAA
GATGAAAACATTAAAGAAGGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATG
GAACAGTTACTTAGGGAACAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAAT
GGGACAGATGTGGCAGATGAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATT
GCTAGTGAATGTGAATGCGATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTT
GAGGTTTATGAGAAAATAAAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAAT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000511633_chr4_170327898_-_2778nt
ATGGATGAATCAGCCTTGTTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCAT
ACGTTTTGCAAGCGATGTTTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTC
GAGGAGCTTCCCAGTAACATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGG
ACCAACTGCACAAATGCATTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAG
CCTCGGGTGCAATCCTGGAGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCT
GGAGACCTTAAATTCAGCAAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCAT
GGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAA
GACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGA
ATGCTGGCAGACAAAATAGGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCT
GTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAA
AAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTC
CTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGT
ACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCT
GCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCT
GCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTAT
GTTGCTATATATCCATACACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGAT
GGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAAT
GCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCC
CAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAG
GCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGC
CCCACGGCAGCAGTGACACCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCC
CCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCA
GCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCC
ACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTT
CCAGATCTCTCAAAGCTGTTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAA
GATGAAAACATTAAAGAAGGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATG
GAACAGTTACTTAGGGAACAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAAT
GGGACAGATGTGGCAGATGAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATT
GCTAGTGAATGTGAATGCGATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTT
GAGGTTTATGAGAAAATAAAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAAT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000510533_chr4_170327898_-_2778nt
ATGGATGAATCAGCCTTGTTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCAT
ACGTTTTGCAAGCGATGTTTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTC
GAGGAGCTTCCCAGTAACATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGG
ACCAACTGCACAAATGCATTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAG
CCTCGGGTGCAATCCTGGAGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCT
GGAGACCTTAAATTCAGCAAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCAT
GGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAA
GACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGA
ATGCTGGCAGACAAAATAGGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCT
GTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAA
AAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTC
CTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGT
ACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCT
GCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCT
GCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTAT
GTTGCTATATATCCATACACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGAT
GGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAAT
GCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCC
CAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAG
GCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGC
CCCACGGCAGCAGTGACACCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCC
CCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCA
GCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCC
ACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTT
CCAGATCTCTCAAAGCTGTTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAA
GATGAAAACATTAAAGAAGGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATG
GAACAGTTACTTAGGGAACAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAAT
GGGACAGATGTGGCAGATGAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATT
GCTAGTGAATGTGAATGCGATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTT
GAGGTTTATGAGAAAATAAAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAAT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000507142_chr4_170327898_-_2778nt
ATGGATGAATCAGCCTTGTTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCAT
ACGTTTTGCAAGCGATGTTTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTC
GAGGAGCTTCCCAGTAACATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGG
ACCAACTGCACAAATGCATTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAG
CCTCGGGTGCAATCCTGGAGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCT
GGAGACCTTAAATTCAGCAAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCAT
GGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAA
GACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGA
ATGCTGGCAGACAAAATAGGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCT
GTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAA
AAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTC
CTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGT
ACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCT
GCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCT
GCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTAT
GTTGCTATATATCCATACACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGAT
GGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAAT
GCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCC
CAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAG
GCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGC
CCCACGGCAGCAGTGACACCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCC
CCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCA
GCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCC
ACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTT
CCAGATCTCTCAAAGCTGTTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAA
GATGAAAACATTAAAGAAGGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATG
GAACAGTTACTTAGGGAACAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAAT
GGGACAGATGTGGCAGATGAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATT
GCTAGTGAATGTGAATGCGATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTT
GAGGTTTATGAGAAAATAAAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAAT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000512193_chr4_170327898_-_2778nt
ATGGATGAATCAGCCTTGTTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCAT
ACGTTTTGCAAGCGATGTTTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTC
GAGGAGCTTCCCAGTAACATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGG
ACCAACTGCACAAATGCATTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAG
CCTCGGGTGCAATCCTGGAGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCT
GGAGACCTTAAATTCAGCAAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCAT
GGCTTTTTCCCCACCAACTTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAA
GACAAGGAAGCAGACAAAGATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGA
ATGCTGGCAGACAAAATAGGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCT
GTGCCAGGAGTTGATGCTGGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAA
AAGCGGCACTCCTTCACTTCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTC
CTCATCAGCTCCAGCAACCCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGT
ACCACCGGGTTAATTGTGACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCT
GCCCTTGGAACTTTGAATCCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCT
GCTGCTGCTGCTGGAATGGGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTAT
GTTGCTATATATCCATACACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGAT
GGCTGGTTCAAAGGGACATCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAAT
GCTTCCCAAGCTAAAGTCCCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCC
CAGAAGCTCCAGGGAAATGGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAG
GCTAAGGTCTTGTTGCACATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGC
CCCACGGCAGCAGTGACACCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCC
CCACAACCTGCGCCTCTGATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCA
GCTGCTCCACTGACTTCCCCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCC
ACATCTCCTGACAGTGCTTCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTT
CCAGATCTCTCAAAGCTGTTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAA
GATGAAAACATTAAAGAAGGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATG
GAACAGTTACTTAGGGAACAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAAT
GGGACAGATGTGGCAGATGAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATT
GCTAGTGAATGTGAATGCGATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTT
GAGGTTTATGAGAAAATAAAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000439128_chr4_170327898_-_4355nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTG
ACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAAT
CCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATG
GGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATAC
ACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACA
TCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTC
CCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAAT
GGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCAC
ATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACA
CCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTG
ATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCC
CCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCT
TCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTTCCAGATCTCTCAAAGCTG
TTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAAGATGAAAACATTAAAGAA
GGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATGGAACAGTTACTTAGGGAA
CAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAATGGGACAGATGTGGCAGAT
GAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATTGCTAGTGAATGTGAATGC
GATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTTGAGGTTTATGAGAAAATA
AAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAATGAACATCAGCATCTTTAT
GCCAAGATTCTTCATTTAGTCATGGCAGATGGAGCCTACCAAGAAGATAATGATGAATAATCCTCAAAATGTTTTTTAATCCTCAACTAT
ATGAAAGCATTTGAATTTGGCTTATCAGAATAACAAGCTTCAGTGGGAAATACAGCAATTATTTATTTAAAAAATCAGATTTAAGATGGA
CTTTCTTATTGCATGAAAAAGATGGAGAAACATGCCATTTTTCAGTGAAGATTCTAATATTTTATCTATTTTGTTCATTGAATTCCATGG
TTAAATCTCATAAAATATATACTTTATTAAATCATCCAACCAAAGCATAGGAAACATTGACCCAGAACCTGACTTAATGGTTTTGAAGAT
TTACTATGCAATAGGGTAACTTTGAGTTTCAGCAAATGTCTTTAGGTTGAAGGAATTACCTATGTCATGAAGGACCTGTCTGTGGTTTTT
CAATGGAGTCTTTAAGCATGATCTTTTTTCTGTCTAGTACTTGTTTTCATTCTGGCCAGCAGTTCTACATTAAATCACCTTGTCAAGGGC
TCTGTTTACATCTATACATTTTGAAGATGAAATTTTTAGCCTTAAAGTTTATATTCTCAAGTCCTTTTACAATCAGTGTGTCTCCTGAAC
TAGCACACAGGCTGTAGAAACAGTCTTAGAAATCATTGAAAGATTTGATTATGAAAGAATAGCAAAATTATATTTCTTGACATATAAAAA
GTTGGTTTAATGCCTTTATTTCTCTTTAAGGACCAGAACCAGGAATACTATATCGAAAAATTAGTCTGTGGATTTAACACTGACTTAGCA
