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Fusion gene ID: 33683 |
FusionGeneSummary for SH3PXD2A_RB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SH3PXD2A_RB1 | Fusion gene ID: 33683 | Hgene | Tgene | Gene symbol | SH3PXD2A | RB1 | Gene ID | 9644 | 5925 |
| Gene name | SH3 and PX domains 2A | RB transcriptional corepressor 1 | |
| Synonyms | FISH|SH3MD1|TKS5 | OSRC|PPP1R130|RB|p105-Rb|pRb|pp110 | |
| Cytomap | 10q24.33 | 13q14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SH3 and PX domain-containing protein 2ASH3 multiple domains 1adapter protein TKS5adaptor protein TKS5five SH3 domain-containing proteintyrosine kinase substrate with five SH3 domains | retinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q5TCZ1 | P06400 | |
| Ensembl transtripts involved in fusion gene | ENST00000427662, ENST00000369774, ENST00000355946, ENST00000315994, ENST00000540321, ENST00000538130, | ENST00000267163, ENST00000484879, | |
| Fusion gene scores | * DoF score | 11 X 13 X 11=1573 | 7 X 5 X 5=175 |
| # samples | 23 | 8 | |
| ** MAII score | log2(23/1573*10)=-2.77381290447131 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SH3PXD2A [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SH3PXD2A | GO:0006801 | superoxide metabolic process | 19755710 |
| Tgene | RB1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Tgene | RB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10783144|12065415|19223331 |
| Tgene | RB1 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 25100735 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-24-1469-01A | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000427662 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5CDS-intron | ENST00000427662 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| In-frame | ENST00000369774 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5CDS-intron | ENST00000369774 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| In-frame | ENST00000355946 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5CDS-intron | ENST00000355946 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5UTR-3CDS | ENST00000315994 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5UTR-intron | ENST00000315994 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| In-frame | ENST00000540321 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5CDS-intron | ENST00000540321 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| In-frame | ENST00000538130 | ENST00000267163 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
| 5CDS-intron | ENST00000538130 | ENST00000484879 | SH3PXD2A | chr10 | 105371338 | - | RB1 | chr13 | 49039134 | + |
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FusionProtFeatures for SH3PXD2A_RB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SH3PXD2A | RB1 |
| Adapter protein involved in invadopodia and podosomeformation, extracellular matrix degradation and invasiveness ofsome cancer cells. Binds matrix metalloproteinases (ADAMs), NADPHoxidases (NOXs) and phosphoinositides. Acts as an organizerprotein that allows NOX1- or NOX3-dependent reactive oxygenspecies (ROS) generation and ROS localization. In association withADAM12, mediates the neurotoxic effect of amyloid-beta peptide.{ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328,ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710,ECO:0000269|PubMed:20609497}. | Key regulator of entry into cell division that acts as atumor suppressor. Promotes G0-G1 transition when phosphorylated byCDK3/cyclin-C. Acts as a transcription repressor of E2F1 targetgenes. The underphosphorylated, active form of RB1 interacts withE2F1 and represses its transcription activity, leading to cellcycle arrest. Directly involved in heterochromatin formation bymaintaining overall chromatin structure and, in particular, thatof constitutive heterochromatin by stabilizing histonemethylation. Recruits and targets histone methyltransferasesSUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptionalrepression. Controls histone H4 'Lys-20' trimethylation. Inhibitsthe intrinsic kinase activity of TAF1. Mediates transcriptionalrepression by SMARCA4/BRG1 by recruiting a histone deacetylase(HDAC) complex to the c-FOS promoter. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependentrecruitment of a phospho-RB1-HDAC1 repressor complex. Upon calciuminflux, RB1 is dephosphorylated by calcineurin, which leads torelease of the repressor complex (By similarity). In case of viralinfections, interactions with SV40 large T antigen, HPV E7 proteinor adenovirus E1A protein induce the disassembly of RB1-E2F1complex thereby disrupting RB1's activity. {ECO:0000250,ECO:0000269|PubMed:15084261}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 166_225 | 408 | 1106 | Domain | SH3 1 |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 266_325 | 408 | 1106 | Domain | SH3 2 |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 4_128 | 408 | 1106 | Domain | PX |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 166_225 | 436 | 1134 | Domain | SH3 1 |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 266_325 | 436 | 1134 | Domain | SH3 2 |
| Hgene | SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 4_128 | 436 | 1134 | Domain | PX |
| Tgene | >RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 870_876 | 737 | 929 | Motif | Nuclear localization signal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 917_946 | 408 | 1106 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 917_946 | 436 | 1134 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 634_724 | 408 | 1106 | Compositional bias | Note=Ser-rich |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 634_724 | 436 | 1134 | Compositional bias | Note=Ser-rich |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 1072_1133 | 408 | 1106 | Domain | SH3 5 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 448_507 | 408 | 1106 | Domain | SH3 3 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000355946 | - | 12 | 14 | 840_899 | 408 | 1106 | Domain | SH3 4 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 1072_1133 | 436 | 1134 | Domain | SH3 5 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 448_507 | 436 | 1134 | Domain | SH3 3 |
| Hgene | >SH3PXD2A | chr10:105371338 | chr13:49039134 | ENST00000369774 | - | 13 | 15 | 840_899 | 436 | 1134 | Domain | SH3 4 |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 10_18 | 737 | 929 | Compositional bias | Note=Poly-Ala |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 20_29 | 737 | 929 | Compositional bias | Note=Poly-Pro |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 373_579 | 737 | 929 | Region | Note=Domain A |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 373_771 | 737 | 929 | Region | Note=Pocket%3B binds T and E1A |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 580_639 | 737 | 929 | Region | Note=Spacer |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 640_771 | 737 | 929 | Region | Note=Domain B |
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FusionGeneSequence for SH3PXD2A_RB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SH3PXD2A_ENST00000427662_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_490aa MSICCCFFFRDYGSSKRKSGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRD DSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPAS YLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPA VARIAPQRAQISSPNLRTRPPPRRESSLTFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRI PGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSK >In-frame_SH3PXD2A_ENST00000369774_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_628aa MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVA VKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEK YVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKE TPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLTFKRVLIKEEEYDS IIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGT >In-frame_SH3PXD2A_ENST00000355946_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_600aa MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVA VKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQ ENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRK NLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASN GSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLTFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTL SPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPP >In-frame_SH3PXD2A_ENST00000540321_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_495aa MNGSFLLRLLFPVASILPETVLLRGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQ NGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEG WAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA QGSPAVARIAPQRAQISSPNLRTRPPPRRESSLTFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPS SPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDE >In-frame_SH3PXD2A_ENST00000538130_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_463aa MILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRW TLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIM EISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESS LTFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMT PRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTSTRTRMQKQKM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SH3PXD2A_ENST00000427662_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_1470nt ATGTCTATCTGTTGTTGCTTCTTTTTCAGGGACTATGGCAGTTCCAAGAGGAAATCAGGTGCCGACGCCACCGCCGAGCCCATGATCCTG GAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTCATCGAGAAG AACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGTACTCGGGAT GACTCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTGGACCCTGGGC GGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATTGGCTTTGAG AAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCGCCAGCATCC TACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATGGAGATCAGC AACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAGAAGGAGATC AGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGCTCTCCAGCT GTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGCCTGACATTC AAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTG CAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATT CCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCA AGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTC AAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAA CATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGC >In-frame_SH3PXD2A_ENST00000369774_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_1884nt ATGCTCGCCTACTGCGTGCAGGATGCCACCGTGGTGGACGTGGAGAAGCGGAGGAACCCCTCCAAGCACTACGTATACATAATCAATGTG ACCTGGTCTGACTCCACCTCCCAGACTATCTACCGGAGGTACAGCAAGTTCTTTGACCTGCAGATGCAGCTTTTGGATAAGTTTCCCATT GAAGGTGGCCAGAAGGACCCCAAGCAAAGGATCATCCCCTTCCTCCCAGGCAAGATCCTCTTCCGCAGAAGCCACATCCGGGACGTAGCT GTGAAGAGACTGAAGCCCATCGATGAATACTGCCGGGCACTTGTCCGGCTGCCCCCCCACATCTCACAGTGTGACGAAGTCTTCCGGTTC TTCGAGGCTCGACCCGAGGATGTCAACCCTCCAAAAGAGGACTATGGCAGTTCCAAGAGGAAATCAGTGTGGCTGTCCAGCTGGGCTGAG TCGCCCAAGAAGGACGTGACAGGTGCCGACGCCACCGCCGAGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAG GAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAG GAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGTG TCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTGGACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAG TATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTG GAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGG AAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAA ACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGT GCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGC TCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCT ATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCA ATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGT CCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACT TCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCA CTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTG >In-frame_SH3PXD2A_ENST00000355946_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_1800nt ATGCTCGCCTACTGCGTGCAGGATGCCACCGTGGTGGACGTGGAGAAGCGGAGGAACCCCTCCAAGCACTACGTATACATAATCAATGTG ACCTGGTCTGACTCCACCTCCCAGACTATCTACCGGAGGTACAGCAAGTTCTTTGACCTGCAGATGCAGCTTTTGGATAAGTTTCCCATT GAAGGTGGCCAGAAGGACCCCAAGCAAAGGATCATCCCCTTCCTCCCAGGCAAGATCCTCTTCCGCAGAAGCCACATCCGGGACGTAGCT GTGAAGAGACTGAAGCCCATCGATGAATACTGCCGGGCACTTGTCCGGCTGCCCCCCCACATCTCACAGTGTGACGAAGTCTTCCGGTTC TTCGAGGCTCGACCCGAGGATGTCAACCCTCCAAAAGAGGACTATGGCAGTTCCAAGAGGAAATCAGTGTGGCTGTCCAGCTGGGCTGAG TCGCCCAAGAAGGACGTGACAGGTGCCGACGCCACCGCCGAGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAG GAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAG GAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGAG GAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAG AATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCA ACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGAC AAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAAT GGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAG ATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTAT GATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTG TCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTG AAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTC GGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCT AAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAG AAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGA >In-frame_SH3PXD2A_ENST00000540321_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_1485nt ATGAACGGGTCGTTCCTGCTCCGGCTCCTGTTTCCTGTAGCGTCCATCCTGCCAGAGACTGTACTGCTTAGGGGTGCCGACGCCACCGCC GAGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTG GATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAG AATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGC CGGTGGACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGAC GAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGC TGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAAC ATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATT GCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCC CAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAA TCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTG AAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGT TCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAA ATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAAC AGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAA GCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAG >In-frame_SH3PXD2A_ENST00000538130_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_1389nt ATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTC ATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGT ACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTGG ACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATT GGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCG CCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATG GAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAG AAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGC TCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGC CTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACA AATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCC TTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACT CCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGAC CGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGAT GGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SH3PXD2A_ENST00000427662_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_3472nt ACATGAGCAGCGGCACCGGGGACCGACCGCAGCCAGCCCGAGGGCGCCCCTGCAGCTGCAGCCCCGCGCTCGCGCCCGGCCCTAACCATG TCTATCTGTTGTTGCTTCTTTTTCAGGGACTATGGCAGTTCCAAGAGGAAATCAGGTGCCGACGCCACCGCCGAGCCCATGATCCTGGAA CAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTCATCGAGAAGAAC GAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGTACTCGGGATGAC TCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTGGACCCTGGGCGGG ATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATTGGCTTTGAGAAG GGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCGCCAGCATCCTAC CTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATGGAGATCAGCAAC CTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAGAAGGAGATCAGC CTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGCTCTCCAGCTGTG GCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGCCTGACATTCAAA CGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAG TATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCT GGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGA ATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAA AGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACAT CTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATG GATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGA CTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGG GTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGC AGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTC TGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAAC ACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAAT GGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTT ATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAG AATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTC AGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTAT ATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAG CCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGA ATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGT TCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAA AGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTA ACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAAT TATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTT TGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGC TTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTT AAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAAT TAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTC >In-frame_SH3PXD2A_ENST00000369774_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_4076nt GCGAGCGGGCGAGCGCAGCGCGGCGGCCGCGCGGGAGTGAAGGGGCGCGCGGCAGGCCGGCGGGGAGTCCCCCGGGGCGCACGGAGCCCG CGCGCCCTCCGGGACCCTCCCCCGTCCCTGGGCCGGACCTGTGGGCGCCGGGAGTCCGGGCAGCGTTCGGCGCGCCGGGCCGGGGTGGCG GGCGGCCCCGGGACCCCGGCAGCTGGAGAAGGAGCCGGAGCCCGGCCGGGATGAGAAGGTGACGCCGCCGGGGGCGCCACTCGCTTTGTG GGGGAAGATGCTCGCCTACTGCGTGCAGGATGCCACCGTGGTGGACGTGGAGAAGCGGAGGAACCCCTCCAAGCACTACGTATACATAAT CAATGTGACCTGGTCTGACTCCACCTCCCAGACTATCTACCGGAGGTACAGCAAGTTCTTTGACCTGCAGATGCAGCTTTTGGATAAGTT TCCCATTGAAGGTGGCCAGAAGGACCCCAAGCAAAGGATCATCCCCTTCCTCCCAGGCAAGATCCTCTTCCGCAGAAGCCACATCCGGGA CGTAGCTGTGAAGAGACTGAAGCCCATCGATGAATACTGCCGGGCACTTGTCCGGCTGCCCCCCCACATCTCACAGTGTGACGAAGTCTT CCGGTTCTTCGAGGCTCGACCCGAGGATGTCAACCCTCCAAAAGAGGACTATGGCAGTTCCAAGAGGAAATCAGTGTGGCTGTCCAGCTG GGCTGAGTCGCCCAAGAAGGACGTGACAGGTGCCGACGCCACCGCCGAGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAA GAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCAC TTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGG AGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTGGACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGA GGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAA GAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCC AACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGA CAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAA TGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCA GATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTA TGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTT GTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCT GAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATT CGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCC TAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCA GAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATG AGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTT ATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTT AGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAA TTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCA TATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTAT CTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAA TTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAA AAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTT TCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCA TCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTC TGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTT GTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTT TGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAA AATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTA GAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAA AATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTG TTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTG ACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACT AAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTT TATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAA TTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTACACTAATGTTCTCTTTTCTGTCTAGGAGAAGATAGATAG >In-frame_SH3PXD2A_ENST00000355946_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_3855nt CCGGGAGTCCGGGCAGCGTTCGGCGCGCCGGGCCGGGGTGGCGGGCGGCCCCGGGACCCCGGCAGCTGGAGAAGGAGCCGGAGCCCGGCC GGGATGAGAAGGTGACGCCGCCGGGGGCGCCACTCGCTTTGTGGGGGAAGATGCTCGCCTACTGCGTGCAGGATGCCACCGTGGTGGACG TGGAGAAGCGGAGGAACCCCTCCAAGCACTACGTATACATAATCAATGTGACCTGGTCTGACTCCACCTCCCAGACTATCTACCGGAGGT ACAGCAAGTTCTTTGACCTGCAGATGCAGCTTTTGGATAAGTTTCCCATTGAAGGTGGCCAGAAGGACCCCAAGCAAAGGATCATCCCCT TCCTCCCAGGCAAGATCCTCTTCCGCAGAAGCCACATCCGGGACGTAGCTGTGAAGAGACTGAAGCCCATCGATGAATACTGCCGGGCAC TTGTCCGGCTGCCCCCCCACATCTCACAGTGTGACGAAGTCTTCCGGTTCTTCGAGGCTCGACCCGAGGATGTCAACCCTCCAAAAGAGG ACTATGGCAGTTCCAAGAGGAAATCAGTGTGGCTGTCCAGCTGGGCTGAGTCGCCCAAGAAGGACGTGACAGGTGCCGACGCCACCGCCG AGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGG ATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGA ATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCA AGGACGAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAG AGGGCTGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTG GGAACATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCC CCATTGCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGC TGGCCCAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCA GAGAATCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGA GACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTC CTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAA CAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTAT GTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAG ATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAA AGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGA TTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAA AATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAAT CCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGG AGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTA TATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATT ATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAAT CTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTA CTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAG TACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGG TATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCAT AAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTG GGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTC AGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAAT GTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGT ATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAA AATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAA ACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAAT CAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCA GAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATT GCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTT >In-frame_SH3PXD2A_ENST00000540321_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_3411nt AGACATTACACATGAACGGGTCGTTCCTGCTCCGGCTCCTGTTTCCTGTAGCGTCCATCCTGCCAGAGACTGTACTGCTTAGGGGTGCCG ACGCCACCGCCGAGCCCATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCG GGGAGGTGGTGGATGTCATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACC TGGAGGCCCAGAATGGTACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGC GCCTGGATCGCCGGTGGACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCC AAAGCAAGGACGAGATTGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGG GCAAAGAGGGCTGGGCGCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGA TCATTGGGAACATCATGGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATG AGGCCCCCATTGCCAAGAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCT CCAGGCTGGCCCAGGGCTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCAC CACGCAGAGAATCCAGCCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCA TGCAGAGACTGAAAACAAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACA AGTTTCCTAGTTCACCCTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAA CACCAACAAAAATGACTCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGA TGGTATGTAACAGCGACCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAG GATCAGATGAAGCAGATGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAA TGCAAAAGCAGAAAATGAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACC TCTGGATTCATTGTCTCTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGG ATATAAAATGTGCAGATGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGT GTAAATCCTGCCATTTAAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAG AGTGGGAGTCCTGATAACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTA TATGTATATTTTTTTAATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACC AAAATTATCCTGAACTCTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTAT TGGAATCTGATATACTGTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATC ATACTACTGAAACAGATTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTAT TGATAGTACTCTTGGTTTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGAT CTTAGGTATAGAGGACCCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTA CTCCATAAACAGACTGTTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTT AATTTGGGAAGGTTTGTGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTT TAAGTCAGTATGGTCTAACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGC ATTAATGTTTCTATCTGATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAA AGGTGTATTTAAACTATCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTT TAGGAAAATCACTTTGTCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAG TTTCAAACTTACTATTTTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCAT ACAAATCAGTTAGTTTTTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGA ACTTCAGAGATCGTGTATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTT AAAATTGCTATGTTACTATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTG >In-frame_SH3PXD2A_ENST00000538130_chr10_105371338_-_RB1_ENST00000267163_chr13_49039134_+_3395nt GAGAAGCTCTCTCCCGCTCTCTCCTCTCCCTCTCCCGCCCGAGGGAGCAGGGCTGCCTTTTCTCTCGGGTGCCGACGCCACCGCCGAGCC CATGATCCTGGAACAGTACGTGGTGGTGTCCAACTATAAGAAGCAGGAGAACTCGGAGCTGAGCCTCCAGGCCGGGGAGGTGGTGGATGT CATCGAGAAGAACGAGAGCGGCTGGTGGTTCGTGAGCACTTCTGAGGAGCAGGGCTGGGTCCCTGCCACCTACCTGGAGGCCCAGAATGG TACTCGGGATGACTCCGACATCAACACCTCTAAGACTGGAGAAGTGTCCAAGAGACGCAAGGCCCATCTGCGGCGCCTGGATCGCCGGTG GACCCTGGGCGGGATGGTCAACAGGCAGCACAGCCGAGAGGAGAAGTATGTCACCGTGCAGCCTTACACCAGCCAAAGCAAGGACGAGAT TGGCTTTGAGAAGGGCGTCACAGTGGAGGTGATCCGGAAGAATCTGGAAGGCTGGTGGTATATCAGATACCTGGGCAAAGAGGGCTGGGC GCCAGCATCCTACCTGAAGAAGGCCAAGGATGACCTGCCAACCCGGAAGAAGAACCTGGCCGGCCCAGTGGAGATCATTGGGAACATCAT GGAGATCAGCAACCTGCTGAACAAGAAGGCGTCTGGGGACAAGGAAACTCCACCAGCCGAAGGCGAGGGCCATGAGGCCCCCATTGCCAA GAAGGAGATCAGCCTGCCCATCCTCTGCAATGCCTCCAATGGCAGTGCCGTGGGCGTTCCTGACAGGACTGTCTCCAGGCTGGCCCAGGG CTCTCCAGCTGTGGCCAGGATTGCCCCTCAGCGGGCCCAGATCAGCTCCCCGAACCTACGGACAAGACCTCCACCACGCAGAGAATCCAG CCTGACATTCAAACGTGTTTTGATCAAAGAAGAGGAGTATGATTCTATTATAGTATTCTATAACTCGGTCTTCATGCAGAGACTGAAAAC AAATATTTTGCAGTATGCTTCCACCAGGCCCCCTACCTTGTCACCAATACCTCACATTCCTCGAAGCCCTTACAAGTTTCCTAGTTCACC CTTACGGATTCCTGGAGGGAACATCTATATTTCACCCCTGAAGAGTCCATATAAAATTTCAGAAGGTCTGCCAACACCAACAAAAATGAC TCCAAGATCAAGAATCTTAGTATCAATTGGTGAATCATTCGGGACTTCTGAGAAGTTCCAGAAAATAAATCAGATGGTATGTAACAGCGA CCGTGTGCTCAAAAGAAGTGCTGAAGGAAGCAACCCTCCTAAACCACTGAAAAAACTACGCTTTGATATTGAAGGATCAGATGAAGCAGA TGGAAGTAAACATCTCCCAGGAGAGTCCAAATTTCAGCAGAAACTGGCAGAAATGACTTCTACTCGAACACGAATGCAAAAGCAGAAAAT GAATGATAGCATGGATACCTCAAACAAGGAAGAGAAATGAGGATCTCAGGACCTTGGTGGACACTGTGTACACCTCTGGATTCATTGTCT CTCACAGATGTGACTGTATAACTTTCCCAGGTTCTGTTTATGGCCACATTTAATATCTTCAGCTCTTTTTGTGGATATAAAATGTGCAGA TGCAATTGTTTGGGTGATTCCTAAGCCACTTGAAATGTTAGTCATTGTTATTTATACAAGATTGAAAATCTTGTGTAAATCCTGCCATTT AAAAAGTTGTAGCAGATTGTTTCCTCTTCCAAAGTAAAATTGCTGTGCTTTATGGATAGTAAGAATGGCCCTAGAGTGGGAGTCCTGATA ACCCAGGCCTGTCTGACTACTTTGCCTTCTTTTGTAGCATATAGGTGATGTTTGCTCTTGTTTTTATTAATTTATATGTATATTTTTTTA ATTTAACATGAACACCCTTAGAAAATGTGTCCTATCTATCTTCCAAATGCAATTTGATTGACTGCCCATTCACCAAAATTATCCTGAACT CTTCTGCAAAAATGGATATTATTAGAAATTAGAAAAAAATTACTAATTTTACACATTAGATTTTATTTTACTATTGGAATCTGATATACT GTGTGCTTGTTTTATAAAATTTTGCTTTTAATTAAATAAAAGCTGGAAGCAAAGTATAACCATATGATACTATCATACTACTGAAACAGA TTTCATACCTCAGAATGTAAAAGAACTTACTGATTATTTTCTTCATCCAACTTATGTTTTTAAATGAGGATTATTGATAGTACTCTTGGT TTTTATACCATTCAGATCACTGAATTTATAAAGTACCCATCTAGTACTTGAAAAAGTAAAGTGTTCTGCCAGATCTTAGGTATAGAGGAC CCTAACACAGTATATCCCAAGTGCACTTTCTAATGTTTCTGGGTCCTGAAGAATTAAGATACAAATTAATTTTACTCCATAAACAGACTG TTAATTATAGGAGCCTTAATTTTTTTTTCATAGAGATTTGTCTAATTGCATCTCAAAATTATTCTGCCCTCCTTAATTTGGGAAGGTTTG TGTTTTCTCTGGAATGGTACATGTCTTCCATGTATCTTTTGAACTGGCAATTGTCTATTTATCTTTTATTTTTTTAAGTCAGTATGGTCT AACACTGGCATGTTCAAAGCCACATTATTTCTAGTCCAAAATTACAAGTAATCAAGGGTCATTATGGGTTAGGCATTAATGTTTCTATCT GATTTTGTGCAAAAGCTTCAAATTAAAACAGCTGCATTAGAAAAAGAGGCGCTTCTCCCCTCCCCTACACCTAAAGGTGTATTTAAACTA TCTTGTGTGATTAACTTATTTAGAGATGCTGTAACTTAAAATAGGGGATATTTAAGGTAGCTTCAGCTAGCTTTTAGGAAAATCACTTTG TCTAACTCAGAATTATTTTTAAAAAGAAATCTGGTCTTGTTAGAAAACAAAATTTTATTTTGTGCTCATTTAAGTTTCAAACTTACTATT TTGACAGTTATTTTGATAACAATGACACTAGAAAACTTGACTCCATTTCATCATTGTTTCTGCATGAATATCATACAAATCAGTTAGTTT TTAGGTCAAGGGCTTACTATTTCTGGGTCTTTTGCTACTAAGTTCACATTAGAATTAGTGCCAGAATTTTAGGAACTTCAGAGATCGTGT ATTGAGATTTCTTAAATAATGCTTCAGATATTATTGCTTTATTGCTTTTTTGTATTGGTTAAAACTGTACATTTAAAATTGCTATGTTAC TATTTTCTACAATTAATAGTTTGTCTATTTTAAAATAAATTAGTTGTTAAGAGTCTTAATGGTCTGATGTTGTGTTCTTTGTATTAAGTA |
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FusionGenePPI for SH3PXD2A_RB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SH3PXD2A | PRKAA2, PRKAB2, SVIL, ELAVL1, KHDRBS1, CTTN, FASLG, ADAM15, GRB2, YWHAB, RTN4, NTRK1, FGD1, PRSS12, KIAA0368, TRAF6, ZNF764, KCTD3, KIF13B, ZBTB21, KSR1, GIGYF1, LRFN1, DENND1A, SRGAP2, EIF4E2, SIPA1L1, RTKN, MAST3, LIMA1, CGN, MAGI1, DENND4C, TESK2, DCLK1, PPM1H, ZNF638, SRSF12, SYDE1, MAPKAP1, AGAP1, CDC25B, CDK16, HDAC4, FAM110B, USP21, ANKRD34A, FAM53C, NF1, CBY1, LPIN3, NADK, FAM110A, TIAM1, CDC25C, KIAA1804, PHLDB2, RASAL2, CAMSAP2, GIGYF2, SH3RF3, PLEKHA7, MELK, GAB2, KIF1C, TBC1D25, NAV1, DENND4A, RPTOR, TANC2, PTPN13, RALGPS2, DEPDC1B, PTPN14, STARD13, OSBPL6, MLLT4, HDAC7, PLEKHA5, LARP1, EDC3, SH3BP4, RAB11FIP2, CHEK1, KIF1B, INPP5E, RAB3IP, TRIM25 | RB1 | CUX1, MCM7, HBP1, TRAP1, AATF, THOC1, LIN9, BRCA1, ABL1, BCR, NCOA6, BAG1, RBBP8, HDAC1, AR, MORF4L2, SERPINB2, TP73, GNB2L1, CBX1, PELP1, PIK3R3, PPARG, HDAC3, RBBP4, E2F1, MORF4L1, MRFAP1, RBBP7, CDK2, DNMT1, HDAC2, ARID4A, NFIX, SP1, SMARCA4, MYOD1, DNMT3A, EID1, BRF1, PRDM2, SUV39H1, CBX5, CBX4, RING1, VDR, KDM5A, CCND3, PML, CCND1, TAF1, PA2G4, TMPO, MYC, TGM2, POLA1, FRK, ATF2, SNW1, ARID3B, SNAPC1, SNAPC3, CCNT2, CDK9, RAF1, E2F4, E4F1, ENC1, RFC1, LMNA, CREG1, CEBPB, HMGB1, PHB, MDM2, JUN, PAX6, MNAT1, RBBP5, E2F2, TRIP11, UBTF, AHR, ARNT, CCNA1, TFDP1, TFDP2, RBBP9, TBP, USP4, L3MBTL1, L3MBTL2, AURKB, CDK4, ZBTB7A, SKP2, HMGA2, KDM5B, KDM4A, STAT3, KDM1A, LIN54, SKI, SKIL, KAT2B, FOXM1, YY1, DNAJA2, SMYD2, UHRF2, TAL1, TCF3, LMO2, LDB1, IRF3, NPM1, CEBPA, KAT5, TRIM27, CCNE1, CDK5, CCND2, PSMA7, CCNA2, CDK1, PSMD10, CDC27, ANAPC2, CDC16, FZR1, MAPK14, TP53, PPP1CA, CDK6, RNF40, UHRF1, UBR4, RBAK, SPI1, E2F3, CHEK2, CHEK1, CEBPD, MDM4, PAX2, PNO1, GTF2H1, PURA, CCNB1, RINT1, FOS, CDK14, PPIA, TOP2A, NOTCH1, RUNX2, ID2, CDK3, DGKZ, INS, HIST4H4, PRMT2, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, MAPK8, UBE2I, CEBPE, MRPS18B, CCNC, PRKCB, TFAP2A, PAX5, HIF1A, CDKN1A, CDKN1C, HDAC11, PLA2G12A, MAGEA11, NEFM, DYRK1A, DYRK1B, USP7, KDM2A, EP300, SIRT1, PAX8, KLK11, RFPL2, FAS, TFDP3, CTBP1, C3orf62, CDK13, NTRK1, RBBP6, GTF3C2, GRB2, RABGAP1L, CHN2, ANKS1A, CLNK, MED23, BAG6, UBL4A, HERC4, RPRD1B, RBM26, FOXA3, FOXK1, FOXK2, FOXO1, FOXO3, PPP1R26, NFATC2, BRD4, FAM208A, RFC5, PPAN, KIAA0430, HELZ, PCGF3, HSP90AA1, WEE1, TUBA1A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | RB1 | chr10:105371338 | chr13:49039134 | ENST00000267163 | + | 20 | 27 | 763_928 | 737 | 929 | LIMD1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SH3PXD2A_RB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | RB1 | P06400 | DB00071 | Insulin Pork | Retinoblastoma-associated protein | biotech | approved |
| Tgene | RB1 | P06400 | DB00030 | Insulin Human | Retinoblastoma-associated protein | biotech | approved|investigational |
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RelatedDiseases for SH3PXD2A_RB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SH3PXD2A | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | RB1 | C0035335 | Retinoblastoma | 9 | CTD_human;HPO;UNIPROT |
| Tgene | RB1 | C1458155 | Mammary Neoplasms | 3 | CTD_human |
| Tgene | RB1 | C0149925 | Small cell carcinoma of lung | 2 | CTD_human;ORPHANET |
| Tgene | RB1 | C2239176 | Liver carcinoma | 2 | CTD_human |
| Tgene | RB1 | C0001624 | Adrenal Gland Neoplasms | 1 | CTD_human |
| Tgene | RB1 | C0007117 | Basal cell carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0007786 | Brain Ischemia | 1 | CTD_human |
| Tgene | RB1 | C0023904 | Liver Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Tgene | RB1 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Tgene | RB1 | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
| Tgene | RB1 | C0029463 | Osteosarcoma | 1 | CTD_human;HPO |
| Tgene | RB1 | C0030297 | Pancreatic Neoplasm | 1 | CTD_human |
| Tgene | RB1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | RB1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| Tgene | RB1 | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | RB1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | RB1 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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