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Fusion gene ID: 33662 |
FusionGeneSummary for SH3GLB1_CLCA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SH3GLB1_CLCA1 | Fusion gene ID: 33662 | Hgene | Tgene | Gene symbol | SH3GLB1 | CLCA1 | Gene ID | 51100 | 1179 |
| Gene name | SH3 domain containing GRB2 like, endophilin B1 | chloride channel accessory 1 | |
| Synonyms | Bif-1|CGI-61|PPP1R70|dJ612B15.2 | CACC|CACC1|CLCRG1|CaCC-1|GOB5|hCLCA1|hCaCC-1 | |
| Cytomap | 1p22.3 | 1p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | endophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172 | calcium-activated chloride channel regulator 1CLCA family member 1, chloride channel regulatorcalcium-activated chloride channel family member 1calcium-activated chloride channel protein 1calcium-dependent chloride channel-1chloride channel regulator | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9Y371 | A8K7I4 | |
| Ensembl transtripts involved in fusion gene | ENST00000370558, ENST00000535010, ENST00000482504, | ENST00000234701, ENST00000394711, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SH3GLB1 [Title/Abstract] AND CLCA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SH3GLB1 | GO:0032461 | positive regulation of protein oligomerization | 19074440 |
| Hgene | SH3GLB1 | GO:0051259 | protein complex oligomerization | 19805544 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-JX-A3PZ-01A | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000370558 | ENST00000234701 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| Frame-shift | ENST00000370558 | ENST00000394711 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| intron-3CDS | ENST00000535010 | ENST00000234701 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| intron-3CDS | ENST00000535010 | ENST00000394711 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| In-frame | ENST00000482504 | ENST00000234701 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
| Frame-shift | ENST00000482504 | ENST00000394711 | SH3GLB1 | chr1 | 87181548 | + | CLCA1 | chr1 | 86934704 | + |
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FusionProtFeatures for SH3GLB1_CLCA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SH3GLB1 | CLCA1 |
| May be required for normal outer mitochondrial membranedynamics (PubMed:15452144). Required for coatomer-mediatedretrograde transport in certain cells (By similarity). May recruitother proteins to membranes with high curvature. May promotemembrane fusion (PubMed:11604418). Involved in activation ofcaspase-dependent apoptosis by promoting BAX/BAK1 activation(PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (Bysimilarity). Involved in caspase-independent apoptosis duringnutrition starvation and involved in the regulation of autophagy.Activates lipid kinase activity of PIK3C3 during autophagyprobably by associating with the PI3K complex II (PI3KC3-C2)(PubMed:17891140). Associated with PI3KC3-C2 during autophagy mayregulate the trafficking of ATG9A from the Golgi complex to theperipheral cytoplasm for the formation of autophagosomes byinducing Golgi membrane tubulation and fragmentation(PubMed:21068542). Involved in regulation of degradative endocytictrafficking and cytokinesis, probably in the context of PI3KC3-C2(PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells;involved in maintenance of mitochondrial morphology and promotesneuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48,ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144,ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123,ECO:0000269|PubMed:21068542}. | May be involved in mediating calcium-activated chlorideconductance. May play critical roles in goblet cell metaplasia,mucus hypersecretion, cystic fibrosis and AHR. May be involved inthe regulation of mucus production and/or secretion by gobletcells. Involved in the regulation of tissue inflammation in theinnate immune response. May play a role as a tumor suppressor.Induces MUC5AC. {ECO:0000269|PubMed:11445004,ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057,ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000370558 | + | 2 | 9 | 1_30 | 71 | 366 | Region | Note=Membrane-binding amphipathic helix |
| Hgene | SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000370558 | + | 2 | 9 | 1_37 | 71 | 366 | Region | Required for membrane binding |
| Hgene | SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000482504 | + | 2 | 11 | 1_30 | 71 | 387 | Region | Note=Membrane-binding amphipathic helix |
| Hgene | SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000482504 | + | 2 | 11 | 1_37 | 71 | 387 | Region | Required for membrane binding |
| Tgene | >CLCA1 | chr1:87181548 | chr1:86934704 | ENST00000234701 | + | 0 | 15 | 306_475 | -117 | 915 | Domain | VWFA |
| Tgene | >CLCA1 | chr1:87181548 | chr1:86934704 | ENST00000394711 | + | 0 | 14 | 306_475 | -43 | 915 | Domain | VWFA |
| Tgene | >CLCA1 | chr1:87181548 | chr1:86934704 | ENST00000234701 | + | 0 | 15 | 46_199 | -117 | 915 | Region | Metalloprotease domain |
| Tgene | >CLCA1 | chr1:87181548 | chr1:86934704 | ENST00000394711 | + | 0 | 14 | 46_199 | -43 | 915 | Region | Metalloprotease domain |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000370558 | + | 2 | 9 | 155_195 | 71 | 366 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000482504 | + | 2 | 11 | 155_195 | 71 | 387 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000535010 | + | 1 | 8 | 155_195 | -147 | 266 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000370558 | + | 2 | 9 | 27_261 | 71 | 366 | Domain | BAR |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000370558 | + | 2 | 9 | 305_365 | 71 | 366 | Domain | SH3 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000482504 | + | 2 | 11 | 27_261 | 71 | 387 | Domain | BAR |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000482504 | + | 2 | 11 | 305_365 | 71 | 387 | Domain | SH3 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000535010 | + | 1 | 8 | 27_261 | -147 | 266 | Domain | BAR |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000535010 | + | 1 | 8 | 305_365 | -147 | 266 | Domain | SH3 |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000535010 | + | 1 | 8 | 1_30 | -147 | 266 | Region | Note=Membrane-binding amphipathic helix |
| Hgene | >SH3GLB1 | chr1:87181548 | chr1:86934704 | ENST00000535010 | + | 1 | 8 | 1_37 | -147 | 266 | Region | Required for membrane binding |