TATAGCTTAAAGTTGCTCTTTTGGTTTTTAACTTCCTCCATACATAAGCTTCAAGGACAATAAGATGTTAAAAAGGAGGAAATAATTATT
TTTATTTTGACACTGTGACAGTTTTGGTAACTAGGATCCTAGGGAGGGAAATGTTTGCCTGTTGAACTTCTTTCTGTTATGAGAGGATTT
AGTTAGGTCATTAAGATGTTGATCACACAGCTTCAATCACAATATGCCAAGTATAACCTGGTTTCGTTAGAGGTGTCTACAGTCCAGATG
TTCTTCGTAATAAAAGCAAAGTTTTTGAACCTCTGAGTCCAAAGCAGGCTGGTTGGCATAATATGTAATTTGAAAAATAAAATCTTATCT
TGCAGCACTATCAGTATGTTGAATTTATTATGTATATTATTTCTAATATCCGAAACTAAATACTTGATTTTTTAATATGTGTGTTTATTT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000511633_chr4_170327898_-_4349nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTG
ACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAAT
CCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATG
GGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATAC
ACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACA
TCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTC
CCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAAT
GGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCAC
ATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACA
CCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTG
ATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCC
CCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCT
TCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTTCCAGATCTCTCAAAGCTG
TTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAAGATGAAAACATTAAAGAA
GGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATGGAACAGTTACTTAGGGAA
CAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAATGGGACAGATGTGGCAGAT
GAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATTGCTAGTGAATGTGAATGC
GATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTTGAGGTTTATGAGAAAATA
AAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAATGAACATCAGCATCTTTAT
GCCAAGATTCTTCATTTAGTCATGGCAGATGGAGCCTACCAAGAAGATAATGATGAATAATCCTCAAAATGTTTTTTAATCCTCAACTAT
ATGAAAGCATTTGAATTTGGCTTATCAGAATAACAAGCTTCAGTGGGAAATACAGCAATTATTTATTTAAAAAATCAGATTTAAGATGGA
CTTTCTTATTGCATGAAAAAGATGGAGAAACATGCCATTTTTCAGTGAAGATTCTAATATTTTATCTATTTTGTTCATTGAATTCCATGG
TTAAATCTCATAAAATATATACTTTATTAAATCATCCAACCAAAGCATAGGAAACATTGACCCAGAACCTGACTTAATGGTTTTGAAGAT
TTACTATGCAATAGGGTAACTTTGAGTTTCAGCAAATGTCTTTAGGTTGAAGGAATTACCTATGTCATGAAGGACCTGTCTGTGGTTTTT
CAATGGAGTCTTTAAGCATGATCTTTTTTCTGTCTAGTACTTGTTTTCATTCTGGCCAGCAGTTCTACATTAAATCACCTTGTCAAGGGC
TCTGTTTACATCTATACATTTTGAAGATGAAATTTTTAGCCTTAAAGTTTATATTCTCAAGTCCTTTTACAATCAGTGTGTCTCCTGAAC
TAGCACACAGGCTGTAGAAACAGTCTTAGAAATCATTGAAAGATTTGATTATGAAAGAATAGCAAAATTATATTTCTTGACATATAAAAA
GTTGGTTTAATGCCTTTATTTCTCTTTAAGGACCAGAACCAGGAATACTATATCGAAAAATTAGTCTGTGGATTTAACACTGACTTAGCA
TATAGCTTAAAGTTGCTCTTTTGGTTTTTAACTTCCTCCATACATAAGCTTCAAGGACAATAAGATGTTAAAAAGGAGGAAATAATTATT
TTTATTTTGACACTGTGACAGTTTTGGTAACTAGGATCCTAGGGAGGGAAATGTTTGCCTGTTGAACTTCTTTCTGTTATGAGAGGATTT
AGTTAGGTCATTAAGATGTTGATCACACAGCTTCAATCACAATATGCCAAGTATAACCTGGTTTCGTTAGAGGTGTCTACAGTCCAGATG
TTCTTCGTAATAAAAGCAAAGTTTTTGAACCTCTGAGTCCAAAGCAGGCTGGTTGGCATAATATGTAATTTGAAAAATAAAATCTTATCT
TGCAGCACTATCAGTATGTTGAATTTATTATGTATATTATTTCTAATATCCGAAACTAAATACTTGATTTTTTAATATGTGTGTTTATTT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000510533_chr4_170327898_-_4240nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTG
ACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAAT
CCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATG
GGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATAC
ACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACA
TCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTC
CCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAAT
GGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCAC
ATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACA
CCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTG
ATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCC
CCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCT
TCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTTCCAGATCTCTCAAAGCTG
TTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAAGATGAAAACATTAAAGAA
GGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATGGAACAGTTACTTAGGGAA
CAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAATGGGACAGATGTGGCAGAT
GAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATTGCTAGTGAATGTGAATGC
GATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTTGAGGTTTATGAGAAAATA
AAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAATGAACATCAGCATCTTTAT
GCCAAGATTCTTCATTTAGTCATGGCAGATGGAGCCTACCAAGAAGATAATGATGAATAATCCTCAAAATGTTTTTTAATCCTCAACTAT
ATGAAAGCATTTGAATTTGGCTTATCAGAATAACAAGCTTCAGTGGGAAATACAGCAATTATTTATTTAAAAAATCAGATTTAAGATGGA
CTTTCTTATTGCATGAAAAAGATGGAGAAACATGCCATTTTTCAGTGAAGATTCTAATATTTTATCTATTTTGTTCATTGAATTCCATGG
TTAAATCTCATAAAATATATACTTTATTAAATCATCCAACCAAAGCATAGGAAACATTGACCCAGAACCTGACTTAATGGTTTTGAAGAT
TTACTATGCAATAGGGTAACTTTGAGTTTCAGCAAATGTCTTTAGGTTGAAGGAATTACCTATGTCATGAAGGACCTGTCTGTGGTTTTT
CAATGGAGTCTTTAAGCATGATCTTTTTTCTGTCTAGTACTTGTTTTCATTCTGGCCAGCAGTTCTACATTAAATCACCTTGTCAAGGGC
TCTGTTTACATCTATACATTTTGAAGATGAAATTTTTAGCCTTAAAGTTTATATTCTCAAGTCCTTTTACAATCAGTGTGTCTCCTGAAC
TAGCACACAGGCTGTAGAAACAGTCTTAGAAATCATTGAAAGATTTGATTATGAAAGAATAGCAAAATTATATTTCTTGACATATAAAAA
GTTGGTTTAATGCCTTTATTTCTCTTTAAGGACCAGAACCAGGAATACTATATCGAAAAATTAGTCTGTGGATTTAACACTGACTTAGCA
TATAGCTTAAAGTTGCTCTTTTGGTTTTTAACTTCCTCCATACATAAGCTTCAAGGACAATAAGATGTTAAAAAGGAGGAAATAATTATT
TTTATTTTGACACTGTGACAGTTTTGGTAACTAGGATCCTAGGGAGGGAAATGTTTGCCTGTTGAACTTCTTTCTGTTATGAGAGGATTT
AGTTAGGTCATTAAGATGTTGATCACACAGCTTCAATCACAATATGCCAAGTATAACCTGGTTTCGTTAGAGGTGTCTACAGTCCAGATG
TTCTTCGTAATAAAAGCAAAGTTTTTGAACCTCTGAGTCCAAAGCAGGCTGGTTGGCATAATATGTAATTTGAAAAATAAAATCTTATCT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000507142_chr4_170327898_-_4235nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTG
ACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAAT
CCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATG
GGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATAC
ACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACA
TCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTC
CCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAAT
GGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCAC
ATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACA
CCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTG
ATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCC
CCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCT
TCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTTCCAGATCTCTCAAAGCTG
TTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAAGATGAAAACATTAAAGAA
GGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATGGAACAGTTACTTAGGGAA
CAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAATGGGACAGATGTGGCAGAT
GAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATTGCTAGTGAATGTGAATGC
GATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTTGAGGTTTATGAGAAAATA
AAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAATGAACATCAGCATCTTTAT
GCCAAGATTCTTCATTTAGTCATGGCAGATGGAGCCTACCAAGAAGATAATGATGAATAATCCTCAAAATGTTTTTTAATCCTCAACTAT
ATGAAAGCATTTGAATTTGGCTTATCAGAATAACAAGCTTCAGTGGGAAATACAGCAATTATTTATTTAAAAAATCAGATTTAAGATGGA
CTTTCTTATTGCATGAAAAAGATGGAGAAACATGCCATTTTTCAGTGAAGATTCTAATATTTTATCTATTTTGTTCATTGAATTCCATGG
TTAAATCTCATAAAATATATACTTTATTAAATCATCCAACCAAAGCATAGGAAACATTGACCCAGAACCTGACTTAATGGTTTTGAAGAT
TTACTATGCAATAGGGTAACTTTGAGTTTCAGCAAATGTCTTTAGGTTGAAGGAATTACCTATGTCATGAAGGACCTGTCTGTGGTTTTT
CAATGGAGTCTTTAAGCATGATCTTTTTTCTGTCTAGTACTTGTTTTCATTCTGGCCAGCAGTTCTACATTAAATCACCTTGTCAAGGGC
