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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33632

FusionGeneSummary for SH3BP2_SH3BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3BP2_SH3BP2
Fusion gene ID: 33632
HgeneTgene
Gene symbol

SH3BP2

SH3BP2

Gene ID

6452

6452

Gene nameSH3 domain binding protein 2SH3 domain binding protein 2
Synonyms3BP-2|3BP2|CRBM|CRPM|RES4-233BP-2|3BP2|CRBM|CRPM|RES4-23
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-binding protein 2Abl-SH3 binding protein 2TNFAIP3 interacting protein 2SH3 domain-binding protein 2Abl-SH3 binding protein 2TNFAIP3 interacting protein 2
Modification date2018052320180523
UniProtAcc

P78314

P78314

Ensembl transtripts involved in fusion geneENST00000389838, ENST00000452765, 
ENST00000442312, ENST00000435136, 
ENST00000511747, ENST00000503393, 
ENST00000356331, ENST00000515183, 
ENST00000389838, ENST00000452765, 
ENST00000442312, ENST00000435136, 
ENST00000511747, ENST00000503393, 
ENST00000356331, ENST00000515183, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 3 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SH3BP2 [Title/Abstract] AND SH3BP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI009363SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000389838ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
intron-intronENST00000389838ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000452765ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000442312ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000435136ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000511747ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000503393ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
5CDS-intronENST00000356331ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000389838SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000452765SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000442312SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000435136SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000511747SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000503393SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000356331SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+
3UTR-intronENST00000515183ENST00000515183SH3BP2chr4

2829032

-SH3BP2chr4

2826796

+

Top

FusionProtFeatures for SH3BP2_SH3BP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH3BP2

P78314

SH3BP2

P78314


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SH3BP2_SH3BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SH3BP2_SH3BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SH3BP2_SH3BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SH3BP2_SH3BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH3BP2C0008029Cherubism3CTD_human;ORPHANET;UNIPROT
TgeneSH3BP2C0008029Cherubism3CTD_human;ORPHANET;UNIPROT