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FusionGeneSequence for SH3GLB1_CLCA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SH3GLB1_ENST00000370558_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_1073aa MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPTSGTAEGRWKYLQVRNLRL RYCYHSPIEDKSNSKTHQVRGLKTCDKPLPISWKRVSIFSYLYIYNGKERHLRNPHFPKREITGRCTAMGPFKSSVFILILHLLEGALSN SLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPP GNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQG GSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQP PNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGG TSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAF GALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVG TWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADAT KDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDV PNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENI >In-frame_SH3GLB1_ENST00000482504_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_1073aa MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPTSGTAEGRWKYLQVRNLRL RYCYHSPIEDKSNSKTHQVRGLKTCDKPLPISWKRVSIFSYLYIYNGKERHLRNPHFPKREITGRCTAMGPFKSSVFILILHLLEGALSN SLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPP GNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQG GSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQP PNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGG TSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAF GALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVG TWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADAT KDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDV PNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SH3GLB1_ENST00000370558_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_3219nt ATGAATATCATGGACTTCAACGTGAAGAAGCTGGCGGCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAAAGCTT GGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTAGAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAATAATG AAACAAACTGAAGTGTTATTGCAGCCAAATCCAACATCTGGCACAGCTGAAGGCAGATGGAAATATTTACAAGTACGCAATTTGAGACTA AGATATTGTTATCATTCTCCTATTGAAGACAAGAGCAATAGTAAAACACATCAGGTCAGGGGGTTAAAGACCTGTGATAAACCACTTCCG ATAAGTTGGAAACGTGTGTCTATATTTTCATATCTGTATATATATAATGGTAAAGAAAGACACCTTCGTAACCCGCATTTTCCAAAGAGA GAAATCACAGGGAGATGTACAGCAATGGGGCCATTTAAGAGTTCTGTGTTCATCTTGATTCTTCACCTTCTAGAAGGGGCCCTGAGTAAT TCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAACAA ATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATTCCT GAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCA GGTAATGATGAACCCTACACTGAGCAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGAAAA AAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAATGAT GAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAGGGA GGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACG GAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAACAAG CAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAGCCA CCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAACCGC CTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCT GCCCATGTACAAAATGAACTCATACAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGAGGG ACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACGGAT GGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCAGCT CAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCTTTT GGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGGATG AATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGG GATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTTGGC ACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACA GTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATTCTC AGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCTACT AAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTTAAC GCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCACCA AGACCTGAAATTAATAAGGATGATGTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGATGTC CCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTGACT TGGACAGCTCCTGGGGATGATTATGACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGACAAG TTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATT ACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGAGTA TCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGCACC >In-frame_SH3GLB1_ENST00000482504_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_3219nt ATGAATATCATGGACTTCAACGTGAAGAAGCTGGCGGCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAAAGCTT GGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTAGAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAATAATG AAACAAACTGAAGTGTTATTGCAGCCAAATCCAACATCTGGCACAGCTGAAGGCAGATGGAAATATTTACAAGTACGCAATTTGAGACTA AGATATTGTTATCATTCTCCTATTGAAGACAAGAGCAATAGTAAAACACATCAGGTCAGGGGGTTAAAGACCTGTGATAAACCACTTCCG ATAAGTTGGAAACGTGTGTCTATATTTTCATATCTGTATATATATAATGGTAAAGAAAGACACCTTCGTAACCCGCATTTTCCAAAGAGA GAAATCACAGGGAGATGTACAGCAATGGGGCCATTTAAGAGTTCTGTGTTCATCTTGATTCTTCACCTTCTAGAAGGGGCCCTGAGTAAT TCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAACAA ATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATTCCT GAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCA GGTAATGATGAACCCTACACTGAGCAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGAAAA AAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAATGAT GAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAGGGA GGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACG GAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAACAAG CAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAGCCA CCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAACCGC CTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCT GCCCATGTACAAAATGAACTCATACAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGAGGG ACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACGGAT GGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCAGCT CAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCTTTT GGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGGATG AATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGG GATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTTGGC ACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACA GTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATTCTC AGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCTACT AAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTTAAC GCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCACCA AGACCTGAAATTAATAAGGATGATGTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGATGTC CCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTGACT TGGACAGCTCCTGGGGATGATTATGACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGACAAG TTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATT ACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGAGTA TCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGCACC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SH3GLB1_ENST00000370558_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_3447nt GTTTTTCCCTTGGGACCCGGGTCCACACGGCGGGGTCGCCCGTCCATCTCCGGCTCGCCCGCGGGGCCCATCGTCGACGTTAGCGGCCGT TCTCCGAGCCGACTGACCCATCCTTGGCGCTGCCGCCGCGCGCTTGTTCTCCTCCCTCGCCCCGCCTTCATCCTCCCCGTTCACGGAAAC GACAGCTGCGGCTGCGGGGCTGGCGCCGCCTCCCTCCACCTACCACGTCTGCCCTCGCCGCTCTAGCCCTGCGCCCCAGCCCGGCCGCGG CACCTCCGCCTCGCCGCCGCTAGGTCGGCCGGCTCCGCCCGGCTGCCGCCTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCG GCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAAAGCTTGGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTA GAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAATAATGAAACAAACTGAAGTGTTATTGCAGCCAAATCCAAAG GGGCCCTGAGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAA CACTCATTCAACAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTG CCATTTTGATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTG AGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATT TCATTGCAGGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACG AGTACAATAATGATGAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAA AGAAGTGTCAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCC AATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAG AAGCTCCAAACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTA TGACAACACAGCCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGG CGACTGGTAACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGA CATTTGACAGTGCTGCCCATGTACAAAATGAACTCATACAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAG CAGCTTCAGGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTG TGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGG GGCCCTCTGCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCC TCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGA ACAGCCAGTGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCC AAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCA TTGCTAAGGTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCC TGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAG CCTCCCCAATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAG GTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTC TGGGAGGAGTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATAC AATGGAATCCACCAAGACCTGAAATTAATAAGGATGATGTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTG TGGCTTCTGATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTC TCATTAATCTGACTTGGACAGCTCCTGGGGATGATTATGACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTG ATCTCAGAGACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTA AACCAGAAAACATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCA ACATTGCACGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTC ATATCAACAGCACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAAGTGGATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAA TTTTTGTCAGATAAATAAAATAAATCATTCATCCTTTTTTTTGATTATAAAATTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGA TATACTAAATGTATATAGTACATTTATACTAAATGTATTCCTGTAGGGGGCGATATACTAAATGTATTTTAGACTTCCTGTAGGGGGCGA >In-frame_SH3GLB1_ENST00000482504_chr1_87181548_+_CLCA1_ENST00000234701_chr1_86934704_+_3128nt CTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCGGCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAA AGCTTGGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTAGAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAA TAATGAAACAAACTGAAGTGTTATTGCAGCCAAATCCAAAGGGGCCCTGAGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGG CATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAACAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCT GCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACC AAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAA CTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATT TGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAATGATGAGAAATTCTACTTATCCAATGGAAGAATACAAGC AGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAA AGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGA TTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGA AGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAGCCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACA AAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCT GCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCTGCCCATGTACAAAATGAACTCATACAGATAAACAG TGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTAC TGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGA GGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGG TTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCA GCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAA GGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGT GGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAAC CTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATT CCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAA TGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAAC TTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGG AGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCACCAAGACCTGAAATTAATAAGGATGATGTTCAACACAA GCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGG CCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTGACTTGGACAGCTCCTGGGGATGATTATGACCATGGAAC AGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCT CATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTAT TCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGAC ACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGCACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAA GTGGATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAATTTTTGTCAGATAAATAAAATAAATCATTCATCCTTTTTTTTGATTATA AAATTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGATATACTAAATGTATATAGTACATTTATACTAAATGTATTCCTGTAGGGG |
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FusionGenePPI for SH3GLB1_CLCA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SH3GLB1 | SH3KBP1, BAX, SH3GLB2, ARHGAP17, USP7, CUL2, KLHDC10, ITCH, ADAM15, APP, GADD45A, GADD45G, AARSD1, ARPC1A, ARPC4, CALR, KIAA1279, NSUN2, PRKACA, RANGAP1, ACTR2, ACTR3, AGFG1, ARPC2, CALU, HSPBP1, LAP3, P3H1, LPP, NIF3L1, PPP2R5D, RPA2, SH3GL1, THG1L, TPD52L2, TPRKB, PSMA1, TFIP11, SH3GLB1, ZNF576, CMTM5, FUNDC1, SERPINB3, CCDC22, COMMD3, DSCR3, FLAD1, RPRD1A, UBE2I, USP14, WARS, XPO7, CEP128, CDK2AP1, HTATIP2, RAB5A, ACSL4, CDH1, FCGRT, SERPINB13, SCYL2, CDK5, PRCC, SEPT7, DIS3, CHORDC1, SUB1, SARNP, COPZ1, GORASP2, SEPT11, DRG1 | CLCA1 | KCNMB1, CFTR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SH3GLB1_CLCA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SH3GLB1_CLCA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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