TCTGTTTACATCTATACATTTTGAAGATGAAATTTTTAGCCTTAAAGTTTATATTCTCAAGTCCTTTTACAATCAGTGTGTCTCCTGAAC
TAGCACACAGGCTGTAGAAACAGTCTTAGAAATCATTGAAAGATTTGATTATGAAAGAATAGCAAAATTATATTTCTTGACATATAAAAA
GTTGGTTTAATGCCTTTATTTCTCTTTAAGGACCAGAACCAGGAATACTATATCGAAAAATTAGTCTGTGGATTTAACACTGACTTAGCA
TATAGCTTAAAGTTGCTCTTTTGGTTTTTAACTTCCTCCATACATAAGCTTCAAGGACAATAAGATGTTAAAAAGGAGGAAATAATTATT
TTTATTTTGACACTGTGACAGTTTTGGTAACTAGGATCCTAGGGAGGGAAATGTTTGCCTGTTGAACTTCTTTCTGTTATGAGAGGATTT
AGTTAGGTCATTAAGATGTTGATCACACAGCTTCAATCACAATATGCCAAGTATAACCTGGTTTCGTTAGAGGTGTCTACAGTCCAGATG
TTCTTCGTAATAAAAGCAAAGTTTTTGAACCTCTGAGTCCAAAGCAGGCTGGTTGGCATAATATGTAATTTGAAAAATAAAATCTTATCT

>In-frame_SH3RF1_ENST00000284637_chr4_170037420_-_NEK1_ENST00000512193_chr4_170327898_-_3402nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGGTTCATATAAGTACCACCGGGTTAATTGTG
ACCCCGCCCCCAAGCAGCCCAGTGACAACTGGCCCCTCGTTTACTTTCCCATCAGATGTTCCCTACCAAGCTGCCCTTGGAACTTTGAAT
CCTCCTCTTCCACCACCCCCTCTCCTGGCTGCCACTGTCCTTGCCTCCACACCACCAGGCGCCACCGCCGCTGCTGCTGCTGCTGGAATG
GGACCGAGGCCCATGGCAGGATCCACTGACCAGATTGCACATTTACGGCCGCAGACTCGCCCCAGTGTGTATGTTGCTATATATCCATAC
ACTCCTCGGAAAGAGGATGAACTAGAGCTGAGAAAAGGGGAGATGTTTTTAGTGTTTGAGCGCTGCCAGGATGGCTGGTTCAAAGGGACA
TCCATGCATACCAGCAAGATAGGGGTTTTCCCTGGCAATTATGTGGCACCAGTCACAAGGGCGGTGACAAATGCTTCCCAAGCTAAAGTC
CCTATGTCTACAGCTGGCCAGACAAGTCGGGGAGTGACCATGGTCAGTCCTTCCACGGCAGGAGGGCCTGCCCAGAAGCTCCAGGGAAAT
GGCGTGGCTGGGAGTCCCAGTGTTGTCCCCGCAGCTGTGGTATCAGCAGCTCACATCCAGACAAGTCCTCAGGCTAAGGTCTTGTTGCAC
ATGACGGGGCAAATGACAGTCAACCAGGCCCGCAATGCTGTGAGGACAGTTGCAGCGCACAACCAGGAACGCCCCACGGCAGCAGTGACA
CCCATCCAGGTACAGAATGCCGCCGGCCTCAGCCCTGCATCTGTGGGCCTGTCCCATCACTCGCTGGCCTCCCCACAACCTGCGCCTCTG
ATGCCAGGCTCAGCCACGCACACTGCTGCCATCAGTATCAGTCGAGCCAGTGCCCCTCTGGCCTGTGCAGCAGCTGCTCCACTGACTTCC
CCAAGCATCACCAGTGCTTCTCTGGAGGCTGAGCCCAGTGGCCGGATAGTGACCGTTCTCCCTGGACTCCCCACATCTCCTGACAGTGCT
TCATCAGCTTGTGGGAACAGTTCAGCAACCAAACCAGACAAGGATAGCAAAATGTTAAGGACATGTTCACTTCCAGATCTCTCAAAGCTG
TTCAGAACCCTTATGGATGTTCCCACCGTAGGAGATGTTCGTCAAGACAATCTTGAAATAGATGAAATTGAAGATGAAAACATTAAAGAA
GGACCTTCTGATTCTGAAGACATTGTGTTTGAAGAAACTGACACAGATTTACAAGAGCTGCAGGCCTCGATGGAACAGTTACTTAGGGAA
CAACCTGGTGAAGAATACAGTGAAGAAGAAGAGTCAGTCTTGAAGAACAGTGATGTGGAGCCAACTGCAAATGGGACAGATGTGGCAGAT
GAAGATGACAATCCCAGCAGTGAAAGTGCCCTGAACGAAGAATGGCACTCAGATAACAGTGATGGTGAAATTGCTAGTGAATGTGAATGC
GATAGTGTCTTTAACCATTTAGAGGAACTGAGACTTCATCTGGAGCAGGAAATGGGCTTTGAAAAATTCTTTGAGGTTTATGAGAAAATA
AAGGCTATTCATGAAGATGAAGATGAAAATATTGAAATTTGTTCAAAAATAGTTCAAAATATTTTGGGAAATGAACATCAGCATCTTTAT
GCCAAGATTCTTCATTTAGTCATGGCAGATGGAGCCTACCAAGAAGATAATGATGAATAATCCTCAAAATGTTTTTTAATCCTCAACTAT
ATGAAAGCATTTGAATTTGGCTTATCAGAATAACAAGCTTCAGTGGGAAATACAGCAATTATTTATTTAAAAAATCAGATTTAAGATGGA
CTTTCTTATTGCATGAAAAAGATGGAGAAACATGCCATTTTTCAGTGAAGATTCTAATATTTTATCTATTTTGTTCATTGAATTCCATGG


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FusionGenePPI for SH3RF1_NEK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SH3RF1AKT2, MAP3K11, MAP4K3, RAC1, PDCD6IP, KCNJ1, SEMA6A, SH3RF2, SIAH1, SIAH2, AKT1, UBE2N, UBE2D3, UBE2D1, YWHAB, NINL, HERPUD1, SH3RF1, FAT1, CDH1, TRIM25NEK1ZNF350, FEZ1, FEZ2, YWHAH, ATRX, TP53BP1, MRE11A, KIF3A, PPP2R5A, TSC2, CTNNAL1, EXOSC4, WDR83, VPS26B, SKAP1, TEKT4, KRAS, CEP104, CEP290, XPO1, TTC25, ALS2, CPNE2, KIF2B, CTDSP2, CAMK2D, VTN, C21orf2, NEK5, RPGRIP1L, SPATA7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012440_543713889AKT2
HgeneSH3RF1chr4:170037420chr4:170327898ENST00000284637-1012292_362713889RAC1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3RF1_NEK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3RF1_NEK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNEK1C0002736Amyotrophic Lateral Sclerosis2CTD_human
TgeneNEK1C0036996Short Rib-Polydactyly Syndrome2CTD_human
TgeneNEK1C0024507Majewski Syndrome1ORPHANET;UNIPROT