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Fusion gene ID: 33611 |
FusionGeneSummary for SH2B3_RBM19 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SH2B3_RBM19 | Fusion gene ID: 33611 | Hgene | Tgene | Gene symbol | SH2B3 | RBM19 | Gene ID | 10019 | 9904 |
| Gene name | SH2B adaptor protein 3 | RNA binding motif protein 19 | |
| Synonyms | IDDM20|LNK | Mrd1 | |
| Cytomap | 12q24.12 | 12q24.13-q24.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SH2B adapter protein 3lymphocyte-specific adapter protein Lnksignal transduction protein Lnk | probable RNA-binding protein 19 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UQQ2 | Q9Y4C8 | |
| Ensembl transtripts involved in fusion gene | ENST00000341259, ENST00000538307, | ENST00000545145, ENST00000392561, ENST00000261741, ENST00000553232, | |
| Fusion gene scores | * DoF score | 6 X 5 X 4=120 | 6 X 4 X 2=48 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/120*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SH2B3 [Title/Abstract] AND RBM19 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-AB37-01A | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000341259 | ENST00000545145 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| In-frame | ENST00000341259 | ENST00000392561 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| In-frame | ENST00000341259 | ENST00000261741 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| 5CDS-intron | ENST00000341259 | ENST00000553232 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| intron-3CDS | ENST00000538307 | ENST00000545145 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| intron-3CDS | ENST00000538307 | ENST00000392561 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| intron-3CDS | ENST00000538307 | ENST00000261741 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
| intron-intron | ENST00000538307 | ENST00000553232 | SH2B3 | chr12 | 111856681 | + | RBM19 | chr12 | 114374941 | - |
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FusionProtFeatures for SH2B3_RBM19 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SH2B3 | RBM19 |
| Links T-cell receptor activation signal to phospholipaseC-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. | Plays a role in embryo pre-implantation development.{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 714_725 | 646 | 961 | Compositional bias | Note=Poly-Glu |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 714_725 | 646 | 1094 | Compositional bias | Note=Poly-Glu |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 714_725 | 646 | 1381 | Compositional bias | Note=Poly-Glu |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 730_811 | 646 | 961 | Domain | RRM 5 |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 832_912 | 646 | 961 | Domain | RRM 6 |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 730_811 | 646 | 1094 | Domain | RRM 5 |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 832_912 | 646 | 1094 | Domain | RRM 6 |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 730_811 | 646 | 1381 | Domain | RRM 5 |
| Tgene | >RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 832_912 | 646 | 1381 | Domain | RRM 6 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SH2B3 | chr12:111856681 | chr12:114374941 | ENST00000341259 | + | 2 | 8 | 194_307 | 244 | 576 | Domain | Note=PH |
| Hgene | >SH2B3 | chr12:111856681 | chr12:114374941 | ENST00000341259 | + | 2 | 8 | 364_462 | 244 | 576 | Domain | SH2 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 225_232 | 646 | 961 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 391_396 | 646 | 961 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 225_232 | 646 | 1094 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 391_396 | 646 | 1094 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 225_232 | 646 | 1381 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 391_396 | 646 | 1381 | Compositional bias | Note=Poly-Glu |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 294_369 | 646 | 961 | Domain | RRM 2 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 2_79 | 646 | 961 | Domain | RRM 1 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 402_480 | 646 | 961 | Domain | RRM 3 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000261741 | - | 14 | 24 | 587_659 | 646 | 961 | Domain | RRM 4 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 294_369 | 646 | 1094 | Domain | RRM 2 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 2_79 | 646 | 1094 | Domain | RRM 1 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 402_480 | 646 | 1094 | Domain | RRM 3 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000392561 | - | 14 | 25 | 587_659 | 646 | 1094 | Domain | RRM 4 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 294_369 | 646 | 1381 | Domain | RRM 2 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 2_79 | 646 | 1381 | Domain | RRM 1 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 402_480 | 646 | 1381 | Domain | RRM 3 |
| Tgene | RBM19 | chr12:111856681 | chr12:114374941 | ENST00000545145 | - | 14 | 25 | 587_659 | 646 | 1381 | Domain | RRM 4 |
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FusionGeneSequence for SH2B3_RBM19 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_559aa MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_559aa MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_559aa MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_1677nt ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_1677nt ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_1677nt ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_3494nt CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGCTGGAGTGCAGTGGCGTGAT CTGGGCTCACCTCCCTGGTTCAAGCGATTGTCCCGCCTCAGCCTCCCAAGGCTGGGATTACAGGTATGCACCACCACGCCCGGCTAATTT TGTATTTTTCATAGAGACTGGGTTTCACCATGTAGACCAGGCTGGTCTCGAATTCCTGACCTCAAGTGATCCACCTACCTCGGCCTCCCA AAGTGTGGGGATTACGGGTGTGAGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGACAGGGTTTCACCATGTGGGCCAGGCTGGT CTTGAACTCCCAACCTCAAGTGATCCACCCACCTTGTTCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTTCCT AACCCTTTCAACTGGGGGGTCTCAAGTGGGTGAGGACTCCATGGCCACGGCAGCAGAACTGTCTCTTCTGAAAACCAGACTCCGGGGCCC CTGGGTCAGCACCTCTAGGTCATTCCACAGACTTACACAGTTTAAAGAAAGAGCCAGCGAACATGGGGTGATCCTGGGGTGCCACTGGGA TCCCAAGCCAGGCCCGGAGGTCTGCCTGTTTCGTCCCCAGAAACTTGAGCTGGCATCCTCCGCTGGTTTGCACTGGGCACGGGGACTGGA GAGCCACCAGGCCACTGAGCGCAGCATGCTATCACTTCTCAGGAAGTTGTGAGGGTGAGGAGAATAGCCGGGCCCACTCTGCAGAGGGGA GGAACAGGCACAGGCTAGAGGCACGGGCTGATAGAGTGAGTCCTCTCCCTCATTCATTCATTCATTCATTCATTCATCCATCAGACACCT GCTGGGCATCTGCTGTGTGCGAGACACTGTGCTGGGTGCCCCAGACACAAGACAGAAACTCGGGTCGCTCTGTGTGCCTCCACACTGGCC TTCCCTGCTGCGTGGACGCAGGCTCTGTCTCCTAGGCTTTAAGCCCCATGCATCAGGTGGAAGACAATTTCCAGCAGCCTCTGCCCGCTT GTTTTTCCTCCTCTCCTTTTCCTGCCGCCTTGGTCTTTTTTGTCTTTTGTGCAGGGCCGTCTCTCGCAGCGCCCGTCTGTGCTCCGCAGC GTCTAGGAAAGGATTAGTGTGAGCAGAGCACGCAGGCTTTGGTGAACAGAGCCGAGCTTGGTTTCAACATCTAATTCAATTTGTTCTGCC GAGATTGAAATATGAAATGGTTGCCAGTCAAACGTTCAAAGGACGGGGAAGGGAGAGTGAGCGCATGCTGAAATTTAAATTTTAATGAAA ATGACTTTAACCCTTTGGTACACCTTGCAAAATGTAACCCATCCTCCCATCCTGTGAAAGCGGCCTCTCGGGTTAGAGCTTTTCCACCCA >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_2639nt CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGGCTGCTGAGCTAGAATTCCC ACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGTCACTTGGGACCACGAGCCCTGGTTC AGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTCCCTGGCTGAGCTGAATGATGTCACT CATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTGGCCAGCAGCATCCCCAGGCTTCTCT CAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCCAGCACCAGGCAGAGGGCAAGACGGA GAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGAGGTGCGACCTCAGACTAATGACATC CTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGACAGTGCCAGAATTAAGTGAGTCAAGC >In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_3201nt CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGTGTGTGGCTCCGGGGCCCTG GGGACCGGGACAGCCGCTCCAGCTTCTGCACTCACCACCATGTGGGCTGGGGGGCGGGGCGGGGAGCGGCAGGCGGCCCCACCCTGCACT GGTCCAAGGTCGGAGGAGACAGGGGATGAGGAAGGCCTCAGGCCACTGCCCAGCGGCCCAGGCATCCTGGGTTTCACCAGTGACGCGTTC TAGCAGACACTGACTGCGCACCTGCTCTGTAGCAGACACGGAAGAGTCCAAGGGAGCAGCCACGTTAGGAAGAGAGACTTGGGAACAGCT ACACAGGGAGCTAGAACCCCTGCTCCCCCTGTCCCCACCCCAGGAGAGTAAGGGGACGAGGGCCAGCTCTCTGGCATCAGGCTGCTTGGA CATGAAACCCCGTCTCCAAGCTCAAGCTGGGAGACCCTGGCCCAGTTTCCTTATCTCCTTGGGCCCAGCCTTCCCCTTGCTAGCTAGTTC TTACTTCATAAGGTTTTAGAGAGAAATAAACGCAGTAATGCATGAAGAGTGCCGGGCATGGTGCTGAGCCCTGTTCCTGCTCTCCCTCCA GGGCTGCTGAGCTAGAATTCCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGTCAC TTGGGACCACGAGCCCTGGTTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTCCCT GGCTGAGCTGAATGATGTCACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTGGCC AGCAGCATCCCCAGGCTTCTCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCCAGC ACCAGGCAGAGGGCAAGACGGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGAGGT GCGACCTCAGACTAATGACATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGACAGT |
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FusionGenePPI for SH2B3_RBM19 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SH2B3 | LCK, GRB2, PLCG1, FLNA, ELAVL1, EGFR, ERBB2, ERBB3, TENC1 | RBM19 | FTSJ3, PTPN12, NXF1, FBXW11, HIST1H1A, NOL12, NIFK, ZC3H3, RPS8, BYSL, DDX27, DHX37, FBL, GRWD1, NOL10, RRP12, UTP18, TSR1, UTP15, IFI16, SRPK2, MEX3C, HIST1H1E, RPS14, HIST1H1T, GPATCH4, ZC3HAV1, ZCRB1, FGF3, FGF8, ZNF2, RPL7, RPL18, CDX1, H2AFY2, H2AFX, ZBTB48, RRS1, FOXA1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SH2B3_RBM19 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | SH2B3 | Q9UQQ2 | DB06589 | Pazopanib | SH2B adapter protein 3 | small molecule | approved |
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RelatedDiseases for SH2B3_RBM19 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SH2B3 | C0021368 | Inflammation | 1 | CTD_human |
| Hgene | SH2B3 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
| Hgene | SH2B3 | C0027051 | Myocardial Infarction | 1 | CTD_human;HPO |
| Hgene | SH2B3 | C0042900 | Vitiligo | 1 | CTD_human |
| Hgene | SH2B3 | C0349639 | Juvenile Myelomonocytic Leukemia | 1 | CTD_human |
| Hgene | SH2B3 | C1956346 | Coronary Artery Disease | 1 | CTD_human |
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