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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33642

FusionGeneSummary for SH3D19_ACSL4

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3D19_ACSL4
Fusion gene ID: 33642
HgeneTgene
Gene symbol

SH3D19

ACSL4

Gene ID

152503

2182

Gene nameSH3 domain containing 19acyl-CoA synthetase long chain family member 4
SynonymsEBP|EVE1|Eve-1|Kryn|SH3P19ACS4|FACL4|LACS4|MRX63|MRX68
Cytomap

4q31.3

Xq23

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing protein 19ADAM-binding protein Eve-1EEN-binding proteinSH3 domain protein D19long-chain-fatty-acid--CoA ligase 4LACS 4acyl-CoA synthetase 4fatty-acid-Coenzyme A ligase, long-chain 4lignoceroyl-CoA synthaselong-chain acyl-CoA synthetase 4long-chain fatty-acid-Coenzyme A ligase 4
Modification date2018052220180527
UniProtAcc

Q5HYK7

O60488

Ensembl transtripts involved in fusion geneENST00000409598, ENST00000424281, 
ENST00000304527, ENST00000455740, 
ENST00000409252, ENST00000514152, 
ENST00000427414, ENST00000604030, 
ENST00000469796, ENST00000340800, 
ENST00000348502, ENST00000504383, 
Fusion gene scores* DoF score4 X 3 X 3=363 X 3 X 1=9
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SH3D19 [Title/Abstract] AND ACSL4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACSL4

GO:0006629

lipid metabolic process

9598324


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI038265SH3D19chr4

152075164

+ACSL4chrX

108960709

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000409598ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409598ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409598ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409598ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000424281ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000424281ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000424281ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000424281ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000304527ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000304527ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000304527ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000304527ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000455740ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000455740ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000455740ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000455740ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409252ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409252ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409252ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000409252ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000514152ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000514152ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000514152ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000514152ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000427414ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000427414ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000427414ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000427414ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000604030ENST00000469796SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000604030ENST00000340800SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000604030ENST00000348502SH3D19chr4

152075164

+ACSL4chrX

108960709

+
intron-intronENST00000604030ENST00000504383SH3D19chr4

152075164

+ACSL4chrX

108960709

+

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FusionProtFeatures for SH3D19_ACSL4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3D19

Q5HYK7

ACSL4

O60488

May play a role in regulating A disintegrin andmetalloproteases (ADAMs) in the signaling of EGFR-ligand shedding.May be involved in suppression of Ras-induced cellulartransformation and Ras-mediated activation of ELK1. Plays a rolein the regulation of cell morphology and cytoskeletalorganization. {ECO:0000269|PubMed:14551139,ECO:0000269|PubMed:15280379, ECO:0000269|PubMed:21834987}. Activation of long-chain fatty acids for both synthesisof cellular lipids, and degradation via beta-oxidation.Preferentially uses arachidonate and eicosapentaenoate assubstrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3D19_ACSL4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SH3D19_ACSL4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH3D19_ACSL4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneACSL4O60488DB00412RosiglitazoneLong-chain-fatty-acid--CoA ligase 4small moleculeapproved|investigational

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RelatedDiseases for SH3D19_ACSL4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneACSL4C0011581Depressive disorder1CTD_human
TgeneACSL4C0033578Prostatic Neoplasms1CTD_human
TgeneACSL4C0036341Schizophrenia1PSYGENET
TgeneACSL4C0041834Erythema1CTD_human
TgeneACSL4C0993582Arthritis, Experimental1CTD_human
TgeneACSL4C1845672Mental Retardation, X-Linked 631CTD_human;UNIPROT
TgeneACSL4C2239176Liver carcinoma1CTD_human