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Fusion gene ID: 33642 |
FusionGeneSummary for SH3D19_ACSL4 |
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Fusion gene information | Fusion gene name: SH3D19_ACSL4 | Fusion gene ID: 33642 | Hgene | Tgene | Gene symbol | SH3D19 | ACSL4 | Gene ID | 152503 | 2182 |
Gene name | SH3 domain containing 19 | acyl-CoA synthetase long chain family member 4 | |
Synonyms | EBP|EVE1|Eve-1|Kryn|SH3P19 | ACS4|FACL4|LACS4|MRX63|MRX68 | |
Cytomap | 4q31.3 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | SH3 domain-containing protein 19ADAM-binding protein Eve-1EEN-binding proteinSH3 domain protein D19 | long-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4 | |
Modification date | 20180522 | 20180527 | |
UniProtAcc | Q5HYK7 | O60488 | |
Ensembl transtripts involved in fusion gene | ENST00000409598, ENST00000424281, ENST00000304527, ENST00000455740, ENST00000409252, ENST00000514152, ENST00000427414, ENST00000604030, | ENST00000469796, ENST00000340800, ENST00000348502, ENST00000504383, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 3 X 3 X 1=9 |
# samples | 4 | 3 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SH3D19 [Title/Abstract] AND ACSL4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACSL4 | GO:0006629 | lipid metabolic process | 9598324 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI038265 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000409598 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409598 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409598 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409598 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000424281 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000424281 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000424281 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000424281 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000304527 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000304527 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000304527 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000304527 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000455740 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000455740 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000455740 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000455740 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409252 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409252 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409252 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000409252 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000514152 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000514152 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000514152 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000514152 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000427414 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000427414 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000427414 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000427414 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000604030 | ENST00000469796 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000604030 | ENST00000340800 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000604030 | ENST00000348502 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
intron-intron | ENST00000604030 | ENST00000504383 | SH3D19 | chr4 | 152075164 | + | ACSL4 | chrX | 108960709 | + |
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FusionProtFeatures for SH3D19_ACSL4 |
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Hgene | Tgene |
SH3D19 | ACSL4 |
May play a role in regulating A disintegrin andmetalloproteases (ADAMs) in the signaling of EGFR-ligand shedding.May be involved in suppression of Ras-induced cellulartransformation and Ras-mediated activation of ELK1. Plays a rolein the regulation of cell morphology and cytoskeletalorganization. {ECO:0000269|PubMed:14551139,ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. | Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SH3D19_ACSL4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SH3D19_ACSL4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SH3D19_ACSL4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ACSL4 | O60488 | DB00412 | Rosiglitazone | Long-chain-fatty-acid--CoA ligase 4 | small molecule | approved|investigational |
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RelatedDiseases for SH3D19_ACSL4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ACSL4 | C0011581 | Depressive disorder | 1 | CTD_human |
Tgene | ACSL4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ACSL4 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | ACSL4 | C0041834 | Erythema | 1 | CTD_human |
Tgene | ACSL4 | C0993582 | Arthritis, Experimental | 1 | CTD_human |
Tgene | ACSL4 | C1845672 | Mental Retardation, X-Linked 63 | 1 | CTD_human;UNIPROT |
Tgene | ACSL4 | C2239176 | Liver carcinoma | 1 | CTD_human |