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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33669

FusionGeneSummary for SH3KBP1_HOPX

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3KBP1_HOPX
Fusion gene ID: 33669
HgeneTgene
Gene symbol

SH3KBP1

HOPX

Gene ID

30011

84525

Gene nameSH3 domain containing kinase binding protein 1HOP homeobox
SynonymsCD2BP3|CIN85|GIG10|HSB-1|HSB1|MIG18CAMEO|HOD|HOP|LAGY|NECC1|OB1|SMAP31|TOTO
Cytomap

Xp22.12

4q12

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing kinase-binding protein 1CD2-binding protein 3SH3-domain kinase binding protein 1Src family kinase-binding protein 1c-Cbl-interacting proteincbl-interacting protein of 85 kDahuman Src family kinase-binding protein 1migration-inhomeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1
Modification date2018052220180523
UniProtAcc

Q96B97

Q9BPY8

Ensembl transtripts involved in fusion geneENST00000397821, ENST00000379716, 
ENST00000379698, ENST00000541422, 
ENST00000379697, ENST00000477102, 
ENST00000554144, ENST00000420433, 
ENST00000556376, ENST00000381260, 
ENST00000337881, ENST00000605395, 
ENST00000508121, ENST00000503639, 
ENST00000553379, ENST00000381255, 
ENST00000317745, ENST00000555760, 
ENST00000556614, 
Fusion gene scores* DoF score8 X 7 X 4=2244 X 3 X 3=36
# samples 85
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SH3KBP1 [Title/Abstract] AND HOPX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHOPX

GO:0001829

trophectodermal cell differentiation

17576768

TgeneHOPX

GO:0045596

negative regulation of cell differentiation

17576768

TgeneHOPX

GO:0051131

chaperone-mediated protein complex assembly

10811660


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DR980990SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000397821ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000397821ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000397821ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000379716ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379716ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000379698ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379698ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000541422ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000541422ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000379697ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000379697ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000554144SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000420433SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000556376SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000381260SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000337881SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-intronENST00000477102ENST00000605395SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000508121SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000503639SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000553379SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000381255SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000317745SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000555760SH3KBP1chrX

19674048

+HOPXchr4

57514363

-
intron-3UTRENST00000477102ENST00000556614SH3KBP1chrX

19674048

+HOPXchr4

57514363

-

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FusionProtFeatures for SH3KBP1_HOPX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3KBP1

Q96B97

HOPX

Q9BPY8

Adapter protein involved in regulating diverse signaltransduction pathways. Involved in the regulation of endocytosisand lysosomal degradation of ligand-induced receptor tyrosinekinases, including EGFR and MET/hepatocyte growth factor receptor,through an association with CBL and endophilins. The associationwith CBL, and thus the receptor internalization, may inhibited byan interaction with PDCD6IP and/or SPRY2. Involved in regulationof ligand-dependent endocytosis of the IgE receptor. Attenuatesphosphatidylinositol 3-kinase activity by interaction with itsregulatory subunit (By similarity). May be involved in regulationof cell adhesion; promotes the interaction between TTK2B andPDCD6IP. May be involved in the regulation of cellular stressresponse via the MAPK pathways through its interaction withMAP3K4. Is involved in modulation of tumor necrosis factormediated apoptosis. Plays a role in the regulation of cellmorphology and cytoskeletal organization. Required in the controlof cell shape and migration. {ECO:0000250,ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096,ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385,ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612,ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060,ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21834987}. Atypical homeodomain protein which does not bind DNA andis required to modulate cardiac growth and development. Acts viaits interaction with SRF, thereby modulating the expression ofSRF-dependent cardiac-specific genes and cardiac development.Prevents SRF-dependent transcription either by inhibiting SRFbinding to DNA or by recruiting histone deacetylase (HDAC)proteins that prevent transcription by SRF. Overexpression causescardiac hypertrophy (By similarity). May act as a tumorsuppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperoneproteins and assists in chaperone-mediated protein refolding(PubMed:27708256). {ECO:0000250|UniProtKB:Q8R1H0,ECO:0000269|PubMed:27708256}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3KBP1_HOPX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3KBP1_HOPX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3KBP1_HOPX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3KBP1_HOPX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3KBP1C0009375Colonic Neoplasms1CTD_human
TgeneHOPXC0023893Liver Cirrhosis, Experimental1CTD_human