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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33643

FusionGeneSummary for SH3D19_INPP4B

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3D19_INPP4B
Fusion gene ID: 33643
HgeneTgene
Gene symbol

SH3D19

INPP4B

Gene ID

152503

8821

Gene nameSH3 domain containing 19inositol polyphosphate-4-phosphatase type II B
SynonymsEBP|EVE1|Eve-1|Kryn|SH3P19-
Cytomap

4q31.3

4q31.21

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing protein 19ADAM-binding protein Eve-1EEN-binding proteinSH3 domain protein D19type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa
Modification date2018052220180523
UniProtAcc

Q5HYK7

O15327

Ensembl transtripts involved in fusion geneENST00000409598, ENST00000424281, 
ENST00000304527, ENST00000455740, 
ENST00000409252, ENST00000514152, 
ENST00000427414, ENST00000604030, 
ENST00000513000, ENST00000509777, 
ENST00000262992, ENST00000308502, 
ENST00000508116, ENST00000507861, 
ENST00000506217, ENST00000508084, 
Fusion gene scores* DoF score4 X 3 X 3=369 X 7 X 6=378
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3D19 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1ZD-06ASH3D19chr4

152147199

-INPP4Bchr4

143352538

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000409598ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409598ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409598ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409598ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409598ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409598ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000409598ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000409598ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000424281ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000424281ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000424281ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000304527ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000304527ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000304527ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000455740ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000455740ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000455740ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000409252ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000409252ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000409252ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000514152ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000514152ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000514152ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-5UTRENST00000427414ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-intronENST00000427414ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
intron-intronENST00000427414ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000513000SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000509777SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000262992SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000308502SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000508116SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-5UTRENST00000604030ENST00000507861SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000604030ENST00000506217SH3D19chr4

152147199

-INPP4Bchr4

143352538

-
5UTR-intronENST00000604030ENST00000508084SH3D19chr4

152147199

-INPP4Bchr4

143352538

-

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FusionProtFeatures for SH3D19_INPP4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3D19

Q5HYK7

INPP4B

O15327

May play a role in regulating A disintegrin andmetalloproteases (ADAMs) in the signaling of EGFR-ligand shedding.May be involved in suppression of Ras-induced cellulartransformation and Ras-mediated activation of ELK1. Plays a rolein the regulation of cell morphology and cytoskeletalorganization. {ECO:0000269|PubMed:14551139,ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3D19_INPP4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3D19_INPP4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SH3D19SH3YL1, GRB2, CDC42, ELAVL1, SH3KBP1, NPHP1, CDH1INPP4BELAVL1, PYCARD, ZNF131


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3D19_INPP4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SH3D19_INPP4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource