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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33611

FusionGeneSummary for SH2B3_RBM19

check button Fusion gene summary
Fusion gene informationFusion gene name: SH2B3_RBM19
Fusion gene ID: 33611
HgeneTgene
Gene symbol

SH2B3

RBM19

Gene ID

10019

9904

Gene nameSH2B adaptor protein 3RNA binding motif protein 19
SynonymsIDDM20|LNKMrd1
Cytomap

12q24.12

12q24.13-q24.21

Type of geneprotein-codingprotein-coding
DescriptionSH2B adapter protein 3lymphocyte-specific adapter protein Lnksignal transduction protein Lnkprobable RNA-binding protein 19
Modification date2018052320180523
UniProtAcc

Q9UQQ2

Q9Y4C8

Ensembl transtripts involved in fusion geneENST00000341259, ENST00000538307, 
ENST00000545145, ENST00000392561, 
ENST00000261741, ENST00000553232, 
Fusion gene scores* DoF score6 X 5 X 4=1206 X 4 X 2=48
# samples 84
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH2B3 [Title/Abstract] AND RBM19 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-AB37-01ASH2B3chr12

111856681

+RBM19chr12

114374941

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000341259ENST00000545145SH2B3chr12

111856681

+RBM19chr12

114374941

-
In-frameENST00000341259ENST00000392561SH2B3chr12

111856681

+RBM19chr12

114374941

-
In-frameENST00000341259ENST00000261741SH2B3chr12

111856681

+RBM19chr12

114374941

-
5CDS-intronENST00000341259ENST00000553232SH2B3chr12

111856681

+RBM19chr12

114374941

-
intron-3CDSENST00000538307ENST00000545145SH2B3chr12

111856681

+RBM19chr12

114374941

-
intron-3CDSENST00000538307ENST00000392561SH2B3chr12

111856681

+RBM19chr12

114374941

-
intron-3CDSENST00000538307ENST00000261741SH2B3chr12

111856681

+RBM19chr12

114374941

-
intron-intronENST00000538307ENST00000553232SH2B3chr12

111856681

+RBM19chr12

114374941

-

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FusionProtFeatures for SH2B3_RBM19


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SH2B3

Q9UQQ2

RBM19

Q9Y4C8

Links T-cell receptor activation signal to phospholipaseC-gamma-1, GRB2 and phosphatidylinositol 3-kinase. {ECO:0000250}. Plays a role in embryo pre-implantation development.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424714_725646961Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425714_7256461094Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425714_7256461381Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424730_811646961DomainRRM 5
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424832_912646961DomainRRM 6
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425730_8116461094DomainRRM 5
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425832_9126461094DomainRRM 6
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425730_8116461381DomainRRM 5
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425832_9126461381DomainRRM 6

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH2B3chr12:111856681chr12:114374941ENST00000341259+28194_307244576DomainNote=PH
HgeneSH2B3chr12:111856681chr12:114374941ENST00000341259+28364_462244576DomainSH2
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424225_232646961Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424391_396646961Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425225_2326461094Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425391_3966461094Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425225_2326461381Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425391_3966461381Compositional biasNote=Poly-Glu
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424294_369646961DomainRRM 2
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-14242_79646961DomainRRM 1
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424402_480646961DomainRRM 3
TgeneRBM19chr12:111856681chr12:114374941ENST00000261741-1424587_659646961DomainRRM 4
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425294_3696461094DomainRRM 2
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-14252_796461094DomainRRM 1
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425402_4806461094DomainRRM 3
TgeneRBM19chr12:111856681chr12:114374941ENST00000392561-1425587_6596461094DomainRRM 4
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425294_3696461381DomainRRM 2
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-14252_796461381DomainRRM 1
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425402_4806461381DomainRRM 3
TgeneRBM19chr12:111856681chr12:114374941ENST00000545145-1425587_6596461381DomainRRM 4


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FusionGeneSequence for SH2B3_RBM19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_559aa
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR
DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL
QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS
KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF
STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_559aa
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR
DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL
QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS
KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF
STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_559aa
MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELVSLQFTDLFQRYFCREVRDGRAPGRDYR
DTGRGPPAKAEASPEPGPGPAAPGLPKARSSEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELFDPPKFHHVPLYLEWAPVGVFSSTAPQKKKL
QDTPSEPMEKDPAEPETVPDGETPEDENPTEEGADNSSAKMEEEEEEEEEEEESLPGCTLFIKNLNFDTTEEKLKEVFSKVGTVKSCSIS
KKKNKAGVLLSMGFGFVEYRKPEQAQKALKQLQGHVVDGHKLEVRISERATKPAVTLARKKQVPRKQTTSKILVRNIPFQAHSREIRELF
STFGELKTVRLPKKMTGTGTHRGFGFVDFLTKQDAKRAFNALCHSTHLYGRRLVLEWADSEVTLQALRRKTAAHFHEPPKKKRSVVLDEI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_1677nt
ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT
GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC
GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG
GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC
TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG
GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG
AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC
ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC
GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC
CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA
GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG
TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC
AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG
CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG
AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC
AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC
ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_1677nt
ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT
GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC
GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG
GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC
TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG
GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG
AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC
ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC
GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC
CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA
GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG
TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC
AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG
CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG
AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC
AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC
ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_1677nt
ATGAACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGT
GAGTTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCC
GAGCTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGG
GACACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGC
TCTGAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCG
GCCGGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAG
AAGTTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCC
ATGGACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTC
GACCCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTC
CAAGACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACA
GAGGAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTG
TTTATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCC
AAGAAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAG
CAGCTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAG
AAACAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTC
AGCACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTC
ACCAAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCC
GAGGTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000545145_chr12_114374941_-_3494nt
CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG
CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC
TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT
CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG
AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG
TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG
CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC
ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT
GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC
GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG
TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG
GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC
CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA
GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG
GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT
ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG
AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG
CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA
CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC
ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC
AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG
GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG
GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGCTGGAGTGCAGTGGCGTGAT
CTGGGCTCACCTCCCTGGTTCAAGCGATTGTCCCGCCTCAGCCTCCCAAGGCTGGGATTACAGGTATGCACCACCACGCCCGGCTAATTT
TGTATTTTTCATAGAGACTGGGTTTCACCATGTAGACCAGGCTGGTCTCGAATTCCTGACCTCAAGTGATCCACCTACCTCGGCCTCCCA
AAGTGTGGGGATTACGGGTGTGAGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGACAGGGTTTCACCATGTGGGCCAGGCTGGT
CTTGAACTCCCAACCTCAAGTGATCCACCCACCTTGTTCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACCATGCCCAGCCTGTTCCT
AACCCTTTCAACTGGGGGGTCTCAAGTGGGTGAGGACTCCATGGCCACGGCAGCAGAACTGTCTCTTCTGAAAACCAGACTCCGGGGCCC
CTGGGTCAGCACCTCTAGGTCATTCCACAGACTTACACAGTTTAAAGAAAGAGCCAGCGAACATGGGGTGATCCTGGGGTGCCACTGGGA
TCCCAAGCCAGGCCCGGAGGTCTGCCTGTTTCGTCCCCAGAAACTTGAGCTGGCATCCTCCGCTGGTTTGCACTGGGCACGGGGACTGGA
GAGCCACCAGGCCACTGAGCGCAGCATGCTATCACTTCTCAGGAAGTTGTGAGGGTGAGGAGAATAGCCGGGCCCACTCTGCAGAGGGGA
GGAACAGGCACAGGCTAGAGGCACGGGCTGATAGAGTGAGTCCTCTCCCTCATTCATTCATTCATTCATTCATTCATCCATCAGACACCT
GCTGGGCATCTGCTGTGTGCGAGACACTGTGCTGGGTGCCCCAGACACAAGACAGAAACTCGGGTCGCTCTGTGTGCCTCCACACTGGCC
TTCCCTGCTGCGTGGACGCAGGCTCTGTCTCCTAGGCTTTAAGCCCCATGCATCAGGTGGAAGACAATTTCCAGCAGCCTCTGCCCGCTT
GTTTTTCCTCCTCTCCTTTTCCTGCCGCCTTGGTCTTTTTTGTCTTTTGTGCAGGGCCGTCTCTCGCAGCGCCCGTCTGTGCTCCGCAGC
GTCTAGGAAAGGATTAGTGTGAGCAGAGCACGCAGGCTTTGGTGAACAGAGCCGAGCTTGGTTTCAACATCTAATTCAATTTGTTCTGCC
GAGATTGAAATATGAAATGGTTGCCAGTCAAACGTTCAAAGGACGGGGAAGGGAGAGTGAGCGCATGCTGAAATTTAAATTTTAATGAAA
ATGACTTTAACCCTTTGGTACACCTTGCAAAATGTAACCCATCCTCCCATCCTGTGAAAGCGGCCTCTCGGGTTAGAGCTTTTCCACCCA

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000392561_chr12_114374941_-_2639nt
CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG
CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC
TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT
CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG
AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG
TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG
CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC
ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT
GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC
GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG
TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG
GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC
CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA
GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG
GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT
ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG
AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG
CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA
CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC
ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC
AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG
GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG
GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGGCTGCTGAGCTAGAATTCCC
ACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGTCACTTGGGACCACGAGCCCTGGTTC
AGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTCCCTGGCTGAGCTGAATGATGTCACT
CATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTGGCCAGCAGCATCCCCAGGCTTCTCT
CAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCCAGCACCAGGCAGAGGGCAAGACGGA
GAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGAGGTGCGACCTCAGACTAATGACATC
CTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGACAGTGCCAGAATTAAGTGAGTCAAGC

>In-frame_SH2B3_ENST00000341259_chr12_111856681_+_RBM19_ENST00000261741_chr12_114374941_-_3201nt
CCCGGGCCACCGCCTCCGCCCGGCTGCCCGCCCGGACTGTCGCGGCCCGCGGTGGCGACGGCGGCCGCTGCAAAGTTTCCCCGGCGGCGG
CGGCCCGGGGGCGCATCCTCCCGCAACTGTCAAGCGCTGGCGGCGGAAATGATGAGGCGCTGGCCATTTTCCGAGCCCGGGTTTCCTGCC
TGAGCCCCGCTCGAGCGAGCCGCGAGCGAGGAGCCGGCGGGCGGGAGAGGACGCGCCCAGGGCGGGGGCCCGCCCGCCCCCTCGGGATTT
CGAGGGCCCGGGGGCGCGCGACGCCATGGGCCGGCCGGGCCCAGAGCTCCTGTCTCTCAGCCCGGCCGCACCACCTGGGTCTCCGCCATG
AACGGGCCTGCCCTGCAGCCCTCCTCGCCCTCTTCCGCGCCCTCAGCCTCCCCGGCGGCGGCCCCGCGGGGCTGGAGCGAGTTCTGTGAG
TTGCACGCCGTAGCGGCGGCCCGGGAGCTGGCCCGCCAGTACTGGCTGTTCGCCCGGGAGCATCCGCAGCACGCGCCGCTGCGCGCCGAG
CTGGTGTCGCTGCAGTTCACCGACCTCTTCCAGCGCTACTTCTGCCGCGAGGTGCGCGACGGACGGGCGCCGGGCCGCGACTACCGGGAC
ACAGGCCGTGGGCCCCCAGCCAAGGCCGAGGCGTCCCCGGAGCCAGGCCCCGGCCCCGCCGCCCCTGGCCTGCCCAAGGCCCGCAGCTCT
GAGGAGCTGGCCCCGCCGCGGCCGCCCGGGCCCTGCTCCTTCCAGCACTTTCGCCGCAGCCTCCGCCACATCTTCCGCCGCCGCTCGGCC
GGGGAGCTGCCAGCGGCCCACACCGCTGCCGCCCCCGGGACCCCCGGAGAGGCTGCTGAGACCCCCGCCCGGCCTGGCCTGGCCAAGAAG
TTCCTGCCCTGGAGCCTGGCCCGGGAGCCGCCACCCGAGGCGCTGAAGGAGGCGGTGCTGCGCTACAGCCTGGCCGACGAGGCCTCCATG
GACAGCGGGGCACGCTGGCAGCGCGGGAGGCTGGCGCTGCGCCGGGCCCCGGGCCCCGATGGCCCCGACCGCGTGCTGGAGCTCTTCGAC
CCACCCAAGTTCCATCATGTCCCCCTCTATCTGGAGTGGGCTCCAGTTGGCGTCTTCTCCAGCACAGCCCCACAGAAGAAAAAGCTCCAA
GACACACCTTCAGAACCCATGGAAAAGGACCCAGCAGAGCCAGAAACAGTGCCTGATGGCGAAACCCCAGAAGATGAAAATCCAACAGAG
GAAGGAGCAGACAACTCTTCAGCAAAGATGGAAGAGGAGGAGGAGGAAGAGGAAGAAGAAGAAGAGAGCCTCCCAGGATGTACTCTGTTT
ATTAAGAATCTCAATTTTGACACAACAGAAGAGAAGCTGAAGGAAGTGTTTTCAAAAGTGGGGACAGTGAAGAGCTGCTCCATCTCCAAG
AAGAAGAACAAAGCAGGAGTGCTCCTTTCCATGGGGTTTGGATTTGTGGAATACAGGAAGCCGGAGCAAGCCCAGAAAGCTCTCAAGCAG
CTCCAGGGTCACGTCGTGGACGGCCACAAGCTGGAAGTGAGGATCTCGGAACGAGCCACTAAGCCAGCCGTGACATTGGCTCGGAAGAAA
CAAGTTCCCAGAAAGCAGACCACCTCCAAGATCCTGGTGCGGAACATCCCCTTCCAGGCCCACAGCCGGGAGATCCGAGAGCTCTTCAGC
ACCTTTGGGGAGTTGAAGACGGTCCGCCTGCCAAAGAAGATGACTGGGACAGGCACACACAGAGGCTTCGGCTTTGTGGACTTCCTCACC
AAGCAGGATGCGAAGAGAGCCTTCAACGCCCTGTGTCACAGCACCCACTTGTACGGGCGGAGGCTGGTGCTGGAGTGGGCCGACTCCGAG
GTGACCCTGCAGGCCCTGCGGCGGAAGACGGCCGCTCACTTTCACGAGCCCCCGAAGAAAAAGCGGTCTGTGGTGTTGGACGAGATCCTG
GAGCAGCTGGAAGGCAGTGACAGCGACAGCGAGGAGCAGACCCTTCAGCTGTGAGCTGGCACCGAGAGGGTGTGTGGCTCCGGGGCCCTG
GGGACCGGGACAGCCGCTCCAGCTTCTGCACTCACCACCATGTGGGCTGGGGGGCGGGGCGGGGAGCGGCAGGCGGCCCCACCCTGCACT
GGTCCAAGGTCGGAGGAGACAGGGGATGAGGAAGGCCTCAGGCCACTGCCCAGCGGCCCAGGCATCCTGGGTTTCACCAGTGACGCGTTC
TAGCAGACACTGACTGCGCACCTGCTCTGTAGCAGACACGGAAGAGTCCAAGGGAGCAGCCACGTTAGGAAGAGAGACTTGGGAACAGCT
ACACAGGGAGCTAGAACCCCTGCTCCCCCTGTCCCCACCCCAGGAGAGTAAGGGGACGAGGGCCAGCTCTCTGGCATCAGGCTGCTTGGA
CATGAAACCCCGTCTCCAAGCTCAAGCTGGGAGACCCTGGCCCAGTTTCCTTATCTCCTTGGGCCCAGCCTTCCCCTTGCTAGCTAGTTC
TTACTTCATAAGGTTTTAGAGAGAAATAAACGCAGTAATGCATGAAGAGTGCCGGGCATGGTGCTGAGCCCTGTTCCTGCTCTCCCTCCA
GGGCTGCTGAGCTAGAATTCCCACCTATGTCTTTCCAAGGGACTGTTCACGGCTTGGGACTTGGTCTCTGTCCTGCCCCATCCTCGTCAC
TTGGGACCACGAGCCCTGGTTCAGTCACCCAGGGAAGCCTCCCAGCGGCTCATGAAGCATCGAGCTCCAAGCCCAGATGCCAAGCTCCCT
GGCTGAGCTGAATGATGTCACTCATGGTGGACGCGTTCTGCTCACGGGCCCAGAGCCCTGTGAAATGCATCAAGGTCCTCTCCGCTGGCC
AGCAGCATCCCCAGGCTTCTCTCAGGCGCCCGTGTTCACATTTTCTCCAGCCTGAGACGCAGCCTCCCGCCTGGAAGGGCCTGTGCCAGC
ACCAGGCAGAGGGCAAGACGGAGAGGGCAGAGCAAGAACTGCACTGCATCTCACTGCAGTCTGAATCTAGACATCGCCATTCCCCGAGGT
GCGACCTCAGACTAATGACATCCTGGCTGAGCCTCTGTTTTTCTCTCTAGGAAATGGGGGTGATAATTGTGCCTACCTCAGATAGACAGT


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FusionGenePPI for SH2B3_RBM19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SH2B3LCK, GRB2, PLCG1, FLNA, ELAVL1, EGFR, ERBB2, ERBB3, TENC1RBM19FTSJ3, PTPN12, NXF1, FBXW11, HIST1H1A, NOL12, NIFK, ZC3H3, RPS8, BYSL, DDX27, DHX37, FBL, GRWD1, NOL10, RRP12, UTP18, TSR1, UTP15, IFI16, SRPK2, MEX3C, HIST1H1E, RPS14, HIST1H1T, GPATCH4, ZC3HAV1, ZCRB1, FGF3, FGF8, ZNF2, RPL7, RPL18, CDX1, H2AFY2, H2AFX, ZBTB48, RRS1, FOXA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SH2B3_RBM19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSH2B3Q9UQQ2DB06589PazopanibSH2B adapter protein 3small moleculeapproved

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RelatedDiseases for SH2B3_RBM19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSH2B3C0021368Inflammation1CTD_human
HgeneSH2B3C0024141Lupus Erythematosus, Systemic1CTD_human
HgeneSH2B3C0027051Myocardial Infarction1CTD_human;HPO
HgeneSH2B3C0042900Vitiligo1CTD_human
HgeneSH2B3C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneSH2B3C1956346Coronary Artery Disease1CTD_human